iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-051917

Ensembl Protein ID

ENSLOCP00000006048.1

UniProt Accession

W5MCD9; W5MCD9_LEPOC

Genbank Protein ID

ENSLOCP00000006048

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

AHAT01010508

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000005017.1	ENSLOCT00000006056.1	ENSLOCP00000006048.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	6.70e-92	309.0	88	539

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 70   gksKAevaaealkelnpdvnveaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikglt 157
           ++++A+++ e l+eln+dv++ ++ees+++l ++++ Ff +f++V+  + ++++ +++  +++na vp++ ++t+G++G++r ++k++ 
   Q: 88   KHNRAQASTELLQELNSDVSGNFVEESPEQLLDNNPeFFHRFSLVIGVQLQESTTLRLGAVLWNAGVPFLVCRTYGFIGYMRLVVKEHS 176
           689************************************************************************************** PP
   S: 158  ecyscsd...dppqktiPfctlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks...... 228
           + +s++d   ++++++ Pf++lk++++         +++++++w+ +++k+le++ +e++ +++++++eke++++++++e ++      
   Q: 177  VVESHPDntlEDLRLDCPFPELKKHIEchdldnmdrKDHSHTPWIIVVAKYLENWCSEHNSQPPKNYKEKEAFRELIRQEKTGirkken 265
           *************************88888888888*****************************************999999999*** PP
   S: 229  ...edeenfeeaieiavkafakttins.ikqllksfecdivtkskspfwv....................................... 274
              edeenf+eai+++++a++ t i+s +++++++ +c+++t+++++fw+                                       
   Q: 266  gspEDEENFDEAIKNVNTALNATKISStVEDIFNDEQCKNITSQSPSFWMmaravkefvekegggslpvrgtipdmiadsdkfislqnv 354
           ***************************************************************************************** PP
   S: 275  ....................................sfcsnaealqvp...........ekvekdeevvkasap.....lylllraler 311
                                                fc+na+ l++            e+ +kde+++ +++p     lyl+lra++r
   Q: 355  yrekakqdaaavskhvafllqsvgkcsesiseqdirLFCKNAAFLRIVrcrslaeeysvESFNKDEITSCMDNPdsemvLYLMLRAVDR 443
           **********************************************555555555555588888888888888888888********** PP
   S: 312  fekkkgrkp.....gelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfe 393
           f ++++r+p     g+ ++++++d+  + ++v++++    +++g++ +++dd+i+e+++ ++++ +t+++++gG aaqE+iK+++++f+
   Q: 444  FYQQHSRYPappqqGVYNYQVEEDIgkLKSCVNSLL----QEYGLNVNVKDDYIHEFCRCGAAEPHTVASFLGGCAAQEAIKTITHQFV 528
           ********9444434678899999555666666555....************************************************* PP
   S: 394  plknfflfdae 404
           p++n+f+++a+
   Q: 529  PFNNTFIYNAM 539
           ********997 PP

Organism

Lepisosteus oculatus

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

MAEVNKGKAT KEQKYDRQLR RLWGDHGQEA LENAHVCLIN ATASGTEILK NLVLPGKMEV 60
KNLICRLGNQ YKGIEAHVCC CRACNMSKHN RAQASTELLQ ELNSDVSGNF VEESPEQLLD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGAAG TCAATAAAGG AAAAGCAACG AAGGAGCAGA AATACGACCG ACAGCTCAGG 60
TAAGGTATCG AAGGCGTGAC AAGCAATGTT TTTTTTTTAA TCGAAACGGA CTTTGAAAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	38.05	2.00e-105	376.00
IUUC-Aml-002333	Ailuropoda melanoleuca	69.85	0.00e+00	800.00
IUUC-Atr-002644	Amborella trichopoda	38.10	2.00e-97	349.00
IUUC-Apl-003446	Anas platyrhynchos	69.32	0.00e+00	751.00
IUUC-Aca-004450	Anolis carolinensis	68.33	0.00e+00	761.00
IUUC-Aly-006187	Arabidopsis lyrata	37.48	7.00e-109	387.00
IUUC-Ath-007600	Arabidopsis thaliana	37.11	5.00e-108	384.00
IUUC-Ago-007900	Ashbya gossypii	25.96	7.00e-34	138.00
IUUC-Acl-008333	Aspergillus clavatus	31.90	2.00e-69	256.00
IUUC-Afl-008529	Aspergillus flavus	33.93	2.00e-76	280.00
IUUC-Afu-009071	Aspergillus fumigatus	31.80	3.00e-70	259.00
IUUC-Ani-009443	Aspergillus nidulans	32.51	2.00e-70	260.00
IUUC-Ang-009669	Aspergillus niger	32.57	1.00e-73	270.00
IUUC-Aor-009914	Aspergillus oryzae	33.80	5.00e-75	275.00
IUUC-Ate-010450	Aspergillus terreus	31.61	9.00e-74	271.00
IUUC-Ame-011183	Astyanax mexicanus	77.26	0.00e+00	860.00
IUUC-Bgr-012111	Blumeria graminis	27.94	4.00e-47	182.00
IUUC-Bta-012583	Bos taurus	69.93	0.00e+00	799.00
IUUC-Bci-013892	Botrytis cinerea	31.61	1.00e-51	197.00
IUUC-Bdi-014592	Brachypodium distachyon	38.97	3.00e-106	378.00
IUUC-Bol-016399	Brassica oleracea	38.38	4.00e-110	391.00
IUUC-Bra-017506	Brassica rapa	37.13	3.00e-105	375.00
IUUC-Cel-018456	Caenorhabditis elegans	34.00	2.00e-77	282.00
IUUC-Cja-020007	Callithrix jacchus	69.93	0.00e+00	800.00
IUUC-Cfa-020324	Canis familiaris	69.74	0.00e+00	795.00
IUUC-Cpo-022248	Cavia porcellus	61.39	1.00e-128	452.00
IUUC-Csa-023149	Chlorocebus sabaeus	70.54	0.00e+00	711.00
IUUC-Cho-024537	Choloepus hoffmanni	62.53	1.00e-172	599.00
IUUC-Cin-025763	Ciona intestinalis	46.40	7.00e-140	490.00
IUUC-Csv-026113	Ciona savignyi	42.50	9.00e-127	447.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	29.79	3.00e-56	213.00
IUUC-Cne-026884	Cryptococcus neoformans	27.96	2.00e-60	227.00
IUUC-Dre-028140	Danio rerio	78.00	0.00e+00	863.00
IUUC-Dno-030033	Dasypus novemcinctus	68.54	0.00e+00	687.00
IUUC-Dor-030513	Dipodomys ordii	52.02	4.00e-85	308.00
IUUC-Dse-031536	Dothistroma septosporum	32.52	2.00e-71	263.00
IUUC-Dme-031683	Drosophila melanogaster	41.14	2.00e-109	389.00
IUUC-Ete-032420	Echinops telfairi	60.15	0.00e+00	641.00
IUUC-Eca-033992	Equus caballus	71.46	0.00e+00	697.00
IUUC-Eeu-034713	Erinaceus europaeus	60.23	2.00e-90	326.00
IUUC-Fca-036548	Felis catus	68.45	0.00e+00	780.00
IUUC-Fal-037600	Ficedula albicollis	68.56	0.00e+00	730.00
IUUC-Fox-038037	Fusarium oxysporum	29.22	6.00e-56	211.00
IUUC-Fso-038387	Fusarium solani	30.60	2.00e-58	219.00
IUUC-Gmo-038562	Gadus morhua	74.44	0.00e+00	830.00
IUUC-Ggr-040005	Gaeumannomyces graminis	30.47	8.00e-57	214.00
IUUC-Gga-041129	Gallus gallus	69.24	0.00e+00	765.00
IUUC-Gac-042558	Gasterosteus aculeatus	75.32	0.00e+00	829.00
IUUC-Gma-043610	Glycine max	37.34	1.00e-103	370.00
IUUC-Ggo-045611	Gorilla gorilla	69.56	0.00e+00	801.00
IUUC-Hsa-046563	Homo sapiens	69.37	0.00e+00	794.00
IUUC-Hvu-047790	Hordeum vulgare	36.66	4.00e-74	271.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	69.37	0.00e+00	790.00
IUUC-Kpa-049309	Komagataella pastoris	30.50	2.00e-65	242.00
IUUC-Lch-050038	Latimeria chalumnae	69.72	0.00e+00	785.00
IUUC-Lpe-051535	Leersia perrieri	37.29	8.00e-97	347.00
IUUC-Lma-053112	Leptosphaeria maculans	33.68	2.00e-79	290.00
IUUC-Laf-053690	Loxodonta africana	70.30	0.00e+00	800.00
IUUC-Mcc-055117	Macaca mulatta	69.41	0.00e+00	796.00
IUUC-Meu-056761	Macropus eugenii	59.85	0.00e+00	655.00
IUUC-Mor-057230	Magnaporthe oryzae	30.21	3.00e-60	226.00
IUUC-Mpo-057514	Magnaporthe poae	30.62	3.00e-55	209.00
IUUC-Mtr-058551	Medicago truncatula	36.03	3.00e-98	352.00
IUUC-Mla-059183	Melampsora laricipopulina	32.92	6.00e-84	305.00
IUUC-Mga-060144	Meleagris gallopavo	69.32	0.00e+00	748.00
IUUC-Mvi-060221	Microbotryum violaceum	31.41	2.00e-65	243.00
IUUC-Mmr-061325	Microcebus murinus	68.44	0.00e+00	783.00
IUUC-Mdo-062532	Monodelphis domestica	70.30	0.00e+00	796.00
IUUC-Mmu-063956	Mus musculus	69.37	0.00e+00	793.00
IUUC-Mac-064521	Musa acuminata	36.93	3.00e-103	368.00
IUUC-Mpu-066716	Mustela putorius furo	68.43	0.00e+00	737.00
IUUC-Mlu-067459	Myotis lucifugus	68.07	0.00e+00	782.00
IUUC-Nfi-068245	Neosartorya fischeri	32.93	4.00e-72	265.00
IUUC-Ncr-068910	Neurospora crassa	30.07	1.00e-63	237.00
IUUC-Nle-070034	Nomascus leucogenys	69.32	0.00e+00	778.00
IUUC-Opr-070552	Ochotona princeps	64.26	0.00e+00	659.00
IUUC-Ont-071426	Oreochromis niloticus	77.08	0.00e+00	862.00
IUUC-Oan-073389	Ornithorhynchus anatinus	71.68	0.00e+00	669.00
IUUC-Ocu-074911	Oryctolagus cuniculus	69.34	0.00e+00	791.00
IUUC-Oba-075437	Oryza barthii	38.48	6.00e-102	364.00
IUUC-Obr-076684	Oryza brachyantha	38.19	8.00e-98	350.00
IUUC-Ogl-077170	Oryza glaberrima	38.48	6.00e-102	364.00
IUUC-Ogu-078844	Oryza glumaepatula	38.40	4.00e-94	338.00
IUUC-Oin-079105	Oryza indica	38.48	3.00e-101	362.00
IUUC-Olo-080943	Oryza longistaminata	37.23	9.00e-95	340.00
IUUC-Oni-082891	Oryza nivara	37.36	2.00e-100	359.00
IUUC-Opu-083457	Oryza punctata	38.24	6.00e-102	364.00
IUUC-Oru-084960	Oryza rufipogon	37.07	6.00e-95	341.00
IUUC-Osa-085358	Oryza sativa	38.43	8.00e-102	364.00
IUUC-Ola-086420	Oryzias latipes	79.00	0.00e+00	627.00
IUUC-Olu-087625	Ostreococcus lucimarinus	29.42	3.00e-58	219.00
IUUC-Oga-088810	Otolemur garnettii	69.37	0.00e+00	792.00
IUUC-Oar-089196	Ovis aries	69.93	0.00e+00	803.00
IUUC-Ptr-090617	Pan troglodytes	69.56	0.00e+00	795.00
IUUC-Pan-092761	Papio anubis	69.56	0.00e+00	793.00
IUUC-Psi-093191	Pelodiscus sinensis	69.89	0.00e+00	781.00
IUUC-Pma-094380	Petromyzon marinus	58.42	3.00e-172	598.00
IUUC-Pno-095084	Phaeosphaeria nodorum	31.05	6.00e-67	249.00
IUUC-Ppa-095798	Physcomitrella patens	38.24	1.00e-107	383.00
IUUC-Pfo-096467	Poecilia formosa	75.46	0.00e+00	842.00
IUUC-Pab-098255	Pongo abelii	68.01	0.00e+00	647.00
IUUC-Pop-099722	Populus trichocarpa	38.88	9.00e-110	390.00
IUUC-Pca-100807	Procavia capensis	53.73	6.00e-78	284.00
IUUC-Ppe-101280	Prunus persica	37.70	2.00e-109	389.00
IUUC-Pva-102333	Pteropus vampyrus	67.34	0.00e+00	758.00
IUUC-Pgr-103401	Puccinia graminis	28.35	6.00e-66	244.00
IUUC-Ptt-103889	Puccinia triticina	24.37	7.00e-46	178.00
IUUC-Pte-104355	Pyrenophora teres	34.32	4.00e-81	295.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	35.01	7.00e-82	298.00
IUUC-Rno-105810	Rattus norvegicus	70.22	0.00e+00	798.00
IUUC-Sce-106397	Saccharomyces cerevisiae	24.95	8.00e-32	131.00
IUUC-Sha-106770	Sarcophilus harrisii	66.55	3.00e-111	394.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	31.73	2.00e-65	243.00
IUUC-Spo-108276	Schizosaccharomyces pombe	31.48	4.00e-70	258.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	31.96	6.00e-54	204.00
IUUC-Smo-109296	Selaginella moellendorffii	39.56	3.00e-109	388.00
IUUC-Sit-110157	Setaria italica	39.31	9.00e-112	397.00
IUUC-Sly-111105	Solanum lycopersicum	36.79	3.00e-106	379.00
IUUC-Stu-112469	Solanum tuberosum	36.69	3.00e-107	382.00
IUUC-Sar-113083	Sorex araneus	52.56	7.00e-156	543.00
IUUC-Sbi-113813	Sorghum bicolor	40.22	2.00e-112	399.00
IUUC-Sre-115058	Sporisorium reilianum	34.14	3.00e-66	246.00
IUUC-Tgu-116772	Taeniopygia guttata	68.76	0.00e+00	749.00
IUUC-Tru-118686	Takifugu rubripes	75.42	0.00e+00	847.00
IUUC-Tsy-119111	Tarsius syrichta	64.31	4.00e-106	378.00
IUUC-Tni-120231	Tetraodon nigroviridis	68.81	0.00e+00	748.00
IUUC-Tca-121491	Theobroma cacao	36.43	5.00e-100	358.00
IUUC-Tre-122103	Trichoderma reesei	31.48	5.00e-65	242.00
IUUC-Tvi-122672	Trichoderma virens	32.09	5.00e-63	235.00
IUUC-Tae-125679	Triticum aestivum	38.79	2.00e-106	379.00
IUUC-Tur-126487	Triticum urartu	37.31	2.00e-102	366.00
IUUC-Tme-127097	Tuber melanosporum	34.99	2.00e-79	289.00
IUUC-Ttr-128465	Tursiops truncatus	65.13	0.00e+00	737.00
IUUC-Uma-129645	Ustilago maydis	30.81	4.00e-74	272.00
IUUC-Vda-129989	Verticillium dahliae	27.03	7.00e-42	164.00
IUUC-Vpa-130529	Vicugna pacos	66.42	0.00e+00	753.00
IUUC-Vvi-131059	Vitis vinifera	37.52	2.00e-105	376.00
IUUC-Xtr-132002	Xenopus tropicalis	68.96	0.00e+00	763.00
IUUC-Xma-133930	Xiphophorus maculatus	75.79	0.00e+00	842.00
IUUC-Yli-134505	Yarrowia lipolytica	29.59	9.00e-67	247.00
IUUC-Zma-135895	Zea mays	39.85	8.00e-112	397.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence