iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mtr-058551

Ensembl Protein ID

AES88130

UniProt Accession

G7JDJ8; G7JDJ8_MEDTR

Genbank Protein ID

AES88130.1; AFK45436.1

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

CM001220; BT145642

Gene Name

MTR_4g048220

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
MTR_4g048220	AES88129	AES88129
MTR_4g048220	KEH29679	KEH29679
MTR_4g048220	KEH29678	KEH29678
MTR_4g048220	AES88130	AES88130

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.20e-111	375.3	8	530

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveaheesitele 101
           YDRQ+r+wG+++q++l++++++l+++g++G+E+lKnLvl+G+gsitvvD+++vev +l+++FL+++ + g +KA++++ +l+eln+ v+++  ee +++l 
   Q: 8    YDRQLRIWGDQGQAALEKSNICLLNCGPTGSETLKNLVLGGIGSITVVDGSKVEVGDLGNNFLVDEASLGEPKAKIVCSFLQELNDAVKAKYIEEYPDKLI 108
           ***************************************************************************************************** PP
   S: 102  eeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfctlketpn.........aaehtiew 189
           e+++ Ff++f++Vv+++  ++++ k++++c++a+v li ++++Gl G+vr+++k++t+++s+++   d++++++P+++lk + +         +a+++i++
   Q: 109  ETNPsFFSQFTLVVATQLVESSMVKLDKICREANVILIFARSYGLAGFVRISLKEHTVIESKPEhflDDLRLNNPWPELKRFAEgfelnvhdpVAHKHIPY 209
           **********************************************************************************99999999999******** PP
   S: 190  avlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttins.ikqllksfecdivtkskspfwv............... 274
           +v++ k+++e+a+++ ++ ++++eek+e+k++ k+++++ de+n++ea+e ++k fa++ i+s  + +l++ +  +v +s+s+fwv               
   Q: 210  VVILVKMADEWAKSHGGRLPSTREEKKEFKELLKAGMVAPDEDNYKEAMESSFKVFAPRGISSeLQLILND-SSVEVDSSSSDFWVlvaalkdfvaneggg 309
           ***************************************************************55555655.77799************************ PP
   S: 275  ............................................................sfcsnaealq............................... 284
                                                                       sfc+na++l+                               
   Q: 310  eaplegsipdmtssteqyvnlqniyqakaeadflaiermarntlkkigrdpnsipratikSFCKNARKLKvcryrpiedefnspnlselqkyltdedhrlc 410
           **********************************************************************7777666666655555544444443333333 PP
   S: 285  ...vpekvekdeevvkasap........lylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiep.kldddlikeiagniipaiattn 373
              v++ ++          p        +y+llra++rf+++++r pg+++  +d+d + +l+ +  +l   +lg+++  l ddli e++++++++++ ++
   Q: 411  pfiVNSPNL----------PelqnfavgIYILLRAVDRFAANYNRFPGQFDSAMDED-IARLKSTSISLL-NELGCNSaTLADDLINEMCRFGASELHAVA 499
           333334444..........155555666*****************************.778887777776.9***************************** PP
   S: 374  avvgGlaaqEviKvvsgkfeplknfflfdae 404
           a vgG+a+qEviK+++ +f+p+  +++f+++
   Q: 500  ALVGGIASQEVIKLITRQFVPITGTYIFNGI 530
           ****************************986 PP

Organism

Medicago truncatula

Functional Description
(View)

Regulatory subunit of the dimeric E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1.

Protein Sequence
(Fasta)

MAEPKVKYDR QLRIWGDQGQ AALEKSNICL LNCGPTGSET LKNLVLGGIG SITVVDGSKV 60
EVGDLGNNFL VDEASLGEPK AKIVCSFLQE LNDAVKAKYI EEYPDKLIET NPSFFSQFTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTTTTATTT ATTTTCATTT TTGTGCACCA TACCAAAGAA TATGCCCTTG GGTAGGCTAG 60
ATGGCACCCC CAAATCTTCC TAGACTCAAG TTTATACAAA GTGAGAGTAG AGAAGAAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	65.50	0.00e+00	731.00
IUUC-Aml-002333	Ailuropoda melanoleuca	40.00	5.00e-122	430.00
IUUC-Atr-002644	Amborella trichopoda	69.94	0.00e+00	743.00
IUUC-Apl-003446	Anas platyrhynchos	39.93	1.00e-114	406.00
IUUC-Aca-004450	Anolis carolinensis	38.93	3.00e-120	424.00
IUUC-Aly-005466	Arabidopsis lyrata	73.52	0.00e+00	827.00
IUUC-Ath-006692	Arabidopsis thaliana	73.89	0.00e+00	829.00
IUUC-Ago-007900	Ashbya gossypii	26.19	5.00e-36	144.00
IUUC-Acl-008333	Aspergillus clavatus	32.80	1.00e-66	246.00
IUUC-Afl-008529	Aspergillus flavus	33.04	1.00e-75	276.00
IUUC-Afu-009071	Aspergillus fumigatus	31.75	8.00e-66	244.00
IUUC-Ani-009443	Aspergillus nidulans	30.12	1.00e-60	226.00
IUUC-Ang-009669	Aspergillus niger	31.51	9.00e-73	267.00
IUUC-Aor-009914	Aspergillus oryzae	32.92	9.00e-75	273.00
IUUC-Ate-010450	Aspergillus terreus	32.68	9.00e-74	270.00
IUUC-Ame-011183	Astyanax mexicanus	38.91	6.00e-120	423.00
IUUC-Bgr-012111	Blumeria graminis	33.21	2.00e-58	219.00
IUUC-Bta-012583	Bos taurus	40.29	5.00e-124	437.00
IUUC-Bci-013892	Botrytis cinerea	32.49	2.00e-55	209.00
IUUC-Bdi-014592	Brachypodium distachyon	65.36	0.00e+00	730.00
IUUC-Bol-016399	Brassica oleracea	73.84	0.00e+00	831.00
IUUC-Bra-017506	Brassica rapa	69.50	0.00e+00	782.00
IUUC-Cel-018456	Caenorhabditis elegans	31.64	7.00e-69	254.00
IUUC-Cja-020007	Callithrix jacchus	39.57	3.00e-121	428.00
IUUC-Cfa-020324	Canis familiaris	40.14	7.00e-124	436.00
IUUC-Cpo-022248	Cavia porcellus	34.73	5.00e-64	238.00
IUUC-Csa-023149	Chlorocebus sabaeus	38.12	8.00e-95	340.00
IUUC-Cho-024537	Choloepus hoffmanni	33.89	5.00e-81	294.00
IUUC-Cin-025763	Ciona intestinalis	38.67	2.00e-105	375.00
IUUC-Csv-026113	Ciona savignyi	37.55	3.00e-102	364.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	29.65	4.00e-55	208.00
IUUC-Cne-026884	Cryptococcus neoformans	33.09	2.00e-67	249.00
IUUC-Cme-027210	Cyanidioschyzon merolae	24.55	6.00e-15	75.10
IUUC-Dre-028140	Danio rerio	39.67	4.00e-123	434.00
IUUC-Dno-030033	Dasypus novemcinctus	39.87	8.00e-104	370.00
IUUC-Dor-030513	Dipodomys ordii	33.47	6.00e-36	144.00
IUUC-Dse-031536	Dothistroma septosporum	32.39	2.00e-70	259.00
IUUC-Dme-031683	Drosophila melanogaster	36.90	2.00e-96	345.00
IUUC-Ete-032420	Echinops telfairi	35.88	5.00e-102	364.00
IUUC-Eca-033992	Equus caballus	38.48	4.00e-94	337.00
IUUC-Eeu-034713	Erinaceus europaeus	33.06	4.00e-35	142.00
IUUC-Fca-036548	Felis catus	39.75	2.00e-122	431.00
IUUC-Fal-037600	Ficedula albicollis	40.04	8.00e-115	406.00
IUUC-Fox-038037	Fusarium oxysporum	32.41	5.00e-53	201.00
IUUC-Fso-038387	Fusarium solani	31.86	2.00e-63	236.00
IUUC-Gmo-038562	Gadus morhua	37.85	3.00e-115	408.00
IUUC-Ggr-040005	Gaeumannomyces graminis	34.67	1.00e-56	213.00
IUUC-Gga-041129	Gallus gallus	39.49	6.00e-116	410.00
IUUC-Gac-042558	Gasterosteus aculeatus	38.62	4.00e-117	414.00
IUUC-Gma-043610	Glycine max	85.34	0.00e+00	904.00
IUUC-Ggo-045611	Gorilla gorilla	40.52	8.00e-121	426.00
IUUC-Hsa-046563	Homo sapiens	40.74	4.00e-122	431.00
IUUC-Hvu-047790	Hordeum vulgare	61.73	4.00e-148	516.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	40.65	1.00e-122	432.00
IUUC-Kpa-049309	Komagataella pastoris	34.40	6.00e-72	264.00
IUUC-Lch-050038	Latimeria chalumnae	38.31	2.00e-115	408.00
IUUC-Lpe-051535	Leersia perrieri	64.31	0.00e+00	657.00
IUUC-Loc-051917	Lepisosteus oculatus	36.20	6.00e-103	367.00
IUUC-Lma-053112	Leptosphaeria maculans	30.91	7.00e-73	267.00
IUUC-Laf-053690	Loxodonta africana	40.83	2.00e-123	435.00
IUUC-Mcc-055117	Macaca mulatta	39.64	8.00e-118	416.00
IUUC-Meu-056761	Macropus eugenii	34.41	4.00e-90	324.00
IUUC-Mor-057230	Magnaporthe oryzae	31.96	2.00e-66	245.00
IUUC-Mpo-057514	Magnaporthe poae	32.44	1.00e-64	239.00
IUUC-Mla-059183	Melampsora laricipopulina	33.51	9.00e-82	296.00
IUUC-Mga-060144	Meleagris gallopavo	39.29	4.00e-113	400.00
IUUC-Mvi-060221	Microbotryum violaceum	33.21	1.00e-69	256.00
IUUC-Mmr-061325	Microcebus murinus	39.35	3.00e-118	418.00
IUUC-Mdo-062532	Monodelphis domestica	40.77	1.00e-123	435.00
IUUC-Mmu-063956	Mus musculus	40.11	6.00e-123	433.00
IUUC-Mac-064521	Musa acuminata	68.41	0.00e+00	758.00
IUUC-Mpu-066716	Mustela putorius furo	39.69	3.00e-113	401.00
IUUC-Mlu-067459	Myotis lucifugus	41.21	7.00e-124	436.00
IUUC-Nfi-068245	Neosartorya fischeri	32.27	5.00e-66	244.00
IUUC-Ncr-068910	Neurospora crassa	33.33	3.00e-69	255.00
IUUC-Nle-070034	Nomascus leucogenys	39.18	8.00e-116	410.00
IUUC-Opr-070552	Ochotona princeps	36.73	2.00e-94	338.00
IUUC-Ont-071426	Oreochromis niloticus	38.39	1.00e-120	426.00
IUUC-Oan-073389	Ornithorhynchus anatinus	37.86	8.00e-89	320.00
IUUC-Ocu-074911	Oryctolagus cuniculus	40.47	4.00e-124	437.00
IUUC-Oba-075437	Oryza barthii	67.04	0.00e+00	707.00
IUUC-Obr-076684	Oryza brachyantha	66.73	0.00e+00	668.00
IUUC-Ogl-077170	Oryza glaberrima	67.04	0.00e+00	707.00
IUUC-Ogu-078844	Oryza glumaepatula	66.21	0.00e+00	657.00
IUUC-Oin-079105	Oryza indica	66.85	0.00e+00	703.00
IUUC-Olo-080943	Oryza longistaminata	64.12	0.00e+00	634.00
IUUC-Oni-082891	Oryza nivara	64.62	0.00e+00	677.00
IUUC-Opu-083457	Oryza punctata	66.85	0.00e+00	706.00
IUUC-Oru-084960	Oryza rufipogon	64.06	0.00e+00	636.00
IUUC-Osa-085358	Oryza sativa	66.67	0.00e+00	700.00
IUUC-Ola-086420	Oryzias latipes	35.71	7.00e-74	270.00
IUUC-Olu-087625	Ostreococcus lucimarinus	31.41	5.00e-58	218.00
IUUC-Oga-088810	Otolemur garnettii	40.14	5.00e-123	434.00
IUUC-Oar-089196	Ovis aries	40.43	1.00e-122	432.00
IUUC-Ptr-090617	Pan troglodytes	40.74	2.00e-122	432.00
IUUC-Pan-092761	Papio anubis	40.47	5.00e-123	434.00
IUUC-Psi-093191	Pelodiscus sinensis	39.14	2.00e-118	418.00
IUUC-Pma-094380	Petromyzon marinus	40.39	1.00e-107	382.00
IUUC-Pno-095084	Phaeosphaeria nodorum	31.44	3.00e-62	233.00
IUUC-Ppa-095798	Physcomitrella patens	55.19	5.00e-178	616.00
IUUC-Pfo-096467	Poecilia formosa	38.89	2.00e-115	409.00
IUUC-Pab-098255	Pongo abelii	40.13	3.00e-100	358.00
IUUC-Pop-099722	Populus trichocarpa	76.62	0.00e+00	852.00
IUUC-Pca-100807	Procavia capensis	47.06	3.00e-50	192.00
IUUC-Ppe-101280	Prunus persica	78.48	0.00e+00	864.00
IUUC-Pva-102333	Pteropus vampyrus	39.35	9.00e-117	413.00
IUUC-Pgr-103401	Puccinia graminis	29.17	5.00e-68	251.00
IUUC-Ptt-103889	Puccinia triticina	28.25	5.00e-62	231.00
IUUC-Pte-104355	Pyrenophora teres	33.04	2.00e-71	262.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	33.04	6.00e-73	267.00
IUUC-Rno-105810	Rattus norvegicus	40.56	2.00e-122	431.00
IUUC-Sce-106397	Saccharomyces cerevisiae	29.53	4.00e-32	131.00
IUUC-Sha-106770	Sarcophilus harrisii	43.59	1.00e-68	251.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	30.67	3.00e-70	258.00
IUUC-Spo-108276	Schizosaccharomyces pombe	31.59	7.00e-76	277.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	32.61	6.00e-58	218.00
IUUC-Smo-109296	Selaginella moellendorffii	52.52	2.00e-162	564.00
IUUC-Sit-110157	Setaria italica	67.35	0.00e+00	758.00
IUUC-Sly-111105	Solanum lycopersicum	76.25	0.00e+00	851.00
IUUC-Stu-112469	Solanum tuberosum	76.62	0.00e+00	855.00
IUUC-Sar-113083	Sorex araneus	37.20	4.00e-42	165.00
IUUC-Sbi-113813	Sorghum bicolor	66.60	0.00e+00	756.00
IUUC-Sre-115058	Sporisorium reilianum	30.87	5.00e-70	258.00
IUUC-Tgu-116772	Taeniopygia guttata	40.99	5.00e-115	407.00
IUUC-Tru-118686	Takifugu rubripes	37.84	1.00e-119	422.00
IUUC-Tsy-119111	Tarsius syrichta	40.88	4.00e-59	221.00
IUUC-Tni-120231	Tetraodon nigroviridis	35.45	7.00e-102	363.00
IUUC-Tca-121491	Theobroma cacao	80.15	0.00e+00	851.00
IUUC-Tre-122103	Trichoderma reesei	32.14	3.00e-68	252.00
IUUC-Tae-125316	Triticum aestivum	66.29	0.00e+00	738.00
IUUC-Tur-126487	Triticum urartu	64.73	0.00e+00	711.00
IUUC-Tme-127097	Tuber melanosporum	34.73	5.00e-80	291.00
IUUC-Ttr-128465	Tursiops truncatus	38.27	3.00e-108	385.00
IUUC-Uma-129645	Ustilago maydis	30.02	9.00e-70	257.00
IUUC-Vda-129989	Verticillium dahliae	28.73	3.00e-48	185.00
IUUC-Vpa-130529	Vicugna pacos	39.35	9.00e-113	400.00
IUUC-Vvi-131059	Vitis vinifera	78.11	0.00e+00	865.00
IUUC-Xtr-132002	Xenopus tropicalis	41.05	3.00e-122	431.00
IUUC-Xma-133930	Xiphophorus maculatus	38.81	6.00e-119	420.00
IUUC-Yli-134505	Yarrowia lipolytica	31.66	3.00e-81	295.00
IUUC-Zma-135895	Zea mays	64.99	0.00e+00	740.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence