iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000070423.17	ENST00000605891.5	ENSP00000475833.1
ENSG00000070423.17	ENST00000292363.9	ENSP00000292363.3
ENSG00000070423.17	ENST00000589762.5	ENSP00000464945.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18819927; 18511420
UBD/ZnF/ZnF_A20	ZnF_A20	23418353

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	8.30e-09	37.5	229	270

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf...kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++C++d+   ++ ++ lpC+H+fh  C+  w        ++++CP+Cr
   Q: 229  CPVCKDDYalgER-VRQLPCNHLFHDGCIVPW------LEQHDSCPVCR 270
           ********99777.******************......**********8 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins (PubMed:23277564, PubMed:24275455, PubMed:24981174). Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates (By similarity). Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome (PubMed:24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). May play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4, by mediating their ubiquitination (PubMed:23418353). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136). May monoubiquitinate AICDA (PubMed:23277564).

Protein Sequence
(Fasta)

MAEASPHPGR YFCHCCSVEI VPRLPDYICP RCESGFIEEL PEETRSTENG SAPSTAPTDQ 60
SRPPLEHVDQ HLFTLPQGYG QFAFGIFDDS FEIPTFPPGA QADDGRDPES RRERDHPSRH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCAGCTTTC GCCGCTCCCG CGCCCCCGCT CCGCCCCGCG TGCCGTGCGT GCCGTGCGTG 60
AGCGTGCGCG GGCGCGTCGG CCGGCGAGGG AGCAGCAAAC GGCCGGCGGC GGGTGCCGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042127--P:regulation of cell proliferation
GO:0042147--P:retrograde transport, endosome to Golgi
GO:0071629--P:ubiquitin-dependent catabolism of misfolded proteins by cytoplasm-associated proteasome
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

KEGG

hsa:55658

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000551	Aegilops tauschii	46.73	1.00e-24	106.00
IUUC-Aml-002001	Ailuropoda melanoleuca	93.93	3.00e-146	510.00
IUUC-Atr-002522	Amborella trichopoda	50.53	4.00e-27	114.00
IUUC-Apl-003778	Anas platyrhynchos	77.60	3.00e-95	341.00
IUUC-Aca-005166	Anolis carolinensis	76.49	3.00e-105	374.00
IUUC-Aly-006495	Arabidopsis lyrata	47.62	2.00e-21	96.70
IUUC-Ath-007616	Arabidopsis thaliana	31.09	2.00e-27	116.00
IUUC-Afl-008423	Aspergillus flavus	43.00	6.00e-18	85.50
IUUC-Afu-008920	Aspergillus fumigatus	43.43	5.00e-17	82.40
IUUC-Ani-009396	Aspergillus nidulans	41.84	1.00e-16	80.90
IUUC-Ang-009638	Aspergillus niger	45.19	2.00e-17	83.60
IUUC-Aor-009896	Aspergillus oryzae	43.00	7.00e-18	85.50
IUUC-Ame-010626	Astyanax mexicanus	71.03	4.00e-113	401.00
IUUC-Bgr-012144	Blumeria graminis	35.94	2.00e-18	87.40
IUUC-Bta-012808	Bos taurus	92.44	3.00e-135	474.00
IUUC-Bdi-014137	Brachypodium distachyon	48.62	6.00e-26	111.00
IUUC-Cel-018216	Caenorhabditis elegans	42.11	1.00e-14	73.60
IUUC-Cja-019575	Callithrix jacchus	91.37	4.00e-138	484.00
IUUC-Cfa-020142	Canis familiaris	94.39	6.00e-130	456.00
IUUC-Cpo-022451	Cavia porcellus	92.23	3.00e-138	484.00
IUUC-Csa-023433	Chlorocebus sabaeus	97.74	3.00e-170	590.00
IUUC-Cgl-026759	Colletotrichum gloeosporioides	38.54	9.00e-17	81.60
IUUC-Cne-026837	Cryptococcus neoformans	30.30	2.00e-16	80.50
IUUC-Cme-027122	Cyanidioschyzon merolae	54.00	2.00e-13	71.20
IUUC-Dre-027400	Danio rerio	72.61	8.00e-115	406.00
IUUC-Dno-029349	Dasypus novemcinctus	90.76	4.00e-105	374.00
IUUC-Dor-030103	Dipodomys ordii	94.06	2.00e-120	425.00
IUUC-Eca-034240	Equus caballus	92.44	3.00e-102	364.00
IUUC-Fal-037027	Ficedula albicollis	81.30	2.00e-102	365.00
IUUC-Fox-037736	Fusarium oxysporum	31.75	1.00e-14	74.30
IUUC-Fso-038447	Fusarium solani	37.50	7.00e-16	79.00
IUUC-Gmo-039694	Gadus morhua	70.03	2.00e-119	422.00
IUUC-Ggr-039947	Gaeumannomyces graminis	34.11	5.00e-12	66.20
IUUC-Gga-040682	Gallus gallus	82.41	3.00e-122	431.00
IUUC-Gac-041369	Gasterosteus aculeatus	67.54	1.00e-110	392.00
IUUC-Gma-044015	Glycine max	33.70	2.00e-30	126.00
IUUC-Ggo-045421	Gorilla gorilla	97.76	2.00e-143	501.00
IUUC-Hvu-047602	Hordeum vulgare	46.73	7.00e-24	104.00
IUUC-Itr-048435	Ictidomys tridecemlineatus	94.38	1.00e-125	442.00
IUUC-Lch-050071	Latimeria chalumnae	79.55	7.00e-123	433.00
IUUC-Lpe-051427	Leersia perrieri	49.54	1.00e-26	113.00
IUUC-Loc-052470	Lepisosteus oculatus	64.63	1.00e-92	332.00
IUUC-Lma-053066	Leptosphaeria maculans	44.00	7.00e-21	95.50
IUUC-Laf-054249	Loxodonta africana	70.82	8.00e-69	253.00
IUUC-Mcc-055739	Macaca mulatta	99.04	7.00e-162	562.00
IUUC-Meu-056622	Macropus eugenii	65.15	9.00e-50	190.00
IUUC-Mor-057098	Magnaporthe oryzae	36.11	2.00e-12	67.40
IUUC-Mpo-057470	Magnaporthe poae	33.06	6.00e-12	65.90
IUUC-Mtr-057711	Medicago truncatula	41.98	4.00e-24	104.00
IUUC-Mga-059349	Meleagris gallopavo	78.62	1.00e-109	389.00
IUUC-Mvi-060434	Microbotryum violaceum	37.69	1.00e-19	91.30
IUUC-Mmr-060653	Microcebus murinus	94.57	2.00e-154	538.00
IUUC-Mdo-062442	Monodelphis domestica	87.59	1.00e-142	499.00
IUUC-Mmu-064148	Mus musculus	93.45	8.00e-143	499.00
IUUC-Mpu-065917	Mustela putorius furo	91.06	7.00e-132	463.00
IUUC-Mlu-067495	Myotis lucifugus	93.45	3.00e-143	500.00
IUUC-Nfi-068352	Neosartorya fischeri	43.43	3.00e-17	82.80
IUUC-Ncr-068908	Neurospora crassa	31.39	3.00e-18	86.70
IUUC-Nle-069274	Nomascus leucogenys	99.31	5.00e-150	523.00
IUUC-Opr-070359	Ochotona princeps	84.87	4.00e-90	324.00
IUUC-Ont-071505	Oreochromis niloticus	72.82	3.00e-116	411.00
IUUC-Oan-073225	Ornithorhynchus anatinus	80.38	4.00e-112	397.00
IUUC-Oba-075047	Oryza barthii	50.46	6.00e-27	114.00
IUUC-Obr-076829	Oryza brachyantha	51.82	9.00e-28	117.00
IUUC-Ogl-077378	Oryza glaberrima	50.46	6.00e-27	114.00
IUUC-Ogu-078709	Oryza glumaepatula	50.46	5.00e-27	114.00
IUUC-Oin-079400	Oryza indica	49.45	5.00e-23	101.00
IUUC-Olo-080762	Oryza longistaminata	50.46	6.00e-27	114.00
IUUC-Ome-081151	Oryza meridionalis	49.49	5.00e-23	101.00
IUUC-Oni-083090	Oryza nivara	50.46	5.00e-27	114.00
IUUC-Opu-083898	Oryza punctata	51.92	1.00e-26	113.00
IUUC-Oru-084267	Oryza rufipogon	50.46	5.00e-27	114.00
IUUC-Osa-086229	Oryza sativa	50.46	5.00e-27	114.00
IUUC-Ola-086315	Oryzias latipes	66.78	1.00e-110	392.00
IUUC-Oga-088067	Otolemur garnettii	94.14	5.00e-139	486.00
IUUC-Ptr-091404	Pan troglodytes	100.00	6.00e-120	422.00
IUUC-Pan-092424	Papio anubis	96.10	9.00e-160	555.00
IUUC-Psi-093171	Pelodiscus sinensis	83.52	6.00e-113	400.00
IUUC-Pma-094408	Petromyzon marinus	45.74	2.00e-63	235.00
IUUC-Ppa-095942	Physcomitrella patens	45.54	2.00e-24	107.00
IUUC-Pfo-097402	Poecilia formosa	70.25	1.00e-113	402.00
IUUC-Pab-097834	Pongo abelii	97.77	5.00e-116	410.00
IUUC-Pop-099462	Populus trichocarpa	50.51	2.00e-25	109.00
IUUC-Pca-100442	Procavia capensis	93.67	4.00e-100	357.00
IUUC-Ppe-101324	Prunus persica	49.54	1.00e-25	110.00
IUUC-Pva-103240	Pteropus vampyrus	92.65	5.00e-155	540.00
IUUC-Pgr-103273	Puccinia graminis	34.42	9.00e-18	84.30
IUUC-Ptt-103768	Puccinia triticina	39.81	8.00e-16	79.00
IUUC-Pte-104223	Pyrenophora teres	40.94	1.00e-21	98.60
IUUC-Pyt-104653	Pyrenophora triticirepentis	40.94	1.00e-21	97.80
IUUC-Rno-105203	Rattus norvegicus	93.79	2.00e-143	501.00
IUUC-Sha-107638	Sarcophilus harrisii	85.35	8.00e-128	449.00
IUUC-Ssl-108600	Sclerotinia sclerotiorum	30.43	1.00e-12	68.60
IUUC-Smo-109651	Selaginella moellendorffii	52.81	1.00e-23	101.00
IUUC-Sit-110648	Setaria italica	51.35	3.00e-28	119.00
IUUC-Sly-111407	Solanum lycopersicum	31.32	5.00e-26	111.00
IUUC-Stu-112467	Solanum tuberosum	30.96	2.00e-26	112.00
IUUC-Sbi-114297	Sorghum bicolor	49.55	3.00e-27	115.00
IUUC-Tgu-117502	Taeniopygia guttata	82.07	2.00e-118	418.00
IUUC-Tru-117681	Takifugu rubripes	69.07	3.00e-112	397.00
IUUC-Tni-120092	Tetraodon nigroviridis	65.51	1.00e-106	379.00
IUUC-Tca-121480	Theobroma cacao	48.08	8.00e-26	110.00
IUUC-Tre-122013	Trichoderma reesei	33.55	2.00e-16	80.90
IUUC-Tvi-122598	Trichoderma virens	32.69	1.00e-16	81.60
IUUC-Tae-122764	Triticum aestivum	52.48	5.00e-21	95.10
IUUC-Tur-126792	Triticum urartu	54.26	1.00e-21	96.70
IUUC-Ttr-128843	Tursiops truncatus	93.45	9.00e-143	499.00
IUUC-Vda-129671	Verticillium dahliae	33.33	3.00e-15	77.40
IUUC-Vvi-131335	Vitis vinifera	29.82	6.00e-26	111.00
IUUC-Xtr-132815	Xenopus tropicalis	56.06	2.00e-91	328.00
IUUC-Xma-133481	Xiphophorus maculatus	69.94	3.00e-113	401.00
IUUC-Zma-135326	Zea mays	50.00	2.00e-25	109.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence