iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-068221

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02052629

Gene Name

RACK1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000015507.2	ENSMLUT00000015509.2	ENSMLUP00000014130.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.10e-41	137.6	102	132
UBD/Beta-Prp	9.00e-57	192.6	10	180

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gHt +v ++af sd + +vsGs+D+tik+W+
   Q: 102  GHTKDVLSVAFsSDnRQIVSGSRDKTIKLWN 132
           8***********88899*************9 PP

UBD/Beta-Prp

   S: 89   tlkghedsvlslsfspsg.dklvsGshdrtirvwdletgqclee....tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkll 172
           tlkgh+  v+ ++  p+  d ++s+s+d+ti +w+l  ++  +      l+gh+++v+ vv+++dg+   sGs D+t+r Wdl tg+  
   Q: 10   TLKGHNGWVTQIATTPQFpDMILSASRDKTIIMWKLTRDETNYGipqrALRGHSHFVSDVVISSDGQFALSGSWDGTLR-WDLTTGTTT 97
           899*************999***************99777666556779*******************************.********* PP
   S: 173  rtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlng..htdnvksvrfs..pnderlvsgssDgsiriWdlrs 253
           r++ g ht++v s++f+s+ +++vsgs+d+t+klw+   g c +t+++  h+++v++vrfs  + + ++vs++ D+ +++W+l +
   Q: 98   RRFVG-HTKDVLSVAFSSDNRQIVSGSRDKTIKLWNT-LGVCKYTVQDesHSEWVSCVRFSpnSSNPIIVSCGWDKLVKVWNLAN 180
           ***99.******************************9.78888888776699*********55557899************9864 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MTEQMTLRGT LKGHNGWVTQ IATTPQFPDM ILSASRDKTI IMWKLTRDET NYGIPQRALR 60
GHSHFVSDVV ISSDGQFALS GSWDGTLRWD LTTGTTTRRF VGHTKDVLSV AFSSDNRQIV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTGCTGCTG CTCTCTCTGA AGTATCCAGG TCCATCCTCG TCGCTGCGGC GACACCCGCA 60
CCCGCCGCCG CCATGACTGA GCAGATGACC CTCCGTGGCA CCCTCAAGGG CCACAATGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0070062--C:extracellular exosome
GO:1990630--C:IRE1-RACK1-PP2A complex
GO:0030496--C:midbody
GO:0005739--C:mitochondrion
GO:0043025--C:neuronal cell body
GO:0005654--C:nucleoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0001891--C:phagocytic cup
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008200--F:ion channel inhibitor activity
GO:0030292--F:protein tyrosine kinase inhibitor activity
GO:0003723--F:RNA binding
GO:0035591--F:signaling adaptor activity
GO:0071333--P:cellular response to glucose stimulus
GO:0071363--P:cellular response to growth factor stimulus
GO:0030308--P:negative regulation of cell growth
GO:0010629--P:negative regulation of gene expression
GO:1903208--P:negative regulation of hydrogen peroxide-induced neuron death
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:0050765--P:negative regulation of phagocytosis
GO:0051898--P:negative regulation of protein kinase B signaling
GO:0043473--P:pigmentation
GO:0030822--P:positive regulation of cAMP catabolic process
GO:0030335--P:positive regulation of cell migration
GO:0051343--P:positive regulation of cyclic-nucleotide phosphodiesterase activity
GO:0042998--P:positive regulation of Golgi to plasma membrane protein transport
GO:0043547--P:positive regulation of GTPase activity
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0051901--P:positive regulation of mitochondrial depolarization
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032464--P:positive regulation of protein homooligomerization
GO:0001934--P:positive regulation of protein phosphorylation
GO:0051726--P:regulation of cell cycle
GO:0006412--P:translation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000395	Aegilops tauschii	64.08	5.00e-101	360.00
IUUC-Aml-001935	Ailuropoda melanoleuca	99.68	0.00e+00	646.00
IUUC-Atr-002694	Amborella trichopoda	67.41	5.00e-123	433.00
IUUC-Apl-003918	Anas platyrhynchos	99.64	1.00e-164	571.00
IUUC-Aca-004869	Anolis carolinensis	99.68	0.00e+00	646.00
IUUC-Aly-005671	Arabidopsis lyrata	65.12	5.00e-123	433.00
IUUC-Ath-007105	Arabidopsis thaliana	65.94	2.00e-123	434.00
IUUC-Ago-007720	Ashbya gossypii	55.91	1.00e-100	359.00
IUUC-Acl-008156	Aspergillus clavatus	72.12	3.00e-136	478.00
IUUC-Afl-008684	Aspergillus flavus	71.15	3.00e-135	474.00
IUUC-Afu-008867	Aspergillus fumigatus	73.08	7.00e-138	483.00
IUUC-Ani-009221	Aspergillus nidulans	72.12	2.00e-136	478.00
IUUC-Ang-009843	Aspergillus niger	71.15	1.00e-134	472.00
IUUC-Aor-010193	Aspergillus oryzae	71.15	3.00e-135	474.00
IUUC-Ate-010420	Aspergillus terreus	72.08	1.00e-122	432.00
IUUC-Ame-010884	Astyanax mexicanus	96.21	0.00e+00	634.00
IUUC-Bgr-012064	Blumeria graminis	69.87	6.00e-133	466.00
IUUC-Bta-013357	Bos taurus	99.68	0.00e+00	646.00
IUUC-Bci-013862	Botrytis cinerea	70.83	2.00e-135	474.00
IUUC-Bdi-014690	Brachypodium distachyon	62.08	6.00e-112	397.00
IUUC-Bol-016231	Brassica oleracea	66.25	7.00e-125	439.00
IUUC-Bra-016879	Brassica rapa	65.84	2.00e-123	435.00
IUUC-Cel-018335	Caenorhabditis elegans	68.75	3.00e-121	427.00
IUUC-Cja-019914	Callithrix jacchus	99.68	0.00e+00	646.00
IUUC-Cfa-020755	Canis familiaris	99.68	0.00e+00	646.00
IUUC-Cpo-022377	Cavia porcellus	99.68	0.00e+00	648.00
IUUC-Cre-022909	Chlamydomonas reinhardtii	74.29	4.00e-135	474.00
IUUC-Csa-023025	Chlorocebus sabaeus	99.68	0.00e+00	645.00
IUUC-Cin-025647	Ciona intestinalis	76.75	1.00e-144	505.00
IUUC-Csv-026027	Ciona savignyi	76.43	2.00e-142	498.00
IUUC-Cgl-026718	Colletotrichum gloeosporioides	74.56	4.00e-127	447.00
IUUC-Cne-026930	Cryptococcus neoformans	70.83	6.00e-135	473.00
IUUC-Cme-027251	Cyanidioschyzon merolae	63.14	5.00e-120	423.00
IUUC-Dre-028669	Danio rerio	95.27	0.00e+00	630.00
IUUC-Dno-029470	Dasypus novemcinctus	84.49	8.00e-149	520.00
IUUC-Dor-031098	Dipodomys ordii	89.56	4.00e-149	520.00
IUUC-Dse-031255	Dothistroma septosporum	70.83	5.00e-135	473.00
IUUC-Dme-032118	Drosophila melanogaster	76.83	8.00e-146	509.00
IUUC-Ete-033182	Echinops telfairi	83.41	1.00e-105	375.00
IUUC-Eca-033296	Equus caballus	100.00	2.00e-87	313.00
IUUC-Eeu-034771	Erinaceus europaeus	94.32	1.00e-174	605.00
IUUC-Fca-036315	Felis catus	99.68	0.00e+00	646.00
IUUC-Fal-036990	Ficedula albicollis	97.22	3.00e-103	367.00
IUUC-Fox-037702	Fusarium oxysporum	72.12	2.00e-137	481.00
IUUC-Fso-038384	Fusarium solani	72.76	8.00e-138	482.00
IUUC-Gmo-039630	Gadus morhua	93.83	2.00e-174	604.00
IUUC-Ggr-039985	Gaeumannomyces graminis	72.44	1.00e-137	482.00
IUUC-Gga-040540	Gallus gallus	99.68	0.00e+00	646.00
IUUC-Gac-041316	Gasterosteus aculeatus	91.00	4.00e-172	596.00
IUUC-Gma-042872	Glycine max	66.15	8.00e-124	436.00
IUUC-Ggo-045253	Gorilla gorilla	99.68	0.00e+00	646.00
IUUC-Hsa-046809	Homo sapiens	99.68	0.00e+00	646.00
IUUC-Hvu-047683	Hordeum vulgare	62.92	1.00e-113	402.00
IUUC-Itr-048025	Ictidomys tridecemlineatus	99.68	0.00e+00	646.00
IUUC-Kpa-049214	Komagataella pastoris	57.74	6.00e-98	350.00
IUUC-Lch-049634	Latimeria chalumnae	94.01	7.00e-180	622.00
IUUC-Lpe-050762	Leersia perrieri	62.58	1.00e-112	399.00
IUUC-Loc-052163	Lepisosteus oculatus	96.85	0.00e+00	637.00
IUUC-Lma-053113	Leptosphaeria maculans	72.44	2.00e-137	481.00
IUUC-Laf-054422	Loxodonta africana	99.68	0.00e+00	646.00
IUUC-Mcc-055348	Macaca mulatta	99.68	0.00e+00	645.00
IUUC-Meu-056543	Macropus eugenii	99.68	0.00e+00	647.00
IUUC-Mor-057107	Magnaporthe oryzae	72.44	2.00e-138	485.00
IUUC-Mpo-057487	Magnaporthe poae	72.76	3.00e-138	484.00
IUUC-Mtr-058808	Medicago truncatula	66.46	2.00e-124	438.00
IUUC-Mla-058909	Melampsora laricipopulina	72.84	2.00e-137	481.00
IUUC-Mga-059387	Meleagris gallopavo	99.68	0.00e+00	646.00
IUUC-Mvi-060392	Microbotryum violaceum	68.91	4.00e-132	464.00
IUUC-Mmr-061141	Microcebus murinus	88.93	3.00e-139	487.00
IUUC-Mdo-062932	Monodelphis domestica	99.68	0.00e+00	646.00
IUUC-Mmu-064132	Mus musculus	99.68	0.00e+00	646.00
IUUC-Mac-064447	Musa acuminata	60.80	5.00e-107	380.00
IUUC-Mpu-066721	Mustela putorius furo	98.74	0.00e+00	634.00
IUUC-Nfi-068344	Neosartorya fischeri	73.08	6.00e-138	483.00
IUUC-Ncr-068722	Neurospora crassa	71.15	2.00e-135	475.00
IUUC-Nle-069865	Nomascus leucogenys	99.68	0.00e+00	646.00
IUUC-Opr-071100	Ochotona princeps	84.54	6.00e-150	523.00
IUUC-Ont-072287	Oreochromis niloticus	94.01	0.00e+00	625.00
IUUC-Oan-072788	Ornithorhynchus anatinus	99.68	0.00e+00	646.00
IUUC-Ocu-073844	Oryctolagus cuniculus	97.16	3.00e-180	624.00
IUUC-Oba-075981	Oryza barthii	59.63	3.00e-101	361.00
IUUC-Obr-076099	Oryza brachyantha	61.16	2.00e-111	395.00
IUUC-Ogl-077804	Oryza glaberrima	62.39	2.00e-113	402.00
IUUC-Ogu-078035	Oryza glumaepatula	63.08	6.00e-113	400.00
IUUC-Oin-079327	Oryza indica	63.08	6.00e-113	400.00
IUUC-Olo-081084	Oryza longistaminata	63.08	6.00e-113	400.00
IUUC-Ome-081366	Oryza meridionalis	62.69	6.00e-114	403.00
IUUC-Oni-082682	Oryza nivara	62.69	6.00e-114	403.00
IUUC-Opu-084010	Oryza punctata	62.39	4.00e-114	404.00
IUUC-Oru-084358	Oryza rufipogon	62.69	6.00e-114	403.00
IUUC-Osa-085296	Oryza sativa	62.69	6.00e-114	403.00
IUUC-Ola-086400	Oryzias latipes	93.69	2.00e-180	624.00
IUUC-Olu-087817	Ostreococcus lucimarinus	75.47	2.00e-140	491.00
IUUC-Oga-088811	Otolemur garnettii	99.68	0.00e+00	646.00
IUUC-Oar-089962	Ovis aries	99.68	0.00e+00	646.00
IUUC-Ptr-091340	Pan troglodytes	99.68	0.00e+00	646.00
IUUC-Pan-091946	Papio anubis	99.68	0.00e+00	646.00
IUUC-Pma-094535	Petromyzon marinus	93.69	2.00e-179	620.00
IUUC-Pno-095100	Phaeosphaeria nodorum	74.53	5.00e-95	340.00
IUUC-Ppa-095752	Physcomitrella patens	74.76	2.00e-137	481.00
IUUC-Pfo-097311	Poecilia formosa	93.69	4.00e-180	623.00
IUUC-Pab-097863	Pongo abelii	99.68	0.00e+00	647.00
IUUC-Pop-099345	Populus trichocarpa	67.49	5.00e-127	446.00
IUUC-Pca-100594	Procavia capensis	98.74	0.00e+00	640.00
IUUC-Ppe-101743	Prunus persica	64.81	2.00e-121	428.00
IUUC-Pva-102746	Pteropus vampyrus	83.60	2.00e-148	518.00
IUUC-Pgr-103375	Puccinia graminis	57.69	4.00e-97	347.00
IUUC-Ptt-103839	Puccinia triticina	72.84	8.00e-136	476.00
IUUC-Pte-104026	Pyrenophora teres	72.44	2.00e-137	481.00
IUUC-Pyt-104584	Pyrenophora triticirepentis	72.44	3.00e-137	481.00
IUUC-Rno-104964	Rattus norvegicus	99.68	0.00e+00	646.00
IUUC-Sce-106224	Saccharomyces cerevisiae	53.50	4.00e-95	340.00
IUUC-Sha-107409	Sarcophilus harrisii	99.68	0.00e+00	646.00
IUUC-Sja-107971	Schizosaccharomyces japonicus	65.50	2.00e-124	438.00
IUUC-Spo-108297	Schizosaccharomyces pombe	63.90	4.00e-121	427.00
IUUC-Ssl-108479	Sclerotinia sclerotiorum	70.83	2.00e-135	474.00
IUUC-Smo-109017	Selaginella moellendorffii	69.30	1.00e-126	445.00
IUUC-Sit-110060	Setaria italica	63.08	2.00e-114	405.00
IUUC-Sly-111496	Solanum lycopersicum	68.12	6.00e-125	440.00
IUUC-Stu-112757	Solanum tuberosum	66.56	7.00e-121	426.00
IUUC-Sar-113173	Sorex araneus	99.68	0.00e+00	646.00
IUUC-Sbi-114681	Sorghum bicolor	62.77	2.00e-114	404.00
IUUC-Sre-115107	Sporisorium reilianum	70.51	1.00e-136	479.00
IUUC-Ssc-116218	Sus scrofa	95.27	2.00e-178	618.00
IUUC-Tru-118202	Takifugu rubripes	92.43	8.00e-178	615.00
IUUC-Tni-120260	Tetraodon nigroviridis	92.11	3.00e-177	613.00
IUUC-Tca-120951	Theobroma cacao	65.84	5.00e-125	440.00
IUUC-Tre-121961	Trichoderma reesei	73.08	1.00e-138	485.00
IUUC-Tvi-122447	Trichoderma virens	72.76	1.00e-137	481.00
IUUC-Tae-123560	Triticum aestivum	62.31	1.00e-112	399.00
IUUC-Tur-126335	Triticum urartu	67.41	2.00e-102	365.00
IUUC-Tme-127105	Tuber melanosporum	67.64	1.00e-123	436.00
IUUC-Tbe-128021	Tupaia belangeri	79.70	3.00e-86	310.00
IUUC-Ttr-128637	Tursiops truncatus	88.01	4.00e-160	557.00
IUUC-Uma-129634	Ustilago maydis	71.47	2.00e-137	481.00
IUUC-Vda-129923	Verticillium dahliae	72.12	5.00e-137	480.00
IUUC-Vpa-130410	Vicugna pacos	76.45	2.00e-108	385.00
IUUC-Vvi-131115	Vitis vinifera	66.36	3.00e-125	441.00
IUUC-Xtr-132105	Xenopus tropicalis	95.90	0.00e+00	635.00
IUUC-Xma-133875	Xiphophorus maculatus	94.01	2.00e-180	624.00
IUUC-Yli-134624	Yarrowia lipolytica	60.76	1.00e-117	416.00
IUUC-Zma-134711	Zea mays	62.77	2.00e-113	401.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence