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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063328
UUCD1 version UUC-MuM-01042
Ensembl Protein ID ENSMUSP00000034775.8
UniProt Accession Q9Z2G0; Q3TV57; Q3ULQ3; Q3V148; Q80U13; Q99NC9; Q9QZL3; FEM1B_MOUSE
Genbank Protein ID AAC82373.1; AAF05315.1; BAB33298.1; BAC27822.1; BAE21305.1; BAE26395.1; BAE28816.1; BAE32347.1; BAE35763.1; AAH68236.1; BAC65554.1
Protein Name Protein fem-1 homolog B; FEM1-beta; Fem-1-like death receptor-binding protein alpha; Fem-1-like in apoptotic pathway protein alpha; mt-Fem
Genbank Nucleotide ID AF064448; AF178633; AB022863; AK032338; AK132692; AK145371; AK149329; AK154060; AK160393; BC068236; AK122272
Gene Name Fem1b; F1aa; Kiaa0396
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000032244.9 ENSMUST00000034775.9 ENSMUSP00000034775.8
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
CPLMPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 99.04 0.00e+00 1293.00 IUUC-Hsa-046964
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1 (By similarity).
 Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1 (By similarity).
Protein Sequence
(Fasta)
MEGLAGYVYK AASEGKVLTL AALLLNRSES DIRYLLGYVS QQGGQRSTPL IIAARNGHAK 60
VVRLLLEHYR VQTQQTGTVR FDGYVIDGAT ALWCAAGAGH FEVVKLLVSH GANVNHTTVT 120
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Protein Fasta Sequence


>IUUC-Mmu-063328|E3,SOCS|Mus musculus
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Nucleotide Sequence
(Fasta)
CTCCCTCCCT TCGGCTCCGT CTGCGGCGGC TGCTTTCCTC CCGCCCTAAG TTCCGGTGCT 60
GGTGCTGCCG GCGCGGTCCG CGAACACCCA CGCGCGGCTC ACGGGAGCCC CGCTCGCCAG 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-063328|E3,SOCS|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0040--ANK repeat
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
Pfam

PF00023--Ank
PF12796--Ank_2
PRINTS

PR01415--ANKYRIN
SMART

SM00248--ANK
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005123--F:death receptor binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006915--P:apoptotic process
GO:0060442--P:branching involved in prostate gland morphogenesis
GO:0002070--P:epithelial cell maturation
GO:0060743--P:epithelial cell maturation involved in prostate gland development
GO:0016567--P:protein ubiquitination
GO:2000001--P:regulation of DNA damage checkpoint
GO:1902041--P:regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0051438--P:regulation of ubiquitin-protein transferase activity
KEGG mmu:14155
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001977 Ailuropoda melanoleuca 98.88 0.00e+00 1292.00
IUUC-Apl-003175 Anas platyrhynchos 90.02 0.00e+00 1144.00
IUUC-Aca-004307 Anolis carolinensis 87.72 0.00e+00 1164.00
IUUC-Ani-009163 Aspergillus nidulans 31.92 1.00e-09 57.80
IUUC-Ame-011780 Astyanax mexicanus 82.62 0.00e+00 1068.00
IUUC-Bta-013169 Bos taurus 99.20 0.00e+00 1295.00
IUUC-Cja-018787 Callithrix jacchus 99.20 0.00e+00 1295.00
IUUC-Cfa-020246 Canis familiaris 97.93 0.00e+00 1278.00
IUUC-Cpo-021778 Cavia porcellus 99.04 0.00e+00 1294.00
IUUC-Csa-023153 Chlorocebus sabaeus 98.00 0.00e+00 1126.00
IUUC-Cin-025726 Ciona intestinalis 46.14 2.00e-153 536.00
IUUC-Csv-026048 Ciona savignyi 47.53 3.00e-165 575.00
IUUC-Dre-028359 Danio rerio 80.70 0.00e+00 1045.00
IUUC-Dno-029353 Dasypus novemcinctus 98.65 0.00e+00 1221.00
IUUC-Dor-030825 Dipodomys ordii 90.10 0.00e+00 1113.00
IUUC-Dme-031842 Drosophila melanogaster 40.51 2.00e-118 419.00
IUUC-Ete-032259 Echinops telfairi 98.16 0.00e+00 1110.00
IUUC-Eca-033405 Equus caballus 99.04 0.00e+00 1293.00
IUUC-Eeu-034682 Erinaceus europaeus 91.21 0.00e+00 1033.00
IUUC-Fca-036111 Felis catus 98.97 0.00e+00 1210.00
IUUC-Fal-036910 Ficedula albicollis 88.01 0.00e+00 1135.00
IUUC-Gmo-039115 Gadus morhua 78.92 0.00e+00 673.00
IUUC-Gga-040350 Gallus gallus 90.91 0.00e+00 1201.00
IUUC-Gac-042402 Gasterosteus aculeatus 79.43 0.00e+00 1041.00
IUUC-Ggo-044845 Gorilla gorilla 99.04 0.00e+00 1294.00
IUUC-Hsa-046964 Homo sapiens 99.04 0.00e+00 1293.00
IUUC-Itr-048687 Ictidomys tridecemlineatus 98.72 0.00e+00 1286.00
IUUC-Lch-049773 Latimeria chalumnae 87.40 0.00e+00 1158.00
IUUC-Loc-052171 Lepisosteus oculatus 85.65 0.00e+00 1130.00
IUUC-Laf-054457 Loxodonta africana 97.79 0.00e+00 1184.00
IUUC-Mcc-054620 Macaca mulatta 74.72 0.00e+00 913.00
IUUC-Meu-056651 Macropus eugenii 90.30 9.00e-146 510.00
IUUC-Mga-059705 Meleagris gallopavo 89.07 0.00e+00 1038.00
IUUC-Mvi-060501 Microbotryum violaceum 31.25 1.00e-16 82.40
IUUC-Mmr-061523 Microcebus murinus 99.52 0.00e+00 1299.00
IUUC-Mdo-062255 Monodelphis domestica 93.14 0.00e+00 1224.00
IUUC-Mpu-065695 Mustela putorius furo 99.04 0.00e+00 1293.00
IUUC-Mlu-067547 Myotis lucifugus 99.04 0.00e+00 1295.00
IUUC-Nle-069891 Nomascus leucogenys 99.04 0.00e+00 1293.00
IUUC-Opr-070956 Ochotona princeps 98.17 0.00e+00 1223.00
IUUC-Ont-072598 Oreochromis niloticus 79.74 0.00e+00 1061.00
IUUC-Oan-073603 Ornithorhynchus anatinus 86.97 0.00e+00 989.00
IUUC-Ocu-074309 Oryctolagus cuniculus 97.26 0.00e+00 1256.00
IUUC-Ola-087018 Oryzias latipes 79.90 0.00e+00 1053.00
IUUC-Oga-088965 Otolemur garnettii 98.88 0.00e+00 1291.00
IUUC-Oar-089640 Ovis aries 97.77 0.00e+00 1268.00
IUUC-Ptr-090739 Pan troglodytes 99.04 0.00e+00 1293.00
IUUC-Pan-091722 Papio anubis 99.04 0.00e+00 1293.00
IUUC-Psi-093697 Pelodiscus sinensis 89.31 0.00e+00 1185.00
IUUC-Pma-094633 Petromyzon marinus 68.21 4.00e-147 514.00
IUUC-Pfo-096128 Poecilia formosa 79.43 0.00e+00 1050.00
IUUC-Pab-098328 Pongo abelii 99.04 0.00e+00 1293.00
IUUC-Pca-100953 Procavia capensis 97.72 0.00e+00 1241.00
IUUC-Rno-105584 Rattus norvegicus 99.84 0.00e+00 1301.00
IUUC-Sha-107455 Sarcophilus harrisii 92.11 0.00e+00 1058.00
IUUC-Sar-113373 Sorex araneus 98.35 0.00e+00 1118.00
IUUC-Ssc-115680 Sus scrofa 99.04 0.00e+00 1293.00
IUUC-Tgu-116500 Taeniopygia guttata 90.50 0.00e+00 1145.00
IUUC-Tru-118757 Takifugu rubripes 79.43 0.00e+00 1046.00
IUUC-Tni-120735 Tetraodon nigroviridis 78.95 0.00e+00 1038.00
IUUC-Tbe-127905 Tupaia belangeri 99.20 0.00e+00 1285.00
IUUC-Ttr-128292 Tursiops truncatus 98.82 0.00e+00 1041.00
IUUC-Vpa-130405 Vicugna pacos 98.88 0.00e+00 1290.00
IUUC-Xtr-132441 Xenopus tropicalis 84.21 0.00e+00 1114.00
Created Date 25-Jun-2017

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