iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mcc-055674

Ensembl Protein ID

ENSMMUP00000007407.3

UniProt Accession

Q861Q8; OPTN_MACMU

Genbank Protein ID

AAO73054.1; AAO73053.1; AAV28653.1; AAV28653.1; AAV28653.1; AAV28653.1; AAV28653.1; AAV28653.1; AAV28653.1; AAV28653.1; AAV28653.1; AAV28653.1; AAV28653.1; AAV28653.1; AAV28653.1

Protein Name

Optineurin

Genbank Nucleotide ID

AY228374; AY228373; AY749122; AY749110; AY749111; AY749112; AY749113; AY749114; AY749115; AY749116; AY749117; AY749118; AY749119; AY749120; AY749121

Gene Name

OPTN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000005601.3	ENSMMUT00000007881.3	ENSMMUP00000007407.3
ENSMMUG00000005601.3	ENSMMUT00000043249.2	ENSMMUP00000036258.2
ENSMMUG00000005601.3	ENSMMUT00000043250.2	ENSMMUP00000036259.2
ENSMMUG00000005601.3	ENSMMUT00000078925.1	ENSMMUP00000052231.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBAN	7.10e-26	91.0	486	545

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBAN

   S: 1    keelletvevLkqQveiYkeDFqaERadRErlneekeeLqeqveklqkqvsklndslkas 60
           +ee+let++vL++Q+e+Y++DF+aERa+RE+++eeke+L+ q+++l+k++++++d++++s
   Q: 486  QEEDLETMTVLRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQS 545
           79********************************************************98 PP

Organism

Macaca mulatta

Functional Description
(View)

Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52 (By similarity).

Protein Sequence
(Fasta)

MNTSLTNLKT WPYQGKGLTL YLVQCPLWRS QCKAGTSAMS HQPLSCLTEK GDSPSESTGN 60
GPPHLAHPNL DTFTPEELLQ QMKELLTENH QLKEAMKLNN QAMKGRFEEL SAWTEKQKEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGATTGAACC TATGAATACT TCGTTAACAA ATTTGAAGAC TTGGCCATAC CAGGGCAAGG 60
GCCTAACCTT GTACCTCGTC CAATGTCCAC TGTGGAGAAG TCAGTGTAAA GCAGGTACCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032419--CC2-LZ_dom
IPR021063--NEMO_N
IPR032939--Optineurin
IPR034735--ZF_CCHC_NOA

PROSITE

PS51801--ZF_CCHC_NOA

Pfam

PF16516--CC2-LZ
PF11577--NEMO

Gene Ontology

GO:0005776--C:autophagosome
GO:0031410--C:cytoplasmic vesicle
GO:0005794--C:Golgi apparatus
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0055037--C:recycling endosome
GO:0005802--C:trans-Golgi network
GO:0070530--F:K63-linked polyubiquitin binding
GO:0046872--F:metal ion binding
GO:0006914--P:autophagy
GO:0090161--P:Golgi ribbon formation
GO:0000042--P:protein targeting to Golgi
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling

KEGG

mcc:574252

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002037	Ailuropoda melanoleuca	83.45	0.00e+00	805.00
IUUC-Apl-003812	Anas platyrhynchos	57.39	6.00e-154	537.00
IUUC-Aca-004625	Anolis carolinensis	56.28	1.00e-149	523.00
IUUC-Aly-005781	Arabidopsis lyrata	55.00	2.30e-02	33.50
IUUC-Ame-011116	Astyanax mexicanus	38.42	4.00e-74	272.00
IUUC-Bta-013240	Bos taurus	84.99	0.00e+00	914.00
IUUC-Cja-019911	Callithrix jacchus	94.28	0.00e+00	969.00
IUUC-Cfa-020330	Canis familiaris	86.53	0.00e+00	863.00
IUUC-Cpo-021753	Cavia porcellus	82.81	0.00e+00	833.00
IUUC-Csa-023662	Chlorocebus sabaeus	98.09	0.00e+00	1001.00
IUUC-Cho-024574	Choloepus hoffmanni	68.10	1.00e-128	452.00
IUUC-Dre-027720	Danio rerio	41.43	4.00e-92	332.00
IUUC-Dno-029079	Dasypus novemcinctus	81.18	0.00e+00	780.00
IUUC-Dor-030890	Dipodomys ordii	81.49	0.00e+00	834.00
IUUC-Dme-032072	Drosophila melanogaster	26.27	4.00e-03	35.80
IUUC-Ete-032568	Echinops telfairi	82.06	0.00e+00	745.00
IUUC-Eca-033528	Equus caballus	85.81	0.00e+00	862.00
IUUC-Eeu-035219	Erinaceus europaeus	75.69	0.00e+00	818.00
IUUC-Fca-035852	Felis catus	85.84	0.00e+00	858.00
IUUC-Fal-036862	Ficedula albicollis	59.35	3.00e-149	521.00
IUUC-Gmo-038735	Gadus morhua	40.47	1.00e-79	290.00
IUUC-Gga-040939	Gallus gallus	58.32	6.00e-154	537.00
IUUC-Gac-041580	Gasterosteus aculeatus	43.28	5.00e-98	351.00
IUUC-Ggo-045034	Gorilla gorilla	87.22	0.00e+00	922.00
IUUC-Hsa-046624	Homo sapiens	95.84	0.00e+00	1014.00
IUUC-Itr-048288	Ictidomys tridecemlineatus	78.35	0.00e+00	813.00
IUUC-Lch-049720	Latimeria chalumnae	50.64	6.00e-82	297.00
IUUC-Loc-052185	Lepisosteus oculatus	46.53	3.00e-108	385.00
IUUC-Laf-054079	Loxodonta africana	84.18	0.00e+00	837.00
IUUC-Meu-056769	Macropus eugenii	55.72	5.00e-74	271.00
IUUC-Mga-060203	Meleagris gallopavo	58.71	2.00e-145	509.00
IUUC-Mmr-061492	Microcebus murinus	88.50	0.00e+00	866.00
IUUC-Mdo-063051	Monodelphis domestica	75.55	0.00e+00	800.00
IUUC-Mmu-063409	Mus musculus	78.63	0.00e+00	870.00
IUUC-Mpu-065907	Mustela putorius furo	79.59	0.00e+00	833.00
IUUC-Mlu-066957	Myotis lucifugus	84.49	0.00e+00	798.00
IUUC-Ncr-068766	Neurospora crassa	27.27	3.60e-01	30.00
IUUC-Nle-069973	Nomascus leucogenys	95.84	0.00e+00	1002.00
IUUC-Opr-071049	Ochotona princeps	79.41	0.00e+00	745.00
IUUC-Ont-071915	Oreochromis niloticus	44.20	4.00e-95	342.00
IUUC-Oan-072965	Ornithorhynchus anatinus	73.96	0.00e+00	777.00
IUUC-Ocu-074029	Oryctolagus cuniculus	77.86	0.00e+00	702.00
IUUC-Ola-087019	Oryzias latipes	43.17	2.00e-93	336.00
IUUC-Oga-088613	Otolemur garnettii	87.95	0.00e+00	895.00
IUUC-Oar-090386	Ovis aries	84.47	0.00e+00	905.00
IUUC-Ptr-091619	Pan troglodytes	95.67	0.00e+00	1010.00
IUUC-Pan-092178	Papio anubis	97.59	0.00e+00	987.00
IUUC-Psi-093214	Pelodiscus sinensis	64.46	2.00e-170	592.00
IUUC-Pfo-096901	Poecilia formosa	42.12	2.00e-87	316.00
IUUC-Pab-097560	Pongo abelii	86.66	0.00e+00	869.00
IUUC-Pca-100853	Procavia capensis	75.90	3.00e-125	442.00
IUUC-Pva-102255	Pteropus vampyrus	84.87	0.00e+00	798.00
IUUC-Rno-105812	Rattus norvegicus	81.06	0.00e+00	867.00
IUUC-Sha-107225	Sarcophilus harrisii	79.95	2.00e-157	548.00
IUUC-Sar-113736	Sorex araneus	74.86	8.00e-132	464.00
IUUC-Ssc-115422	Sus scrofa	85.54	0.00e+00	892.00
IUUC-Tgu-116924	Taeniopygia guttata	60.69	4.00e-154	538.00
IUUC-Tru-117695	Takifugu rubripes	39.46	7.00e-91	328.00
IUUC-Tsy-119090	Tarsius syrichta	86.55	2.00e-157	548.00
IUUC-Tni-120645	Tetraodon nigroviridis	42.75	8.00e-96	344.00
IUUC-Tbe-127970	Tupaia belangeri	69.38	0.00e+00	669.00
IUUC-Ttr-129244	Tursiops truncatus	84.52	0.00e+00	830.00
IUUC-Vpa-130313	Vicugna pacos	84.35	0.00e+00	803.00
IUUC-Xtr-132115	Xenopus tropicalis	45.89	2.00e-101	363.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence