iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000055536.5	ENSDART00000077897.5	ENSDARP00000072363.4
ENSDARG00000055536.5	ENSDART00000140229.1	ENSDARP00000115717.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	5.20e-46	157.4	78	267

Active Site

Position(s)	Description	Evidence
84	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
87	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
261		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 3    ilktkgDGnCLlrAvsqs..........................................................llgvfdddslsda 33
           ++kt++DGnC++rA+++s                                                          ll +f+++s+sd+
   Q: 78   VRKTRPDGNCFYRAFGFShleslledskelhrfkaiaakskldlvsqgfteftiedfhntfmdlieacdkqtsvgeLLTSFNEQSVSDY 166
           79*************************************************************************************** PP
   S: 34   lveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklkk 121
           lv++Lr+ ts ylq+e+dff++fie+++++ efcq++vep++k +++ihi+aLaq+L + i+v+++d++e   gg++++++fpe   ++
   Q: 167  LVVYLRLVTSGYLQREEDFFQHFIEGGRTVREFCQQEVEPMSKeSDHIHIIALAQALGVCIQVEYMDRGE---GGTVNHHIFPEGG-EP 251
           *********************************************************************9...9************.** PP
   S: 122  pivLlYrsgHYdaLva 137
           +i LlYr+gHYd+L++
   Q: 252  KIFLLYRPGHYDILYK 267
           **************96 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MAEEQQQEIS QKEADGLNCL AYDEAIIAQQ DKIQQEIATS ISLVSERQEL SVLKREYADE 60
DTIYQQKIRD LQKKYSSVRK TRPDGNCFYR AFGFSHLESL LEDSKELHRF KAIAAKSKLD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAATGACTGT TCAGCTGGAA CATGGCGGAG GAGCAACAGC AGGAGATCTC TCAAAAGGAG 60
GCTGATGGTG AGAATATTAA ATAAGGTTTA ATTGCGTTTT GGCCAGAATT GATTTTGATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom
IPR030298--OTUB1
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043130--F:ubiquitin binding
GO:0071108--P:protein K48-linked deubiquitination

KEGG

dre:436684

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001871	Ailuropoda melanoleuca	78.39	2.00e-125	441.00
IUUC-Aly-005710	Arabidopsis lyrata	42.96	3.00e-55	208.00
IUUC-Ath-007112	Arabidopsis thaliana	43.51	3.00e-54	205.00
IUUC-Afl-008439	Aspergillus flavus	34.18	1.00e-08	53.50
IUUC-Ame-010740	Astyanax mexicanus	89.58	3.00e-141	494.00
IUUC-Bta-013533	Bos taurus	80.39	2.00e-124	437.00
IUUC-Bol-016100	Brassica oleracea	42.59	3.00e-53	202.00
IUUC-Bra-017705	Brassica rapa	39.93	3.00e-47	182.00
IUUC-Cel-018295	Caenorhabditis elegans	34.30	5.00e-41	161.00
IUUC-Cja-019190	Callithrix jacchus	81.57	5.00e-125	440.00
IUUC-Cfa-020430	Canis familiaris	82.54	1.00e-124	439.00
IUUC-Cpo-022355	Cavia porcellus	81.18	2.00e-125	441.00
IUUC-Cre-022997	Chlamydomonas reinhardtii	39.26	3.00e-47	182.00
IUUC-Csa-023286	Chlorocebus sabaeus	78.79	5.00e-123	433.00
IUUC-Cho-024411	Choloepus hoffmanni	34.15	9.00e-30	123.00
IUUC-Cin-025507	Ciona intestinalis	44.06	3.00e-47	181.00
IUUC-Csv-026273	Ciona savignyi	51.84	1.00e-71	263.00
IUUC-Dno-029165	Dasypus novemcinctus	84.00	3.00e-101	360.00
IUUC-Dor-030943	Dipodomys ordii	81.18	2.00e-125	441.00
IUUC-Dme-031922	Drosophila melanogaster	56.00	2.00e-76	278.00
IUUC-Ete-032296	Echinops telfairi	81.13	2.00e-76	279.00
IUUC-Eca-033695	Equus caballus	81.75	7.00e-124	436.00
IUUC-Eeu-034775	Erinaceus europaeus	46.05	3.00e-60	224.00
IUUC-Fca-036441	Felis catus	82.54	9.00e-125	439.00
IUUC-Gma-043712	Glycine max	41.94	5.00e-54	204.00
IUUC-Ggo-044552	Gorilla gorilla	84.91	2.00e-79	289.00
IUUC-Hsa-046766	Homo sapiens	81.57	1.00e-125	442.00
IUUC-Itr-048312	Ictidomys tridecemlineatus	81.18	2.00e-125	441.00
IUUC-Loc-052003	Lepisosteus oculatus	45.78	5.00e-53	200.00
IUUC-Laf-053705	Loxodonta africana	81.18	2.00e-125	441.00
IUUC-Mcc-055745	Macaca mulatta	76.19	4.00e-122	431.00
IUUC-Meu-056569	Macropus eugenii	71.75	3.00e-111	394.00
IUUC-Mtr-057712	Medicago truncatula	43.49	2.00e-48	186.00
IUUC-Mmr-061123	Microcebus murinus	80.56	4.00e-102	364.00
IUUC-Mdo-062613	Monodelphis domestica	73.98	4.00e-102	364.00
IUUC-Mmu-063658	Mus musculus	81.18	2.00e-125	441.00
IUUC-Mpu-066172	Mustela putorius furo	81.57	1.00e-125	442.00
IUUC-Mlu-066966	Myotis lucifugus	81.96	2.00e-125	442.00
IUUC-Nle-069519	Nomascus leucogenys	75.27	4.00e-80	291.00
IUUC-Opr-070761	Ochotona princeps	38.27	9.00e-29	119.00
IUUC-Oan-072922	Ornithorhynchus anatinus	46.70	6.00e-62	230.00
IUUC-Ocu-074643	Oryctolagus cuniculus	45.61	2.00e-60	225.00
IUUC-Oni-082026	Oryza nivara	29.21	7.00e-14	72.00
IUUC-Oru-084761	Oryza rufipogon	29.21	7.00e-14	72.00
IUUC-Oga-088064	Otolemur garnettii	81.57	1.00e-125	442.00
IUUC-Oar-089251	Ovis aries	81.27	9.00e-123	432.00
IUUC-Ptr-091430	Pan troglodytes	81.57	7.00e-125	439.00
IUUC-Pan-091969	Papio anubis	45.61	4.00e-61	227.00
IUUC-Pma-094366	Petromyzon marinus	68.52	2.00e-98	351.00
IUUC-Pab-097919	Pongo abelii	80.56	3.00e-101	361.00
IUUC-Pop-099401	Populus trichocarpa	40.55	3.00e-51	195.00
IUUC-Pca-100252	Procavia capensis	44.44	3.00e-20	91.70
IUUC-Ppe-101977	Prunus persica	42.22	4.00e-53	201.00
IUUC-Pva-102499	Pteropus vampyrus	82.47	2.00e-124	437.00
IUUC-Pgr-103552	Puccinia graminis	30.99	1.40e-01	29.30
IUUC-Rno-105233	Rattus norvegicus	81.18	2.00e-125	441.00
IUUC-Sha-107081	Sarcophilus harrisii	82.54	1.00e-124	439.00
IUUC-Sly-111640	Solanum lycopersicum	40.52	6.00e-50	191.00
IUUC-Sar-113295	Sorex araneus	46.05	2.00e-59	222.00
IUUC-Ssc-116202	Sus scrofa	81.57	1.00e-125	442.00
IUUC-Tni-120440	Tetraodon nigroviridis	36.44	7.00e-34	137.00
IUUC-Tca-121467	Theobroma cacao	41.18	2.00e-52	199.00
IUUC-Tbe-128116	Tupaia belangeri	84.91	4.00e-80	291.00
IUUC-Ttr-128622	Tursiops truncatus	80.78	8.00e-123	432.00
IUUC-Uma-129443	Ustilago maydis	31.05	1.00e-24	107.00
IUUC-Vvi-131389	Vitis vinifera	43.01	3.00e-54	205.00
IUUC-Xtr-131951	Xenopus tropicalis	46.67	4.00e-58	218.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence