iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pab-098203

Ensembl Protein ID

ENSPPYP00000022019.2

UniProt Accession

H2PTI8; H2PTI8_PONAB

Genbank Protein ID

ENSPPYP00000022019

Protein Name

Ubiquitin-related modifier 1

Genbank Nucleotide ID

ABGA01253120

Gene Name

URM1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000019649.2	ENSPPYT00000022926.2	ENSPPYP00000022019.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UDP/UBQ/UBQ_Other	42.42	2.00e-14	71.60	IUUC-Sce-106366

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Pongo abelii

Functional Description
(View)

Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.

Protein Sequence
(Fasta)

MAAPLSVDVE FGGGAELLFD GIKKHRVTLP GQEEPWDIRN LLIWIKKNLL KERPELFIQG 60
DSVRPGILVL INDADWELLG ELDYQLQDQD SVLFISTLHG G 101

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Nucleotide Sequence
(Fasta)

CCTCGATGTC TTCCTCCAAC AGCTGACGAA GCTGGATTCC TGGGCACCGC CTTTTCCGTC 60
CGCGGCGCCC GGAGACACCC GGAAATTTGC GGGCGCGCCG GAAGTTGAGG GGAGTTTCCT 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway

Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1

Pfam

PF09138--Urm1

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016783--F:sulfurtransferase activity
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002254	Ailuropoda melanoleuca	96.04	5.00e-53	198.00
IUUC-Atr-003089	Amborella trichopoda	55.56	1.00e-29	120.00
IUUC-Apl-003382	Anas platyrhynchos	86.81	8.00e-43	164.00
IUUC-Aca-004981	Anolis carolinensis	83.17	2.00e-47	179.00
IUUC-Aly-005517	Arabidopsis lyrata	53.26	2.00e-27	112.00
IUUC-Ath-006718	Arabidopsis thaliana	53.57	6.00e-24	101.00
IUUC-Ago-007917	Ashbya gossypii	42.42	3.00e-19	86.30
IUUC-Acl-008054	Aspergillus clavatus	66.00	4.00e-15	72.40
IUUC-Afl-008704	Aspergillus flavus	55.06	2.00e-20	89.70
IUUC-Aor-009890	Aspergillus oryzae	57.43	5.00e-25	105.00
IUUC-Bta-012448	Bos taurus	94.06	2.00e-52	196.00
IUUC-Bci-013865	Botrytis cinerea	46.53	2.00e-21	93.60
IUUC-Bdi-014980	Brachypodium distachyon	60.71	4.00e-24	102.00
IUUC-Bol-016055	Brassica oleracea	55.00	9.00e-24	101.00
IUUC-Bra-016845	Brassica rapa	55.00	9.00e-24	101.00
IUUC-Cel-018485	Caenorhabditis elegans	33.98	1.00e-11	60.80
IUUC-Cja-019587	Callithrix jacchus	96.04	5.00e-53	198.00
IUUC-Cfa-020653	Canis familiaris	93.07	4.00e-52	195.00
IUUC-Cpo-021622	Cavia porcellus	96.04	5.00e-53	198.00
IUUC-Cre-023015	Chlamydomonas reinhardtii	53.06	4.00e-25	105.00
IUUC-Csa-023756	Chlorocebus sabaeus	96.20	4.00e-40	156.00
IUUC-Cgl-026518	Colletotrichum gloeosporioides	45.54	1.00e-20	90.90
IUUC-Cne-026953	Cryptococcus neoformans	56.31	2.00e-27	114.00
IUUC-Cme-027314	Cyanidioschyzon merolae	42.27	8.00e-18	81.30
IUUC-Dre-027884	Danio rerio	77.23	4.00e-44	168.00
IUUC-Dno-029262	Dasypus novemcinctus	92.59	3.00e-39	154.00
IUUC-Dor-030601	Dipodomys ordii	65.35	1.00e-27	113.00
IUUC-Dme-031893	Drosophila melanogaster	64.71	2.00e-32	130.00
IUUC-Ete-032773	Echinops telfairi	89.11	1.00e-47	180.00
IUUC-Eca-034187	Equus caballus	95.05	9.00e-53	197.00
IUUC-Eeu-034808	Erinaceus europaeus	92.08	2.00e-51	192.00
IUUC-Fca-036107	Felis catus	94.06	2.00e-52	196.00
IUUC-Fal-036607	Ficedula albicollis	85.71	2.00e-42	162.00
IUUC-Fox-037698	Fusarium oxysporum	48.08	2.00e-23	100.00
IUUC-Gmo-039492	Gadus morhua	74.26	2.00e-43	166.00
IUUC-Ggr-039965	Gaeumannomyces graminis	47.12	7.00e-20	89.40
IUUC-Gga-041268	Gallus gallus	86.14	4.00e-48	182.00
IUUC-Gac-042111	Gasterosteus aculeatus	78.22	5.00e-46	175.00
IUUC-Gma-043240	Glycine max	53.57	8.00e-23	97.80
IUUC-Ggo-045176	Gorilla gorilla	98.73	2.00e-32	131.00
IUUC-Hsa-046077	Homo sapiens	99.01	2.00e-45	173.00
IUUC-Itr-048111	Ictidomys tridecemlineatus	96.63	6.00e-38	147.00
IUUC-Kpa-049157	Komagataella pastoris	47.47	7.00e-20	88.20
IUUC-Lch-049889	Latimeria chalumnae	79.21	2.00e-45	173.00
IUUC-Lpe-050783	Leersia perrieri	59.04	4.00e-23	99.00
IUUC-Loc-052400	Lepisosteus oculatus	78.22	5.00e-45	171.00
IUUC-Lma-053259	Leptosphaeria maculans	45.54	1.00e-20	90.90
IUUC-Laf-053596	Loxodonta africana	93.20	5.00e-51	191.00
IUUC-Mcc-054845	Macaca mulatta	91.84	2.00e-47	179.00
IUUC-Meu-055968	Macropus eugenii	91.09	1.00e-50	190.00
IUUC-Mor-057126	Magnaporthe oryzae	45.19	9.00e-19	85.10
IUUC-Mpo-057311	Magnaporthe poae	48.51	5.00e-21	92.80
IUUC-Mtr-058266	Medicago truncatula	51.16	2.00e-22	97.10
IUUC-Mla-058847	Melampsora laricipopulina	40.78	6.00e-12	62.40
IUUC-Mga-059468	Meleagris gallopavo	86.81	7.00e-43	164.00
IUUC-Mvi-060235	Microbotryum violaceum	36.42	4.00e-19	86.70
IUUC-Mdo-061948	Monodelphis domestica	90.10	2.00e-50	189.00
IUUC-Mmu-063946	Mus musculus	93.07	1.00e-51	193.00
IUUC-Mac-064812	Musa acuminata	63.89	1.00e-24	103.00
IUUC-Mpu-066763	Mustela putorius furo	93.07	3.00e-51	192.00
IUUC-Mlu-066970	Myotis lucifugus	94.94	5.00e-40	154.00
IUUC-Ncr-068824	Neurospora crassa	44.55	2.00e-19	87.00
IUUC-Nle-069849	Nomascus leucogenys	97.47	1.00e-40	158.00
IUUC-Opr-070227	Ochotona princeps	96.04	5.00e-53	198.00
IUUC-Ont-072530	Oreochromis niloticus	79.21	6.00e-46	174.00
IUUC-Oan-073191	Ornithorhynchus anatinus	85.39	1.00e-41	160.00
IUUC-Ocu-074460	Oryctolagus cuniculus	92.86	3.00e-50	189.00
IUUC-Oba-075499	Oryza barthii	67.19	2.00e-22	98.20
IUUC-Obr-076896	Oryza brachyantha	56.79	7.00e-22	97.10
IUUC-Ogl-077834	Oryza glaberrima	67.19	5.00e-23	98.60
IUUC-Ogu-078622	Oryza glumaepatula	67.19	5.00e-23	98.60
IUUC-Oin-079358	Oryza indica	67.19	2.00e-22	99.00
IUUC-Olo-081035	Oryza longistaminata	55.21	2.00e-23	101.00
IUUC-Oni-082425	Oryza nivara	67.19	5.00e-23	98.60
IUUC-Opu-083461	Oryza punctata	66.67	3.00e-22	97.40
IUUC-Oru-084875	Oryza rufipogon	60.56	6.00e-21	91.70
IUUC-Oga-089128	Otolemur garnettii	94.06	2.00e-52	196.00
IUUC-Oar-089896	Ovis aries	94.06	2.00e-52	196.00
IUUC-Ptr-091618	Pan troglodytes	98.73	2.00e-32	131.00
IUUC-Pan-092238	Papio anubis	96.20	4.00e-40	156.00
IUUC-Psi-093879	Pelodiscus sinensis	86.14	8.00e-48	181.00
IUUC-Pma-094484	Petromyzon marinus	79.21	6.00e-36	141.00
IUUC-Ppa-095801	Physcomitrella patens	58.02	3.00e-22	96.30
IUUC-Pfo-097192	Poecilia formosa	78.22	9.00e-46	174.00
IUUC-Pop-099614	Populus trichocarpa	54.76	1.00e-23	100.00
IUUC-Pca-100507	Procavia capensis	93.67	7.00e-40	154.00
IUUC-Ppe-101174	Prunus persica	54.55	2.00e-28	116.00
IUUC-Pva-102735	Pteropus vampyrus	94.06	4.00e-49	185.00
IUUC-Pgr-103510	Puccinia graminis	39.81	5.00e-12	62.80
IUUC-Ptt-103918	Puccinia triticina	35.92	6.00e-10	55.80
IUUC-Pte-104173	Pyrenophora teres	47.57	9.00e-23	97.80
IUUC-Pyt-104806	Pyrenophora triticirepentis	47.57	7.00e-23	98.20
IUUC-Rno-105820	Rattus norvegicus	93.07	7.00e-52	194.00
IUUC-Sce-106366	Saccharomyces cerevisiae	42.42	3.00e-17	79.30
IUUC-Sja-107727	Schizosaccharomyces japonicus	41.67	3.00e-16	76.30
IUUC-Spo-108074	Schizosaccharomyces pombe	39.80	2.00e-09	53.10
IUUC-Smo-108944	Selaginella moellendorffii	59.55	5.00e-26	108.00
IUUC-Sit-110277	Setaria italica	57.14	7.00e-24	101.00
IUUC-Sly-111505	Solanum lycopersicum	53.57	3.00e-24	102.00
IUUC-Stu-112076	Solanum tuberosum	54.76	9.00e-25	104.00
IUUC-Sbi-114274	Sorghum bicolor	58.44	6.00e-24	102.00
IUUC-Sre-114953	Sporisorium reilianum	59.80	7.00e-28	115.00
IUUC-Ssc-115418	Sus scrofa	93.07	3.00e-52	195.00
IUUC-Tgu-117311	Taeniopygia guttata	85.71	3.00e-42	162.00
IUUC-Tru-118598	Takifugu rubripes	79.78	4.00e-40	155.00
IUUC-Tni-120109	Tetraodon nigroviridis	76.47	5.00e-43	165.00
IUUC-Tca-120942	Theobroma cacao	54.22	5.00e-23	98.60
IUUC-Tre-122099	Trichoderma reesei	47.87	1.00e-15	73.90
IUUC-Tvi-122285	Trichoderma virens	52.88	5.00e-21	92.40
IUUC-Tae-125193	Triticum aestivum	59.26	3.00e-23	99.80
IUUC-Tur-126677	Triticum urartu	50.53	1.00e-20	91.30
IUUC-Tme-127120	Tuber melanosporum	48.08	6.00e-24	102.00
IUUC-Tbe-128050	Tupaia belangeri	69.31	4.00e-33	132.00
IUUC-Ttr-129019	Tursiops truncatus	92.08	3.00e-49	185.00
IUUC-Uma-129483	Ustilago maydis	57.84	3.00e-25	106.00
IUUC-Vda-129690	Verticillium dahliae	41.07	2.00e-16	77.00
IUUC-Vvi-131174	Vitis vinifera	55.42	6.00e-24	101.00
IUUC-Xma-133862	Xiphophorus maculatus	78.22	9.00e-46	174.00
IUUC-Yli-134398	Yarrowia lipolytica	46.46	3.00e-19	85.90
IUUC-Zma-134964	Zea mays	58.54	2.00e-22	96.70

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence