iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ncr-068862

Ensembl Protein ID

EAA31722

UniProt Accession

Q7S7L4; Q86ZG2; LIS12_NEUCR

Genbank Protein ID

CAD71040.1; EAA31722.3

Protein Name

Nuclear distribution protein nudF-1; Lissencephaly-1 homolog 2; Nuclear migration protein 2; nudF homolog 1

Genbank Nucleotide ID

BX294026; CM002240

Gene Name

nudf-1; nmp-2; dyn-5; lis1-2; mtb4B; pac1-2; B7H23.150; NCU04312

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
NCU04312	EAA31722	EAA31722

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.00e-44	145.0	209	256
UBD/Beta-Prp	4.90e-56	189.1	121	409

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..........sdtllvsGsdDgtikvWDlrtgvllks 38
           gH   v++++f          s++llvs+s D+++k+WD++tg ++k+
   Q: 209  GHDHIVSSVRFipsgaagapaSGNLLVSASKDNSLKIWDVTTGYCVKT 256
           79999**************9877********************99875 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk..ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfsp 104
           ++h  ++tcv+f+p  + la+gs+d tik+wd++ g l r+++gh+++v +v+f   +   +l+++s+D tik+wd+s  +k ++tl gh++ v s++f p
   Q: 121  ESHRLPVTCVAFHPVFTSLASGSEDYTIKIWDWELGELERTIKGHTKAVLDVDFGGPRGgtLLASCSSDLTIKLWDPSdEYKNIRTLPGHDHIVSSVRFIP 221
           57899*************************************************8544446**************887699*******************9 PP
   S: 105  ........sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl...ktgkllrtltgghtdsvyslsfdsng.. 192
                   sg+ lvs+s+d+ +++wd+ tg+c++ t  gh ++ + v+ + dg++l s + D+ vrlWdl   + +++   + g h+++  + +f +    
   Q: 222  sgaagapaSGNLLVSASKDNSLKIWDVTTGYCVK-TILGHVDWPRAVCPSHDGRYLLSTGSDKSVRLWDLaggRDAECRLVMFG-HENYNLCCAFAPPTay 320
           9999999999************************.999********************************88866666555556.9999999998888888 PP
   S: 193  ...................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdl.rsgdllktlql 262
                              +++++gs+d++++lwd  +g+c++ l gh+++v+ + f+p +++l+s+++D++ r+Wdl + g +++tl++
   Q: 321  phlaklaglerapppsssaEFMATGSRDKQIRLWDG-RGNCIKVLVGHDNWVRGLVFHPGGKYLLSVADDRTMRCWDLsQEGRCVQTLTG 409
           8889999999999999999****************8.899************************************97367899999986 PP

Organism

Neurospora crassa

Functional Description
(View)

Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.

Protein Sequence
(Fasta)

MAQASVQIGT PLLTTRQAEE LHKSILAYLA SKNLATTAAT LRDELDLAEE SFDAEKAKKY 60
EGLLEKKWTS VVRLQKKILD LESRNHLLQS EIDNATPSSL SRRTQDPTNW LPKAPPRYVL 120

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Nucleotide Sequence
(Fasta)

ATTCCACTGC TTCTCTGTGC CAATCTGCTC CGCCATTCCA CATCAAATCG TACCAGGCCA 60
CTTCACAAAT GTGACGCCTC GACTCGGACG CGTGGCACAT TGTGCCCATG CTCTAGACTA 120

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Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005938--C:cell cortex
GO:0000776--C:kinetochore
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0000922--C:spindle pole
GO:0008017--F:microtubule binding
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0031023--P:microtubule organizing center organization
GO:0007067--P:mitotic nuclear division
GO:0007097--P:nuclear migration
GO:2000574--P:regulation of microtubule motor activity
GO:0000003--P:reproduction
GO:0047496--P:vesicle transport along microtubule

KEGG

ncr:NCU04312

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Acl-008360	Aspergillus clavatus	69.05	0.00e+00	633.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence