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Tag Content
iUUCD ID IUUC-Ssc-115361
Ensembl Protein ID ENSSSCP00000028760.1
UniProt Accession A5GFW1; AURKA_PIG
Genbank Protein ID CAN13135.1
Protein Name Aurora kinase A; Aurora 2; Aurora/IPL1-related kinase 1; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A
Genbank Nucleotide ID CR956640
Gene Name AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSSSCG00000007493.3 ENSSSCT00000036639.1 ENSSSCP00000028760.1
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/Other 88.83 0.00e+00 724.00 IUUC-Hsa-046968
Active Site
Position(s) Description Evidence
256 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU00159,
ECO:0000255|PROSITE-ProRule:PRU10027}
Organism Sus scrofa
Functional Description
(View)

Functional Description



     Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (By similarity). Necessary for proper cilia disassembly prior to mitosis (By similarity). Interacts with SIRT2 (By similarity).
Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (By similarity). Necessary for proper cilia disassembly prior to mitosis (By similarity). Interacts with SIRT2 (By similarity).
Protein Sequence
(Fasta)
MDKCKENCIS GLKTTVPPGD GPKRVPVTQH FPAQHLPSAN SGQAQRVLCP SNSSQRLPSH 60
TQKLVSSHKP VQNLKQKQSQ ATSGPRPVSR PLSNTQQSEQ PQPAAPGNNP EKEAASKQKN 120
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Protein Fasta Sequence



>IUUC-Ssc-115361|E3,E3 activity/Other|Sus scrofa
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Nucleotide Sequence
(Fasta)
GCAAGTGGGA GGTGTTGTGG GGAACAGTGT TTTTTAACTA CACACTGCCC CCTGGAGAAT 60
TACTGAGGCT AATGATAATA AGAAGAGCTA ACATTTATTG AGTTTTTTTT TTTTTACCAT 120
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Nucleotide Fasta Sequence



>IUUC-Ssc-115361|E3,E3 activity/Other|Sus scrofa
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0966--Cell projection
KW-0969--Cilium
KW-0970--Cilium biogenesis/degradation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0418--Kinase
KW-0493--Microtubule
KW-0498--Mitosis
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0832--Ubl conjugation

Interpro

IPR030616--Aur
IPR030611--AURKA
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0005814--C:centriole
GO:0005813--C:centrosome
GO:0032133--C:chromosome passenger complex
GO:0005929--C:cilium
GO:0000780--C:condensed nuclear chromosome, centromeric region
GO:0005876--C:spindle microtubule
GO:0051233--C:spindle midzone
GO:0031616--C:spindle pole centrosome
GO:0005524--F:ATP binding
GO:0035174--F:histone serine kinase activity
GO:0004672--F:protein kinase activity
GO:0004712--F:protein serine/threonine/tyrosine kinase activity
GO:0051301--P:cell division
GO:0030030--P:cell projection organization
GO:0000212--P:meiotic spindle organization
GO:0007100--P:mitotic centrosome separation
GO:0007052--P:mitotic spindle organization
GO:1904146--P:positive regulation of meiotic cell cycle process involved in oocyte maturation
GO:0045727--P:positive regulation of translation
GO:0032465--P:regulation of cytokinesis

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000930 Aegilops tauschii 61.64 4.00e-105 374.00
IUUC-Aml-001426 Ailuropoda melanoleuca 91.47 0.00e+00 728.00
IUUC-Atr-002453 Amborella trichopoda 63.14 2.00e-108 384.00
IUUC-Apl-003626 Anas platyrhynchos 70.62 4.00e-156 543.00
IUUC-Aca-004602 Anolis carolinensis 69.01 1.00e-148 518.00
IUUC-Aly-005878 Arabidopsis lyrata 63.27 8.00e-105 372.00
IUUC-Ath-007117 Arabidopsis thaliana 61.22 3.00e-105 374.00
IUUC-Acl-008199 Aspergillus clavatus 56.52 4.00e-87 314.00
IUUC-Afl-008419 Aspergillus flavus 59.22 5.00e-86 310.00
IUUC-Afu-008751 Aspergillus fumigatus 59.61 2.00e-86 312.00
IUUC-Ani-009181 Aspergillus nidulans 48.70 2.00e-90 325.00
IUUC-Ang-009787 Aspergillus niger 59.61 8.00e-87 313.00
IUUC-Aor-009980 Aspergillus oryzae 59.22 5.00e-86 310.00
IUUC-Ate-010286 Aspergillus terreus 57.30 3.00e-86 311.00
IUUC-Ame-010849 Astyanax mexicanus 60.61 3.00e-128 451.00
IUUC-Bgr-012110 Blumeria graminis 60.69 3.00e-87 315.00
IUUC-Bta-013474 Bos taurus 90.52 0.00e+00 750.00
IUUC-Bci-013756 Botrytis cinerea 55.85 5.00e-94 337.00
IUUC-Bdi-014257 Brachypodium distachyon 62.12 9.00e-107 379.00
IUUC-Bol-016310 Brassica oleracea 62.14 3.00e-103 367.00
IUUC-Bra-017438 Brassica rapa 61.89 3.00e-104 370.00
IUUC-Cel-018157 Caenorhabditis elegans 61.96 5.00e-102 363.00
IUUC-Cja-019282 Callithrix jacchus 88.06 0.00e+00 706.00
IUUC-Cfa-020162 Canis familiaris 89.92 0.00e+00 721.00
IUUC-Cpo-021764 Cavia porcellus 82.47 0.00e+00 652.00
IUUC-Cre-022827 Chlamydomonas reinhardtii 67.04 2.00e-107 381.00
IUUC-Csa-023694 Chlorocebus sabaeus 87.81 0.00e+00 663.00
IUUC-Cho-024350 Choloepus hoffmanni 96.94 5.00e-113 399.00
IUUC-Cin-025542 Ciona intestinalis 73.76 1.00e-119 421.00
IUUC-Csv-025873 Ciona savignyi 65.99 2.00e-119 421.00
IUUC-Cgl-026632 Colletotrichum gloeosporioides 50.15 7.00e-82 296.00
IUUC-Cne-026928 Cryptococcus neoformans 59.40 1.00e-93 336.00
IUUC-Cme-027336 Cyanidioschyzon merolae 72.08 4.00e-118 417.00
IUUC-Dre-028198 Danio rerio 62.47 5.00e-130 457.00
IUUC-Dno-029928 Dasypus novemcinctus 86.82 0.00e+00 648.00
IUUC-Dor-030238 Dipodomys ordii 78.22 0.00e+00 625.00
IUUC-Dse-031266 Dothistroma septosporum 52.46 2.00e-92 332.00
IUUC-Dme-032007 Drosophila melanogaster 61.60 1.00e-100 359.00
IUUC-Ete-032911 Echinops telfairi 66.93 7.00e-130 456.00
IUUC-Eca-033749 Equus caballus 90.86 0.00e+00 736.00
IUUC-Eeu-035170 Erinaceus europaeus 87.13 0.00e+00 708.00
IUUC-Fca-035498 Felis catus 92.05 0.00e+00 736.00
IUUC-Fal-037397 Ficedula albicollis 68.49 3.00e-150 524.00
IUUC-Fox-037747 Fusarium oxysporum 52.17 1.00e-90 325.00
IUUC-Fso-038429 Fusarium solani 55.22 4.00e-90 324.00
IUUC-Gmo-039378 Gadus morhua 59.90 2.00e-128 451.00
IUUC-Ggr-039939 Gaeumannomyces graminis 58.13 3.00e-94 338.00
IUUC-Gga-040187 Gallus gallus 70.98 5.00e-153 533.00
IUUC-Gac-042223 Gasterosteus aculeatus 61.27 1.00e-131 462.00
IUUC-Gma-042870 Glycine max 62.77 4.00e-99 353.00
IUUC-Ggo-045617 Gorilla gorilla 88.34 0.00e+00 721.00
IUUC-Hsa-046968 Homo sapiens 88.83 0.00e+00 724.00
IUUC-Hvu-047072 Hordeum vulgare 55.06 2.00e-82 298.00
IUUC-Itr-048233 Ictidomys tridecemlineatus 75.68 2.00e-171 594.00
IUUC-Kpa-049093 Komagataella pastoris 56.32 1.00e-76 279.00
IUUC-Lch-050346 Latimeria chalumnae 67.27 6.00e-147 513.00
IUUC-Lpe-051466 Leersia perrieri 66.05 8.00e-107 379.00
IUUC-Lma-053006 Leptosphaeria maculans 58.43 3.00e-89 321.00
IUUC-Laf-053422 Loxodonta africana 85.61 0.00e+00 691.00
IUUC-Mcc-055245 Macaca mulatta 87.63 0.00e+00 652.00
IUUC-Mor-056952 Magnaporthe oryzae 59.16 3.00e-90 325.00
IUUC-Mpo-057605 Magnaporthe poae 59.71 4.00e-95 341.00
IUUC-Mtr-057726 Medicago truncatula 62.90 3.00e-106 377.00
IUUC-Mla-059174 Melampsora laricipopulina 62.93 8.00e-98 350.00
IUUC-Mga-059562 Meleagris gallopavo 61.23 2.00e-119 421.00
IUUC-Mvi-060305 Microbotryum violaceum 61.60 2.00e-93 335.00
IUUC-Mmr-061588 Microcebus murinus 85.07 0.00e+00 704.00
IUUC-Mdo-061914 Monodelphis domestica 77.32 3.00e-174 603.00
IUUC-Mmu-063288 Mus musculus 82.13 0.00e+00 646.00
IUUC-Mac-064969 Musa acuminata 62.98 5.00e-106 376.00
IUUC-Mpu-066855 Mustela putorius furo 89.92 0.00e+00 717.00
IUUC-Mlu-068046 Myotis lucifugus 90.18 0.00e+00 716.00
IUUC-Nfi-068527 Neosartorya fischeri 60.00 2.00e-86 312.00
IUUC-Ncr-068678 Neurospora crassa 61.22 2.00e-92 332.00
IUUC-Nle-069848 Nomascus leucogenys 88.59 0.00e+00 721.00
IUUC-Opr-070589 Ochotona princeps 80.85 3.00e-180 624.00
IUUC-Ont-071733 Oreochromis niloticus 62.83 3.00e-125 441.00
IUUC-Oan-073399 Ornithorhynchus anatinus 86.99 3.00e-151 527.00
IUUC-Ocu-074063 Oryctolagus cuniculus 85.11 0.00e+00 697.00
IUUC-Oba-075264 Oryza barthii 63.01 4.00e-106 377.00
IUUC-Obr-076048 Oryza brachyantha 64.84 1.00e-105 375.00
IUUC-Ogl-077637 Oryza glaberrima 65.68 1.00e-105 375.00
IUUC-Ogu-078830 Oryza glumaepatula 63.01 3.00e-106 377.00
IUUC-Oin-079150 Oryza indica 63.01 2.00e-106 378.00
IUUC-Olo-080398 Oryza longistaminata 57.56 1.00e-81 295.00
IUUC-Ome-081544 Oryza meridionalis 54.61 3.00e-90 324.00
IUUC-Oni-082250 Oryza nivara 63.01 2.00e-106 378.00
IUUC-Opu-083638 Oryza punctata 63.36 5.00e-107 380.00
IUUC-Oru-084981 Oryza rufipogon 63.99 1.00e-106 378.00
IUUC-Osa-085961 Oryza sativa 63.99 1.00e-106 378.00
IUUC-Olu-087880 Ostreococcus lucimarinus 70.08 1.00e-112 399.00
IUUC-Oga-088891 Otolemur garnettii 86.75 0.00e+00 686.00
IUUC-Oar-090021 Ovis aries 90.27 0.00e+00 726.00
IUUC-Ptr-091458 Pan troglodytes 88.83 0.00e+00 724.00
IUUC-Pan-092546 Papio anubis 87.56 0.00e+00 661.00
IUUC-Psi-093280 Pelodiscus sinensis 73.75 4.00e-164 570.00
IUUC-Pma-094298 Petromyzon marinus 77.27 2.00e-120 424.00
IUUC-Pno-094847 Phaeosphaeria nodorum 49.71 5.00e-89 320.00
IUUC-Ppa-095855 Physcomitrella patens 61.59 2.00e-108 385.00
IUUC-Pfo-096428 Poecilia formosa 60.14 4.00e-132 464.00
IUUC-Pab-098696 Pongo abelii 88.12 0.00e+00 706.00
IUUC-Pop-099405 Populus trichocarpa 61.94 3.00e-106 377.00
IUUC-Pca-100740 Procavia capensis 80.40 0.00e+00 654.00
IUUC-Ppe-101854 Prunus persica 61.77 9.00e-107 379.00
IUUC-Pva-103212 Pteropus vampyrus 89.92 0.00e+00 709.00
IUUC-Pgr-103474 Puccinia graminis 59.72 3.00e-98 351.00
IUUC-Ptt-103933 Puccinia triticina 48.86 8.00e-62 230.00
IUUC-Pte-104089 Pyrenophora teres 57.65 3.00e-89 321.00
IUUC-Pyt-104555 Pyrenophora triticirepentis 57.65 3.00e-89 322.00
IUUC-Rno-105057 Rattus norvegicus 83.62 0.00e+00 662.00
IUUC-Sha-107137 Sarcophilus harrisii 79.84 5.00e-180 623.00
IUUC-Sja-107767 Schizosaccharomyces japonicus 59.34 1.00e-97 349.00
IUUC-Spo-108078 Schizosaccharomyces pombe 52.87 1.00e-102 366.00
IUUC-Smo-109288 Selaginella moellendorffii 65.81 3.00e-108 384.00
IUUC-Sit-110246 Setaria italica 63.86 9.00e-107 379.00
IUUC-Sly-111379 Solanum lycopersicum 64.06 5.00e-107 380.00
IUUC-Stu-112777 Solanum tuberosum 60.62 1.00e-106 379.00
IUUC-Sbi-114325 Sorghum bicolor 63.51 2.00e-106 378.00
IUUC-Sre-115203 Sporisorium reilianum 59.55 5.00e-81 294.00
IUUC-Tgu-116967 Taeniopygia guttata 72.53 6.00e-151 526.00
IUUC-Tru-117570 Takifugu rubripes 62.27 4.00e-136 477.00
IUUC-Tsy-119280 Tarsius syrichta 65.76 2.00e-133 468.00
IUUC-Tni-120721 Tetraodon nigroviridis 63.76 2.00e-134 471.00
IUUC-Tca-121494 Theobroma cacao 60.41 2.00e-105 374.00
IUUC-Tre-121869 Trichoderma reesei 58.11 5.00e-94 337.00
IUUC-Tvi-122510 Trichoderma virens 61.60 2.00e-91 328.00
IUUC-Tae-123071 Triticum aestivum 61.64 4.00e-105 374.00
IUUC-Tur-126240 Triticum urartu 61.64 1.00e-104 372.00
IUUC-Tme-126921 Tuber melanosporum 61.51 2.00e-95 342.00
IUUC-Tbe-127872 Tupaia belangeri 82.05 0.00e+00 627.00
IUUC-Ttr-129134 Tursiops truncatus 92.76 0.00e+00 709.00
IUUC-Uma-129412 Ustilago maydis 58.65 8.00e-80 290.00
IUUC-Vda-130003 Verticillium dahliae 52.00 1.00e-91 329.00
IUUC-Vvi-131272 Vitis vinifera 61.28 4.00e-106 377.00
IUUC-Xtr-132019 Xenopus tropicalis 66.92 8.00e-154 536.00
IUUC-Xma-134203 Xiphophorus maculatus 62.60 1.00e-133 469.00
IUUC-Yli-134503 Yarrowia lipolytica 54.23 6.00e-86 310.00
IUUC-Zma-135232 Zea mays 64.39 1.00e-104 372.00
Created Date 25-Jun-2017

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