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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045918
UUCD1 version UUC-HoS-00293
Ensembl Protein ID ENSP00000263694.4
UniProt Accession Q96DI7; B4DQJ1; O75938; O95320; SNR40_HUMAN
Genbank Protein ID AAC69625.1; BAG60953.1; CAH71848.1; CAH71848.1; AAH01494.1; AAC64084.1
Protein Name U5 small nuclear ribonucleoprotein 40 kDa protein; 38 kDa-splicing factor; Prp8-binding protein; U5 snRNP-specific 40 kDa protein; WD repeat-containing protein 57
Genbank Nucleotide ID AF090988; AK298823; AL451070; AC114495; BC001494; AF083383
Gene Name SNRNP40; PRP8BP; SFP38; WDR57
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000060688.12 ENST00000263694.8 ENSP00000263694.4
ENSG00000060688.12 ENST00000373720.3 ENSP00000362825.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDBioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 17588513
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 5.20e-46 154.2 149 183
UBD/Beta-Prp 3.70e-79 267.7 62 265
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlrt 32
           gHt+ v+++     +  l+++GsdDgt+k+WD+r+
   Q: 149  GHTSFVNSCYParRGpQLVCTGSDDGTVKLWDIRK 183
           8*******9659955588999***********876 PP
   

   UBD/Beta-Prp
   S: 48   lsgheaevtavkfspdgkilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdg 138
           lsghe+ev+++kf+p+g++l++++ Dr+i +w++  +++   tlkgh+  v+ l+++ +g+ l s+s d+t+ vwd etg+ ++  l+gh++
   Q: 62   LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYgDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVK-RLKGHTS 152
           8*******************************8765999*********************************************.******* PP
   S: 139  vvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvr 229
           +vn+      g +l+ +Gs+D+tv+lWd++ +  ++t++  +t +v  ++f++++ +++sg+ d+++k+wdl++++  +t++gh d v+ + 
   Q: 153  FVNSCYPARRGpQLVCTGSDDGTVKLWDIRKKAAIQTFQ--NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLS 242
           **************************************7..6************************************************** PP
   S: 230  fspnderlvsgssDgsiriWdlr 252
           +s+++ +l+s ++D+++r+Wd+r
   Q: 243  LSSEGSYLLSNAMDNTVRVWDVR 265
           *********************87 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the U5 small nuclear ribonucleoprotein (snRNP) complex. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs.
 Component of the U5 small nuclear ribonucleoprotein (snRNP) complex. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs.
Protein Sequence
(Fasta)
MIEQQKRKGP ELPLVPVKRQ RHELLLGAGS GPGAGQQQAT PGALLQAGPP RCSSLQAPIM 60
LLSGHEGEVY CCKFHPNGST LASAGFDRLI LLWNVYGDCD NYATLKGHSG AVMELHYNTD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045918|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTGGCGGCG CTGAAGAGAC CGGTTGCCGC CATGATAGAA CAGCAGAAGC GTAAGGGCCC 60
AGAGTTGCCG CTGGTTCCAG TCAAGCGGCA GCGGCATGAG TTGCTGTTGG GAGCGGGGTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045918|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0488--Methylation
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0747--Spliceosome
KW-0832--Ubl conjugation
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0005829--C:cytosol
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0071011--C:precatalytic spliceosome
GO:0005732--C:small nucleolar ribonucleoprotein complex
GO:0005682--C:U5 snRNP
GO:0003723--F:RNA binding
GO:0000398--P:mRNA splicing, via spliceosome
GO:0006396--P:RNA processing
GO:0008380--P:RNA splicing
GO:0000375--P:RNA splicing, via transesterification reactions
KEGG hsa:9410
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000138 Aegilops tauschii 56.59 7.00e-120 423.00
IUUC-Aml-001428 Ailuropoda melanoleuca 99.12 0.00e+00 629.00
IUUC-Atr-003164 Amborella trichopoda 58.99 1.00e-121 429.00
IUUC-Apl-003447 Anas platyrhynchos 96.86 6.00e-162 563.00
IUUC-Aca-004270 Anolis carolinensis 84.17 3.00e-169 587.00
IUUC-Aly-005659 Arabidopsis lyrata 59.76 1.00e-124 439.00
IUUC-Ath-006764 Arabidopsis thaliana 59.16 4.00e-124 437.00
IUUC-Acl-008324 Aspergillus clavatus 47.80 2.00e-95 342.00
IUUC-Afl-008607 Aspergillus flavus 49.66 1.00e-89 323.00
IUUC-Afu-008998 Aspergillus fumigatus 47.51 3.00e-95 341.00
IUUC-Ani-009363 Aspergillus nidulans 49.05 1.00e-95 342.00
IUUC-Ang-009513 Aspergillus niger 48.51 4.00e-85 308.00
IUUC-Aor-010237 Aspergillus oryzae 48.09 2.00e-96 345.00
IUUC-Ate-010374 Aspergillus terreus 46.20 2.00e-83 302.00
IUUC-Ame-010728 Astyanax mexicanus 83.84 6.00e-172 596.00
IUUC-Bgr-012297 Blumeria graminis 46.15 2.00e-70 258.00
IUUC-Bta-012433 Bos taurus 94.41 0.00e+00 650.00
IUUC-Bci-013763 Botrytis cinerea 50.16 7.00e-95 340.00
IUUC-Bdi-014490 Brachypodium distachyon 58.92 2.00e-119 422.00
IUUC-Bol-016479 Brassica oleracea 61.86 4.00e-124 437.00
IUUC-Bra-017219 Brassica rapa 62.14 5.00e-124 437.00
IUUC-Cel-018512 Caenorhabditis elegans 56.04 1.00e-113 403.00
IUUC-Cja-019308 Callithrix jacchus 94.69 0.00e+00 654.00
IUUC-Cfa-020998 Canis familiaris 94.97 0.00e+00 656.00
IUUC-Cpo-021580 Cavia porcellus 97.77 0.00e+00 650.00
IUUC-Cre-022859 Chlamydomonas reinhardtii 53.37 1.00e-107 383.00
IUUC-Csa-023456 Chlorocebus sabaeus 100.00 0.00e+00 661.00
IUUC-Cho-024644 Choloepus hoffmanni 99.35 3.00e-179 620.00
IUUC-Cin-025463 Ciona intestinalis 59.01 2.00e-126 445.00
IUUC-Cgl-026497 Colletotrichum gloeosporioides 45.61 4.00e-94 338.00
IUUC-Cne-026780 Cryptococcus neoformans 40.90 7.00e-67 247.00
IUUC-Dre-027671 Danio rerio 81.34 2.00e-176 611.00
IUUC-Dno-029769 Dasypus novemcinctus 94.97 0.00e+00 659.00
IUUC-Dor-030776 Dipodomys ordii 88.76 9.00e-85 306.00
IUUC-Dse-031316 Dothistroma septosporum 43.24 6.00e-87 314.00
IUUC-Dme-031756 Drosophila melanogaster 61.46 3.00e-124 438.00
IUUC-Ete-032753 Echinops telfairi 87.11 3.00e-164 570.00
IUUC-Eca-033979 Equus caballus 94.41 0.00e+00 650.00
IUUC-Eeu-034862 Erinaceus europaeus 99.28 4.00e-72 265.00
IUUC-Fca-036110 Felis catus 94.48 9.00e-159 552.00
IUUC-Fal-037648 Ficedula albicollis 96.77 1.00e-176 612.00
IUUC-Fox-037861 Fusarium oxysporum 45.95 4.00e-91 328.00
IUUC-Fso-038405 Fusarium solani 45.95 5.00e-91 327.00
IUUC-Gmo-039383 Gadus morhua 83.29 2.00e-172 598.00
IUUC-Ggr-040082 Gaeumannomyces graminis 44.14 2.00e-84 306.00
IUUC-Gga-040785 Gallus gallus 90.83 7.00e-180 623.00
IUUC-Gac-041645 Gasterosteus aculeatus 83.01 1.00e-169 588.00
IUUC-Gma-044329 Glycine max 60.44 3.00e-122 431.00
IUUC-Ggo-044800 Gorilla gorilla 90.35 1.00e-159 556.00
IUUC-Hvu-047342 Hordeum vulgare 57.23 2.00e-119 421.00
IUUC-Itr-048047 Ictidomys tridecemlineatus 91.78 2.00e-111 394.00
IUUC-Kpa-049149 Komagataella pastoris 33.98 3.00e-36 145.00
IUUC-Lch-050395 Latimeria chalumnae 87.43 0.00e+00 655.00
IUUC-Lpe-051275 Leersia perrieri 57.83 1.00e-120 427.00
IUUC-Loc-052666 Lepisosteus oculatus 86.15 3.00e-173 600.00
IUUC-Lma-053129 Leptosphaeria maculans 43.40 2.00e-89 322.00
IUUC-Laf-054512 Loxodonta africana 93.84 0.00e+00 649.00
IUUC-Mcc-055819 Macaca mulatta 100.00 0.00e+00 661.00
IUUC-Meu-056350 Macropus eugenii 81.72 5.00e-159 553.00
IUUC-Mor-057063 Magnaporthe oryzae 46.20 1.00e-91 329.00
IUUC-Mpo-057369 Magnaporthe poae 45.05 2.00e-85 309.00
IUUC-Mtr-058228 Medicago truncatula 59.49 9.00e-122 429.00
IUUC-Mla-059093 Melampsora laricipopulina 40.57 3.00e-70 258.00
IUUC-Mga-059719 Meleagris gallopavo 96.50 5.00e-178 616.00
IUUC-Mvi-060285 Microbotryum violaceum 40.06 1.00e-63 236.00
IUUC-Mmr-061685 Microcebus murinus 88.27 7.00e-170 589.00
IUUC-Mdo-062121 Monodelphis domestica 90.58 0.00e+00 635.00
IUUC-Mmu-063216 Mus musculus 94.41 0.00e+00 660.00
IUUC-Mac-065463 Musa acuminata 54.79 1.00e-110 392.00
IUUC-Mpu-066390 Mustela putorius furo 95.81 0.00e+00 664.00
IUUC-Mlu-066932 Myotis lucifugus 94.15 4.00e-180 624.00
IUUC-Nfi-068509 Neosartorya fischeri 47.51 4.00e-95 341.00
IUUC-Ncr-068870 Neurospora crassa 47.19 2.00e-92 332.00
IUUC-Nle-069539 Nomascus leucogenys 100.00 0.00e+00 660.00
IUUC-Opr-070555 Ochotona princeps 82.12 2.00e-166 578.00
IUUC-Ont-071490 Oreochromis niloticus 82.78 5.00e-170 590.00
IUUC-Oan-073044 Ornithorhynchus anatinus 79.29 1.00e-153 536.00
IUUC-Ocu-073764 Oryctolagus cuniculus 95.53 0.00e+00 666.00
IUUC-Oba-075704 Oryza barthii 58.51 1.00e-120 426.00
IUUC-Obr-076455 Oryza brachyantha 58.82 2.00e-120 426.00
IUUC-Ogl-077382 Oryza glaberrima 58.82 8.00e-121 426.00
IUUC-Ogu-078739 Oryza glumaepatula 58.51 9.00e-121 426.00
IUUC-Oin-079072 Oryza indica 58.51 9.00e-121 426.00
IUUC-Olo-080809 Oryza longistaminata 58.51 9.00e-121 426.00
IUUC-Ome-081677 Oryza meridionalis 58.51 3.00e-120 424.00
IUUC-Oni-082937 Oryza nivara 58.51 9.00e-121 426.00
IUUC-Opu-083510 Oryza punctata 58.51 9.00e-121 426.00
IUUC-Oru-084360 Oryza rufipogon 58.51 1.00e-120 426.00
IUUC-Osa-085640 Oryza sativa 58.51 1.00e-120 426.00
IUUC-Ola-086504 Oryzias latipes 82.45 3.00e-171 593.00
IUUC-Olu-087869 Ostreococcus lucimarinus 41.64 3.00e-63 234.00
IUUC-Oga-088773 Otolemur garnettii 94.41 0.00e+00 654.00
IUUC-Oar-089677 Ovis aries 93.63 0.00e+00 644.00
IUUC-Ptr-090724 Pan troglodytes 99.71 0.00e+00 630.00
IUUC-Pan-092683 Papio anubis 100.00 0.00e+00 661.00
IUUC-Psi-093415 Pelodiscus sinensis 97.72 9.00e-176 609.00
IUUC-Pma-094562 Petromyzon marinus 76.54 2.00e-169 588.00
IUUC-Pno-095014 Phaeosphaeria nodorum 46.93 1.00e-89 323.00
IUUC-Ppa-095822 Physcomitrella patens 57.87 1.00e-121 429.00
IUUC-Pfo-096579 Poecilia formosa 82.45 2.00e-168 584.00
IUUC-Pab-098313 Pongo abelii 100.00 0.00e+00 661.00
IUUC-Pop-099747 Populus trichocarpa 61.49 2.00e-123 434.00
IUUC-Pca-100871 Procavia capensis 85.00 1.00e-129 456.00
IUUC-Ppe-101389 Prunus persica 62.14 5.00e-124 437.00
IUUC-Pva-102468 Pteropus vampyrus 80.17 5.00e-149 520.00
IUUC-Pgr-103523 Puccinia graminis 41.77 8.00e-73 267.00
IUUC-Ptt-103930 Puccinia triticina 41.69 2.00e-72 266.00
IUUC-Pte-104299 Pyrenophora teres 46.33 1.00e-94 340.00
IUUC-Pyt-104564 Pyrenophora triticirepentis 46.63 2.00e-94 339.00
IUUC-Rno-105796 Rattus norvegicus 94.41 0.00e+00 653.00
IUUC-Sha-107191 Sarcophilus harrisii 90.58 0.00e+00 635.00
IUUC-Sja-107952 Schizosaccharomyces japonicus 37.92 2.00e-63 236.00
IUUC-Spo-108249 Schizosaccharomyces pombe 43.53 2.00e-80 292.00
IUUC-Ssl-108448 Sclerotinia sclerotiorum 49.53 3.00e-94 338.00
IUUC-Sit-110805 Setaria italica 57.59 1.00e-119 423.00
IUUC-Sly-111567 Solanum lycopersicum 61.71 3.00e-125 441.00
IUUC-Stu-112562 Solanum tuberosum 61.71 3.00e-126 444.00
IUUC-Sar-112991 Sorex araneus 98.63 1.00e-120 424.00
IUUC-Sbi-114010 Sorghum bicolor 58.58 1.00e-118 419.00
IUUC-Sre-114947 Sporisorium reilianum 42.99 4.00e-74 271.00
IUUC-Ssc-115371 Sus scrofa 94.41 0.00e+00 650.00
IUUC-Tgu-117429 Taeniopygia guttata 94.14 3.00e-174 604.00
IUUC-Tru-118081 Takifugu rubripes 83.06 3.00e-171 594.00
IUUC-Tsy-119101 Tarsius syrichta 82.40 3.00e-158 551.00
IUUC-Tni-120532 Tetraodon nigroviridis 83.01 2.00e-169 588.00
IUUC-Tca-121373 Theobroma cacao 59.64 9.00e-125 439.00
IUUC-Tre-122050 Trichoderma reesei 45.31 5.00e-90 324.00
IUUC-Tvi-122394 Trichoderma virens 42.77 2.00e-84 305.00
IUUC-Tae-124661 Triticum aestivum 57.36 4.00e-119 421.00
IUUC-Tme-126998 Tuber melanosporum 51.46 3.00e-94 338.00
IUUC-Tbe-128032 Tupaia belangeri 94.13 0.00e+00 655.00
IUUC-Ttr-129102 Tursiops truncatus 83.80 1.00e-158 552.00
IUUC-Uma-129363 Ustilago maydis 43.61 1.00e-77 283.00
IUUC-Vda-129891 Verticillium dahliae 47.37 2.00e-93 335.00
IUUC-Vpa-130827 Vicugna pacos 93.85 0.00e+00 647.00
IUUC-Vvi-131202 Vitis vinifera 56.57 3.00e-123 434.00
IUUC-Xtr-132769 Xenopus tropicalis 85.52 3.00e-171 594.00
IUUC-Xma-133147 Xiphophorus maculatus 82.45 5.00e-168 583.00
IUUC-Yli-134352 Yarrowia lipolytica 33.77 3.00e-36 145.00
IUUC-Zma-135294 Zea mays 58.39 1.00e-118 419.00
Created Date 25-Jun-2017

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