iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

DNA & RNA Element
circRNADb	CircNet
Protein-protein Interaction
IID	iRefIndex	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
PhosphositePlus	UniProt
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/ZnF/UBZ	UBZ	20935496

Classification

Family	E-value	Score	Start	End
UBD/ZnF/UBZ	6.30e-09	37.5	41	64

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/UBZ

   S: 1    llvCPvCqkmvdqtdfeeHlDe.C 23
           +l CPvC+kmv+++d+++HlDe C
   Q: 41   KLACPVCSKMVPRYDLNRHLDEmC 64
           689******************988 PP

Organism

Homo sapiens

Functional Description
(View)

Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed:25430771). Also has endonuclease activity toward 5'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866).

Protein Sequence
(Fasta)

MMSEGKPPDK KRPRRSLSIS KNKKKASNSI ISCFNNAPPA KLACPVCSKM VPRYDLNRHL 60
DEMCANNDFV QVDPGQVGLI NSNVSMVDLT SVTLEDVTPK KSPPPKTNLT PGQSDSAKRE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGCGCGGA GCCAGGTGGG AGGTGCGAGG TGGCCGCGCG GGGATCTTGG GTGACAGGGC 60
ACCGAGGGAA GGAGGACGCG AGGGCAGCCA GGCCCTAGGG AGCAGGGAGA GTGGCTCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0227--DNA damage
KW-0234--DNA repair
KW-0255--Endonuclease
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0460--Magnesium
KW-0464--Manganese
KW-0479--Metal-binding
KW-0540--Nuclease
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033315--Fan1-like
IPR011990--TPR-like_helical_dom
IPR014883--VRR_NUC
IPR006642--Znf_Rad18_put

Pfam

PF08774--VRR_NUC

SMART

SM00990--VRR_NUC
SM00734--ZnF_Rad18

Gene Ontology

GO:0005829--C:cytosol
GO:0045171--C:intercellular bridge
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0008409--F:5'-3' exonuclease activity
GO:0017108--F:5'-flap endonuclease activity
GO:0070336--F:flap-structured DNA binding
GO:0000287--F:magnesium ion binding
GO:0004528--F:phosphodiesterase I activity
GO:0043130--F:ubiquitin binding
GO:0006281--P:DNA repair
GO:0000724--P:double-strand break repair via homologous recombination
GO:0036297--P:interstrand cross-link repair
GO:0006289--P:nucleotide-excision repair
GO:0033683--P:nucleotide-excision repair, DNA incision

KEGG

hsa:22909

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000306	Aegilops tauschii	34.78	1.00e-58	220.00
IUUC-Aml-001380	Ailuropoda melanoleuca	78.70	0.00e+00	1585.00
IUUC-Atr-002873	Amborella trichopoda	31.11	1.00e-78	288.00
IUUC-Apl-003430	Anas platyrhynchos	53.75	0.00e+00	949.00
IUUC-Aca-005376	Anolis carolinensis	50.49	0.00e+00	875.00
IUUC-Aly-005463	Arabidopsis lyrata	29.94	4.00e-69	256.00
IUUC-Ath-007392	Arabidopsis thaliana	30.26	5.00e-72	266.00
IUUC-Acl-008285	Aspergillus clavatus	25.87	2.00e-55	210.00
IUUC-Afl-008680	Aspergillus flavus	27.53	2.00e-60	227.00
IUUC-Afu-008795	Aspergillus fumigatus	26.76	2.00e-52	201.00
IUUC-Ani-009329	Aspergillus nidulans	26.67	4.00e-52	199.00
IUUC-Ang-009526	Aspergillus niger	25.75	5.00e-45	176.00
IUUC-Aor-009880	Aspergillus oryzae	27.53	8.00e-60	225.00
IUUC-Ate-010269	Aspergillus terreus	27.14	2.00e-59	224.00
IUUC-Ame-011630	Astyanax mexicanus	60.00	6.00e-176	611.00
IUUC-Bgr-012168	Blumeria graminis	24.36	2.00e-35	144.00
IUUC-Bta-013504	Bos taurus	71.56	0.00e+00	1368.00
IUUC-Bci-013838	Botrytis cinerea	24.31	2.00e-50	194.00
IUUC-Bdi-014522	Brachypodium distachyon	30.78	6.00e-68	253.00
IUUC-Bol-016153	Brassica oleracea	30.88	2.00e-72	267.00
IUUC-Bra-017548	Brassica rapa	29.29	1.00e-61	231.00
IUUC-Cel-018711	Caenorhabditis elegans	29.94	1.00e-64	241.00
IUUC-Cja-018810	Callithrix jacchus	89.81	0.00e+00	1726.00
IUUC-Cfa-020147	Canis familiaris	78.62	0.00e+00	1580.00
IUUC-Cpo-021787	Cavia porcellus	72.51	0.00e+00	1437.00
IUUC-Cre-022863	Chlamydomonas reinhardtii	45.45	6.00e-03	32.70
IUUC-Csa-023730	Chlorocebus sabaeus	95.38	0.00e+00	1877.00
IUUC-Cho-024754	Choloepus hoffmanni	73.27	3.00e-128	452.00
IUUC-Cin-025459	Ciona intestinalis	47.34	2.00e-40	158.00
IUUC-Cgl-026724	Colletotrichum gloeosporioides	25.61	8.00e-42	165.00
IUUC-Cne-026815	Cryptococcus neoformans	26.06	7.00e-35	142.00
IUUC-Cme-027208	Cyanidioschyzon merolae	32.14	4.00e-24	106.00
IUUC-Dre-027725	Danio rerio	60.28	0.00e+00	761.00
IUUC-Dno-029713	Dasypus novemcinctus	75.39	0.00e+00	1531.00
IUUC-Dse-031534	Dothistroma septosporum	24.65	2.00e-39	157.00
IUUC-Dme-032015	Drosophila melanogaster	32.04	5.20e-02	32.30
IUUC-Ete-033004	Echinops telfairi	62.89	0.00e+00	921.00
IUUC-Eca-034119	Equus caballus	80.39	0.00e+00	1583.00
IUUC-Eeu-034618	Erinaceus europaeus	64.62	0.00e+00	1209.00
IUUC-Fca-035411	Felis catus	79.94	0.00e+00	1627.00
IUUC-Fal-037505	Ficedula albicollis	66.62	0.00e+00	847.00
IUUC-Fox-038070	Fusarium oxysporum	25.80	2.00e-50	194.00
IUUC-Fso-038376	Fusarium solani	26.83	2.00e-51	197.00
IUUC-Gmo-039093	Gadus morhua	60.40	0.00e+00	753.00
IUUC-Ggr-040081	Gaeumannomyces graminis	26.35	5.00e-48	186.00
IUUC-Gac-041973	Gasterosteus aculeatus	60.69	0.00e+00	807.00
IUUC-Gma-043421	Glycine max	30.47	4.00e-74	273.00
IUUC-Ggo-044431	Gorilla gorilla	99.02	0.00e+00	1969.00
IUUC-Hvu-047632	Hordeum vulgare	31.67	3.00e-77	283.00
IUUC-Itr-048263	Ictidomys tridecemlineatus	79.24	0.00e+00	1579.00
IUUC-Kpa-049398	Komagataella pastoris	29.23	3.40e-02	30.80
IUUC-Lch-049799	Latimeria chalumnae	52.61	0.00e+00	1009.00
IUUC-Lpe-051149	Leersia perrieri	31.50	1.00e-82	301.00
IUUC-Loc-051964	Lepisosteus oculatus	50.19	0.00e+00	865.00
IUUC-Lma-053161	Leptosphaeria maculans	26.58	1.00e-53	205.00
IUUC-Laf-054446	Loxodonta africana	75.73	0.00e+00	1502.00
IUUC-Mcc-055087	Macaca mulatta	94.89	0.00e+00	1867.00
IUUC-Meu-055930	Macropus eugenii	69.42	0.00e+00	682.00
IUUC-Mor-056966	Magnaporthe oryzae	28.57	2.00e-48	187.00
IUUC-Mpo-057393	Magnaporthe poae	27.34	4.00e-42	166.00
IUUC-Mtr-058315	Medicago truncatula	31.53	1.00e-75	278.00
IUUC-Mla-058859	Melampsora laricipopulina	25.25	5.00e-36	146.00
IUUC-Mga-059870	Meleagris gallopavo	67.45	0.00e+00	898.00
IUUC-Mvi-060226	Microbotryum violaceum	28.10	5.00e-51	196.00
IUUC-Mmr-060892	Microcebus murinus	83.51	0.00e+00	1622.00
IUUC-Mdo-062896	Monodelphis domestica	60.21	0.00e+00	1193.00
IUUC-Mmu-064276	Mus musculus	71.29	0.00e+00	1449.00
IUUC-Mac-064503	Musa acuminata	30.93	1.00e-68	254.00
IUUC-Mpu-066820	Mustela putorius furo	77.10	0.00e+00	1557.00
IUUC-Mlu-068131	Myotis lucifugus	67.80	0.00e+00	1285.00
IUUC-Nfi-068480	Neosartorya fischeri	26.09	1.00e-52	201.00
IUUC-Ncr-068646	Neurospora crassa	26.70	1.00e-55	211.00
IUUC-Nle-069545	Nomascus leucogenys	94.30	0.00e+00	1893.00
IUUC-Opr-070722	Ochotona princeps	84.32	0.00e+00	876.00
IUUC-Ont-072561	Oreochromis niloticus	49.26	0.00e+00	887.00
IUUC-Oan-072811	Ornithorhynchus anatinus	58.95	0.00e+00	1149.00
IUUC-Ocu-073884	Oryctolagus cuniculus	74.54	0.00e+00	1493.00
IUUC-Oba-075112	Oryza barthii	30.16	1.00e-62	235.00
IUUC-Obr-076057	Oryza brachyantha	32.43	6.00e-81	296.00
IUUC-Ogl-077002	Oryza glaberrima	32.24	1.00e-73	271.00
IUUC-Ogu-078683	Oryza glumaepatula	31.01	3.00e-61	230.00
IUUC-Oin-079952	Oryza indica	30.78	2.00e-61	231.00
IUUC-Olo-080278	Oryza longistaminata	31.50	3.00e-61	230.00
IUUC-Ome-081094	Oryza meridionalis	31.62	1.00e-61	231.00
IUUC-Oni-083059	Oryza nivara	31.93	1.00e-61	231.00
IUUC-Opu-084144	Oryza punctata	31.20	5.00e-76	279.00
IUUC-Oru-084897	Oryza rufipogon	31.50	3.00e-61	230.00
IUUC-Osa-085924	Oryza sativa	31.74	2.00e-73	270.00
IUUC-Oga-088979	Otolemur garnettii	80.74	0.00e+00	1589.00
IUUC-Oar-090362	Ovis aries	71.49	0.00e+00	1425.00
IUUC-Ptr-090823	Pan troglodytes	99.02	0.00e+00	1969.00
IUUC-Pan-092863	Papio anubis	95.28	0.00e+00	1882.00
IUUC-Psi-093006	Pelodiscus sinensis	55.54	0.00e+00	1019.00
IUUC-Pma-094523	Petromyzon marinus	50.31	1.00e-132	466.00
IUUC-Pno-094770	Phaeosphaeria nodorum	26.39	6.00e-44	172.00
IUUC-Ppa-095372	Physcomitrella patens	31.88	5.00e-75	276.00
IUUC-Pfo-096875	Poecilia formosa	59.72	0.00e+00	778.00
IUUC-Pab-097665	Pongo abelii	97.42	0.00e+00	1905.00
IUUC-Pop-099082	Populus trichocarpa	30.77	3.00e-78	287.00
IUUC-Pca-100138	Procavia capensis	66.98	1.00e-121	431.00
IUUC-Ppe-101167	Prunus persica	28.02	6.00e-30	126.00
IUUC-Pva-103199	Pteropus vampyrus	62.18	2.00e-120	426.00
IUUC-Pgr-103480	Puccinia graminis	27.57	1.00e-44	176.00
IUUC-Ptt-103783	Puccinia triticina	30.99	2.00e-46	181.00
IUUC-Pte-104357	Pyrenophora teres	25.81	1.00e-39	158.00
IUUC-Pyt-104788	Pyrenophora triticirepentis	26.61	6.00e-46	179.00
IUUC-Rno-104958	Rattus norvegicus	69.88	0.00e+00	1382.00
IUUC-Sha-106828	Sarcophilus harrisii	59.01	0.00e+00	1232.00
IUUC-Sja-107731	Schizosaccharomyces japonicus	28.38	1.00e-45	177.00
IUUC-Spo-108086	Schizosaccharomyces pombe	24.82	3.00e-43	170.00
IUUC-Ssl-108610	Sclerotinia sclerotiorum	25.23	1.00e-47	184.00
IUUC-Smo-108690	Selaginella moellendorffii	34.06	2.00e-80	293.00
IUUC-Sit-110385	Setaria italica	36.18	2.00e-49	191.00
IUUC-Sly-111187	Solanum lycopersicum	32.22	2.00e-76	280.00
IUUC-Stu-112673	Solanum tuberosum	43.90	5.00e-32	130.00
IUUC-Sar-113548	Sorex araneus	56.83	0.00e+00	694.00
IUUC-Sbi-114131	Sorghum bicolor	37.02	9.00e-60	225.00
IUUC-Sre-114921	Sporisorium reilianum	38.46	8.00e-33	135.00
IUUC-Ssc-115484	Sus scrofa	77.17	0.00e+00	1506.00
IUUC-Tgu-116749	Taeniopygia guttata	64.52	0.00e+00	847.00
IUUC-Tru-118772	Takifugu rubripes	59.82	0.00e+00	741.00
IUUC-Tsy-119359	Tarsius syrichta	79.40	0.00e+00	1276.00
IUUC-Tni-120878	Tetraodon nigroviridis	48.49	0.00e+00	799.00
IUUC-Tca-120912	Theobroma cacao	31.66	1.00e-80	294.00
IUUC-Tre-122171	Trichoderma reesei	26.59	4.00e-57	216.00
IUUC-Tvi-122483	Trichoderma virens	27.96	4.00e-56	213.00
IUUC-Tae-125125	Triticum aestivum	31.48	4.00e-74	273.00
IUUC-Tur-126497	Triticum urartu	31.57	1.00e-73	271.00
IUUC-Tbe-127473	Tupaia belangeri	60.75	8.00e-89	321.00
IUUC-Ttr-128458	Tursiops truncatus	70.98	0.00e+00	1368.00
IUUC-Uma-129558	Ustilago maydis	40.00	4.00e-34	140.00
IUUC-Vda-129683	Verticillium dahliae	25.03	2.00e-48	187.00
IUUC-Vvi-131226	Vitis vinifera	35.52	2.00e-63	236.00
IUUC-Xtr-132517	Xenopus tropicalis	53.46	0.00e+00	734.00
IUUC-Xma-133763	Xiphophorus maculatus	59.41	0.00e+00	773.00
IUUC-Zma-135455	Zea mays	32.51	1.00e-80	295.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence