iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
Mentha
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.10e-67	226.5	177	475

Active Site

Position(s)	Description	Evidence
185	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
435	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflafl 99
           Gl NlgN+C++NSv Qc +++ +l e ll+ ++ +++     ++  +++++++  +e+ +  ++  ++p  +++ l+ +++ f+ y+q+Da+Efl+ +
   Q: 177  GLWNLGNSCFLNSVFQCFTHTVPLIESLLS-FRYEVPCHC-GNEFFCVIRAIRYHIEAALRPERCPIAPYFFFDNLNYFSPDFQRYQQEDAHEFLQAF 272
           9*****************************.777776654.68899**************************************************** PP
   S: 100  ldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftke 197
           l++le                          ++++  +++ + +d+F g+l s ++c +cd vs+++e+ + lsl++++ +     +l ++Lesft+ 
   Q: 273  LEKLEICG-----------------------SDRTSFRGDITSQDVFSGRLISGLRCCNCDYVSETYEKSVGLSLEIEDVD-----TLGSALESFTRV 342
           ****9877.......................568899999*****************************************.....9*********** PP
   S: 198  eelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG.slssGH 294
           e+l+  +++ c++c++k+  ek+l l+klP v ++hLkRf  ++++   eki k+v++ple+dl+p++ + +e++ +++kY L+a v H G s+  GH
   Q: 343  EKLD--EQLTCDNCNEKVSKEKQLLLDKLPLVATFHLKRF--KNNGLYMEKIYKHVKIPLEIDLQPYMRNIQENE-VSTKYHLYALVEHFGySVAYGH 435
           ***8..58********************************..78889999********************88776.6********************* PP
   S: 295  YvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           Y +yv++  + W +fdDskVt ++e+ vl+   ++ Y+lfY r
   Q: 436  YSSYVRSAPKIWHHFDDSKVTRIDEDMVLS---QDSYILFYAR 475
           *******9999*******************...********87 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Protein Sequence
(Fasta)

MLMAKPDVPS SILPRSSSIL PNSIETLDEN ESIEAQVNNV QSLALSSPNR DRSDDDDNNN 60
NHDSVSIPPP IYDGYSSSSS DESQSVPSPP INLDHDDDEC QIPIRNTSQA LDDIDDDIWG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACACACTTT ACAGTTTTAC GACGCCCAAA ATTCAATTCC CGGAGATTAA AAACCCTAAA 60
ACAAACACTG GCGATTCGAT TTTCCCTCCC AATTCAAATC ATCTCTTAAT CTTCTTCTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT4G17895

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-006314	Arabidopsis lyrata	84.38	0.00e+00	1033.00
IUUC-Bol-015783	Brassica oleracea	59.63	2.00e-171	595.00
IUUC-Bra-017262	Brassica rapa	59.25	1.00e-174	606.00
IUUC-Dor-031053	Dipodomys ordii	30.86	4.00e-35	142.00
IUUC-Gma-044214	Glycine max	53.47	5.00e-107	381.00
IUUC-Mtr-057925	Medicago truncatula	52.94	1.00e-102	366.00
IUUC-Mac-065610	Musa acuminata	43.90	5.00e-78	284.00
IUUC-Sly-111383	Solanum lycopersicum	52.33	1.00e-106	380.00
IUUC-Stu-112476	Solanum tuberosum	52.87	1.00e-103	370.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence