iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067326

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02019630

Gene Name

HERC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000004291.2	ENSMLUT00000004300.2	ENSMLUP00000003916.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.80e-101	338.9	733	1056

Active Site

Position(s)	Description	Evidence
1025	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           d kk l+v fvgE+++d+gGv +ef+ l+++el +p++g+f+y e+++  ++ +++      e  +lF+++G+++g+a+++  ++dl
   Q: 733  DYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTF-----EDSDLFHLIGVICGLAIYNFTIVDL 814
           78999***********************************************88877.....689********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll+kk sl+dl+e++p++ +s+++++++ e+d+ee+ ++l+f+++ e++g t+++eL+ +G+++ V+++N++e+v+++
   Q: 815  HFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQLLDYPEDDVEET-FCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAY 900
           *************************************99999997.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y++++++++ ++af++Gf++v+  ++l+lF+++el+ ++ G++++d+++l+k+t+ykg+y +++p+i+ Fwev++e+  e++k f
   Q: 901  VDYIFNKSVASLFDAFHAGFHKVCGGKVLQLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKLF 987
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+++lk    vi+   + ++ lP s+TCfn+L+LP+Y+ ke+l++kL+ Ai++++gF+l
   Q: 988  LLFLTGSDRIPILGMKSLK---LVIQStGGGEEYLPVSHTCFNLLDLPKYTDKETLRSKLIQAIDHNEGFSL 1056
           *******************...7777758889**************************************86 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MLCWGNASFG QLGLGGIDEE IVLEPRKSDF FINKKVRDVG CGLRHTVFVL DDGTVYTCGC 60
NDLGQLGHEK SRKKPEQVVA LDAQNIIAVS CGEAHTLALN DKGQVYAWGL DSDGQLGLLG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGCCCTGC ATGGTGTTCG CCGCCACGGG TTAAAGGAGG AGGGTCCAAG CGCTGGAGAC 60
CTGCCTCAGC GGCCGCGCCG CCTCGCTGTC TGGGGAGGCG CCGCCCTCCG CTGCCCGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0001650--C:fibrillar center
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007283--P:spermatogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001666	Ailuropoda melanoleuca	97.73	0.00e+00	1999.00
IUUC-Apl-003295	Anas platyrhynchos	88.28	0.00e+00	1873.00
IUUC-Aca-004336	Anolis carolinensis	85.66	0.00e+00	1813.00
IUUC-Ame-010768	Astyanax mexicanus	72.68	0.00e+00	1569.00
IUUC-Bta-013279	Bos taurus	97.82	0.00e+00	1998.00
IUUC-Cja-019023	Callithrix jacchus	97.07	0.00e+00	1989.00
IUUC-Cfa-021074	Canis familiaris	97.92	0.00e+00	2004.00
IUUC-Cpo-021461	Cavia porcellus	94.90	0.00e+00	1931.00
IUUC-Csa-024261	Chlorocebus sabaeus	97.92	0.00e+00	2006.00
IUUC-Cho-024513	Choloepus hoffmanni	77.39	0.00e+00	1477.00
IUUC-Cin-025232	Ciona intestinalis	42.48	0.00e+00	815.00
IUUC-Dre-028829	Danio rerio	74.53	0.00e+00	1562.00
IUUC-Dno-029445	Dasypus novemcinctus	94.14	0.00e+00	1608.00
IUUC-Dor-030158	Dipodomys ordii	96.26	0.00e+00	874.00
IUUC-Dme-032103	Drosophila melanogaster	45.16	0.00e+00	895.00
IUUC-Ete-033072	Echinops telfairi	86.09	0.00e+00	1711.00
IUUC-Eca-033317	Equus caballus	95.55	0.00e+00	1949.00
IUUC-Fca-035682	Felis catus	97.35	0.00e+00	1984.00
IUUC-Fal-036969	Ficedula albicollis	86.66	0.00e+00	1843.00
IUUC-Gmo-038671	Gadus morhua	74.04	0.00e+00	1577.00
IUUC-Gga-041174	Gallus gallus	87.98	0.00e+00	1873.00
IUUC-Gac-042600	Gasterosteus aculeatus	73.96	0.00e+00	1514.00
IUUC-Gma-043616	Glycine max	37.50	2.00e-52	199.00
IUUC-Ggo-044589	Gorilla gorilla	97.35	0.00e+00	2028.00
IUUC-Hsa-046772	Homo sapiens	97.35	0.00e+00	2024.00
IUUC-Lch-050147	Latimeria chalumnae	79.69	0.00e+00	1426.00
IUUC-Loc-052684	Lepisosteus oculatus	81.08	0.00e+00	1716.00
IUUC-Laf-053844	Loxodonta africana	96.50	0.00e+00	1977.00
IUUC-Mcc-055531	Macaca mulatta	95.65	0.00e+00	1991.00
IUUC-Mtr-058277	Medicago truncatula	37.46	5.00e-53	201.00
IUUC-Mga-060151	Meleagris gallopavo	87.22	0.00e+00	1558.00
IUUC-Mmr-060954	Microcebus murinus	97.07	0.00e+00	1987.00
IUUC-Mdo-062246	Monodelphis domestica	91.75	0.00e+00	1766.00
IUUC-Mmu-063369	Mus musculus	94.99	0.00e+00	1957.00
IUUC-Mpu-065936	Mustela putorius furo	97.56	0.00e+00	1844.00
IUUC-Nle-069453	Nomascus leucogenys	96.97	0.00e+00	1978.00
IUUC-Ont-071720	Oreochromis niloticus	74.43	0.00e+00	1566.00
IUUC-Oan-073464	Ornithorhynchus anatinus	92.67	0.00e+00	1794.00
IUUC-Ocu-074207	Oryctolagus cuniculus	94.57	0.00e+00	1825.00
IUUC-Ola-086762	Oryzias latipes	73.67	0.00e+00	1526.00
IUUC-Oga-088435	Otolemur garnettii	97.16	0.00e+00	1990.00
IUUC-Oar-089233	Ovis aries	97.63	0.00e+00	1996.00
IUUC-Ptr-091368	Pan troglodytes	97.54	0.00e+00	2028.00
IUUC-Pan-092300	Papio anubis	97.92	0.00e+00	2006.00
IUUC-Psi-093406	Pelodiscus sinensis	89.50	0.00e+00	1894.00
IUUC-Pma-094113	Petromyzon marinus	72.14	0.00e+00	1147.00
IUUC-Ppa-095354	Physcomitrella patens	33.52	2.00e-146	513.00
IUUC-Pfo-097021	Poecilia formosa	72.71	0.00e+00	1575.00
IUUC-Pab-098327	Pongo abelii	97.63	0.00e+00	2028.00
IUUC-Pca-101075	Procavia capensis	95.10	0.00e+00	814.00
IUUC-Pva-102909	Pteropus vampyrus	86.00	0.00e+00	1680.00
IUUC-Rno-105457	Rattus norvegicus	95.93	0.00e+00	1980.00
IUUC-Sha-106632	Sarcophilus harrisii	93.00	0.00e+00	1940.00
IUUC-Sit-110415	Setaria italica	37.25	4.00e-53	202.00
IUUC-Sar-113679	Sorex araneus	87.20	0.00e+00	1129.00
IUUC-Tgu-116849	Taeniopygia guttata	82.69	0.00e+00	1731.00
IUUC-Tru-118206	Takifugu rubripes	72.80	0.00e+00	1479.00
IUUC-Tsy-119521	Tarsius syrichta	82.59	0.00e+00	1596.00
IUUC-Tni-120233	Tetraodon nigroviridis	72.05	0.00e+00	1462.00
IUUC-Tbe-127941	Tupaia belangeri	79.96	0.00e+00	1350.00
IUUC-Ttr-128926	Tursiops truncatus	97.12	0.00e+00	1167.00
IUUC-Vpa-130448	Vicugna pacos	97.26	0.00e+00	1987.00
IUUC-Xtr-132719	Xenopus tropicalis	70.60	0.00e+00	1384.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence