iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aly-006358

Ensembl Protein ID

scaffold_603626.1

UniProt Accession

D7M0C1; D7M0C1_ARALL

Genbank Protein ID

EFH50992.1

Protein Name

WD-40 repeat family protein

Genbank Nucleotide ID

GL348718

Gene Name

CCS52A2; ARALYDRAFT_911569

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
scaffold_603626.1	scaffold_603626.1	scaffold_603626.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.20e-24	83.8	289	319
E3 adaptor/Cullin RING/APC_C/CDC20	9.40e-142	472.4	155	456
UBD/Beta-Prp	3.30e-42	145.4	210	450

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWD 29
           gH++++++l++  +++ l+sG++D+++ vW+
   Q: 289  GHKSEICGLKWsfDNRELASGGNDNKLFVWN 319
           8***********54499*************9 PP

E3 adaptor/Cullin RING/APC_C/CDC20

   S: 1    pekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladleekdlvtsvswieegtllavGtkkgeveiyDveekkkvrtl 92
           p+kvldap l+ddfylnL+dWs++nvlav+Lg++vylw+a++++v+kl+dl  +++v+sv w  +gt+la+Gt++g+v+i+Dv +++++rt+
   Q: 155  PYKVLDAPALQDDFYLNLVDWSAHNVLAVGLGNCVYLWNACSSNVTKLCDLGVDESVCSVGWALRGTHLAIGTSSGTVQIWDVLRCNRIRTM 246
           79****************************************************************************************** PP
   S: 93   tghsarvgaLsWnaevlssGsrdgeilhrdvrvkelklstlqahaqevCGlkwnedaklLasGGnDnsvsvwdasssePlkkfkehkaavka 184
           +gh  rvgaL+W + vlssGsrd++il+rd+r++e ++s+l++h++e+CGlkw+ d+++LasGGnDn++ vw+++s++P+ ++ eh aavka
   Q: 247  EGHRLRVGALAWSSSVLSSGSRDKSILQRDIRTQEDHVSKLKGHKSEICGLKWSFDNRELASGGNDNKLFVWNQHSTQPVLRYCEHAAAVKA 338
           ******************************************************************************************** PP
   S: 185  iawsPwqkslLasGGGtaDrcikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkypslskvaelkgheaRvlslals 276
           iawsP++++lLasGGGtaDrci+fwnt+t + l++idt+sqvc+l+wsk+ +elvsthG+++n+i++wkyp++sk+a+l+gh++Rvl+la+s
   Q: 339  IAWSPHHHGLLASGGGTADRCIRFWNTTTNTHLSCIDTNSQVCNLVWSKNVNELVSTHGYSQNQIIVWKYPTMSKLATLTGHTYRVLYLAVS 430
           ******************************************************************************************** PP
   S: 277  pdgeaivtaagDetlrfwklfdkkka 302
           pdg++ivt+agDetlrfw++f + k+
   Q: 431  PDGQTIVTGAGDETLRFWNVFPSPKS 456
           *********************87665 PP

UBD/Beta-Prp

   S: 12   vitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsf 102
            +++v ++  +++la g  +gt+++wdv + + +r+++gh   v a+ +s++  +l +gs+D+ i   d++ + + v++lkgh+++++ l++
   Q: 210  SVCSVGWALRGTHLAIGTSSGTVQIWDVLRCNRIRTMEGHRLRVGALAWSSS--VLSSGSRDKSILQRDIRtQEDHVSKLKGHKSEICGLKW 299
           566688888999****************************************..9*******99988899945689**************** PP
   S: 103  spsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsG..slDrtvrlWdlktgkllrtltgghtdsvyslsfdsn 191
           s ++  l+sG++d+ + vw+ ++ q +     +h ++v  ++++p    ll+sG  ++Dr++r+W+  t++ l       +++v  l +++n
   Q: 300  SFDNRELASGGNDNKLFVWNQHSTQPVL-RYCEHAAAVKAIAWSPHHhGLLASGggTADRCIRFWNTTTNTHLSCID--TNSQVCNLVWSKN 388
           ***************************9.999***************9*****73369************9999995..5999********* PP
   S: 192  gkelvs..gsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdl 251
            +elvs  g   +++++w + t + + tl+ght  v+ +++sp+++ +v+g+ D+++r+W++
   Q: 389  VNELVSthGYSQNQIIVWKYPTMSKLATLTGHTYRVLYLAVSPDGQTIVTGAGDETLRFWNV 450
           *****977889*************************************************95 PP

Organism

Arabidopsis lyrata

Protein Sequence
(Fasta)

MEEDESTTPK KKTDSQLNLP PSMNRPTVSL ESRINRLIDS NHYHSPSKPI YSDRFIPSRS 60
GSNFALFDLA SSSPKKDGKE DGAGSYASLL KTALFGPVTP EKSDVVNGFS PSRNIFRFKT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTAAGAGGTT GAAATCAACC ATGGAAGAAG ATGAATCAAC AACACCGAAG AAGAAGACAG 60
ATTCTCAGCT GAATCTTCCA CCGTCGATGA ATCGACCGAC GGTCTCACTT GAGTCACGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0010492--P:maintenance of shoot apical meristem identity
GO:0032877--P:positive regulation of DNA endoreduplication
GO:1904668--P:positive regulation of ubiquitin protein ligase activity
GO:0008361--P:regulation of cell size

KEGG

aly:ARALYDRAFT_911569

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ath-006892	Arabidopsis thaliana	96.63	0.00e+00	869.00
IUUC-Bol-015548	Brassica oleracea	85.36	0.00e+00	796.00
IUUC-Bra-018065	Brassica rapa	85.53	0.00e+00	767.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence