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Tag Content
iUUCD ID IUUC-Ocu-074221
Ensembl Protein ID ENSOCUP00000003181.2
UniProt Accession G1SK64; G1SK64_RABIT
Protein Name Tyrosine-protein kinase
Gene Name LCK
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSOCUG00000003668.3 ENSOCUT00000003670.3 ENSOCUP00000003181.2
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 2.90e-19 68.8 62 120
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
    ++++v++l++ye+++d++L ++kG++++++ eq+++W+k+++ ++g++G++P nFv+k++
   Q: 62 QDNLVIALHSYEPSHDGDLGFEKGEQLRIL---EQNGEWWKAQSLTTGQEGFIPFNFVAKAN 120
    6899**************************...**************************987 PP
   

Organism Oryctolagus cuniculus
Protein Sequence
(Fasta)
MGCSCSSNPE DDWMENIDVC ENCHYPIVPL EGKATLPIRN GSEVRDPLVT YEGSNPPASP 60
LQDNLVIALH SYEPSHDGDL GFEKGEQLRI LEQNGEWWKA QSLTTGQEGF IPFNFVAKAN 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Ocu-074221|UBD,SH3|Oryctolagus cuniculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGACCATGGG CTGTAGCTGC AGCTCAAACC CTGAAGATGA CTGGATGGAA AACATCGACG 60
TGTGTGAGAA CTGCCACTAC CCCATAGTCC CACTGGAAGG CAAGGCCACG GTAAGAGGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Ocu-074221|UBD,SH3|Oryctolagus cuniculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0001772--C:immunological synapse
GO:0045121--C:membrane raft
GO:0000242--C:pericentriolar material
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004722--F:protein serine/threonine phosphatase activity
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006882--P:cellular zinc ion homeostasis
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0050870--P:positive regulation of T cell activation
GO:0042493--P:response to drug
GO:0030217--P:T cell differentiation

KEGG ocu:100349102
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001315 Ailuropoda melanoleuca 92.04 0.00e+00 1020.00
IUUC-Apl-004134 Anas platyrhynchos 79.22 0.00e+00 718.00
IUUC-Bta-013264 Bos taurus 95.29 0.00e+00 1017.00
IUUC-Cja-019574 Callithrix jacchus 97.16 0.00e+00 707.00
IUUC-Cfa-021161 Canis familiaris 91.11 0.00e+00 1012.00
IUUC-Cpo-022492 Cavia porcellus 95.10 0.00e+00 1008.00
IUUC-Csa-023270 Chlorocebus sabaeus 77.65 0.00e+00 790.00
IUUC-Dre-028005 Danio rerio 74.16 0.00e+00 705.00
IUUC-Dno-029365 Dasypus novemcinctus 93.14 0.00e+00 976.00
IUUC-Dor-030892 Dipodomys ordii 90.46 0.00e+00 933.00
IUUC-Eca-033325 Equus caballus 94.52 0.00e+00 994.00
IUUC-Eeu-035004 Erinaceus europaeus 87.78 0.00e+00 795.00
IUUC-Fca-035908 Felis catus 97.06 0.00e+00 1033.00
IUUC-Fal-036804 Ficedula albicollis 70.42 0.00e+00 727.00
IUUC-Gmo-038984 Gadus morhua 63.88 0.00e+00 686.00
IUUC-Gga-040997 Gallus gallus 81.18 0.00e+00 884.00
IUUC-Gac-041854 Gasterosteus aculeatus 68.69 0.00e+00 726.00
IUUC-Gma-043628 Glycine max 31.84 3.00e-20 94.00
IUUC-Ggo-045238 Gorilla gorilla 91.48 0.00e+00 1014.00
IUUC-Hsa-047039 Homo sapiens 96.86 0.00e+00 1030.00
IUUC-Itr-048479 Ictidomys tridecemlineatus 96.27 0.00e+00 1023.00
IUUC-Lch-049568 Latimeria chalumnae 76.65 0.00e+00 832.00
IUUC-Loc-052222 Lepisosteus oculatus 66.67 0.00e+00 664.00
IUUC-Laf-054499 Loxodonta africana 90.93 0.00e+00 1009.00
IUUC-Mcc-054872 Macaca mulatta 76.41 0.00e+00 839.00
IUUC-Meu-056879 Macropus eugenii 90.86 0.00e+00 971.00
IUUC-Mtr-058765 Medicago truncatula 33.66 7.00e-20 92.80
IUUC-Mga-059971 Meleagris gallopavo 80.59 0.00e+00 875.00
IUUC-Mmr-060740 Microcebus murinus 96.47 0.00e+00 1028.00
IUUC-Mdo-062192 Monodelphis domestica 92.16 0.00e+00 986.00
IUUC-Mmu-064241 Mus musculus 95.49 0.00e+00 1020.00
IUUC-Mpu-066595 Mustela putorius furo 96.86 0.00e+00 1028.00
IUUC-Mlu-067069 Myotis lucifugus 95.50 0.00e+00 1017.00
IUUC-Opr-070472 Ochotona princeps 91.96 0.00e+00 1012.00
IUUC-Ont-071711 Oreochromis niloticus 67.71 0.00e+00 690.00
IUUC-Ola-087000 Oryzias latipes 68.37 0.00e+00 719.00
IUUC-Oga-088225 Otolemur garnettii 95.49 0.00e+00 1016.00
IUUC-Oar-090244 Ovis aries 86.76 0.00e+00 984.00
IUUC-Ptr-090751 Pan troglodytes 98.00 0.00e+00 722.00
IUUC-Pan-091804 Papio anubis 96.27 0.00e+00 1019.00
IUUC-Psi-093252 Pelodiscus sinensis 74.90 0.00e+00 796.00
IUUC-Pfo-096542 Poecilia formosa 67.57 0.00e+00 723.00
IUUC-Pab-098168 Pongo abelii 96.31 0.00e+00 976.00
IUUC-Pca-100547 Procavia capensis 95.34 0.00e+00 637.00
IUUC-Rno-105542 Rattus norvegicus 95.29 0.00e+00 1019.00
IUUC-Sha-107524 Sarcophilus harrisii 91.76 0.00e+00 988.00
IUUC-Sar-113235 Sorex araneus 88.77 0.00e+00 854.00
IUUC-Ssc-115624 Sus scrofa 96.27 0.00e+00 1025.00
IUUC-Tru-118559 Takifugu rubripes 66.92 0.00e+00 717.00
IUUC-Tca-121341 Theobroma cacao 36.76 7.00e-22 99.40
IUUC-Ttr-129002 Tursiops truncatus 87.41 0.00e+00 954.00
IUUC-Xtr-132224 Xenopus tropicalis 74.90 0.00e+00 816.00
Created Date 25-Jun-2017

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