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Tag Content
UUCD2 ID IUUC-Dre-028134
UUCD1 version UUC-DaR-01398
Ensembl Protein ID ENSDARP00000074782.3
UniProt Accession Q6PC30; CSN5_DANRE
Genbank Protein ID AAH59493.1
Protein Name COP9 signalosome complex subunit 5
Genbank Nucleotide ID BC059493
Gene Name cops5; zgc:73130
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSDARG00000057624.3 ENSDART00000080332.3 ENSDARP00000074782.3
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/JAMM 2.00e-07 31.7 136 149
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/JAMM
   S: 1    HSHPgftcwlSsVD 14
           HSHPg++cwlS++D
   Q: 136  HSHPGYGCWLSGID 149
           *************9 PP
   
Organism Danio rerio
Functional Description
(View)

Functional Description


     Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity. In the complex, it probably acts as the catalytic center that mediates the cleavage of nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex (By similarity).
 Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity. In the complex, it probably acts as the catalytic center that mediates the cleavage of nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex (By similarity).
Protein Sequence
(Fasta)
MAGSSIAMKT WELSNSMQEV QSIDEIYKYD KKQQQEILAA KPWTKDHHYF KYCKLSALAL 60
LKMVMHARSG GNLEVMGLML GKVDGETMII MDSFALPVEG TETRVNAQAA AYEYMAAYIE 120
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Protein Fasta Sequence


>IUUC-Dre-028134|DUB,JAMM|Danio rerio
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Nucleotide Sequence
(Fasta)
TCCTTAGTAA CCCGTACGGT CGCTCGCTTC GCTTCACTCA GGTTGTAGAG TTGTTCAGAA 60
AAGGAGTACT GCAAGAGCTT TGTTAATTAT TGCTAAATGA TCTATTTAAA TAGTTAGATA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dre-028134|DUB,JAMM|Danio rerio
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0736--Signalosome
KW-0862--Zinc
Interpro

IPR000555--JAMM/MPN+_dom
Pfam

PF01398--JAB
SMART

SM00232--JAB_MPN
Gene Ontology

GO:0008180--C:COP9 signalosome
GO:0048471--C:perinuclear region of cytoplasm
GO:0046872--F:metal ion binding
GO:0008237--F:metallopeptidase activity
KEGG dre:393698
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000468 Aegilops tauschii 65.97 2.00e-121 429.00
IUUC-Aml-001429 Ailuropoda melanoleuca 97.53 1.00e-177 615.00
IUUC-Atr-003048 Amborella trichopoda 67.94 9.00e-124 436.00
IUUC-Apl-003610 Anas platyrhynchos 88.55 3.00e-161 561.00
IUUC-Aca-004662 Anolis carolinensis 96.89 1.00e-154 538.00
IUUC-Aly-005914 Arabidopsis lyrata 66.67 5.00e-123 434.00
IUUC-Ath-007496 Arabidopsis thaliana 67.65 7.00e-124 437.00
IUUC-Ago-007860 Ashbya gossypii 43.21 1.00e-47 184.00
IUUC-Acl-008155 Aspergillus clavatus 54.38 5.00e-98 350.00
IUUC-Afu-008820 Aspergillus fumigatus 54.43 4.00e-98 351.00
IUUC-Ani-009303 Aspergillus nidulans 53.68 5.00e-96 344.00
IUUC-Ang-009617 Aspergillus niger 54.09 4.00e-94 338.00
IUUC-Aor-009888 Aspergillus oryzae 56.17 2.00e-95 342.00
IUUC-Ate-010575 Aspergillus terreus 56.44 1.00e-101 362.00
IUUC-Ame-010617 Astyanax mexicanus 97.62 0.00e+00 632.00
IUUC-Bgr-012019 Blumeria graminis 55.62 7.00e-102 363.00
IUUC-Bta-013211 Bos taurus 96.07 3.00e-179 620.00
IUUC-Bci-013645 Botrytis cinerea 57.89 7.00e-105 373.00
IUUC-Bdi-014727 Brachypodium distachyon 66.86 2.00e-117 415.00
IUUC-Bol-015205 Brassica oleracea 66.96 5.00e-121 427.00
IUUC-Bra-017649 Brassica rapa 66.96 5.00e-121 427.00
IUUC-Cel-018469 Caenorhabditis elegans 56.97 4.00e-104 371.00
IUUC-Cja-019703 Callithrix jacchus 96.37 2.00e-179 621.00
IUUC-Cfa-020181 Canis familiaris 96.37 2.00e-179 621.00
IUUC-Cpo-021499 Cavia porcellus 96.37 2.00e-179 621.00
IUUC-Cre-022735 Chlamydomonas reinhardtii 60.74 5.00e-112 397.00
IUUC-Csa-024200 Chlorocebus sabaeus 96.37 2.00e-179 621.00
IUUC-Cho-024915 Choloepus hoffmanni 96.15 3.00e-118 417.00
IUUC-Cin-025353 Ciona intestinalis 80.24 1.00e-138 485.00
IUUC-Csv-026118 Ciona savignyi 79.82 5.00e-140 490.00
IUUC-Cgl-026511 Colletotrichum gloeosporioides 52.34 9.00e-97 347.00
IUUC-Cne-026988 Cryptococcus neoformans 50.00 3.00e-85 308.00
IUUC-Dno-029658 Dasypus novemcinctus 96.37 2.00e-179 621.00
IUUC-Dor-031074 Dipodomys ordii 96.37 2.00e-179 621.00
IUUC-Dse-031497 Dothistroma septosporum 56.35 9.00e-98 350.00
IUUC-Dme-032199 Drosophila melanogaster 74.54 2.00e-142 498.00
IUUC-Ete-032739 Echinops telfairi 93.98 4.00e-81 294.00
IUUC-Eca-034095 Equus caballus 96.37 9.00e-180 622.00
IUUC-Eeu-034934 Erinaceus europaeus 81.87 2.00e-143 501.00
IUUC-Fca-035569 Felis catus 96.37 2.00e-179 621.00
IUUC-Fal-037553 Ficedula albicollis 97.55 2.00e-154 538.00
IUUC-Fox-037945 Fusarium oxysporum 49.55 6.00e-89 320.00
IUUC-Fso-038385 Fusarium solani 52.52 1.00e-95 342.00
IUUC-Gmo-039438 Gadus morhua 97.30 7.00e-179 619.00
IUUC-Ggr-039968 Gaeumannomyces graminis 51.85 2.00e-96 345.00
IUUC-Gga-040344 Gallus gallus 96.60 2.00e-176 611.00
IUUC-Gac-042256 Gasterosteus aculeatus 97.30 5.00e-179 620.00
IUUC-Gma-043226 Glycine max 66.09 2.00e-123 436.00
IUUC-Ggo-044523 Gorilla gorilla 90.55 1.00e-159 555.00
IUUC-Hsa-046659 Homo sapiens 96.37 2.00e-179 621.00
IUUC-Itr-048834 Ictidomys tridecemlineatus 96.66 4.00e-179 620.00
IUUC-Kpa-049139 Komagataella pastoris 57.86 2.00e-52 200.00
IUUC-Lch-049562 Latimeria chalumnae 97.00 0.00e+00 630.00
IUUC-Lpe-050737 Leersia perrieri 66.57 1.00e-125 442.00
IUUC-Loc-051798 Lepisosteus oculatus 97.55 6.00e-176 609.00
IUUC-Lma-052979 Leptosphaeria maculans 52.52 1.00e-93 337.00
IUUC-Laf-053391 Loxodonta africana 96.31 7.00e-116 409.00
IUUC-Mcc-055667 Macaca mulatta 96.37 2.00e-179 621.00
IUUC-Meu-056067 Macropus eugenii 67.44 3.00e-82 298.00
IUUC-Mor-057084 Magnaporthe oryzae 53.31 2.00e-98 352.00
IUUC-Mpo-057347 Magnaporthe poae 53.71 1.00e-98 352.00
IUUC-Mtr-057781 Medicago truncatula 68.37 5.00e-125 440.00
IUUC-Mla-059106 Melampsora laricipopulina 51.59 2.00e-102 365.00
IUUC-Mga-059473 Meleagris gallopavo 97.55 2.00e-154 538.00
IUUC-Mvi-060540 Microbotryum violaceum 54.78 1.00e-108 386.00
IUUC-Mmr-061138 Microcebus murinus 96.41 1.00e-97 348.00
IUUC-Mdo-062893 Monodelphis domestica 96.07 4.00e-179 620.00
IUUC-Mmu-063637 Mus musculus 96.07 3.00e-179 620.00
IUUC-Mac-064683 Musa acuminata 66.57 1.00e-127 449.00
IUUC-Mpu-066096 Mustela putorius furo 83.13 1.00e-144 505.00
IUUC-Mlu-067872 Myotis lucifugus 93.05 1.00e-171 595.00
IUUC-Nfi-068443 Neosartorya fischeri 53.78 3.00e-97 348.00
IUUC-Ncr-068953 Neurospora crassa 53.23 2.00e-91 328.00
IUUC-Nle-068972 Nomascus leucogenys 96.37 2.00e-179 621.00
IUUC-Opr-070215 Ochotona princeps 86.10 8.00e-152 529.00
IUUC-Ont-072538 Oreochromis niloticus 97.01 6.00e-179 619.00
IUUC-Oan-073143 Ornithorhynchus anatinus 96.37 2.00e-179 621.00
IUUC-Ocu-074197 Oryctolagus cuniculus 96.37 2.00e-179 621.00
IUUC-Oba-075884 Oryza barthii 61.60 4.00e-119 421.00
IUUC-Obr-076874 Oryza brachyantha 65.78 1.00e-123 436.00
IUUC-Ogl-077169 Oryza glaberrima 66.47 4.00e-123 434.00
IUUC-Ogu-078258 Oryza glumaepatula 66.47 6.00e-123 434.00
IUUC-Oin-079101 Oryza indica 61.88 2.00e-119 422.00
IUUC-Olo-080708 Oryza longistaminata 66.31 2.00e-96 345.00
IUUC-Ome-081571 Oryza meridionalis 61.88 2.00e-119 422.00
IUUC-Oni-082888 Oryza nivara 61.88 2.00e-119 422.00
IUUC-Opu-083182 Oryza punctata 66.47 4.00e-123 434.00
IUUC-Oru-084895 Oryza rufipogon 61.88 2.00e-119 422.00
IUUC-Osa-085331 Oryza sativa 66.47 4.00e-123 434.00
IUUC-Ola-086850 Oryzias latipes 97.90 1.00e-180 625.00
IUUC-Olu-087607 Ostreococcus lucimarinus 57.20 2.00e-80 292.00
IUUC-Oga-088640 Otolemur garnettii 97.53 2.00e-177 615.00
IUUC-Oar-090299 Ovis aries 97.22 3.00e-177 614.00
IUUC-Ptr-091499 Pan troglodytes 96.37 2.00e-179 621.00
IUUC-Pan-091751 Papio anubis 98.25 1.00e-154 539.00
IUUC-Psi-092978 Pelodiscus sinensis 95.68 5.00e-175 606.00
IUUC-Pma-094634 Petromyzon marinus 91.13 1.00e-168 585.00
IUUC-Pno-095094 Phaeosphaeria nodorum 51.83 6.00e-94 337.00
IUUC-Ppa-095440 Physcomitrella patens 69.32 2.00e-128 451.00
IUUC-Pfo-097332 Poecilia formosa 97.31 1.00e-179 622.00
IUUC-Pab-097998 Pongo abelii 96.37 2.00e-179 621.00
IUUC-Pop-098905 Populus trichocarpa 66.28 5.00e-130 457.00
IUUC-Pca-100521 Procavia capensis 98.26 8.00e-61 227.00
IUUC-Ppe-101309 Prunus persica 67.06 4.00e-130 457.00
IUUC-Pva-102953 Pteropus vampyrus 96.37 2.00e-179 621.00
IUUC-Pgr-103452 Puccinia graminis 60.29 2.00e-91 328.00
IUUC-Ptt-103777 Puccinia triticina 62.65 9.00e-88 317.00
IUUC-Pte-104273 Pyrenophora teres 52.37 1.00e-94 339.00
IUUC-Pyt-104627 Pyrenophora triticirepentis 52.68 1.00e-93 336.00
IUUC-Rno-105666 Rattus norvegicus 96.07 2.00e-178 618.00
IUUC-Sce-106319 Saccharomyces cerevisiae 39.81 6.00e-34 138.00
IUUC-Sha-106602 Sarcophilus harrisii 96.07 4.00e-179 620.00
IUUC-Sja-107822 Schizosaccharomyces japonicus 45.89 1.00e-47 182.00
IUUC-Spo-108318 Schizosaccharomyces pombe 40.26 4.00e-64 238.00
IUUC-Ssl-108428 Sclerotinia sclerotiorum 58.51 5.00e-106 377.00
IUUC-Smo-108821 Selaginella moellendorffii 66.47 1.00e-124 439.00
IUUC-Sit-110526 Setaria italica 66.37 2.00e-117 415.00
IUUC-Sly-111466 Solanum lycopersicum 65.99 9.00e-130 456.00
IUUC-Stu-112776 Solanum tuberosum 66.57 4.00e-130 457.00
IUUC-Sar-113459 Sorex araneus 96.07 3.00e-179 620.00
IUUC-Sbi-114873 Sorghum bicolor 66.86 1.00e-121 429.00
IUUC-Sre-114919 Sporisorium reilianum 63.14 7.00e-93 333.00
IUUC-Ssc-116102 Sus scrofa 96.37 2.00e-179 621.00
IUUC-Tgu-116937 Taeniopygia guttata 98.45 2.00e-138 484.00
IUUC-Tru-118615 Takifugu rubripes 96.71 8.00e-179 619.00
IUUC-Tsy-119173 Tarsius syrichta 96.12 2.00e-166 578.00
IUUC-Tni-120246 Tetraodon nigroviridis 96.71 6.00e-179 619.00
IUUC-Tca-121859 Theobroma cacao 68.47 2.00e-128 452.00
IUUC-Tre-122030 Trichoderma reesei 52.12 4.00e-96 344.00
IUUC-Tvi-122506 Trichoderma virens 53.45 3.00e-101 362.00
IUUC-Tae-125382 Triticum aestivum 65.97 3.00e-121 428.00
IUUC-Tur-126517 Triticum urartu 69.03 3.00e-119 421.00
IUUC-Tme-127122 Tuber melanosporum 56.59 6.00e-102 363.00
IUUC-Tbe-128108 Tupaia belangeri 95.17 1.00e-174 605.00
IUUC-Ttr-128644 Tursiops truncatus 96.37 2.00e-179 621.00
IUUC-Uma-129390 Ustilago maydis 51.48 8.00e-94 337.00
IUUC-Vda-129932 Verticillium dahliae 48.58 4.00e-90 324.00
IUUC-Vpa-130110 Vicugna pacos 96.37 2.00e-179 621.00
IUUC-Vvi-131534 Vitis vinifera 68.25 3.00e-131 461.00
IUUC-Xtr-132739 Xenopus tropicalis 97.29 0.00e+00 630.00
IUUC-Xma-133919 Xiphophorus maculatus 97.60 5.00e-180 623.00
IUUC-Yli-134677 Yarrowia lipolytica 48.58 7.00e-91 327.00
IUUC-Zma-135578 Zea mays 67.26 1.00e-122 432.00
Created Date 25-Jun-2017

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