iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ago-007910

Ensembl Protein ID

AAS51886

UniProt Accession

Q75AF2; UBC12_ASHGO

Genbank Protein ID

AAS51886.1

Protein Name

NEDD8-conjugating enzyme UBC12; RUB1-conjugating enzyme; RUB1-protein ligase; Ubiquitin carrier protein 12

Genbank Nucleotide ID

AE016817

Gene Name

UBC12; ADL035C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AGOS_ADL035C	AAS51886	AAS51886

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.10e-32	110.7	50	182

Active Site

Position(s)	Description	Evidence
112	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWspalsvesv 101
           R++k+l++le  ++ ++  k+  ++  ++  + i  pe+ +Y+gg F++++ f ++YP++PP+vk+l++i+hPn++ +G++Cl++l+  e+Wsp++++++v
   Q: 50   RVEKDLATLELPTTVTLDTKCLGSE--NKVYLRIS-PEEGVYRGGHFRFSVVFRDTYPIEPPTVKCLNTIYHPNIDYSGNICLNVLR--EDWSPVMDLQTV 145
           7888899988888888888888886..55666666.**************************************************9..************ PP
   S: 102  llsiqsllaepnpesplneeaaellkknreeykkkvr 138
           +l++  l+ epn ++pln +aa+++ +++ +++++v+
   Q: 146  VLGLLFLFLEPNGSDPLNRQAADTMLRDPYRFETNVQ 182
           *********************************9997 PP

Organism

Ashbya gossypii

Functional Description
(View)

Accepts the ubiquitin-like protein NEDD8/RUB1 from the UBA3-ULA1 E1 complex and catalyzes its covalent attachment to other proteins.

Protein Sequence
(Fasta)

MLRRMPPATE PATRYTMLKL RQLQKEKQRQ AAQAQAPAQG RSAASPAQLR VEKDLATLEL 60
PTTVTLDTKC LGSENKVYLR ISPEEGVYRG GHFRFSVVFR DTYPIEPPTV KCLNTIYHPN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTCCGCC GAATGCCTCC CGCTACCGAG CCCGCCACGC GCTACACTAT GGTATGGTAG 60
CACCGTGCAC CCGCCGGCGC CCGCCGCTAC TAACAGAAAC CAGCTCAAGC TGCGCCAGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0016874--F:ligase activity
GO:0019788--F:NEDD8 transferase activity
GO:0045116--P:protein neddylation

KEGG

ago:AGOS_ADL035C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000196	Aegilops tauschii	43.45	5.00e-30	121.00
IUUC-Aml-002007	Ailuropoda melanoleuca	44.06	1.00e-29	119.00
IUUC-Atr-003170	Amborella trichopoda	43.79	2.00e-31	125.00
IUUC-Aca-005037	Anolis carolinensis	42.78	1.00e-36	143.00
IUUC-Aly-006219	Arabidopsis lyrata	39.56	2.00e-32	129.00
IUUC-Ath-006876	Arabidopsis thaliana	40.88	2.00e-32	129.00
IUUC-Acl-008364	Aspergillus clavatus	48.00	2.00e-34	135.00
IUUC-Afl-008463	Aspergillus flavus	48.57	6.00e-33	131.00
IUUC-Afu-008803	Aspergillus fumigatus	47.33	3.00e-34	135.00
IUUC-Ani-009422	Aspergillus nidulans	46.67	8.00e-34	134.00
IUUC-Ang-009728	Aspergillus niger	50.83	3.00e-31	124.00
IUUC-Aor-009962	Aspergillus oryzae	48.57	6.00e-33	131.00
IUUC-Ate-010430	Aspergillus terreus	42.77	2.00e-31	126.00
IUUC-Ame-011382	Astyanax mexicanus	43.65	1.00e-35	140.00
IUUC-Bgr-012306	Blumeria graminis	46.70	1.00e-41	159.00
IUUC-Bta-012818	Bos taurus	41.67	7.00e-35	137.00
IUUC-Bci-013626	Botrytis cinerea	44.51	1.00e-38	149.00
IUUC-Bdi-014079	Brachypodium distachyon	45.86	6.00e-34	134.00
IUUC-Bol-016135	Brassica oleracea	40.88	3.00e-32	129.00
IUUC-Bra-017368	Brassica rapa	40.33	2.00e-33	133.00
IUUC-Cel-018579	Caenorhabditis elegans	36.96	3.00e-14	68.90
IUUC-Cja-019213	Callithrix jacchus	40.54	7.00e-33	131.00
IUUC-Cfa-020242	Canis familiaris	41.21	3.00e-33	132.00
IUUC-Cpo-022405	Cavia porcellus	41.11	3.00e-33	132.00
IUUC-Cre-022865	Chlamydomonas reinhardtii	44.22	3.00e-30	122.00
IUUC-Csa-023269	Chlorocebus sabaeus	41.67	7.00e-35	137.00
IUUC-Cin-025333	Ciona intestinalis	43.33	3.00e-34	135.00
IUUC-Csv-025898	Ciona savignyi	45.07	7.00e-29	117.00
IUUC-Cgl-026477	Colletotrichum gloeosporioides	48.34	3.00e-33	132.00
IUUC-Cne-027097	Cryptococcus neoformans	45.05	6.00e-38	147.00
IUUC-Cme-027287	Cyanidioschyzon merolae	47.83	4.00e-19	85.50
IUUC-Dre-028514	Danio rerio	45.64	6.00e-33	130.00
IUUC-Dno-029678	Dasypus novemcinctus	44.06	1.00e-29	120.00
IUUC-Dse-031265	Dothistroma septosporum	45.60	1.00e-38	150.00
IUUC-Dme-032076	Drosophila melanogaster	44.44	9.00e-36	140.00
IUUC-Eca-034075	Equus caballus	41.11	9.00e-34	134.00
IUUC-Fca-035654	Felis catus	44.06	1.00e-29	119.00
IUUC-Fox-037877	Fusarium oxysporum	44.26	4.00e-33	131.00
IUUC-Fso-038428	Fusarium solani	43.17	2.00e-36	142.00
IUUC-Gmo-039402	Gadus morhua	43.65	9.00e-36	140.00
IUUC-Ggr-039731	Gaeumannomyces graminis	43.96	1.00e-34	136.00
IUUC-Gga-041122	Gallus gallus	41.28	2.00e-31	127.00
IUUC-Gma-043805	Glycine max	43.65	3.00e-32	129.00
IUUC-Ggo-044436	Gorilla gorilla	41.67	7.00e-35	137.00
IUUC-Hsa-046026	Homo sapiens	41.67	7.00e-35	137.00
IUUC-Hvu-047056	Hordeum vulgare	44.44	2.00e-33	132.00
IUUC-Itr-047889	Ictidomys tridecemlineatus	41.67	7.00e-35	137.00
IUUC-Kpa-049315	Komagataella pastoris	49.45	2.00e-43	166.00
IUUC-Lch-050360	Latimeria chalumnae	46.00	8.00e-21	91.30
IUUC-Lpe-050743	Leersia perrieri	45.21	1.00e-31	126.00
IUUC-Lma-053001	Leptosphaeria maculans	49.68	2.00e-37	145.00
IUUC-Laf-053463	Loxodonta africana	44.06	1.00e-29	119.00
IUUC-Mcc-054966	Macaca mulatta	53.03	5.00e-19	83.60
IUUC-Meu-056085	Macropus eugenii	44.37	7.00e-30	120.00
IUUC-Mor-057250	Magnaporthe oryzae	48.67	2.00e-32	129.00
IUUC-Mpo-057481	Magnaporthe poae	48.00	2.00e-32	129.00
IUUC-Mtr-058251	Medicago truncatula	43.41	7.00e-32	127.00
IUUC-Mla-059119	Melampsora laricipopulina	50.65	2.00e-38	149.00
IUUC-Mga-059881	Meleagris gallopavo	46.88	2.00e-22	94.70
IUUC-Mvi-060449	Microbotryum violaceum	48.70	1.00e-36	143.00
IUUC-Mmr-061511	Microcebus murinus	53.03	3.00e-19	84.00
IUUC-Mmu-063962	Mus musculus	41.67	7.00e-35	137.00
IUUC-Mac-064967	Musa acuminata	41.24	3.00e-34	135.00
IUUC-Mpu-066423	Mustela putorius furo	40.85	2.00e-18	83.20
IUUC-Mlu-066955	Myotis lucifugus	43.54	7.00e-30	120.00
IUUC-Nfi-068300	Neosartorya fischeri	47.33	3.00e-34	135.00
IUUC-Ncr-068944	Neurospora crassa	46.45	3.00e-34	135.00
IUUC-Nle-069051	Nomascus leucogenys	44.06	1.00e-29	119.00
IUUC-Opr-070635	Ochotona princeps	49.15	5.00e-29	117.00
IUUC-Ont-072348	Oreochromis niloticus	43.09	3.00e-35	139.00
IUUC-Oan-072779	Ornithorhynchus anatinus	44.14	2.00e-16	75.50
IUUC-Ocu-074905	Oryctolagus cuniculus	41.67	7.00e-35	137.00
IUUC-Oba-075203	Oryza barthii	45.00	1.00e-34	136.00
IUUC-Obr-076431	Oryza brachyantha	46.05	5.00e-33	131.00
IUUC-Ogl-077404	Oryza glaberrima	45.95	7.00e-33	130.00
IUUC-Ogu-078347	Oryza glumaepatula	45.00	1.00e-34	136.00
IUUC-Oin-079115	Oryza indica	45.00	1.00e-34	136.00
IUUC-Olo-080697	Oryza longistaminata	45.00	1.00e-34	137.00
IUUC-Ome-081682	Oryza meridionalis	45.00	1.00e-34	137.00
IUUC-Oni-082123	Oryza nivara	47.77	1.00e-34	137.00
IUUC-Opu-083937	Oryza punctata	47.20	5.00e-35	138.00
IUUC-Oru-084723	Oryza rufipogon	45.00	1.00e-34	136.00
IUUC-Osa-086013	Oryza sativa	45.00	1.00e-34	136.00
IUUC-Olu-087854	Ostreococcus lucimarinus	44.30	1.00e-33	133.00
IUUC-Oga-088580	Otolemur garnettii	41.67	7.00e-35	137.00
IUUC-Oar-089623	Ovis aries	42.36	8.00e-28	113.00
IUUC-Ptr-091020	Pan troglodytes	49.15	5.00e-29	117.00
IUUC-Pan-092119	Papio anubis	44.06	1.00e-29	119.00
IUUC-Psi-093494	Pelodiscus sinensis	45.45	3.00e-31	124.00
IUUC-Pma-094321	Petromyzon marinus	49.02	2.00e-17	78.60
IUUC-Pno-094972	Phaeosphaeria nodorum	44.17	5.00e-34	135.00
IUUC-Ppa-095439	Physcomitrella patens	44.44	2.00e-33	132.00
IUUC-Pfo-097205	Poecilia formosa	44.37	7.00e-31	124.00
IUUC-Pab-098434	Pongo abelii	41.67	7.00e-35	137.00
IUUC-Pop-099789	Populus trichocarpa	44.75	2.00e-33	132.00
IUUC-Pca-100300	Procavia capensis	43.66	5.00e-29	117.00
IUUC-Ppe-101216	Prunus persica	42.22	9.00e-26	107.00
IUUC-Pva-102143	Pteropus vampyrus	41.67	7.00e-35	137.00
IUUC-Pgr-103675	Puccinia graminis	43.92	4.00e-37	145.00
IUUC-Ptt-103997	Puccinia triticina	45.05	3.00e-37	145.00
IUUC-Pte-104042	Pyrenophora teres	49.68	8.00e-37	144.00
IUUC-Pyt-104616	Pyrenophora triticirepentis	54.17	1.00e-32	129.00
IUUC-Rno-105107	Rattus norvegicus	41.67	7.00e-35	137.00
IUUC-Sce-106385	Saccharomyces cerevisiae	46.88	3.00e-35	139.00
IUUC-Sha-106899	Sarcophilus harrisii	43.67	5.00e-31	124.00
IUUC-Sja-107789	Schizosaccharomyces japonicus	48.41	2.00e-38	149.00
IUUC-Spo-108143	Schizosaccharomyces pombe	46.41	1.00e-42	163.00
IUUC-Ssl-108427	Sclerotinia sclerotiorum	45.05	5.00e-38	148.00
IUUC-Smo-109330	Selaginella moellendorffii	41.99	2.00e-34	135.00
IUUC-Sit-109702	Setaria italica	44.44	3.00e-32	128.00
IUUC-Sly-111045	Solanum lycopersicum	43.65	2.00e-33	132.00
IUUC-Stu-112655	Solanum tuberosum	42.54	3.00e-32	129.00
IUUC-Sar-113632	Sorex araneus	41.11	9.00e-34	134.00
IUUC-Sbi-114410	Sorghum bicolor	46.58	8.00e-35	137.00
IUUC-Sre-114912	Sporisorium reilianum	47.68	1.00e-37	146.00
IUUC-Ssc-115597	Sus scrofa	41.01	2.00e-18	83.20
IUUC-Tsy-119639	Tarsius syrichta	36.67	9.00e-23	97.10
IUUC-Tni-119674	Tetraodon nigroviridis	39.23	4.00e-30	121.00
IUUC-Tca-121359	Theobroma cacao	42.54	5.00e-32	127.00
IUUC-Tre-122115	Trichoderma reesei	48.73	7.00e-37	144.00
IUUC-Tvi-122656	Trichoderma virens	47.47	3.00e-35	139.00
IUUC-Tae-124489	Triticum aestivum	44.44	2.00e-33	132.00
IUUC-Tur-126045	Triticum urartu	44.44	2.00e-33	132.00
IUUC-Tme-126950	Tuber melanosporum	46.45	6.00e-34	134.00
IUUC-Tbe-127874	Tupaia belangeri	47.87	3.00e-18	82.40
IUUC-Ttr-128213	Tursiops truncatus	47.62	1.00e-32	130.00
IUUC-Uma-129329	Ustilago maydis	47.65	5.00e-37	144.00
IUUC-Vda-129754	Verticillium dahliae	47.10	1.00e-33	133.00
IUUC-Vvi-131182	Vitis vinifera	42.70	1.00e-31	127.00
IUUC-Xtr-132742	Xenopus tropicalis	42.22	5.00e-36	141.00
IUUC-Xma-133558	Xiphophorus maculatus	44.97	2.00e-32	129.00
IUUC-Yli-134467	Yarrowia lipolytica	48.43	8.00e-39	150.00
IUUC-Zma-135527	Zea mays	43.79	1.00e-31	127.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence