iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Afu-009052

Ensembl Protein ID

CADAFUAP00004863

UniProt Accession

Q4WZJ6; RAD18_ASPFU

Genbank Protein ID

EAL93969.1

Protein Name

Postreplication repair E3 ubiquitin-protein ligase rad18; RING-type E3 ubiquitin transferase rad18

Genbank Nucleotide ID

AAHF01000001

Gene Name

AFUA_2G16700; rad18

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADAFUAG00004863	CADAFUAT00004863	CADAFUAP00004863

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	4.60e-07	28.8	26	91

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawce 70
           + ++C + ++ + +Pv++++ +t+   +I+++l++ gk cP +r++ +e +l  n ++++l++a+ +
   Q: 26   SSLRCQVCKDFFDNPVITSCSHTFCSLCIRRCLSTEGK-CPACRSSDQELKLRRNWAVQELVEAFQN 91
           5789**********************************.*********************9999966 PP

Organism

Aspergillus fumigatus

Functional Description
(View)

E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.

Protein Sequence
(Fasta)

MEQTFDLPDS TDWLETPLSL VSPLESSLRC QVCKDFFDNP VITSCSHTFC SLCIRRCLST 60
EGKCPACRSS DQELKLRRNW AVQELVEAFQ NARPSMLELA RKAANSRLDG GYVTGQPAAK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAACAGA CATTTGATCT TCCTGACTCT ACAGACTGGC TGGAAACGCC GTTGTCGCTC 60
GTCTCGCCGC TGGAATCCTC TCTCCGTTGT CAAGTCTGCA AGGACTTTTT CGACAACCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004580--Rad18
IPR003034--SAP_dom
IPR006642--Znf_Rad18_put
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50800--SAP
PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING
SM00513--SAP
SM00734--ZnF_Rad18

Gene Ontology

GO:0005634--C:nucleus
GO:0003684--F:damaged DNA binding
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016567--P:protein ubiquitination

KEGG

afm:AFUA_2G16700

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002086	Ailuropoda melanoleuca	23.98	9.00e-22	96.70
IUUC-Apl-003657	Anas platyrhynchos	27.53	2.00e-26	112.00
IUUC-Aca-005369	Anolis carolinensis	32.28	2.00e-15	72.80
IUUC-Ath-006986	Arabidopsis thaliana	28.12	3.00e-07	49.30
IUUC-Ago-007876	Ashbya gossypii	28.75	1.00e-31	128.00
IUUC-Acl-008246	Aspergillus clavatus	77.51	0.00e+00	632.00
IUUC-Afl-008666	Aspergillus flavus	71.54	9.00e-164	567.00
IUUC-Ani-009488	Aspergillus nidulans	65.37	1.00e-142	497.00
IUUC-Ang-009681	Aspergillus niger	76.55	6.00e-162	561.00
IUUC-Aor-010037	Aspergillus oryzae	75.80	1.00e-169	587.00
IUUC-Ate-010516	Aspergillus terreus	67.02	1.00e-65	240.00
IUUC-Ame-010630	Astyanax mexicanus	25.60	8.00e-27	112.00
IUUC-Bgr-012178	Blumeria graminis	41.50	4.00e-72	263.00
IUUC-Bta-012976	Bos taurus	24.92	6.00e-19	87.00
IUUC-Bci-013680	Botrytis cinerea	43.44	4.00e-80	290.00
IUUC-Bol-016476	Brassica oleracea	21.32	2.00e-07	50.10
IUUC-Bra-017176	Brassica rapa	28.12	2.00e-07	49.70
IUUC-Cja-019453	Callithrix jacchus	36.05	2.00e-12	65.50
IUUC-Cfa-020856	Canis familiaris	24.62	4.00e-20	90.90
IUUC-Cpo-021950	Cavia porcellus	27.67	1.00e-22	99.40
IUUC-Csa-023997	Chlorocebus sabaeus	25.71	6.00e-22	97.10
IUUC-Cho-024771	Choloepus hoffmanni	40.54	1.00e-12	65.90
IUUC-Cin-025364	Ciona intestinalis	28.38	7.00e-09	52.80
IUUC-Cgl-026668	Colletotrichum gloeosporioides	49.72	7.00e-82	295.00
IUUC-Cme-027202	Cyanidioschyzon merolae	38.30	7.00e-16	76.60
IUUC-Dre-028479	Danio rerio	26.16	4.00e-27	113.00
IUUC-Dno-028943	Dasypus novemcinctus	25.90	1.00e-21	95.90
IUUC-Dor-031046	Dipodomys ordii	30.34	3.00e-09	55.10
IUUC-Dse-031235	Dothistroma septosporum	42.37	5.00e-54	203.00
IUUC-Ete-032503	Echinops telfairi	29.31	6.00e-12	63.50
IUUC-Eca-033725	Equus caballus	25.62	8.00e-21	93.20
IUUC-Eeu-034573	Erinaceus europaeus	38.96	7.00e-12	63.20
IUUC-Fca-036495	Felis catus	38.10	3.00e-13	68.20
IUUC-Fal-036791	Ficedula albicollis	29.86	1.00e-20	92.80
IUUC-Fox-037868	Fusarium oxysporum	45.06	1.00e-77	281.00
IUUC-Fso-038144	Fusarium solani	48.14	1.00e-84	304.00
IUUC-Gmo-039152	Gadus morhua	27.27	2.00e-24	104.00
IUUC-Ggr-039737	Gaeumannomyces graminis	39.49	3.00e-72	264.00
IUUC-Gga-040788	Gallus gallus	43.02	1.00e-14	73.20
IUUC-Gac-041993	Gasterosteus aculeatus	26.22	3.00e-27	114.00
IUUC-Ggo-044889	Gorilla gorilla	27.05	1.00e-22	99.40
IUUC-Hsa-045957	Homo sapiens	27.27	5.00e-22	97.40
IUUC-Itr-048998	Ictidomys tridecemlineatus	26.78	7.00e-24	103.00
IUUC-Kpa-049300	Komagataella pastoris	26.26	5.00e-29	119.00
IUUC-Lch-050172	Latimeria chalumnae	41.33	3.00e-13	67.40
IUUC-Loc-052609	Lepisosteus oculatus	29.59	3.00e-25	108.00
IUUC-Lma-053037	Leptosphaeria maculans	46.00	2.00e-75	275.00
IUUC-Laf-053889	Loxodonta africana	26.80	1.00e-20	92.40
IUUC-Mcc-055853	Macaca mulatta	38.10	9.00e-14	69.70
IUUC-Meu-056866	Macropus eugenii	27.11	8.00e-13	66.20
IUUC-Mor-057071	Magnaporthe oryzae	43.54	1.00e-82	298.00
IUUC-Mpo-057628	Magnaporthe poae	42.74	3.00e-42	164.00
IUUC-Mla-058953	Melampsora laricipopulina	24.69	5.00e-20	90.90
IUUC-Mga-059687	Meleagris gallopavo	42.86	1.00e-12	66.20
IUUC-Mvi-060412	Microbotryum violaceum	26.63	7.00e-25	107.00
IUUC-Mmr-061563	Microcebus murinus	25.21	5.00e-21	94.00
IUUC-Mdo-062655	Monodelphis domestica	28.10	1.00e-22	99.80
IUUC-Mmu-063647	Mus musculus	24.75	1.00e-22	99.40
IUUC-Mpu-065778	Mustela putorius furo	36.90	4.00e-13	67.80
IUUC-Mlu-068205	Myotis lucifugus	26.78	3.00e-23	101.00
IUUC-Nfi-068501	Neosartorya fischeri	97.13	0.00e+00	803.00
IUUC-Ncr-068917	Neurospora crassa	42.43	6.00e-79	286.00
IUUC-Nle-068990	Nomascus leucogenys	27.00	4.00e-22	97.40
IUUC-Opr-071146	Ochotona princeps	27.53	5.00e-23	100.00
IUUC-Ont-071835	Oreochromis niloticus	28.42	1.00e-27	115.00
IUUC-Oan-072827	Ornithorhynchus anatinus	42.86	1.00e-16	78.20
IUUC-Ocu-073986	Oryctolagus cuniculus	27.22	6.00e-22	97.10
IUUC-Oin-079762	Oryza indica	37.68	2.00e-10	58.90
IUUC-Olo-081000	Oryza longistaminata	37.68	1.00e-10	58.20
IUUC-Ome-081927	Oryza meridionalis	37.68	2.00e-10	58.20
IUUC-Opu-083381	Oryza punctata	37.68	2.00e-10	56.60
IUUC-Ola-086997	Oryzias latipes	41.38	1.00e-13	68.90
IUUC-Olu-087771	Ostreococcus lucimarinus	42.11	3.00e-13	68.20
IUUC-Oga-088092	Otolemur garnettii	26.83	3.00e-23	101.00
IUUC-Oar-089651	Ovis aries	36.90	4.00e-13	67.80
IUUC-Ptr-091103	Pan troglodytes	27.27	3.00e-22	98.20
IUUC-Pan-092478	Papio anubis	26.23	6.00e-22	97.10
IUUC-Psi-093356	Pelodiscus sinensis	27.84	2.00e-16	79.00
IUUC-Ppa-095735	Physcomitrella patens	40.32	3.00e-07	48.90
IUUC-Pfo-096663	Poecilia formosa	28.81	2.00e-13	68.90
IUUC-Pab-098515	Pongo abelii	27.27	9.00e-23	99.80
IUUC-Pca-100588	Procavia capensis	33.33	2.00e-09	55.10
IUUC-Pva-102377	Pteropus vampyrus	24.03	6.00e-20	90.10
IUUC-Pgr-103556	Puccinia graminis	25.16	2.00e-16	79.00
IUUC-Pte-104362	Pyrenophora teres	41.73	2.00e-77	281.00
IUUC-Pyt-104823	Pyrenophora triticirepentis	41.53	1.00e-75	275.00
IUUC-Rno-105866	Rattus norvegicus	39.29	3.00e-14	71.20
IUUC-Sce-106454	Saccharomyces cerevisiae	39.13	1.00e-17	82.80
IUUC-Sha-107515	Sarcophilus harrisii	44.59	1.00e-14	72.80
IUUC-Sja-107689	Schizosaccharomyces japonicus	52.69	5.00e-25	107.00
IUUC-Spo-108248	Schizosaccharomyces pombe	29.90	3.00e-42	164.00
IUUC-Ssl-108430	Sclerotinia sclerotiorum	43.95	2.00e-76	278.00
IUUC-Sly-111863	Solanum lycopersicum	29.69	9.00e-08	51.20
IUUC-Stu-112154	Solanum tuberosum	28.12	4.00e-07	48.50
IUUC-Sre-115123	Sporisorium reilianum	29.50	2.00e-14	72.00
IUUC-Ssc-115992	Sus scrofa	27.48	8.00e-10	56.20
IUUC-Tgu-117286	Taeniopygia guttata	26.23	5.00e-17	80.50
IUUC-Tru-117959	Takifugu rubripes	26.21	7.00e-14	69.70
IUUC-Tni-120570	Tetraodon nigroviridis	27.37	4.00e-22	97.10
IUUC-Tre-121893	Trichoderma reesei	46.61	1.00e-84	305.00
IUUC-Tvi-122405	Trichoderma virens	47.92	5.00e-88	316.00
IUUC-Tbe-127758	Tupaia belangeri	37.18	7.00e-12	63.50
IUUC-Ttr-128841	Tursiops truncatus	25.48	9.00e-22	96.30
IUUC-Uma-129563	Ustilago maydis	33.68	1.00e-12	66.20
IUUC-Vda-130021	Verticillium dahliae	46.56	4.00e-33	132.00
IUUC-Vpa-130169	Vicugna pacos	38.27	2.00e-12	65.10
IUUC-Xtr-132308	Xenopus tropicalis	28.98	1.00e-15	75.50
IUUC-Xma-133868	Xiphophorus maculatus	24.75	2.00e-12	65.10
IUUC-Yli-134474	Yarrowia lipolytica	29.75	5.00e-34	136.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence