iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000007971.5	ENSGALT00000058006.1	ENSGALP00000053235.1
ENSGALG00000007971.5	ENSGALT00000012943.4	ENSGALP00000012928.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UBL/SUMO	4.10e-33	114.3	14	93

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/SUMO

   S: 5    fkapvslkvagqdGsevlfklklsaqlkklmeavYvkrinldensvrfvfngqkireqetpeelevededkiellcqksGG 85
           +  +++lkvagqdGs v+fk+k++++l+klm+a Y++r++l+++++rf+f+gq+i+e++tp++le+eded+i++++q++GG
   Q: 14   NNDHINLKVAGQDGSVVQFKIKRHTPLSKLMKA-YCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGG 93
           789******************************.**********************************************9 PP

Organism

Gallus gallus

Functional Description
(View)

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity).

Protein Sequence
(Fasta)

MADEKPKEGV KTENNDHINL KVAGQDGSVV QFKIKRHTPL SKLMKAYCER QGLSMRQIRF 60
RFDGQPINET DTPAQLEMED EDTIDVFQQQ TGGVY 95

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Nucleotide Sequence
(Fasta)

GCCTTCCCCT CTCCCTCTCT CTCCCTCCTC TCTCCGCCGC CGCGCTCGGT CGATCCTTCC 60
CCCCCTTTGT GAAGCGCTCG GAGCGTCCCG GACACCGCCG ACTTCACCAT GGCCGACGAG 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR022617--Rad60/SUMO-like_dom
IPR033950--Sumo
IPR027218--SUMO_2/3
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF11976--Rad60-SLD

SMART

SM00213--UBQ

Gene Ontology

GO:0005634--C:nucleus
GO:0031386--F:protein tag
GO:0016925--P:protein sumoylation

KEGG

gga:770125

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001918	Ailuropoda melanoleuca	100.00	1.00e-53	199.00
IUUC-Atr-002794	Amborella trichopoda	57.14	3.00e-20	89.40
IUUC-Apl-003372	Anas platyrhynchos	98.88	2.00e-49	186.00
IUUC-Aca-005284	Anolis carolinensis	100.00	1.00e-53	199.00
IUUC-Aly-005765	Arabidopsis lyrata	52.17	2.00e-21	93.20
IUUC-Ath-007391	Arabidopsis thaliana	52.75	2.00e-21	93.20
IUUC-Acl-008286	Aspergillus clavatus	50.00	3.00e-17	79.30
IUUC-Afl-008650	Aspergillus flavus	47.31	5.00e-18	81.60
IUUC-Afu-008969	Aspergillus fumigatus	46.81	7.00e-18	81.30
IUUC-Ang-009651	Aspergillus niger	51.28	4.00e-17	79.00
IUUC-Ame-011427	Astyanax mexicanus	96.81	2.00e-51	192.00
IUUC-Bgr-012250	Blumeria graminis	46.51	3.00e-17	79.30
IUUC-Bta-013208	Bos taurus	95.79	4.00e-51	191.00
IUUC-Bci-013625	Botrytis cinerea	49.37	3.00e-18	82.40
IUUC-Bdi-014847	Brachypodium distachyon	53.85	4.00e-21	92.40
IUUC-Bol-015977	Brassica oleracea	52.17	2.00e-21	93.60
IUUC-Bra-017377	Brassica rapa	53.26	2.00e-21	93.20
IUUC-Cja-019875	Callithrix jacchus	96.70	1.00e-47	180.00
IUUC-Cfa-020546	Canis familiaris	100.00	1.00e-53	199.00
IUUC-Cpo-021498	Cavia porcellus	100.00	1.00e-53	199.00
IUUC-Csa-023133	Chlorocebus sabaeus	100.00	1.00e-53	199.00
IUUC-Cin-025314	Ciona intestinalis	76.04	2.00e-38	149.00
IUUC-Cme-027181	Cyanidioschyzon merolae	55.32	1.00e-23	100.00
IUUC-Dre-027994	Danio rerio	98.92	1.00e-51	193.00
IUUC-Dno-029390	Dasypus novemcinctus	100.00	5.00e-54	202.00
IUUC-Dse-031390	Dothistroma septosporum	49.00	4.00e-21	92.00
IUUC-Dme-031967	Drosophila melanogaster	70.21	1.00e-33	133.00
IUUC-Ete-032934	Echinops telfairi	81.05	3.00e-42	162.00
IUUC-Eca-033260	Equus caballus	100.00	1.00e-53	199.00
IUUC-Fca-036393	Felis catus	93.68	9.00e-50	187.00
IUUC-Fal-037226	Ficedula albicollis	98.89	6.00e-50	188.00
IUUC-Fox-037950	Fusarium oxysporum	52.50	1.00e-19	87.40
IUUC-Fso-038430	Fusarium solani	51.85	7.00e-20	88.20
IUUC-Gmo-038535	Gadus morhua	92.55	1.00e-49	186.00
IUUC-Ggr-040015	Gaeumannomyces graminis	54.43	8.00e-21	91.30
IUUC-Gac-041723	Gasterosteus aculeatus	92.55	2.00e-49	186.00
IUUC-Gma-043216	Glycine max	53.85	2.00e-21	93.60
IUUC-Ggo-045467	Gorilla gorilla	100.00	1.00e-53	199.00
IUUC-Hsa-046419	Homo sapiens	100.00	1.00e-53	199.00
IUUC-Hvu-047514	Hordeum vulgare	57.69	7.00e-21	91.30
IUUC-Itr-048667	Ictidomys tridecemlineatus	95.70	6.00e-50	187.00
IUUC-Kpa-049243	Komagataella pastoris	50.00	9.00e-13	64.30
IUUC-Lch-050572	Latimeria chalumnae	89.69	3.00e-46	175.00
IUUC-Loc-052560	Lepisosteus oculatus	97.89	8.00e-53	197.00
IUUC-Laf-054343	Loxodonta africana	98.95	4.00e-53	198.00
IUUC-Mcc-054832	Macaca mulatta	100.00	3.00e-52	196.00
IUUC-Mor-057132	Magnaporthe oryzae	54.43	2.00e-20	90.10
IUUC-Mpo-057351	Magnaporthe poae	55.84	2.00e-20	89.70
IUUC-Mtr-057985	Medicago truncatula	52.75	3.00e-21	92.80
IUUC-Mga-059768	Meleagris gallopavo	98.88	2.00e-49	186.00
IUUC-Mmr-061593	Microcebus murinus	100.00	3.00e-52	196.00
IUUC-Mdo-062678	Monodelphis domestica	98.95	2.00e-53	199.00
IUUC-Mmu-063990	Mus musculus	100.00	1.00e-53	199.00
IUUC-Mac-064925	Musa acuminata	51.65	3.00e-20	89.70
IUUC-Mpu-065909	Mustela putorius furo	98.89	3.00e-50	188.00
IUUC-Mlu-067634	Myotis lucifugus	93.68	2.00e-49	186.00
IUUC-Nfi-068364	Neosartorya fischeri	50.00	2.00e-17	79.70
IUUC-Ncr-068663	Neurospora crassa	51.28	6.00e-19	85.10
IUUC-Nle-069631	Nomascus leucogenys	96.84	8.00e-52	194.00
IUUC-Opr-071104	Ochotona princeps	30.56	1.00e-04	40.80
IUUC-Ont-071512	Oreochromis niloticus	96.77	3.00e-50	189.00
IUUC-Oan-073080	Ornithorhynchus anatinus	93.55	2.00e-46	176.00
IUUC-Ocu-074239	Oryctolagus cuniculus	98.95	3.00e-53	198.00
IUUC-Obr-076884	Oryza brachyantha	61.04	2.00e-22	96.70
IUUC-Ogu-078983	Oryza glumaepatula	53.26	8.00e-21	92.40
IUUC-Ome-081885	Oryza meridionalis	59.74	7.00e-22	95.10
IUUC-Ola-086710	Oryzias latipes	97.85	7.00e-51	191.00
IUUC-Oga-088989	Otolemur garnettii	94.74	8.00e-50	187.00
IUUC-Oar-089624	Ovis aries	94.74	1.00e-50	190.00
IUUC-Ptr-091082	Pan troglodytes	100.00	1.00e-53	199.00
IUUC-Pan-091949	Papio anubis	100.00	2.00e-52	196.00
IUUC-Psi-094000	Pelodiscus sinensis	100.00	1.00e-53	199.00
IUUC-Pfo-097304	Poecilia formosa	97.85	2.00e-51	192.00
IUUC-Pab-098572	Pongo abelii	100.00	1.00e-53	199.00
IUUC-Ppe-101648	Prunus persica	51.61	8.00e-22	94.40
IUUC-Pte-104358	Pyrenophora teres	47.25	1.00e-19	87.40
IUUC-Pyt-104485	Pyrenophora triticirepentis	47.25	1.00e-19	87.40
IUUC-Rno-105391	Rattus norvegicus	98.94	2.00e-52	195.00
IUUC-Sha-106682	Sarcophilus harrisii	95.51	2.00e-46	176.00
IUUC-Sar-113337	Sorex araneus	84.04	4.00e-43	165.00
IUUC-Sbi-114801	Sorghum bicolor	53.85	2.00e-21	93.20
IUUC-Ssc-115915	Sus scrofa	100.00	1.00e-53	199.00
IUUC-Tgu-116815	Taeniopygia guttata	98.89	3.00e-50	188.00
IUUC-Tca-120927	Theobroma cacao	52.17	4.00e-21	93.20
IUUC-Tre-121926	Trichoderma reesei	49.45	2.00e-21	93.20
IUUC-Tvi-122514	Trichoderma virens	53.75	5.00e-20	88.60
IUUC-Tae-122900	Triticum aestivum	52.75	4.00e-22	95.50
IUUC-Tur-126333	Triticum urartu	40.68	2.00e-17	81.30
IUUC-Tbe-127363	Tupaia belangeri	92.55	5.00e-48	181.00
IUUC-Vda-129731	Verticillium dahliae	46.15	3.00e-19	86.30
IUUC-Vvi-131092	Vitis vinifera	53.26	8.00e-22	94.70
IUUC-Xtr-132691	Xenopus tropicalis	95.79	1.00e-51	193.00
IUUC-Xma-133892	Xiphophorus maculatus	97.85	6.00e-52	194.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence