iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
UniProt
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E1	E1_ThiF	17644626; 20682785

Classification

Family	E-value	Score	Start	End
E1	1.10e-75	256.4	14	167

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfra.edv..gksKAevaaealkelnpdvnveahee 95
           YDRQir+wG++aq++l +a++l++G++g+ +E++Kn+vlaGvgs+t++D++  +++ ln++FL+ + e+v  gk+ Ae++ ++lk++np+v+v++ + 
   Q: 14   YDRQIRVWGANAQRRLTKAHILVSGIKGTVAEFCKNIVLAGVGSVTLMDDRLANMEALNANFLIPPdENVysGKTVAEICSDSLKDFNPMVRVSVEKG 111
           *****************************************************************97888**************************** PP
   S: 96   siteleeeivFfkkfdvVvlaldnrearrkvnrlclna..rvpliesgtlGllGqvrviikgltecyscsddppqktiPfc 174
           ++++l+++  Ff++fdvVv+++ +r+++++vn+ c+++  rv ++++++++ +G++                       f+
   Q: 112  DLSMLGTD--FFEQFDVVVIGYGSRATKKYVNEKCRKLkkRVAFYTVDCRDSCGEI-----------------------FV 167
           ********..****************************999**************9.......................44 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

The dimeric enzyme acts as an E1 ligase for SUMO1 and SUMO2. It mediates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2. Functionally redundant with its paralog SAE1B.

Protein Sequence
(Fasta)

MDGEELTEQE TALYDRQIRV WGANAQRRLT KAHILVSGIK GTVAEFCKNI VLAGVGSVTL 60
MDDRLANMEA LNANFLIPPD ENVYSGKTVA EICSDSLKDF NPMVRVSVEK GDLSMLGTDF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAAACACTG TGAGAGAGTT GACCAAAATC GACCCAGTGG GAGGACTAGG TTTATCGAAA 60
GCTCCAGTTT TCATAGATAA ATCCAGTAAA ATTATACACG CAAATTCTAG TTTCTTAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0436--Ligase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0005634--C:nucleus
GO:0019948--F:SUMO activating enzyme activity
GO:0016925--P:protein sumoylation

KEGG

ath:AT4G24940

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000695	Aegilops tauschii	56.97	3.00e-108	384.00
IUUC-Aly-006162	Arabidopsis lyrata	94.72	0.00e+00	626.00
IUUC-Bdi-014800	Brachypodium distachyon	57.14	2.00e-110	391.00
IUUC-Bol-015744	Brassica oleracea	89.75	5.00e-166	576.00
IUUC-Bra-016683	Brassica rapa	90.06	2.00e-165	573.00
IUUC-Eeu-035135	Erinaceus europaeus	37.96	4.00e-17	81.30
IUUC-Fox-037928	Fusarium oxysporum	29.28	5.00e-30	125.00
IUUC-Gmo-038867	Gadus morhua	31.76	3.00e-35	141.00
IUUC-Lpe-051620	Leersia perrieri	59.49	9.00e-111	392.00
IUUC-Mtr-058633	Medicago truncatula	71.70	3.00e-141	493.00
IUUC-Mdo-062827	Monodelphis domestica	33.82	1.00e-46	179.00
IUUC-Mac-064495	Musa acuminata	64.89	1.00e-125	442.00
IUUC-Opr-071077	Ochotona princeps	26.75	1.00e-22	99.80
IUUC-Ont-072576	Oreochromis niloticus	31.76	3.00e-33	135.00
IUUC-Oba-075956	Oryza barthii	61.18	9.00e-113	399.00
IUUC-Obr-076004	Oryza brachyantha	61.56	5.00e-113	400.00
IUUC-Ogl-077740	Oryza glaberrima	62.81	2.00e-40	157.00
IUUC-Ogu-078335	Oryza glumaepatula	61.18	5.00e-113	400.00
IUUC-Oin-079177	Oryza indica	61.51	6.00e-114	402.00
IUUC-Olo-080537	Oryza longistaminata	59.27	5.00e-105	373.00
IUUC-Ome-081880	Oryza meridionalis	61.51	6.00e-114	402.00
IUUC-Oni-082688	Oryza nivara	61.84	2.00e-114	404.00
IUUC-Opu-083231	Oryza punctata	62.74	3.00e-119	420.00
IUUC-Oru-084759	Oryza rufipogon	61.51	6.00e-114	402.00
IUUC-Osa-085601	Oryza sativa	60.86	1.00e-112	398.00
IUUC-Ola-086496	Oryzias latipes	31.18	2.00e-35	142.00
IUUC-Pop-099424	Populus trichocarpa	72.96	1.00e-142	498.00
IUUC-Ppe-101274	Prunus persica	72.98	2.00e-125	441.00
IUUC-Pgr-103426	Puccinia graminis	32.93	4.00e-39	154.00
IUUC-Pte-104082	Pyrenophora teres	27.56	3.00e-30	125.00
IUUC-Sha-107120	Sarcophilus harrisii	32.61	3.00e-37	148.00
IUUC-Sit-110166	Setaria italica	63.06	4.00e-119	420.00
IUUC-Sbi-114548	Sorghum bicolor	61.66	1.00e-115	409.00
IUUC-Sre-115022	Sporisorium reilianum	41.44	4.00e-16	78.20
IUUC-Tae-123151	Triticum aestivum	61.31	8.00e-111	392.00
IUUC-Tur-126224	Triticum urartu	58.44	2.00e-108	385.00
IUUC-Uma-129422	Ustilago maydis	26.59	1.00e-23	103.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence