iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tre-121977

Ensembl Protein ID

EGR48986

UniProt Accession

G0RI28; G0RI28_HYPJQ

Genbank Protein ID

EGR48986.1

Protein Name

Nuclear distribution protein PAC1; Lissencephaly-1 homolog; nudF homolog

Genbank Nucleotide ID

GL985063

Gene Name

PAC1; LIS1; TRIREDRAFT_77642

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
TRIREDRAFT_77642	EGR48986	EGR48986

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.70e-48	157.0	127	164
UBD/Beta-Prp	8.60e-64	214.4	125	419

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           H +svtc+af +  t ++sGs D+tik+WD+  g+l++
   Q: 127  HRASVTCVAFhPRfTSIASGSEDCTIKIWDWELGDLEQ 164
           999*******988899**************98888777 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk..ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfsp 104
           ++h + +tcv+f+p  + +a+gs+d tik+wd++ g+l ++++gh+ +v ++++   +   +l+++s+D tik+wd+   +k ++tl+ghe+sv +++f p
   Q: 125  ESHRASVTCVAFHPRFTSIASGSEDCTIKIWDWELGDLEQTIKGHTRPVLDLDYGGPKTgiLLASCSSDTTIKLWDPAdGYKNIRTLSGHEHSVSAVRFIP 225
           456667888*********************************************87766679*************765489***************88888 PP
   S: 105  ........sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl..ktgkllrtltgghtdsvyslsfdsng... 192
                   sg+ lvsG  d+t+++wd +tg+c++ tl+gh g+v+ v+ + dgn+l s + D t rlW l  ++ +   tl g h++ v + +f +     
   Q: 226  sggtgffsSGNMLVSGCGDKTLKIWDANTGYCVK-TLNGHAGWVRDVCPSLDGNYLLSTGGDHTGRLWELtvANPETKVTLIG-HEHVVGCCAFAPPAaye 324
           7777777688************************.**********************************97777777788898.*********88877888 PP
   S: 193  ..................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdl.rsgdllktlqlhnssvis 269
                             +++++gs+d+t+klwd  +g+c++tl gh+++v+ v f+p +++l+s+++D+s+r+Wdl + g++++tl++ ++++i 
   Q: 325  hlaalaglkkpppasstaEFMATGSRDKTIKLWDA-RGNCIKTLVGHDNWVSGVMFHPGGKYLLSVADDKSLRCWDLsQDGKCVRTLSNAHEHFIT 419
           888888888999999998****************9.899************************************983568********9987765 PP

Organism

Trichoderma reesei

Functional Description
(View)

Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.

Protein Sequence
(Fasta)

MSRTLPVRQA EELHKSIIAY LAANNLAESA TVLRQELGLG EDVFDAATTK KYEGLLEKKW 60
TSIVRLQKKA CPRNVFLRPP QIMDLETRNA ELQSEVDNAT PSSLSQKNKD PVSWLPKAPS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCATTGTCT AGAGCTGCGC AAGGCTGACG CGTGGCCAGA GGCGCATCCC AAACACCGTC 60
ACCATGAGTC GAACACTGCC CGTGCGGCAG GCCGAGGAGC TGTAGGTAAT ATGGCCACTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR002469--Peptidase_S9B_N
IPR033510--PLAA/Doa1/Lub1
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0000922--C:spindle pole
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007067--P:mitotic nuclear division
GO:0006810--P:transport

KEGG

tre:TRIREDRAFT_77642

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001589	Ailuropoda melanoleuca	43.16	5.00e-101	359.00
IUUC-Apl-004024	Anas platyrhynchos	44.03	4.00e-104	369.00
IUUC-Aca-004564	Anolis carolinensis	43.51	2.00e-101	360.00
IUUC-Ago-007862	Ashbya gossypii	28.48	5.00e-35	140.00
IUUC-Acl-008360	Aspergillus clavatus	64.54	9.00e-172	594.00
IUUC-Afl-008502	Aspergillus flavus	60.30	9.00e-164	567.00
IUUC-Afu-008848	Aspergillus fumigatus	65.22	0.00e+00	625.00
IUUC-Ani-009173	Aspergillus nidulans	55.56	5.00e-152	528.00
IUUC-Ang-009873	Aspergillus niger	55.37	2.00e-151	526.00
IUUC-Aor-009973	Aspergillus oryzae	57.65	1.00e-157	547.00
IUUC-Ate-010523	Aspergillus terreus	54.28	3.00e-151	526.00
IUUC-Ame-011154	Astyanax mexicanus	43.51	1.00e-104	370.00
IUUC-Bgr-011972	Blumeria graminis	63.39	0.00e+00	627.00
IUUC-Bta-013106	Bos taurus	43.31	1.00e-103	368.00
IUUC-Bci-013615	Botrytis cinerea	64.18	0.00e+00	636.00
IUUC-Cel-018459	Caenorhabditis elegans	37.00	6.00e-86	309.00
IUUC-Cja-018755	Callithrix jacchus	43.01	1.00e-101	361.00
IUUC-Cfa-020749	Canis familiaris	43.31	1.00e-103	368.00
IUUC-Cpo-022371	Cavia porcellus	43.31	1.00e-103	368.00
IUUC-Csa-023524	Chlorocebus sabaeus	44.36	2.00e-88	317.00
IUUC-Cho-024764	Choloepus hoffmanni	40.38	1.00e-83	301.00
IUUC-Cin-025753	Ciona intestinalis	40.30	7.00e-92	328.00
IUUC-Csv-025817	Ciona savignyi	40.51	3.00e-96	343.00
IUUC-Cgl-026529	Colletotrichum gloeosporioides	66.88	0.00e+00	646.00
IUUC-Cne-027087	Cryptococcus neoformans	49.42	3.00e-105	373.00
IUUC-Dre-027554	Danio rerio	43.51	2.00e-102	363.00
IUUC-Dno-029050	Dasypus novemcinctus	43.31	1.00e-103	368.00
IUUC-Dor-030222	Dipodomys ordii	40.04	4.00e-93	333.00
IUUC-Dse-031164	Dothistroma septosporum	58.79	1.00e-167	580.00
IUUC-Dme-031745	Drosophila melanogaster	40.34	2.00e-88	317.00
IUUC-Ete-032508	Echinops telfairi	44.21	4.00e-72	263.00
IUUC-Eca-034288	Equus caballus	42.74	7.00e-100	355.00
IUUC-Eeu-034984	Erinaceus europaeus	39.83	4.00e-92	329.00
IUUC-Fca-036498	Felis catus	43.31	1.00e-103	368.00
IUUC-Fal-036920	Ficedula albicollis	44.03	4.00e-104	369.00
IUUC-Fox-037996	Fusarium oxysporum	68.76	0.00e+00	673.00
IUUC-Fso-038160	Fusarium solani	64.93	0.00e+00	644.00
IUUC-Gmo-038983	Gadus morhua	42.89	3.00e-102	363.00
IUUC-Ggr-040051	Gaeumannomyces graminis	64.44	0.00e+00	641.00
IUUC-Gga-040623	Gallus gallus	44.03	4.00e-104	369.00
IUUC-Gac-041613	Gasterosteus aculeatus	42.71	3.00e-102	363.00
IUUC-Ggo-045410	Gorilla gorilla	38.65	8.00e-82	295.00
IUUC-Hsa-046358	Homo sapiens	43.72	1.00e-103	368.00
IUUC-Itr-047890	Ictidomys tridecemlineatus	43.31	1.00e-103	368.00
IUUC-Kpa-049351	Komagataella pastoris	27.63	3.00e-42	164.00
IUUC-Lch-049936	Latimeria chalumnae	42.68	9.00e-103	365.00
IUUC-Loc-052476	Lepisosteus oculatus	43.59	1.00e-101	361.00
IUUC-Lma-053170	Leptosphaeria maculans	62.18	2.00e-169	586.00
IUUC-Laf-053713	Loxodonta africana	43.31	5.00e-102	362.00
IUUC-Mcc-054628	Macaca mulatta	43.40	1.00e-103	367.00
IUUC-Meu-055927	Macropus eugenii	39.01	1.00e-55	207.00
IUUC-Mor-056962	Magnaporthe oryzae	66.11	0.00e+00	650.00
IUUC-Mpo-057583	Magnaporthe poae	64.44	9.00e-179	617.00
IUUC-Mla-058819	Melampsora laricipopulina	42.65	1.00e-103	368.00
IUUC-Mga-059945	Meleagris gallopavo	43.82	8.00e-104	368.00
IUUC-Mvi-060403	Microbotryum violaceum	45.61	8.00e-118	415.00
IUUC-Mmr-061289	Microcebus murinus	42.74	5.00e-101	359.00
IUUC-Mdo-061912	Monodelphis domestica	43.13	3.00e-103	366.00
IUUC-Mmu-063253	Mus musculus	43.31	1.00e-103	368.00
IUUC-Mpu-066638	Mustela putorius furo	43.31	1.00e-103	368.00
IUUC-Mlu-067267	Myotis lucifugus	42.56	2.00e-101	360.00
IUUC-Nfi-068571	Neosartorya fischeri	60.94	6.00e-165	572.00
IUUC-Ncr-068895	Neurospora crassa	68.55	0.00e+00	652.00
IUUC-Nle-069087	Nomascus leucogenys	43.51	3.00e-80	290.00
IUUC-Opr-070579	Ochotona princeps	43.31	1.00e-103	368.00
IUUC-Ont-072432	Oreochromis niloticus	43.10	1.00e-102	365.00
IUUC-Oan-073072	Ornithorhynchus anatinus	43.31	1.00e-103	368.00
IUUC-Ocu-074180	Oryctolagus cuniculus	43.31	1.00e-103	368.00
IUUC-Ola-086815	Oryzias latipes	43.12	5.00e-103	366.00
IUUC-Oga-088219	Otolemur garnettii	42.80	3.00e-101	360.00
IUUC-Oar-090394	Ovis aries	43.31	1.00e-103	368.00
IUUC-Ptr-091517	Pan troglodytes	43.31	1.00e-103	368.00
IUUC-Pan-092421	Papio anubis	43.40	1.00e-103	367.00
IUUC-Psi-093370	Pelodiscus sinensis	43.72	2.00e-103	367.00
IUUC-Pma-094319	Petromyzon marinus	42.82	7.00e-86	308.00
IUUC-Pno-094815	Phaeosphaeria nodorum	61.01	2.00e-172	597.00
IUUC-Pfo-097089	Poecilia formosa	43.51	5.00e-103	366.00
IUUC-Pab-098421	Pongo abelii	43.31	1.00e-103	368.00
IUUC-Pca-100120	Procavia capensis	36.99	3.00e-57	213.00
IUUC-Pva-102960	Pteropus vampyrus	43.10	1.00e-102	364.00
IUUC-Pgr-103538	Puccinia graminis	44.31	1.00e-110	391.00
IUUC-Ptt-103990	Puccinia triticina	37.36	1.00e-34	140.00
IUUC-Pte-104261	Pyrenophora teres	61.84	9.00e-173	597.00
IUUC-Pyt-104780	Pyrenophora triticirepentis	62.05	3.00e-173	599.00
IUUC-Rno-105123	Rattus norvegicus	43.31	1.00e-103	368.00
IUUC-Sce-106208	Saccharomyces cerevisiae	28.70	1.00e-35	142.00
IUUC-Sha-107010	Sarcophilus harrisii	43.13	2.00e-103	367.00
IUUC-Sja-107899	Schizosaccharomyces japonicus	33.97	3.00e-63	233.00
IUUC-Ssl-108571	Sclerotinia sclerotiorum	67.42	4.00e-179	619.00
IUUC-Sar-113309	Sorex araneus	42.52	3.00e-98	350.00
IUUC-Sre-115003	Sporisorium reilianum	48.64	1.00e-120	424.00
IUUC-Ssc-116148	Sus scrofa	43.31	1.00e-103	368.00
IUUC-Tgu-117299	Taeniopygia guttata	43.61	6.00e-104	369.00
IUUC-Tru-118179	Takifugu rubripes	43.33	9.00e-103	365.00
IUUC-Tsy-119493	Tarsius syrichta	42.68	4.00e-102	363.00
IUUC-Tni-120355	Tetraodon nigroviridis	42.71	7.00e-101	358.00
IUUC-Tvi-122661	Trichoderma virens	93.11	0.00e+00	849.00
IUUC-Tme-127031	Tuber melanosporum	60.00	8.00e-168	581.00
IUUC-Tbe-127492	Tupaia belangeri	43.48	8.00e-51	192.00
IUUC-Ttr-128929	Tursiops truncatus	43.31	2.00e-103	367.00
IUUC-Uma-129347	Ustilago maydis	48.22	6.00e-118	416.00
IUUC-Vda-129837	Verticillium dahliae	65.62	5.00e-175	605.00
IUUC-Vpa-130532	Vicugna pacos	40.43	3.00e-82	296.00
IUUC-Xtr-131985	Xenopus tropicalis	42.89	5.00e-103	365.00
IUUC-Xma-133314	Xiphophorus maculatus	43.51	3.00e-103	366.00
IUUC-Yli-134403	Yarrowia lipolytica	38.55	4.00e-88	316.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence