iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059335

UUCD1 version

UUC-MeG-00872

Ensembl Protein ID

ENSMGAP00000000929.1

UniProt Accession

H9H092; H9H092_MELGA

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Gene Name

PAN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000001439.1	ENSMGAT00000001577.1	ENSMGAP00000000929.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.20e-19	69.0	525	916

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.gyeqqDaqEfl 96
             Y+N+++Q+L++++++r+l+ +   + +++      + +l ++l  lf+ l  s+    + +++l+a++++ e    g    D+ E +
   Q: 525  NAYCNCMIQVLYFLEPVRCLVQN---HLCQK------EFCLGCELGLLFHMLDLSRGDPCQGSNFLRAFRTIPEASAlGLILADSDEAT 604
           56*********************...55654......57********************************999944599999999998 PP
   S: 97   afl.ldqleeelkk....eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgke 180
             + l +l ++ ++    + +++++e+e+ +  +     ++   ++++s+i +lF  ++++  +c +c+++++r ++ l ++l+ p++ 
   Q: 605  GKVnLGRLIQSWNRfiltQLHQETQEQEGPQ--AYRGAGSSTFGSSGDSVIGQLFSCEVENCSMC-RCGKETVRVSSTLLFTLSYPESA 690
           6544899999998875433333333333333..4444577888999***************9999.8*******************999 PP
   S: 181  etkkeslqdc.Lesftkeee.legenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp.fct 266
           e+    ++d  ++++ k+   le++ + +ce+c+k+q ++++  ++ lP+vL+++    s +e+     k + ++ f + L  +  f +
   Q: 691  EK---PVKDYeFAQILKRSIcLEQNTQAWCENCEKYQPTVQTRNIRCLPDVLVINCEVNSSKEA--DFWKTQAEYAFQRALMKRGgFEI 774
           87...4444325555555542677778****************************999955444..44589999999877655533555 PP
   S: 267  s...............................................peekqke.................kkkYeLiavvvHsG.sl 290
           +                                               +     +                  + Y+L+a vvH   s 
   Q: 775  TkgkeislgdwkelgnpevgrsypsveelkniwiphaikmrltknkelD-----VcnwsesdelsssddpesVYVYDLMATVVHILdSR 858
           5456666666666666666666666666666666666665555555550.....0555555555556666669*************9** PP
   S: 291  ssGHYvayvkn...........ekgkWllfdDskVtevkeeevleetg..staYvlfY 335
            +G  v ++k            ++++W+lf+D  +++v++ e +++    + + +l+Y
   Q: 859  TGGSLVGHIKVgetyhqrkegvTHQQWYLFNDFLIEPVDKCEAVQFDMswKVPAILYY 916
           ***********999988877777888*********99998776665444555555555 PP

Organism

Meleagris gallopavo

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Protein Sequence
(Fasta)

MNFEGLDPSL AEYAPTLHPA LDPVLDPHLN PSLLQNVELD PEGVPLEGIA VPESVHIVEG 60
MYSELHTAVS EVGVPVSVSH FDLHEEMLWV GNHGGHATSF FGPTLERYSS FQVNSSDDIR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGAGACGTT GGTTTTCACC ATGAATTTTG AAGGTCTCGA CCCCTCCCTT GCTGAGTATG 60
CTCCCACGCT GCACCCGGCG CTGGATCCCG TCCTGGACCC CCACCTCAAC CCCAGCCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0010606--P:positive regulation of cytoplasmic mRNA processing body assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	85.89	0.00e+00	1988.00
IUUC-Apl-003500	Anas platyrhynchos	97.41	0.00e+00	2108.00
IUUC-Aca-004930	Anolis carolinensis	90.05	0.00e+00	2063.00
IUUC-Acl-008214	Aspergillus clavatus	32.28	2.00e-154	540.00
IUUC-Afu-009112	Aspergillus fumigatus	32.17	1.00e-143	503.00
IUUC-Ang-009531	Aspergillus niger	29.57	7.00e-80	291.00
IUUC-Ame-011259	Astyanax mexicanus	78.71	0.00e+00	1823.00
IUUC-Bta-012371	Bos taurus	86.38	0.00e+00	1993.00
IUUC-Bci-013684	Botrytis cinerea	43.09	2.00e-70	260.00
IUUC-Cja-019297	Callithrix jacchus	83.12	0.00e+00	1929.00
IUUC-Cfa-020489	Canis familiaris	85.95	0.00e+00	1976.00
IUUC-Cpo-022392	Cavia porcellus	85.28	0.00e+00	1993.00
IUUC-Csa-023220	Chlorocebus sabaeus	85.89	0.00e+00	1992.00
IUUC-Csv-025841	Ciona savignyi	45.63	0.00e+00	885.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	30.64	1.00e-91	330.00
IUUC-Cne-026932	Cryptococcus neoformans	44.73	2.00e-68	254.00
IUUC-Dre-028482	Danio rerio	76.16	0.00e+00	1779.00
IUUC-Dno-029398	Dasypus novemcinctus	85.92	0.00e+00	1988.00
IUUC-Dor-030307	Dipodomys ordii	78.62	0.00e+00	1063.00
IUUC-Dme-032111	Drosophila melanogaster	42.31	0.00e+00	864.00
IUUC-Eca-033985	Equus caballus	86.38	0.00e+00	1994.00
IUUC-Eeu-034928	Erinaceus europaeus	75.60	0.00e+00	701.00
IUUC-Fca-035587	Felis catus	85.80	0.00e+00	1989.00
IUUC-Fal-037587	Ficedula albicollis	94.81	0.00e+00	2132.00
IUUC-Fso-038133	Fusarium solani	30.15	3.00e-128	452.00
IUUC-Gmo-039076	Gadus morhua	76.20	0.00e+00	1744.00
IUUC-Ggr-039957	Gaeumannomyces graminis	32.24	5.00e-137	482.00
IUUC-Gga-040948	Gallus gallus	99.65	0.00e+00	2264.00
IUUC-Gac-042396	Gasterosteus aculeatus	77.06	0.00e+00	1804.00
IUUC-Ggo-045412	Gorilla gorilla	85.71	0.00e+00	1985.00
IUUC-Hsa-046076	Homo sapiens	85.89	0.00e+00	1990.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	79.85	0.00e+00	1803.00
IUUC-Kpa-049178	Komagataella pastoris	40.84	4.00e-63	236.00
IUUC-Lch-050279	Latimeria chalumnae	77.93	0.00e+00	927.00
IUUC-Loc-052872	Lepisosteus oculatus	79.67	0.00e+00	1827.00
IUUC-Lma-052986	Leptosphaeria maculans	31.59	3.00e-91	329.00
IUUC-Laf-054181	Loxodonta africana	84.22	0.00e+00	1954.00
IUUC-Mcc-054812	Macaca mulatta	85.95	0.00e+00	1984.00
IUUC-Meu-056325	Macropus eugenii	88.20	0.00e+00	2026.00
IUUC-Mor-057246	Magnaporthe oryzae	29.14	9.00e-120	424.00
IUUC-Mpo-057464	Magnaporthe poae	32.18	5.00e-141	495.00
IUUC-Mla-058911	Melampsora laricipopulina	32.52	1.00e-98	354.00
IUUC-Mvi-060461	Microbotryum violaceum	34.24	5.00e-143	501.00
IUUC-Mmr-060636	Microcebus murinus	86.21	0.00e+00	1989.00
IUUC-Mmu-063503	Mus musculus	84.66	0.00e+00	1950.00
IUUC-Mpu-066670	Mustela putorius furo	86.12	0.00e+00	1986.00
IUUC-Mlu-068119	Myotis lucifugus	85.52	0.00e+00	2013.00
IUUC-Nfi-068398	Neosartorya fischeri	31.54	2.00e-88	320.00
IUUC-Ncr-068927	Neurospora crassa	29.95	1.00e-120	427.00
IUUC-Nle-069651	Nomascus leucogenys	82.12	0.00e+00	1895.00
IUUC-Opr-070614	Ochotona princeps	84.54	0.00e+00	1940.00
IUUC-Ont-072433	Oreochromis niloticus	77.32	0.00e+00	1822.00
IUUC-Oan-073283	Ornithorhynchus anatinus	73.73	0.00e+00	1357.00
IUUC-Ocu-074401	Oryctolagus cuniculus	84.93	0.00e+00	1976.00
IUUC-Ola-087522	Oryzias latipes	77.07	0.00e+00	1769.00
IUUC-Oga-088226	Otolemur garnettii	85.13	0.00e+00	1977.00
IUUC-Oar-089241	Ovis aries	86.23	0.00e+00	2019.00
IUUC-Pan-092297	Papio anubis	86.39	0.00e+00	1772.00
IUUC-Psi-094043	Pelodiscus sinensis	89.45	0.00e+00	1995.00
IUUC-Pma-094394	Petromyzon marinus	69.90	0.00e+00	1540.00
IUUC-Pno-095053	Phaeosphaeria nodorum	32.84	8.00e-146	511.00
IUUC-Ppa-095188	Physcomitrella patens	30.87	1.00e-86	314.00
IUUC-Pfo-097517	Poecilia formosa	77.94	0.00e+00	1828.00
IUUC-Pca-100471	Procavia capensis	85.77	0.00e+00	1864.00
IUUC-Pva-102805	Pteropus vampyrus	81.69	0.00e+00	1540.00
IUUC-Pte-104021	Pyrenophora teres	32.30	4.00e-157	548.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	32.21	1.00e-156	547.00
IUUC-Rno-105471	Rattus norvegicus	84.80	0.00e+00	1949.00
IUUC-Sce-106235	Saccharomyces cerevisiae	37.62	4.00e-55	209.00
IUUC-Sha-106883	Sarcophilus harrisii	87.73	0.00e+00	1866.00
IUUC-Spo-108169	Schizosaccharomyces pombe	32.10	1.00e-136	480.00
IUUC-Sar-113323	Sorex araneus	85.85	0.00e+00	1459.00
IUUC-Sre-115075	Sporisorium reilianum	48.65	1.00e-58	221.00
IUUC-Ssc-116363	Sus scrofa	85.53	0.00e+00	2004.00
IUUC-Tru-118427	Takifugu rubripes	77.78	0.00e+00	1864.00
IUUC-Tni-120218	Tetraodon nigroviridis	77.92	0.00e+00	1868.00
IUUC-Tre-122177	Trichoderma reesei	31.83	5.00e-151	528.00
IUUC-Tme-127176	Tuber melanosporum	32.77	5.00e-141	495.00
IUUC-Tbe-127641	Tupaia belangeri	78.30	0.00e+00	724.00
IUUC-Ttr-128888	Tursiops truncatus	84.63	0.00e+00	1206.00
IUUC-Uma-129361	Ustilago maydis	50.00	2.00e-61	231.00
IUUC-Xtr-132811	Xenopus tropicalis	82.00	0.00e+00	1896.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence