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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064313
Ensembl Protein ID ENSMUSP00000026833.5
UniProt Accession Q8CFJ9; WDR24_MOUSE
Genbank Protein ID AAH37651.1
Protein Name WD repeat-containing protein 24
Genbank Nucleotide ID BC037651
Gene Name Wdr24
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000025737.5 ENSMUST00000026833.5 ENSMUSP00000026833.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.50e-27 94.8 206 241
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf..sd.tllvsGsdDgtikvWDlrtgv 34
           H+++v+c+++   d + l++G++D+ +kvWD++t++
   Q: 206  HNGPVFCCDWhpEDrGWLATGGRDKMVKVWDMTTHR 241
           ***********655899****************987 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and GATSL3. In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux.
 As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and GATSL3. In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux.
Protein Sequence
(Fasta)
MEKMSRVSTA LSGSALTGRT MHCHLDAPAN AISVCRDAAQ VVVAGRSIFK IYAIEEEQFV 60
EKLNLRVGRK PSLNLSCADV VWHQMDENLL ATAATNGVVV TWNLGRPSRN KQDQLFTEHK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064313|E3,WD_repeat|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGACTACTTC CGGTAATGGG CGGGCAGTAG GTGAGTCTCT TCCGGTACTG TAGCTGAAGA 60
CCACTCTGTG CTTTCGGTAA ATGACTGGCG TGCGACGGGG CAGAGGCTTT TCTAGCACCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064313|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0061700--C:GATOR2 complex
GO:0006914--P:autophagy
GO:0034198--P:cellular response to amino acid starvation
GO:0032008--P:positive regulation of TOR signaling
GO:0010506--P:regulation of autophagy
KEGG mmu:268933
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001294 Ailuropoda melanoleuca 94.94 0.00e+00 1527.00
IUUC-Apl-004177 Anas platyrhynchos 82.21 0.00e+00 1298.00
IUUC-Ago-007803 Ashbya gossypii 24.85 6.00e-22 100.00
IUUC-Acl-008356 Aspergillus clavatus 28.65 9.00e-37 149.00
IUUC-Afu-009013 Aspergillus fumigatus 29.21 3.00e-35 144.00
IUUC-Ani-009185 Aspergillus nidulans 27.88 1.00e-34 142.00
IUUC-Ang-009533 Aspergillus niger 28.65 1.00e-36 149.00
IUUC-Aor-010148 Aspergillus oryzae 29.97 2.00e-38 155.00
IUUC-Ate-010528 Aspergillus terreus 30.37 1.00e-36 149.00
IUUC-Ame-011386 Astyanax mexicanus 72.22 0.00e+00 1110.00
IUUC-Bgr-012040 Blumeria graminis 27.40 1.00e-25 112.00
IUUC-Bta-013092 Bos taurus 95.06 0.00e+00 1561.00
IUUC-Bci-013751 Botrytis cinerea 28.45 6.00e-34 140.00
IUUC-Cel-018274 Caenorhabditis elegans 33.04 3.00e-54 209.00
IUUC-Cja-019083 Callithrix jacchus 89.58 0.00e+00 827.00
IUUC-Cfa-020652 Canis familiaris 94.45 0.00e+00 1156.00
IUUC-Cpo-021847 Cavia porcellus 96.08 0.00e+00 1538.00
IUUC-Csa-023407 Chlorocebus sabaeus 95.44 0.00e+00 1522.00
IUUC-Cin-025129 Ciona intestinalis 36.68 2.00e-127 449.00
IUUC-Csv-025991 Ciona savignyi 34.73 7.00e-120 424.00
IUUC-Cgl-026445 Colletotrichum gloeosporioides 27.76 4.00e-22 100.00
IUUC-Dre-028566 Danio rerio 69.80 0.00e+00 1095.00
IUUC-Dno-029775 Dasypus novemcinctus 90.86 0.00e+00 651.00
IUUC-Dor-030655 Dipodomys ordii 79.19 2.00e-133 469.00
IUUC-Dse-031422 Dothistroma septosporum 26.98 3.00e-36 147.00
IUUC-Dme-032155 Drosophila melanogaster 37.36 8.00e-147 514.00
IUUC-Ete-032984 Echinops telfairi 87.61 0.00e+00 1363.00
IUUC-Eca-034065 Equus caballus 95.70 0.00e+00 1520.00
IUUC-Eeu-034460 Erinaceus europaeus 86.02 0.00e+00 1340.00
IUUC-Fca-035432 Felis catus 95.44 0.00e+00 1504.00
IUUC-Fal-037575 Ficedula albicollis 83.44 0.00e+00 1397.00
IUUC-Fox-037810 Fusarium oxysporum 24.94 1.00e-22 102.00
IUUC-Fso-038116 Fusarium solani 24.54 3.00e-19 91.30
IUUC-Gmo-038937 Gadus morhua 73.53 0.00e+00 1146.00
IUUC-Ggr-039930 Gaeumannomyces graminis 26.81 5.00e-23 103.00
IUUC-Gga-040827 Gallus gallus 82.32 0.00e+00 1239.00
IUUC-Gac-042168 Gasterosteus aculeatus 74.18 0.00e+00 1176.00
IUUC-Ggo-044772 Gorilla gorilla 94.77 0.00e+00 1204.00
IUUC-Hsa-046676 Homo sapiens 94.77 0.00e+00 1204.00
IUUC-Itr-048506 Ictidomys tridecemlineatus 96.46 0.00e+00 1500.00
IUUC-Kpa-049109 Komagataella pastoris 34.66 2.00e-39 158.00
IUUC-Lch-050410 Latimeria chalumnae 75.09 0.00e+00 1269.00
IUUC-Loc-051786 Lepisosteus oculatus 76.39 0.00e+00 1251.00
IUUC-Lma-053068 Leptosphaeria maculans 30.13 2.00e-37 152.00
IUUC-Laf-054171 Loxodonta africana 92.03 0.00e+00 1484.00
IUUC-Mcc-055764 Macaca mulatta 89.86 0.00e+00 1117.00
IUUC-Meu-055941 Macropus eugenii 81.21 7.00e-173 601.00
IUUC-Mor-056918 Magnaporthe oryzae 27.83 7.00e-18 87.00
IUUC-Mla-058924 Melampsora laricipopulina 24.12 2.00e-21 97.10
IUUC-Mga-059495 Meleagris gallopavo 82.32 0.00e+00 1239.00
IUUC-Mvi-060314 Microbotryum violaceum 25.22 3.00e-21 98.60
IUUC-Mmr-061375 Microcebus murinus 94.96 0.00e+00 1479.00
IUUC-Mdo-062605 Monodelphis domestica 85.70 0.00e+00 1442.00
IUUC-Mpu-066860 Mustela putorius furo 95.32 0.00e+00 1522.00
IUUC-Mlu-067268 Myotis lucifugus 94.13 0.00e+00 1243.00
IUUC-Nfi-068523 Neosartorya fischeri 29.21 1.00e-35 146.00
IUUC-Ncr-068694 Neurospora crassa 24.16 8.00e-21 96.70
IUUC-Opr-070270 Ochotona princeps 88.84 0.00e+00 1097.00
IUUC-Ont-071681 Oreochromis niloticus 72.89 0.00e+00 1180.00
IUUC-Ola-086651 Oryzias latipes 67.68 0.00e+00 1181.00
IUUC-Oga-088730 Otolemur garnettii 87.59 0.00e+00 1474.00
IUUC-Oar-090328 Ovis aries 98.74 2.00e-142 498.00
IUUC-Ptr-091668 Pan troglodytes 95.60 0.00e+00 698.00
IUUC-Pan-092619 Papio anubis 95.70 0.00e+00 1524.00
IUUC-Psi-093906 Pelodiscus sinensis 82.93 0.00e+00 1397.00
IUUC-Pno-094980 Phaeosphaeria nodorum 29.60 9.00e-36 146.00
IUUC-Pfo-096284 Poecilia formosa 73.58 0.00e+00 1203.00
IUUC-Pab-097668 Pongo abelii 89.70 0.00e+00 1436.00
IUUC-Pca-100865 Procavia capensis 89.63 0.00e+00 1417.00
IUUC-Pva-102869 Pteropus vampyrus 84.71 0.00e+00 1439.00
IUUC-Pte-104040 Pyrenophora teres 29.33 6.00e-36 147.00
IUUC-Pyt-104648 Pyrenophora triticirepentis 28.57 1.00e-16 82.40
IUUC-Rno-105555 Rattus norvegicus 98.61 0.00e+00 1548.00
IUUC-Sce-106263 Saccharomyces cerevisiae 28.41 6.00e-13 70.50
IUUC-Sha-106936 Sarcophilus harrisii 83.57 0.00e+00 1132.00
IUUC-Sja-107793 Schizosaccharomyces japonicus 22.57 3.00e-44 173.00
IUUC-Spo-108236 Schizosaccharomyces pombe 26.72 4.00e-40 160.00
IUUC-Ssl-108603 Sclerotinia sclerotiorum 28.57 1.00e-33 138.00
IUUC-Sar-113686 Sorex araneus 89.31 0.00e+00 633.00
IUUC-Ssc-116279 Sus scrofa 93.50 0.00e+00 1236.00
IUUC-Tgu-116557 Taeniopygia guttata 69.44 0.00e+00 907.00
IUUC-Tru-118545 Takifugu rubripes 71.92 0.00e+00 1200.00
IUUC-Tni-120098 Tetraodon nigroviridis 73.14 0.00e+00 1198.00
IUUC-Tre-121960 Trichoderma reesei 22.92 3.00e-15 78.20
IUUC-Tvi-122484 Trichoderma virens 23.44 1.00e-15 79.30
IUUC-Tme-127028 Tuber melanosporum 33.41 6.00e-66 246.00
IUUC-Ttr-128346 Tursiops truncatus 85.51 0.00e+00 1436.00
IUUC-Vda-129729 Verticillium dahliae 24.48 3.00e-25 111.00
IUUC-Xtr-131862 Xenopus tropicalis 78.32 0.00e+00 1129.00
IUUC-Xma-133385 Xiphophorus maculatus 73.84 0.00e+00 1207.00
IUUC-Yli-134444 Yarrowia lipolytica 25.49 1.00e-37 152.00
Created Date 25-Jun-2017

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