iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020063

Ensembl Protein ID

ENSCAFP00000036075.1

UniProt Accession

A6Q0K4; A6Q0K4_CANLF

Genbank Protein ID

CAO03078.1

Protein Name

Frataxin

Genbank Nucleotide ID

AAEX03000578

Gene Name

fxn; FXN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000029645.1	ENSCAFT00000045995.1	ENSCAFP00000036075.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Other/Other	75.12	2.00e-80	295.00	IUUC-Hsa-046921

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Canis familiaris

Protein Sequence
(Fasta)

MWTLGRRAAA GLLPRSAPPG SAAAGAGTRG PTRAAPLHGG RGLRVGTGAA RGPSHANLSL 60
HHLNQLVNVK KQSVCLMNMR TVGTVSSPGS LDETTYERLA ETTLDSLAEF FEDLADKPYT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGAAGTGA ATTAACCCGC CCACTGGTCA CACAGCTGCC AAGTACAGAG TTCGGCCGCA 60
AACCGGGCAA TCCCTCTGCA GTGTGCGGGT CCCAAGGGCT CCAACCTCGC ACAGCCAAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR017789--Frataxin
IPR002908--Frataxin/CyaY
IPR020895--Frataxin_CS

PROSITE

PS01344--FRATAXIN_1
PS50810--FRATAXIN_2

Pfam

PF01491--Frataxin_Cyay

PRINTS

PR00904--FRATAXIN

SMART

SM01219--Frataxin_Cyay

Gene Ontology

GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0051537--F:2 iron, 2 sulfur cluster binding
GO:0008199--F:ferric iron binding
GO:0008198--F:ferrous iron binding
GO:0004322--F:ferroxidase activity
GO:0034986--F:iron chaperone activity
GO:0007628--P:adult walking behavior
GO:0009060--P:aerobic respiration
GO:0006879--P:cellular iron ion homeostasis
GO:0070301--P:cellular response to hydrogen peroxide
GO:0034599--P:cellular response to oxidative stress
GO:0009792--P:embryo development ending in birth or egg hatching
GO:0018283--P:iron incorporation into metallo-sulfur cluster
GO:0007005--P:mitochondrion organization
GO:0040015--P:negative regulation of multicellular organism growth
GO:0046621--P:negative regulation of organ growth
GO:0090201--P:negative regulation of release of cytochrome c from mitochondria
GO:0006119--P:oxidative phosphorylation
GO:1904234--P:positive regulation of aconitate hydratase activity
GO:0030307--P:positive regulation of cell growth
GO:0008284--P:positive regulation of cell proliferation
GO:1904231--P:positive regulation of succinate dehydrogenase activity
GO:0019230--P:proprioception
GO:0016540--P:protein autoprocessing
GO:0010722--P:regulation of ferrochelatase activity
GO:0010039--P:response to iron ion

KEGG

cfa:609051

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002122	Ailuropoda melanoleuca	82.93	7.00e-90	322.00
IUUC-Apl-003853	Anas platyrhynchos	82.50	7.00e-56	208.00
IUUC-Aca-005026	Anolis carolinensis	71.43	7.00e-60	222.00
IUUC-Aly-006200	Arabidopsis lyrata	45.83	1.00e-19	89.00
IUUC-Ath-007033	Arabidopsis thaliana	45.83	1.00e-19	89.40
IUUC-Ago-007707	Ashbya gossypii	44.44	5.00e-18	82.40
IUUC-Acl-008146	Aspergillus clavatus	38.52	2.00e-18	85.90
IUUC-Afl-008501	Aspergillus flavus	38.39	5.00e-15	73.90
IUUC-Afu-008851	Aspergillus fumigatus	37.10	8.00e-18	83.60
IUUC-Ani-009129	Aspergillus nidulans	40.00	8.00e-12	63.50
IUUC-Ang-009557	Aspergillus niger	37.90	3.00e-17	81.60
IUUC-Ate-010486	Aspergillus terreus	39.52	4.00e-18	84.30
IUUC-Bgr-012108	Blumeria graminis	41.88	4.00e-16	77.80
IUUC-Bta-013437	Bos taurus	75.36	9.00e-79	285.00
IUUC-Bci-013810	Botrytis cinerea	50.56	8.00e-16	77.00
IUUC-Bdi-014226	Brachypodium distachyon	43.86	1.00e-22	99.40
IUUC-Bol-015092	Brassica oleracea	48.86	5.00e-20	90.50
IUUC-Bra-017945	Brassica rapa	46.08	7.00e-20	89.70
IUUC-Cel-018466	Caenorhabditis elegans	53.54	2.00e-25	107.00
IUUC-Cja-019306	Callithrix jacchus	73.46	1.00e-74	271.00
IUUC-Cpo-021325	Cavia porcellus	70.28	4.00e-79	287.00
IUUC-Cre-022889	Chlamydomonas reinhardtii	51.49	1.00e-21	96.30
IUUC-Csa-023739	Chlorocebus sabaeus	75.60	2.00e-84	304.00
IUUC-Cho-024324	Choloepus hoffmanni	73.46	5.00e-74	270.00
IUUC-Cgl-026402	Colletotrichum gloeosporioides	44.17	8.00e-20	90.10
IUUC-Cne-027094	Cryptococcus neoformans	42.86	1.00e-13	69.30
IUUC-Cme-027112	Cyanidioschyzon merolae	46.67	9.00e-13	65.90
IUUC-Dre-028813	Danio rerio	66.67	7.00e-44	169.00
IUUC-Dno-029949	Dasypus novemcinctus	82.35	7.00e-54	202.00
IUUC-Dse-031482	Dothistroma septosporum	39.50	6.00e-19	87.00
IUUC-Dme-031608	Drosophila melanogaster	50.78	5.00e-33	133.00
IUUC-Ete-032937	Echinops telfairi	96.88	3.00e-13	67.80
IUUC-Eca-033899	Equus caballus	88.24	2.00e-66	244.00
IUUC-Fca-036579	Felis catus	83.71	1.00e-74	271.00
IUUC-Fox-037940	Fusarium oxysporum	46.55	1.00e-22	99.40
IUUC-Fso-038465	Fusarium solani	49.14	4.00e-23	100.00
IUUC-Ggr-040089	Gaeumannomyces graminis	43.33	2.00e-20	92.00
IUUC-Gga-040910	Gallus gallus	73.65	9.00e-63	232.00
IUUC-Gma-044349	Glycine max	44.63	4.00e-24	104.00
IUUC-Ggo-044854	Gorilla gorilla	77.03	3.00e-74	271.00
IUUC-Hsa-046921	Homo sapiens	76.08	6.00e-73	266.00
IUUC-Hvu-047142	Hordeum vulgare	42.75	2.00e-24	105.00
IUUC-Kpa-049187	Komagataella pastoris	42.48	2.00e-16	78.60
IUUC-Lch-050614	Latimeria chalumnae	72.66	3.00e-53	201.00
IUUC-Lpe-051184	Leersia perrieri	38.17	1.00e-22	99.00
IUUC-Loc-052083	Lepisosteus oculatus	70.09	4.00e-47	179.00
IUUC-Lma-053209	Leptosphaeria maculans	41.96	9.00e-16	76.30
IUUC-Laf-054090	Loxodonta africana	74.16	2.00e-79	287.00
IUUC-Meu-056814	Macropus eugenii	74.83	8.00e-64	235.00
IUUC-Mor-057169	Magnaporthe oryzae	47.46	4.00e-22	97.80
IUUC-Mpo-057483	Magnaporthe poae	45.00	7.00e-22	97.10
IUUC-Mtr-058166	Medicago truncatula	50.48	9.00e-20	89.70
IUUC-Mla-059015	Melampsora laricipopulina	42.59	6.00e-18	83.20
IUUC-Mvi-060356	Microbotryum violaceum	50.00	1.00e-19	89.70
IUUC-Mdo-062658	Monodelphis domestica	76.19	3.00e-63	234.00
IUUC-Mmu-063470	Mus musculus	72.77	2.00e-80	291.00
IUUC-Mac-065327	Musa acuminata	49.55	1.00e-24	105.00
IUUC-Mpu-065761	Mustela putorius furo	87.01	4.00e-72	263.00
IUUC-Mlu-067175	Myotis lucifugus	71.95	4.00e-85	306.00
IUUC-Nfi-068535	Neosartorya fischeri	37.10	9.00e-18	83.20
IUUC-Ncr-068966	Neurospora crassa	39.33	7.00e-23	100.00
IUUC-Opr-070533	Ochotona princeps	52.63	8.00e-32	129.00
IUUC-Oan-073024	Ornithorhynchus anatinus	78.15	8.00e-59	219.00
IUUC-Ocu-074451	Oryctolagus cuniculus	77.65	2.00e-70	258.00
IUUC-Oba-075540	Oryza barthii	43.86	2.00e-22	98.60
IUUC-Obr-076285	Oryza brachyantha	36.99	7.00e-23	100.00
IUUC-Ogl-077827	Oryza glaberrima	43.86	2.00e-22	98.60
IUUC-Ogu-078491	Oryza glumaepatula	43.86	2.00e-22	99.00
IUUC-Oin-080149	Oryza indica	43.86	2.00e-22	98.60
IUUC-Olo-080318	Oryza longistaminata	41.67	2.00e-20	91.30
IUUC-Oni-083037	Oryza nivara	43.86	2.00e-22	98.60
IUUC-Opu-083448	Oryza punctata	43.86	1.00e-22	99.40
IUUC-Oru-084793	Oryza rufipogon	43.86	2.00e-22	98.60
IUUC-Osa-086032	Oryza sativa	43.86	2.00e-22	98.60
IUUC-Ola-086956	Oryzias latipes	63.28	4.00e-43	167.00
IUUC-Olu-087806	Ostreococcus lucimarinus	40.00	4.00e-18	84.00
IUUC-Oga-089029	Otolemur garnettii	79.52	2.00e-83	301.00
IUUC-Oar-089471	Ovis aries	74.41	8.00e-78	282.00
IUUC-Pan-092091	Papio anubis	75.12	9.00e-84	302.00
IUUC-Psi-093193	Pelodiscus sinensis	72.37	2.00e-64	238.00
IUUC-Pma-094540	Petromyzon marinus	61.34	4.00e-41	159.00
IUUC-Pno-094873	Phaeosphaeria nodorum	43.33	2.00e-17	82.40
IUUC-Ppa-095343	Physcomitrella patens	46.59	5.00e-18	84.30
IUUC-Pfo-097093	Poecilia formosa	64.96	6.00e-43	166.00
IUUC-Pab-098781	Pongo abelii	96.25	2.00e-29	120.00
IUUC-Pop-098983	Populus trichocarpa	41.41	1.00e-22	99.40
IUUC-Pca-100872	Procavia capensis	69.19	2.00e-58	218.00
IUUC-Ppe-101711	Prunus persica	42.61	6.00e-21	93.60
IUUC-Pva-102256	Pteropus vampyrus	75.83	1.00e-80	291.00
IUUC-Pgr-103607	Puccinia graminis	45.16	2.00e-21	95.50
IUUC-Pte-104220	Pyrenophora teres	37.82	2.00e-15	74.70
IUUC-Pyt-104562	Pyrenophora triticirepentis	38.14	4.00e-16	77.80
IUUC-Rno-105021	Rattus norvegicus	69.19	2.00e-76	278.00
IUUC-Sce-106182	Saccharomyces cerevisiae	49.30	3.00e-15	74.70
IUUC-Sha-107279	Sarcophilus harrisii	67.39	3.00e-65	241.00
IUUC-Sja-107819	Schizosaccharomyces japonicus	42.02	2.00e-20	91.30
IUUC-Spo-108197	Schizosaccharomyces pombe	42.98	4.00e-21	94.00
IUUC-Smo-108810	Selaginella moellendorffii	53.57	5.00e-21	92.40
IUUC-Sit-110256	Setaria italica	38.93	4.00e-22	98.20
IUUC-Sly-111448	Solanum lycopersicum	47.62	2.00e-22	98.60
IUUC-Stu-112702	Solanum tuberosum	45.61	2.00e-22	99.00
IUUC-Sbi-113956	Sorghum bicolor	46.09	5.00e-24	103.00
IUUC-Sre-115024	Sporisorium reilianum	38.76	1.00e-17	82.80
IUUC-Ssc-116034	Sus scrofa	78.67	3.00e-83	300.00
IUUC-Tgu-117503	Taeniopygia guttata	73.24	3.00e-55	206.00
IUUC-Tsy-119166	Tarsius syrichta	62.58	4.00e-42	163.00
IUUC-Tni-120703	Tetraodon nigroviridis	44.63	8.00e-24	103.00
IUUC-Tca-121473	Theobroma cacao	51.14	5.00e-20	90.50
IUUC-Tre-122241	Trichoderma reesei	44.83	1.00e-19	88.60
IUUC-Tvi-122347	Trichoderma virens	42.24	4.00e-18	84.00
IUUC-Tae-124560	Triticum aestivum	43.33	7.00e-24	103.00
IUUC-Tur-126452	Triticum urartu	45.54	2.00e-23	101.00
IUUC-Tme-127205	Tuber melanosporum	48.15	2.00e-19	87.00
IUUC-Ttr-128186	Tursiops truncatus	79.56	4.00e-80	290.00
IUUC-Uma-129523	Ustilago maydis	35.21	1.00e-15	76.30
IUUC-Vda-129793	Verticillium dahliae	43.44	2.00e-20	92.40
IUUC-Vpa-130040	Vicugna pacos	88.39	9.00e-77	278.00
IUUC-Vvi-131588	Vitis vinifera	38.76	1.00e-21	96.30
IUUC-Yli-134631	Yarrowia lipolytica	47.62	3.00e-17	81.30
IUUC-Zma-135478	Zea mays	47.15	5.00e-25	107.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence