iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037271

Ensembl Protein ID

ENSFALP00000004877.1

UniProt Accession

U3JQ23; U3JQ23_FICAL

Genbank Protein ID

ENSFALP00000004877

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AGTO01001119

Gene Name

USP5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000004685.1	ENSFALT00000004901.1	ENSFALP00000004877.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.20e-62	211.7	280	784
UBD/Alpha-Helix/UBA	5.60e-23	80.1	653	691

Active Site

Position(s)	Description	Evidence
289	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
747	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel..................wkskkkavspr 71
           tG++NlgN+CY+NSv+Q+L++ip++++ + + k ek+ +++p++p+++++++++kl + l                  +k+ ++ ++pr
   Q: 280  TGIRNLGNSCYLNSVMQVLFSIPDFQRKYVD-KLEKIFQSAPSDPTQDFSTQVAKLGHGLlsgeysrpasadgeqqpdQKGMQNGIAPR 367
           7******************************.99999999********************777666666666655443366666***** PP
   S: 72   ellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecd 160
           ++++ ++k ++efs+++qqDaqEf+ ++++ +e+++                             ++++  +++F++ +++++kcl+ +
   Q: 368  MFKSLIGKGHPEFSTNRQQDAQEFFLHFINMVERNC-----------------------------RSSENPNEVFRFLVEEKLKCLATE 427
           ************************************.............................6788899***************** PP
   S: 161  nvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeaekklk 222
           +v+ ++   + ++lpvp++   +k                             +++cLe++ ++e++++   ++++  ++k+ a k+++
   Q: 428  KVKYTQRVDYIMQLPVPMDAALNKDelleyeekkrqaeeekqplpelvrakvPFSSCLEAYGAPEQVDD---FWSTALQAKSVALKTTR 513
           ******************998877799****************************************97...***************** PP
   S: 223  lkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts............................................ 267
           + ++P++L++++k+f+f  + ++++k++ ++e+p+eLd+s    +                                            
   Q: 514  FASFPDYLVIQIKKFTFGLD-WVPKKLDVSIEMPEELDISALQGTglqegeeempdiapplvtpdepkapmldesviiqlvemgfpmda 601
           *****************997.*******************8666666666666666666666666666666666666666666666666 PP
   S: 268  ...............................................peekqke................................... 274
                                                          p     +                                   
   Q: 602  crkavyytgnsgveaamnwvmshmddpdfanplvlpgssgpgstiacP-----Dppsedsvativsmgfsrdqamkalratnnslerav 685
           666666666655555555555555555555555555555555555550.....055555555666666666666666666666677777 PP
   S: 275  .........................................kkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeee 321
                                                    + kY+L+a ++H+G s+ +GHYv+++k+ +g+W+ ++D+kV ++  e+
   Q: 686  dwifshiddldaeaamdisegrsaaesisesvpvgpkvrdgPGKYQLFAFISHMGtSTMCGHYVCHIKK-DGRWVIYNDQKVCAS--EK 771
           77777777777777777888888888888888999999999****************************.9***********999..78 PP
   S: 322  vleetgstaYvlfYkr 337
             +   + +Y++fY+r
   Q: 772  PPK---DLGYIYFYQR 784
           888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           +ed ++ +v+MGF+r++a +aLra+nn+le+Av++++++
   Q: 653  SEDSVATIVSMGFSRDQAMKALRATNNSLERAVDWIFSH 691
           699**********************************97 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MNTFLGFGKQ YVEKHYQKTG QRVYLHLKRT RKPKEEDTNS SAGDPPRKKP TRLAIGVEGG 60
FDITEEKFEY DEDVKIVILP DHLDIPRDGL EGLPDMVKDR IASAIEAILT ADSASRKQEV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCATGCCTAT CCTAGCAGCT GGAATGGCAT TCCTTACCAC CTCCCTTCAG TTTTGTCCCT 60
CCTTCCTTCC AGGAGTCAGA TGGCGGCTTG TATATCTGCA TGAACACGTT CCTGGGCTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071108--P:protein K48-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	45.27	0.00e+00	661.00
IUUC-Aml-002104	Ailuropoda melanoleuca	87.96	0.00e+00	1417.00
IUUC-Atr-002580	Amborella trichopoda	47.34	0.00e+00	713.00
IUUC-Apl-003774	Anas platyrhynchos	95.19	0.00e+00	1576.00
IUUC-Aca-005368	Anolis carolinensis	94.54	0.00e+00	1536.00
IUUC-Aly-005727	Arabidopsis lyrata	48.99	0.00e+00	728.00
IUUC-Ath-006974	Arabidopsis thaliana	49.24	0.00e+00	729.00
IUUC-Ago-007890	Ashbya gossypii	29.45	2.00e-77	283.00
IUUC-Acl-008057	Aspergillus clavatus	35.88	4.00e-126	445.00
IUUC-Afl-008547	Aspergillus flavus	37.30	3.00e-121	428.00
IUUC-Afu-008805	Aspergillus fumigatus	35.02	1.00e-120	427.00
IUUC-Ani-009441	Aspergillus nidulans	34.04	8.00e-103	367.00
IUUC-Ang-009720	Aspergillus niger	35.69	2.00e-114	406.00
IUUC-Aor-010111	Aspergillus oryzae	35.72	3.00e-126	446.00
IUUC-Ate-010531	Aspergillus terreus	33.21	1.00e-99	357.00
IUUC-Ame-011893	Astyanax mexicanus	66.11	0.00e+00	940.00
IUUC-Bgr-012183	Blumeria graminis	35.34	7.00e-122	431.00
IUUC-Bta-013179	Bos taurus	87.93	0.00e+00	1417.00
IUUC-Bci-013858	Botrytis cinerea	34.84	3.00e-126	445.00
IUUC-Bdi-014904	Brachypodium distachyon	48.18	0.00e+00	690.00
IUUC-Bol-015296	Brassica oleracea	49.43	0.00e+00	736.00
IUUC-Bra-017619	Brassica rapa	49.43	0.00e+00	739.00
IUUC-Cel-018625	Caenorhabditis elegans	36.16	4.00e-130	458.00
IUUC-Cja-019063	Callithrix jacchus	86.26	0.00e+00	1387.00
IUUC-Cfa-020976	Canis familiaris	91.00	0.00e+00	1442.00
IUUC-Cpo-022265	Cavia porcellus	90.76	0.00e+00	1434.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	40.24	1.00e-118	420.00
IUUC-Csa-024177	Chlorocebus sabaeus	90.00	0.00e+00	1301.00
IUUC-Cho-024702	Choloepus hoffmanni	81.72	0.00e+00	893.00
IUUC-Cin-025411	Ciona intestinalis	51.13	0.00e+00	805.00
IUUC-Csv-026347	Ciona savignyi	46.37	0.00e+00	756.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	37.52	3.00e-111	395.00
IUUC-Cne-026831	Cryptococcus neoformans	36.43	2.00e-127	449.00
IUUC-Dre-027982	Danio rerio	64.27	0.00e+00	1016.00
IUUC-Dno-029034	Dasypus novemcinctus	88.18	0.00e+00	1431.00
IUUC-Dse-031467	Dothistroma septosporum	36.44	3.00e-128	452.00
IUUC-Dme-032075	Drosophila melanogaster	51.24	0.00e+00	791.00
IUUC-Ete-032865	Echinops telfairi	78.57	0.00e+00	1238.00
IUUC-Eca-034059	Equus caballus	88.30	0.00e+00	1422.00
IUUC-Eeu-035304	Erinaceus europaeus	87.29	0.00e+00	1320.00
IUUC-Fca-035515	Felis catus	88.05	0.00e+00	1422.00
IUUC-Fox-037745	Fusarium oxysporum	36.82	1.00e-126	446.00
IUUC-Fso-038158	Fusarium solani	36.67	1.00e-124	440.00
IUUC-Gmo-039071	Gadus morhua	65.33	0.00e+00	1015.00
IUUC-Ggr-040098	Gaeumannomyces graminis	34.58	5.00e-117	415.00
IUUC-Gga-040635	Gallus gallus	95.56	0.00e+00	1582.00
IUUC-Gac-042528	Gasterosteus aculeatus	64.58	0.00e+00	1032.00
IUUC-Gma-043614	Glycine max	48.31	0.00e+00	694.00
IUUC-Ggo-044602	Gorilla gorilla	87.81	0.00e+00	1415.00
IUUC-Hsa-045959	Homo sapiens	87.81	0.00e+00	1415.00
IUUC-Hvu-047563	Hordeum vulgare	49.47	7.00e-175	607.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	87.08	0.00e+00	1417.00
IUUC-Kpa-049156	Komagataella pastoris	33.99	1.00e-111	397.00
IUUC-Lch-049648	Latimeria chalumnae	83.74	0.00e+00	1339.00
IUUC-Lpe-051523	Leersia perrieri	47.70	0.00e+00	695.00
IUUC-Lma-053216	Leptosphaeria maculans	35.19	5.00e-112	399.00
IUUC-Laf-054327	Loxodonta africana	87.56	0.00e+00	1414.00
IUUC-Mcc-055443	Macaca mulatta	87.68	0.00e+00	1412.00
IUUC-Meu-056298	Macropus eugenii	90.57	0.00e+00	967.00
IUUC-Mor-057106	Magnaporthe oryzae	37.27	1.00e-127	450.00
IUUC-Mpo-057589	Magnaporthe poae	35.30	5.00e-122	431.00
IUUC-Mtr-058680	Medicago truncatula	48.68	0.00e+00	709.00
IUUC-Mla-058903	Melampsora laricipopulina	33.37	4.00e-119	422.00
IUUC-Mga-059669	Meleagris gallopavo	94.84	0.00e+00	1565.00
IUUC-Mvi-060476	Microbotryum violaceum	36.49	1.00e-120	426.00
IUUC-Mmr-060575	Microcebus murinus	87.93	0.00e+00	1420.00
IUUC-Mdo-062183	Monodelphis domestica	89.65	0.00e+00	1424.00
IUUC-Mmu-063592	Mus musculus	88.30	0.00e+00	1426.00
IUUC-Mac-065634	Musa acuminata	44.07	0.00e+00	671.00
IUUC-Mpu-066082	Mustela putorius furo	90.49	0.00e+00	1432.00
IUUC-Mlu-067345	Myotis lucifugus	85.28	0.00e+00	1389.00
IUUC-Nfi-068558	Neosartorya fischeri	35.82	2.00e-129	456.00
IUUC-Ncr-068960	Neurospora crassa	35.61	1.00e-111	397.00
IUUC-Nle-070173	Nomascus leucogenys	90.49	0.00e+00	1431.00
IUUC-Opr-070556	Ochotona princeps	87.56	0.00e+00	1427.00
IUUC-Ont-071502	Oreochromis niloticus	66.20	0.00e+00	1038.00
IUUC-Ocu-074861	Oryctolagus cuniculus	90.49	0.00e+00	1449.00
IUUC-Oba-075109	Oryza barthii	48.17	0.00e+00	702.00
IUUC-Obr-076292	Oryza brachyantha	49.18	0.00e+00	700.00
IUUC-Ogl-077065	Oryza glaberrima	49.31	0.00e+00	729.00
IUUC-Ogu-078776	Oryza glumaepatula	48.04	0.00e+00	708.00
IUUC-Oin-080048	Oryza indica	49.05	0.00e+00	721.00
IUUC-Olo-080711	Oryza longistaminata	46.78	0.00e+00	689.00
IUUC-Ome-081506	Oryza meridionalis	48.17	0.00e+00	701.00
IUUC-Oni-082320	Oryza nivara	47.16	0.00e+00	697.00
IUUC-Opu-083801	Oryza punctata	48.04	0.00e+00	688.00
IUUC-Oru-085139	Oryza rufipogon	47.04	0.00e+00	701.00
IUUC-Osa-085713	Oryza sativa	49.43	0.00e+00	732.00
IUUC-Ola-086951	Oryzias latipes	63.07	0.00e+00	991.00
IUUC-Olu-087822	Ostreococcus lucimarinus	41.42	2.00e-173	602.00
IUUC-Oga-088625	Otolemur garnettii	86.96	0.00e+00	1399.00
IUUC-Oar-089995	Ovis aries	85.28	0.00e+00	1391.00
IUUC-Ptr-090640	Pan troglodytes	85.47	0.00e+00	1409.00
IUUC-Pan-091974	Papio anubis	86.75	0.00e+00	1395.00
IUUC-Psi-093957	Pelodiscus sinensis	92.00	0.00e+00	1558.00
IUUC-Pma-094242	Petromyzon marinus	71.77	1.00e-170	592.00
IUUC-Pno-094835	Phaeosphaeria nodorum	34.85	8.00e-109	387.00
IUUC-Ppa-095901	Physcomitrella patens	50.31	0.00e+00	768.00
IUUC-Pfo-097148	Poecilia formosa	67.68	0.00e+00	1043.00
IUUC-Pab-098068	Pongo abelii	80.93	0.00e+00	1249.00
IUUC-Pop-098943	Populus trichocarpa	48.68	0.00e+00	706.00
IUUC-Pca-100738	Procavia capensis	80.42	0.00e+00	1263.00
IUUC-Ppe-101315	Prunus persica	48.12	0.00e+00	708.00
IUUC-Pva-102154	Pteropus vampyrus	87.04	0.00e+00	1395.00
IUUC-Pgr-103343	Puccinia graminis	35.36	3.00e-104	372.00
IUUC-Ptt-103928	Puccinia triticina	31.00	6.00e-102	365.00
IUUC-Pte-104306	Pyrenophora teres	32.59	4.00e-101	362.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	34.56	1.00e-104	374.00
IUUC-Rno-105801	Rattus norvegicus	87.93	0.00e+00	1421.00
IUUC-Sce-106304	Saccharomyces cerevisiae	29.96	4.00e-74	272.00
IUUC-Sha-107635	Sarcophilus harrisii	91.63	0.00e+00	1442.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	32.44	5.00e-104	372.00
IUUC-Spo-108144	Schizosaccharomyces pombe	33.38	1.00e-111	397.00
IUUC-Smo-108848	Selaginella moellendorffii	49.05	0.00e+00	727.00
IUUC-Sit-110728	Setaria italica	48.81	0.00e+00	743.00
IUUC-Sly-111523	Solanum lycopersicum	49.12	0.00e+00	757.00
IUUC-Sbi-114419	Sorghum bicolor	48.30	0.00e+00	732.00
IUUC-Sre-115225	Sporisorium reilianum	35.34	1.00e-120	427.00
IUUC-Ssc-115686	Sus scrofa	85.98	0.00e+00	1408.00
IUUC-Tgu-117346	Taeniopygia guttata	96.79	0.00e+00	1561.00
IUUC-Tru-118350	Takifugu rubripes	62.80	0.00e+00	1031.00
IUUC-Tni-120658	Tetraodon nigroviridis	64.30	0.00e+00	1015.00
IUUC-Tca-121585	Theobroma cacao	49.18	0.00e+00	713.00
IUUC-Tre-122043	Trichoderma reesei	35.64	4.00e-115	408.00
IUUC-Tvi-122303	Trichoderma virens	35.44	5.00e-118	418.00
IUUC-Tae-123798	Triticum aestivum	48.06	0.00e+00	710.00
IUUC-Tur-126732	Triticum urartu	45.40	0.00e+00	664.00
IUUC-Tme-126909	Tuber melanosporum	36.08	2.00e-112	400.00
IUUC-Tbe-127261	Tupaia belangeri	82.36	0.00e+00	928.00
IUUC-Uma-129599	Ustilago maydis	34.47	1.00e-126	447.00
IUUC-Vda-129688	Verticillium dahliae	34.82	4.00e-116	412.00
IUUC-Vvi-131116	Vitis vinifera	48.57	0.00e+00	690.00
IUUC-Xtr-131953	Xenopus tropicalis	77.46	0.00e+00	1255.00
IUUC-Xma-133837	Xiphophorus maculatus	67.80	0.00e+00	1046.00
IUUC-Yli-134510	Yarrowia lipolytica	36.47	5.00e-122	431.00
IUUC-Zma-135786	Zea mays	48.05	0.00e+00	696.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence