iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000005150.16	ENSMUST00000093357.11	ENSMUSP00000091048.5
ENSMUSG00000005150.16	ENSMUST00000142201.1	ENSMUSP00000122737.1
ENSMUSG00000005150.16	ENSMUST00000152785.7	ENSMUSP00000122127.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
miRNAMap	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.80e-33	113.2	107	142
UBD/Beta-Prp	1.80e-51	176.2	16	183

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gH+++v+ ++f  + t ++sGs D ++++WD r+ +
   Q: 107  GHAGKVNTVQFnEEaTVILSGSIDSSVRCWDCRSRK 142
           8**********54489***************98865 PP

UBD/Beta-Prp

   S: 43   kllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee 131
           k +++l   +++v+av+f+ dg++ +t+++D+t+k+w++  g+ ++t++gh ++vl+ + s ++++l sG+ d+t+ +wd+ tgq+++ 
   Q: 16   KRMKTLDCSQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLWDVATGQVVR- 103
           4455555556666666666666666666666666666666666666666666666666665556666666666666666666666666. PP
   S: 132  tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl..ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtg 212
            ++gh g vn+v++++++ ++ sGs D+ vr Wd   +  + ++tl +   d + s+++++   e+++gs dg+v+ +dl+ g
   Q: 104  KFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWDCrsRKPEPVQTLDE-ARDGISSVKVSD--HEILAGSVDGRVRRYDLRMG 183
           666666666666666666666666666666666663344445566655.666666666666..45666666666666666554 PP

Organism

Mus musculus

Functional Description
(View)

Molecular scaffold protein for various multimeric protein complexes. Involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). Also acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. May also be involved in pre-mRNA splicing.

Protein Sequence
(Fasta)

MAFPEPKPRA PELPQKRMKT LDCSQGAVRA VRFNVDGNYC LTCGSDKTLK LWNPLRGTLL 60
RTYSGHGYEV LDAAGSFDNS HLCSGGGDKT VVLWDVATGQ VVRKFRGHAG KVNTVQFNEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACACTCAGGG AGGTTCATCC CCACCCACCT TAAGCATGAG GCCACACATG CTGAAGATCA 60
TGCCAAGAAG ATTCATGTAG TCCGGAGTCG GGTCGTCTAA AGCCGGGTTG CACTCACTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0747--Spliceosome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005681--C:spliceosomal complex
GO:0000398--P:mRNA splicing, via spliceosome
GO:0000375--P:RNA splicing, via transesterification reactions

KEGG

mmu:67836

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002160	Ailuropoda melanoleuca	92.99	2.00e-176	611.00
IUUC-Atr-002647	Amborella trichopoda	49.66	1.00e-89	322.00
IUUC-Aca-004948	Anolis carolinensis	79.62	7.00e-146	509.00
IUUC-Aly-006489	Arabidopsis lyrata	50.84	3.00e-82	298.00
IUUC-Ath-007099	Arabidopsis thaliana	51.18	4.00e-82	297.00
IUUC-Acl-008374	Aspergillus clavatus	36.67	6.00e-49	187.00
IUUC-Afl-008506	Aspergillus flavus	37.33	1.00e-50	193.00
IUUC-Afu-009098	Aspergillus fumigatus	32.93	1.00e-43	170.00
IUUC-Ang-009705	Aspergillus niger	33.55	8.00e-45	174.00
IUUC-Aor-010031	Aspergillus oryzae	37.33	9.00e-51	193.00
IUUC-Ame-011056	Astyanax mexicanus	72.35	1.00e-139	489.00
IUUC-Bgr-012109	Blumeria graminis	41.90	1.00e-56	213.00
IUUC-Bta-012476	Bos taurus	93.02	1.00e-176	611.00
IUUC-Bci-013860	Botrytis cinerea	35.71	2.00e-45	176.00
IUUC-Bdi-014565	Brachypodium distachyon	49.15	3.00e-87	315.00
IUUC-Bol-016204	Brassica oleracea	50.85	1.00e-81	296.00
IUUC-Bra-018093	Brassica rapa	50.85	2.00e-81	295.00
IUUC-Cel-018500	Caenorhabditis elegans	48.46	3.00e-84	305.00
IUUC-Cja-019279	Callithrix jacchus	93.65	5.00e-166	576.00
IUUC-Cfa-020516	Canis familiaris	92.70	2.00e-176	611.00
IUUC-Cpo-021427	Cavia porcellus	91.11	1.00e-165	575.00
IUUC-Cre-022775	Chlamydomonas reinhardtii	45.48	6.00e-74	270.00
IUUC-Csa-023449	Chlorocebus sabaeus	93.02	3.00e-166	577.00
IUUC-Cin-025637	Ciona intestinalis	59.31	5.00e-108	384.00
IUUC-Cgl-026458	Colletotrichum gloeosporioides	37.15	1.00e-50	193.00
IUUC-Cne-026994	Cryptococcus neoformans	34.85	1.00e-49	189.00
IUUC-Dre-028239	Danio rerio	73.57	2.00e-132	464.00
IUUC-Dno-029408	Dasypus novemcinctus	91.75	7.00e-175	605.00
IUUC-Dor-030684	Dipodomys ordii	90.24	6.00e-109	387.00
IUUC-Dse-031344	Dothistroma septosporum	46.56	2.00e-55	209.00
IUUC-Dme-031634	Drosophila melanogaster	48.26	1.00e-77	282.00
IUUC-Ete-033126	Echinops telfairi	84.13	3.00e-157	547.00
IUUC-Eca-034356	Equus caballus	83.17	5.00e-151	526.00
IUUC-Eeu-035196	Erinaceus europaeus	88.76	1.00e-77	283.00
IUUC-Fca-036231	Felis catus	92.38	3.00e-175	607.00
IUUC-Fox-038076	Fusarium oxysporum	37.41	1.00e-54	206.00
IUUC-Fso-038093	Fusarium solani	36.33	6.00e-47	181.00
IUUC-Gmo-039056	Gadus morhua	72.67	1.00e-133	468.00
IUUC-Ggr-039981	Gaeumannomyces graminis	34.04	2.00e-44	172.00
IUUC-Gga-041042	Gallus gallus	75.88	5.00e-146	509.00
IUUC-Gac-042638	Gasterosteus aculeatus	73.53	1.00e-137	482.00
IUUC-Gma-042689	Glycine max	50.68	7.00e-90	323.00
IUUC-Ggo-044720	Gorilla gorilla	93.33	8.00e-167	579.00
IUUC-Hsa-046056	Homo sapiens	93.97	2.00e-167	581.00
IUUC-Hvu-047675	Hordeum vulgare	46.93	4.00e-85	308.00
IUUC-Itr-048733	Ictidomys tridecemlineatus	92.11	3.00e-169	587.00
IUUC-Lch-050634	Latimeria chalumnae	76.97	2.00e-131	461.00
IUUC-Lpe-051470	Leersia perrieri	49.49	1.00e-87	315.00
IUUC-Loc-052452	Lepisosteus oculatus	76.24	6.00e-134	470.00
IUUC-Lma-053235	Leptosphaeria maculans	41.99	5.00e-29	121.00
IUUC-Laf-054315	Loxodonta africana	93.33	6.00e-166	576.00
IUUC-Mcc-054923	Macaca mulatta	93.02	2.00e-166	577.00
IUUC-Mor-056936	Magnaporthe oryzae	38.51	1.00e-47	183.00
IUUC-Mtr-058595	Medicago truncatula	50.67	8.00e-89	320.00
IUUC-Mla-058902	Melampsora laricipopulina	39.19	2.00e-61	229.00
IUUC-Mvi-060471	Microbotryum violaceum	42.62	1.00e-71	262.00
IUUC-Mmr-061665	Microcebus murinus	92.38	2.00e-176	611.00
IUUC-Mdo-062750	Monodelphis domestica	81.63	1.00e-133	468.00
IUUC-Mac-065441	Musa acuminata	50.68	7.00e-89	320.00
IUUC-Mpu-066863	Mustela putorius furo	91.75	6.00e-175	606.00
IUUC-Mlu-067645	Myotis lucifugus	90.48	1.00e-172	598.00
IUUC-Nfi-068549	Neosartorya fischeri	35.71	6.00e-48	184.00
IUUC-Ncr-068816	Neurospora crassa	34.59	6.00e-41	161.00
IUUC-Nle-069457	Nomascus leucogenys	93.65	4.00e-167	580.00
IUUC-Opr-070874	Ochotona princeps	90.41	2.00e-75	275.00
IUUC-Ont-071674	Oreochromis niloticus	73.95	9.00e-123	432.00
IUUC-Oan-073391	Ornithorhynchus anatinus	79.42	7.00e-152	529.00
IUUC-Ocu-074186	Oryctolagus cuniculus	90.79	8.00e-168	582.00
IUUC-Oba-075414	Oryza barthii	50.90	2.00e-84	305.00
IUUC-Obr-076739	Oryza brachyantha	48.47	7.00e-86	310.00
IUUC-Ogl-076962	Oryza glaberrima	49.49	2.00e-86	312.00
IUUC-Ogu-078831	Oryza glumaepatula	49.49	1.00e-86	312.00
IUUC-Oin-079985	Oryza indica	49.15	2.00e-86	312.00
IUUC-Ome-081333	Oryza meridionalis	48.72	4.00e-79	288.00
IUUC-Oni-082558	Oryza nivara	49.15	2.00e-86	312.00
IUUC-Opu-084091	Oryza punctata	49.83	3.00e-88	318.00
IUUC-Oru-085253	Oryza rufipogon	49.45	6.00e-81	293.00
IUUC-Osa-086077	Oryza sativa	49.15	2.00e-86	312.00
IUUC-Ola-086946	Oryzias latipes	72.93	7.00e-137	479.00
IUUC-Olu-087604	Ostreococcus lucimarinus	40.97	1.00e-55	210.00
IUUC-Oga-088681	Otolemur garnettii	91.32	8.00e-172	595.00
IUUC-Oar-089913	Ovis aries	92.06	2.00e-173	600.00
IUUC-Ptr-091343	Pan troglodytes	93.33	4.00e-165	573.00
IUUC-Pan-092078	Papio anubis	93.02	3.00e-166	577.00
IUUC-Psi-093190	Pelodiscus sinensis	79.42	2.00e-152	531.00
IUUC-Pno-095078	Phaeosphaeria nodorum	40.58	5.00e-55	207.00
IUUC-Ppa-095777	Physcomitrella patens	49.32	1.00e-87	315.00
IUUC-Pfo-097153	Poecilia formosa	74.59	2.00e-130	458.00
IUUC-Pab-098307	Pongo abelii	92.72	6.00e-165	573.00
IUUC-Pop-099315	Populus trichocarpa	52.03	2.00e-83	302.00
IUUC-Pca-100538	Procavia capensis	91.08	1.00e-145	508.00
IUUC-Ppe-101632	Prunus persica	49.32	5.00e-89	320.00
IUUC-Pva-102484	Pteropus vampyrus	93.33	6.00e-178	616.00
IUUC-Pgr-103495	Puccinia graminis	40.29	1.00e-63	236.00
IUUC-Ptt-103975	Puccinia triticina	39.56	3.00e-62	231.00
IUUC-Pte-104354	Pyrenophora teres	37.68	7.00e-43	167.00
IUUC-Pyt-104692	Pyrenophora triticirepentis	38.41	9.00e-43	167.00
IUUC-Rno-105655	Rattus norvegicus	97.46	0.00e+00	638.00
IUUC-Sha-107130	Sarcophilus harrisii	80.93	1.00e-108	385.00
IUUC-Sja-107933	Schizosaccharomyces japonicus	41.20	1.00e-58	219.00
IUUC-Spo-108131	Schizosaccharomyces pombe	41.26	2.00e-58	219.00
IUUC-Ssl-108405	Sclerotinia sclerotiorum	35.71	9.00e-46	177.00
IUUC-Smo-108996	Selaginella moellendorffii	48.47	1.00e-80	292.00
IUUC-Sit-110508	Setaria italica	50.17	5.00e-88	317.00
IUUC-Sly-111093	Solanum lycopersicum	48.65	5.00e-80	290.00
IUUC-Stu-112380	Solanum tuberosum	48.65	6.00e-80	290.00
IUUC-Sar-113127	Sorex araneus	85.52	3.00e-70	258.00
IUUC-Sbi-114461	Sorghum bicolor	49.15	1.00e-86	312.00
IUUC-Sre-115020	Sporisorium reilianum	37.01	2.00e-41	164.00
IUUC-Ssc-115632	Sus scrofa	93.57	2.00e-175	607.00
IUUC-Tru-118039	Takifugu rubripes	70.59	2.00e-127	448.00
IUUC-Tsy-119239	Tarsius syrichta	94.67	4.00e-95	341.00
IUUC-Tni-120097	Tetraodon nigroviridis	69.28	2.00e-125	441.00
IUUC-Tca-121695	Theobroma cacao	51.70	1.00e-91	330.00
IUUC-Tre-122182	Trichoderma reesei	36.16	7.00e-49	187.00
IUUC-Tvi-122429	Trichoderma virens	36.36	6.00e-52	197.00
IUUC-Tae-125136	Triticum aestivum	50.85	1.00e-89	322.00
IUUC-Tur-126216	Triticum urartu	50.84	6.00e-89	320.00
IUUC-Tme-127030	Tuber melanosporum	42.28	1.00e-59	223.00
IUUC-Tbe-127686	Tupaia belangeri	91.01	1.00e-100	359.00
IUUC-Ttr-128770	Tursiops truncatus	91.75	1.00e-174	605.00
IUUC-Uma-129446	Ustilago maydis	34.74	1.00e-36	148.00
IUUC-Vda-129680	Verticillium dahliae	38.52	3.00e-42	165.00
IUUC-Vvi-131292	Vitis vinifera	51.88	2.00e-90	325.00
IUUC-Xtr-132204	Xenopus tropicalis	76.11	1.00e-147	515.00
IUUC-Xma-133727	Xiphophorus maculatus	73.31	6.00e-130	456.00
IUUC-Zma-135908	Zea mays	49.15	4.00e-81	294.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence