iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	dbPTM	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/UCH	UCH	17709260

Classification

Family	E-value	Score	Start	End
DUB/UCH	4.10e-56	189.1	1	235

Active Site

Position(s)	Description	Evidence
90	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10091}
166	Proton donor	ECO:0000255\|PROSITE-ProRule:PRU10091}

Domain Profile

DUB/UCH

   S: 1    mnsqvkewleLesdPglftllvedfgvkrdiqveelysL.dpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvigNsCat 101
           m++++++++++es+P++ft++ +++g+k+++ + ++ysL +pe l+++++pv++++llF+ine+r+ss+++q+t       ++d+i    ++kq+++N+C++
   Q: 1    MSGENRAVVPIESNPEVFTNFAHKLGLKNEWAYFDIYSLtEPELLAFLPRPVKAIVLLFPINEDRKSSTSQQIT------SSYDVI----WFKQSVKNACGL 92
           788999***************************************************************99976......679***....************ PP
   S: 102  yAllsvllncedklldlGttlsrlk.estkaespenkalalgnqq.vlecihnsl..ariesrseperqdedneqytkeafhfvsyvningrlyeldglkpf 199
           yA+l++l+n+++ l + G++l++++ ++++++s++n++++++++q vl++i++++  ++++++++pe +       +++++h+++yv+ ng ++eldg++  
   Q: 93   YAILHSLSNNQSLL-EPGSDLDNFLkSQSDTSSSKNRFDDVTTDQfVLNVIKENVqtFSTGQSEAPEAT-------ADTNLHYITYVEENGGIFELDGRNLS 186
           ************95.********988**************************99877999999999998.......6789********************87 PP
   S: 200  .Pldlgkk..keteelkdklkvvr..aflerikllesdeirfnllaivadr 245
            Pl+lgk+  + t+ ++++l +vr  +++e+ +  e+d ++f++l + +++
   Q: 187  gPLYLGKSdpTATDLIEQELVRVRvaSYMENAN--EEDVLNFAMLGLGPNW 235
           7******988899**********9999****77..9**********99987 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or RUB1. Preferentially cleaves ubiquitin from peptides and small adducts.

Protein Sequence
(Fasta)

MSGENRAVVP IESNPEVFTN FAHKLGLKNE WAYFDIYSLT EPELLAFLPR PVKAIVLLFP 60
INEDRKSSTS QQITSSYDVI WFKQSVKNAC GLYAILHSLS NNQSLLEPGS DLDNFLKSQS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCGGAG AAAATCGTGC TGTGGTGCCG ATTGAATCAA ACCCTGAAGT TTTTACAAAT 60
TTTGCACATA AATTAGGTTT AAAAAATGAA TGGGCGTATT TCGATATCTA TAGCTTAACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH

PROSITE

PS00140--UCH_1

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0010992--P:ubiquitin homeostasis
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

sce:YJR099W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000360	Aegilops tauschii	27.95	2.00e-17	80.10
IUUC-Aml-001344	Ailuropoda melanoleuca	34.90	2.00e-26	110.00
IUUC-Atr-002931	Amborella trichopoda	30.41	8.00e-18	81.60
IUUC-Apl-003949	Anas platyrhynchos	30.94	2.00e-20	90.10
IUUC-Aca-004924	Anolis carolinensis	31.36	4.00e-22	95.90
IUUC-Aly-005939	Arabidopsis lyrata	31.03	5.00e-18	82.40
IUUC-Ath-006827	Arabidopsis thaliana	32.11	1.00e-19	87.80
IUUC-Ago-007950	Ashbya gossypii	44.16	1.00e-53	200.00
IUUC-Acl-008305	Aspergillus clavatus	32.19	3.00e-30	123.00
IUUC-Afl-008611	Aspergillus flavus	34.82	5.00e-36	142.00
IUUC-Afu-008945	Aspergillus fumigatus	32.79	8.00e-33	131.00
IUUC-Ani-009339	Aspergillus nidulans	34.44	2.00e-33	133.00
IUUC-Ang-009691	Aspergillus niger	34.02	2.00e-33	133.00
IUUC-Aor-009961	Aspergillus oryzae	35.22	3.00e-36	142.00
IUUC-Ate-010316	Aspergillus terreus	33.61	2.00e-33	133.00
IUUC-Ame-011157	Astyanax mexicanus	35.71	3.00e-27	113.00
IUUC-Bgr-012125	Blumeria graminis	37.30	1.00e-36	144.00
IUUC-Bta-012673	Bos taurus	35.42	1.00e-26	110.00
IUUC-Bci-013734	Botrytis cinerea	34.84	4.00e-33	132.00
IUUC-Bdi-014248	Brachypodium distachyon	34.15	2.00e-17	80.90
IUUC-Bol-015214	Brassica oleracea	34.85	4.00e-21	92.40
IUUC-Bra-017721	Brassica rapa	31.76	1.00e-20	90.90
IUUC-Cel-018236	Caenorhabditis elegans	27.62	2.00e-08	50.10
IUUC-Cja-018752	Callithrix jacchus	26.09	2.00e-11	60.50
IUUC-Cfa-020371	Canis familiaris	34.84	3.00e-18	83.20
IUUC-Cpo-022036	Cavia porcellus	31.40	4.00e-24	102.00
IUUC-Cre-022599	Chlamydomonas reinhardtii	31.25	2.00e-13	67.00
IUUC-Csa-023854	Chlorocebus sabaeus	34.90	2.00e-26	110.00
IUUC-Cho-024548	Choloepus hoffmanni	37.93	3.00e-03	33.10
IUUC-Cin-025545	Ciona intestinalis	31.18	1.00e-23	100.00
IUUC-Csv-026149	Ciona savignyi	24.88	3.00e-06	43.90
IUUC-Cgl-026659	Colletotrichum gloeosporioides	31.98	7.00e-27	111.00
IUUC-Cne-026914	Cryptococcus neoformans	33.47	2.00e-17	80.50
IUUC-Cme-027216	Cyanidioschyzon merolae	29.44	4.00e-14	69.30
IUUC-Dre-028356	Danio rerio	35.82	2.00e-26	110.00
IUUC-Dno-029325	Dasypus novemcinctus	26.23	3.00e-11	60.10
IUUC-Dor-030114	Dipodomys ordii	29.89	2.00e-17	80.10
IUUC-Dse-031461	Dothistroma septosporum	32.03	5.00e-28	115.00
IUUC-Dme-032146	Drosophila melanogaster	29.44	3.00e-21	93.20
IUUC-Ete-033092	Echinops telfairi	29.36	5.00e-08	48.90
IUUC-Eca-033220	Equus caballus	34.90	1.00e-26	110.00
IUUC-Eeu-034493	Erinaceus europaeus	24.59	1.00e-08	51.20
IUUC-Fca-036421	Felis catus	34.90	2.00e-26	110.00
IUUC-Fal-036773	Ficedula albicollis	32.22	8.00e-21	91.70
IUUC-Fox-037830	Fusarium oxysporum	36.36	4.00e-31	125.00
IUUC-Fso-038259	Fusarium solani	35.98	6.00e-31	127.00
IUUC-Gmo-038848	Gadus morhua	33.51	5.00e-24	102.00
IUUC-Ggr-039832	Gaeumannomyces graminis	33.50	5.00e-28	115.00
IUUC-Gga-041205	Gallus gallus	31.62	3.00e-24	102.00
IUUC-Gac-041629	Gasterosteus aculeatus	35.20	6.00e-29	118.00
IUUC-Gma-043057	Glycine max	32.45	3.00e-18	83.20
IUUC-Ggo-044533	Gorilla gorilla	34.72	4.00e-25	105.00
IUUC-Hsa-046754	Homo sapiens	34.90	2.00e-26	110.00
IUUC-Hvu-047176	Hordeum vulgare	32.66	6.00e-17	79.00
IUUC-Itr-047992	Ictidomys tridecemlineatus	37.23	2.00e-20	89.70
IUUC-Kpa-049123	Komagataella pastoris	37.50	8.00e-41	157.00
IUUC-Lch-049685	Latimeria chalumnae	34.03	2.00e-27	113.00
IUUC-Lpe-051377	Leersia perrieri	30.85	2.00e-16	77.00
IUUC-Loc-051988	Lepisosteus oculatus	34.73	9.00e-28	114.00
IUUC-Lma-053316	Leptosphaeria maculans	31.91	3.00e-28	116.00
IUUC-Laf-053985	Loxodonta africana	34.98	1.00e-25	107.00
IUUC-Mcc-055888	Macaca mulatta	34.90	3.00e-25	106.00
IUUC-Meu-056478	Macropus eugenii	29.35	6.00e-16	75.50
IUUC-Mor-057271	Magnaporthe oryzae	34.70	2.00e-33	133.00
IUUC-Mpo-057343	Magnaporthe poae	48.62	2.00e-26	110.00
IUUC-Mtr-057713	Medicago truncatula	32.51	7.00e-19	85.10
IUUC-Mla-058942	Melampsora laricipopulina	31.22	2.00e-18	83.60
IUUC-Mga-059702	Meleagris gallopavo	30.94	1.00e-20	90.90
IUUC-Mvi-060249	Microbotryum violaceum	33.20	3.00e-31	126.00
IUUC-Mmr-061284	Microcebus murinus	37.23	1.00e-19	88.20
IUUC-Mdo-062639	Monodelphis domestica	28.94	4.00e-23	99.40
IUUC-Mmu-063299	Mus musculus	35.64	6.00e-27	112.00
IUUC-Mac-065075	Musa acuminata	31.20	1.00e-20	90.90
IUUC-Mpu-066769	Mustela putorius furo	34.90	2.00e-26	110.00
IUUC-Mlu-066937	Myotis lucifugus	34.90	8.00e-26	108.00
IUUC-Nfi-068320	Neosartorya fischeri	31.98	2.00e-32	130.00
IUUC-Ncr-068673	Neurospora crassa	33.88	8.00e-35	138.00
IUUC-Nle-069175	Nomascus leucogenys	30.80	3.00e-22	96.70
IUUC-Opr-070652	Ochotona princeps	37.04	5.00e-09	52.80
IUUC-Ont-072170	Oreochromis niloticus	36.73	1.00e-29	120.00
IUUC-Oan-073247	Ornithorhynchus anatinus	33.91	5.00e-14	67.40
IUUC-Ocu-074422	Oryctolagus cuniculus	34.33	2.00e-26	110.00
IUUC-Oba-075098	Oryza barthii	31.03	3.00e-23	99.80
IUUC-Obr-076327	Oryza brachyantha	32.99	1.00e-19	87.40
IUUC-Ogl-077483	Oryza glaberrima	31.03	3.00e-23	99.80
IUUC-Ogu-078978	Oryza glumaepatula	27.31	1.00e-19	87.80
IUUC-Oin-079285	Oryza indica	30.60	2.00e-22	97.10
IUUC-Olo-080671	Oryza longistaminata	31.47	2.00e-23	100.00
IUUC-Ome-081428	Oryza meridionalis	30.60	5.00e-22	95.50
IUUC-Oni-082406	Oryza nivara	31.03	3.00e-23	99.80
IUUC-Opu-083305	Oryza punctata	31.03	2.00e-23	100.00
IUUC-Oru-084969	Oryza rufipogon	31.03	3.00e-23	99.80
IUUC-Osa-085830	Oryza sativa	30.08	2.00e-18	83.60
IUUC-Ola-086893	Oryzias latipes	36.73	1.00e-29	120.00
IUUC-Olu-087858	Ostreococcus lucimarinus	33.62	4.00e-30	122.00
IUUC-Oga-088055	Otolemur garnettii	34.72	4.00e-25	105.00
IUUC-Oar-090319	Ovis aries	34.38	1.00e-26	110.00
IUUC-Ptr-091536	Pan troglodytes	26.78	1.00e-11	61.20
IUUC-Pan-092714	Papio anubis	34.72	4.00e-25	105.00
IUUC-Psi-094036	Pelodiscus sinensis	30.84	5.00e-20	89.00
IUUC-Pma-094412	Petromyzon marinus	32.14	2.00e-17	79.30
IUUC-Pno-094997	Phaeosphaeria nodorum	30.00	3.00e-26	109.00
IUUC-Ppa-095519	Physcomitrella patens	28.94	2.00e-22	97.40
IUUC-Pfo-096182	Poecilia formosa	33.62	8.00e-27	111.00
IUUC-Pab-098048	Pongo abelii	26.23	1.00e-11	60.80
IUUC-Pop-099282	Populus trichocarpa	35.38	4.00e-21	92.40
IUUC-Pca-100818	Procavia capensis	25.49	1.00e-06	43.90
IUUC-Ppe-101332	Prunus persica	31.03	4.00e-19	85.90
IUUC-Pva-102954	Pteropus vampyrus	25.84	1.00e-10	58.20
IUUC-Pgr-103430	Puccinia graminis	29.84	7.00e-23	98.60
IUUC-Ptt-103955	Puccinia triticina	29.75	1.00e-22	97.40
IUUC-Pte-104414	Pyrenophora teres	31.58	2.00e-28	117.00
IUUC-Pyt-104600	Pyrenophora triticirepentis	39.45	1.00e-23	99.80
IUUC-Rno-105096	Rattus norvegicus	35.32	7.00e-27	111.00
IUUC-Sha-106677	Sarcophilus harrisii	32.46	5.00e-24	102.00
IUUC-Sja-107753	Schizosaccharomyces japonicus	30.15	3.00e-16	76.30
IUUC-Spo-108322	Schizosaccharomyces pombe	28.96	8.00e-16	75.10
IUUC-Ssl-108641	Sclerotinia sclerotiorum	33.20	4.00e-30	122.00
IUUC-Smo-109283	Selaginella moellendorffii	31.55	4.00e-22	95.90
IUUC-Sit-110834	Setaria italica	31.36	1.00e-20	91.30
IUUC-Sly-111832	Solanum lycopersicum	33.01	4.00e-20	89.00
IUUC-Stu-112526	Solanum tuberosum	31.51	3.00e-20	89.70
IUUC-Sar-113294	Sorex araneus	30.53	3.00e-08	50.80
IUUC-Sbi-114048	Sorghum bicolor	31.65	2.00e-21	93.60
IUUC-Sre-114961	Sporisorium reilianum	35.00	4.00e-28	115.00
IUUC-Ssc-115255	Sus scrofa	34.48	2.00e-22	97.10
IUUC-Tgu-117003	Taeniopygia guttata	31.62	3.00e-23	99.40
IUUC-Tru-118330	Takifugu rubripes	35.16	1.00e-24	105.00
IUUC-Tsy-119488	Tarsius syrichta	37.04	4.00e-09	53.10
IUUC-Tni-120042	Tetraodon nigroviridis	35.52	4.00e-25	107.00
IUUC-Tca-120976	Theobroma cacao	32.61	1.00e-22	97.40
IUUC-Tre-122149	Trichoderma reesei	34.85	1.00e-31	127.00
IUUC-Tvi-122450	Trichoderma virens	34.12	3.00e-32	129.00
IUUC-Tae-124197	Triticum aestivum	29.49	3.00e-20	89.70
IUUC-Tur-126250	Triticum urartu	27.56	6.00e-18	82.00
IUUC-Tme-126961	Tuber melanosporum	31.95	4.00e-28	116.00
IUUC-Tbe-128048	Tupaia belangeri	32.11	7.00e-09	51.20
IUUC-Ttr-128494	Tursiops truncatus	26.23	2.00e-10	57.00
IUUC-Uma-129382	Ustilago maydis	34.73	2.00e-32	130.00
IUUC-Vda-129850	Verticillium dahliae	30.77	6.00e-21	92.00
IUUC-Vpa-130783	Vicugna pacos	35.63	2.00e-09	53.90
IUUC-Vvi-131661	Vitis vinifera	30.21	7.00e-21	91.70
IUUC-Xtr-132428	Xenopus tropicalis	34.41	1.00e-26	110.00
IUUC-Xma-134245	Xiphophorus maculatus	33.05	1.00e-26	110.00
IUUC-Yli-134570	Yarrowia lipolytica	32.76	3.00e-26	109.00
IUUC-Zma-134954	Zea mays	31.22	2.00e-21	93.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence