iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sit-110728

Ensembl Protein ID

Si000361m

UniProt Accession

K3XEP4; K3XEP4_SETIT

Genbank Protein ID

KQL04659.1

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

CM003532

Gene Name

LOC101752864; SETIT_000361mg

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
Si000361m.g	Si000361m	Si000361m

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.70e-54	184.5	310	791
UBD/Alpha-Helix/UBA	1.90e-16	60.5	668	707

Active Site

Position(s)	Description	Evidence
319	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
754	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelw........kskkkavsprellkalkkeaeefsgyeqqD 91
           tGl NlgN+CYm S++Q++++++++   ++e +  ++  +++p +p+ +l ++++kl + l+        k+ ++ + pr++++++++ ++efs+++qqD
   Q: 310  TGLANLGNSCYMASIMQVMFSTHPFILRYFEkQSLKAAFATAPADPTVDLNMQMTKLGHGLLsgkysartKEGQEGIRPRMFKSVIAANHPEFSSMRQQD 409
           7************************8666663555666677899*****************65555555577888************************* PP
   S: 92   aqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke...... 185
           a +f+ +l+d++e++                           + +++ ++    F++ ++++++c++ + vs  + + + lsl +p +e t+ke      
   Q: 410  ALDFFLHLIDRVEQAN--------------------------PGNHELNPC-SGFKFIIEERVQCPSGK-VSYNKRSDYILSLGIPLHEATNKEeleafn 481
           *************988..........................444455554.57***********9865.55555566777777777777777778**** PP
   S: 186  .......................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls 262
                                   l+ cL++f+ +ee+ +   +y++  ++k++a+k+ +++++P++L+lh+ +f + e++++++k++ ++++p+++d+s
   Q: 482  ekkvtmdldgkevsneeivrprvPLEACLANFAGPEEIPD---FYSTALNSKTTATKTAGFNTFPDYLVLHMRKF-VMEAGWVPKKLDVYIDVPDTIDIS 577
           **************************************97...********************************.77889******************* PP
   S: 263  pfcts......................................................................................peekqke.. 274
           ++ ++                                                                                      +     e  
   Q: 578  HMRSKgvqpgeellpdgasgdnkaepalpvasedivsqlasmgfnylhcqkaaintsntgveeamnwllshmddpdindpiskdsrasesvD-----Eas 672
           99999999999999988888888888888888888888888888888877777777777777777777777777666666666665555550.....055 PP
   S: 275  .............................................................kkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDs 312
                                                                        + +Y+L+a v+H+G s+++GHYva+v + +g+W  f+Ds
   Q: 673  vqtlisfgfpedvaikalkasggniekatdwifshpeasssasadsstsnvnaddtyvpdgSGRYKLMAFVSHMGtSTHCGHYVAHVLK-DGRWTIFNDS 771
           5555555555555555556666666666666666666666667777778888899999999****************************.9********* PP
   S: 313  kVtevkeeevleetgstaYvlfYkr 337
           kV ++   +  +   + +Y++f++r
   Q: 772  KVAAS--VDLPK---DMGYLYFFQR 791
           **999..68888...999**99997 PP

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraannnleaAveyLldg 41
            de  ++ l++ GF+++ a++aL a+++n+e A+++++++
   Q: 668  VDEASVQTLISFGFPEDVAIKALKASGGNIEKATDWIFSH 707
           58899*********************************97 PP

Organism

Setaria italica

Protein Sequence
(Fasta)

MDLLRSHLHK VRIPEPTNRI HKDECCVSFD TPRSEGGLYV DMSSFLGFGR EHVEWNFEKT 60
GNPVYLHIVQ RRKPEPDEAD RPLKKPTLLA IGVEGGFGDQ EPEYDEHFEI IILPDFISLP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTCATCTCT CTCGCCGTCT CCAACCCCAA AACCCTAGAC GCGACCCTCC GCCGGCGCCG 60
CTCGCCGCCG CCCGCGGCCA TGGATCTCCT CCGCTCGCAC CTCCACAAGG TCCGCATCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

sita:101752864

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	81.26	0.00e+00	1268.00
IUUC-Aml-002104	Ailuropoda melanoleuca	48.13	0.00e+00	761.00
IUUC-Atr-002580	Amborella trichopoda	74.02	1.00e-177	615.00
IUUC-Apl-003774	Anas platyrhynchos	48.24	0.00e+00	741.00
IUUC-Aca-005368	Anolis carolinensis	48.86	0.00e+00	782.00
IUUC-Aly-005727	Arabidopsis lyrata	70.57	0.00e+00	1145.00
IUUC-Ath-006974	Arabidopsis thaliana	70.95	0.00e+00	1147.00
IUUC-Ago-007890	Ashbya gossypii	26.75	1.00e-68	253.00
IUUC-Acl-008057	Aspergillus clavatus	34.22	5.00e-114	404.00
IUUC-Afl-008547	Aspergillus flavus	35.02	6.00e-107	380.00
IUUC-Afu-008805	Aspergillus fumigatus	32.99	2.00e-99	356.00
IUUC-Ani-009441	Aspergillus nidulans	34.37	5.00e-94	338.00
IUUC-Ang-009720	Aspergillus niger	33.37	3.00e-107	382.00
IUUC-Aor-010111	Aspergillus oryzae	33.62	7.00e-116	410.00
IUUC-Ate-010531	Aspergillus terreus	32.68	3.00e-96	345.00
IUUC-Ame-011470	Astyanax mexicanus	42.00	0.00e+00	671.00
IUUC-Bgr-012183	Blumeria graminis	31.56	3.00e-100	358.00
IUUC-Bta-013179	Bos taurus	48.36	0.00e+00	766.00
IUUC-Bci-013858	Botrytis cinerea	33.46	9.00e-111	393.00
IUUC-Bdi-014904	Brachypodium distachyon	89.43	0.00e+00	1426.00
IUUC-Bol-015536	Brassica oleracea	71.48	0.00e+00	1146.00
IUUC-Bra-017939	Brassica rapa	71.41	0.00e+00	1148.00
IUUC-Cel-018625	Caenorhabditis elegans	33.70	6.00e-116	410.00
IUUC-Cja-019063	Callithrix jacchus	47.31	0.00e+00	757.00
IUUC-Cfa-020976	Canis familiaris	49.82	0.00e+00	779.00
IUUC-Cpo-022265	Cavia porcellus	49.82	0.00e+00	782.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	41.68	9.00e-118	416.00
IUUC-Csa-024177	Chlorocebus sabaeus	50.20	0.00e+00	686.00
IUUC-Cho-024702	Choloepus hoffmanni	42.26	5.00e-117	414.00
IUUC-Cin-025411	Ciona intestinalis	43.77	0.00e+00	635.00
IUUC-Csv-026347	Ciona savignyi	41.96	5.00e-177	613.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	31.90	2.00e-98	352.00
IUUC-Cne-026831	Cryptococcus neoformans	35.04	9.00e-117	414.00
IUUC-Cme-027335	Cyanidioschyzon merolae	29.45	5.00e-36	145.00
IUUC-Dre-027982	Danio rerio	44.57	0.00e+00	662.00
IUUC-Dno-029034	Dasypus novemcinctus	48.36	0.00e+00	768.00
IUUC-Dor-030130	Dipodomys ordii	42.16	6.00e-97	348.00
IUUC-Dse-031467	Dothistroma septosporum	34.39	8.00e-113	400.00
IUUC-Dme-032075	Drosophila melanogaster	45.51	0.00e+00	679.00
IUUC-Ete-032865	Echinops telfairi	45.15	0.00e+00	678.00
IUUC-Eca-034059	Equus caballus	48.37	0.00e+00	765.00
IUUC-Eeu-035304	Erinaceus europaeus	45.67	0.00e+00	683.00
IUUC-Fca-035515	Felis catus	48.48	0.00e+00	771.00
IUUC-Fal-037271	Ficedula albicollis	48.81	0.00e+00	722.00
IUUC-Fox-037745	Fusarium oxysporum	34.16	3.00e-114	405.00
IUUC-Fso-038158	Fusarium solani	33.09	6.00e-107	381.00
IUUC-Gmo-039071	Gadus morhua	45.10	0.00e+00	665.00
IUUC-Ggr-040098	Gaeumannomyces graminis	32.56	2.00e-104	373.00
IUUC-Gga-040635	Gallus gallus	47.78	0.00e+00	773.00
IUUC-Gac-042528	Gasterosteus aculeatus	43.81	0.00e+00	681.00
IUUC-Gma-043614	Glycine max	69.14	0.00e+00	1112.00
IUUC-Ggo-044602	Gorilla gorilla	48.48	0.00e+00	769.00
IUUC-Hsa-045959	Homo sapiens	48.48	0.00e+00	769.00
IUUC-Hvu-047563	Hordeum vulgare	84.02	0.00e+00	1074.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	47.89	0.00e+00	772.00
IUUC-Kpa-049156	Komagataella pastoris	32.26	2.00e-104	373.00
IUUC-Lch-049648	Latimeria chalumnae	48.62	0.00e+00	768.00
IUUC-Lpe-051523	Leersia perrieri	86.23	0.00e+00	1398.00
IUUC-Loc-052072	Lepisosteus oculatus	43.06	0.00e+00	671.00
IUUC-Lma-053216	Leptosphaeria maculans	33.83	6.00e-101	362.00
IUUC-Laf-054327	Loxodonta africana	48.36	0.00e+00	768.00
IUUC-Mcc-055443	Macaca mulatta	48.48	0.00e+00	766.00
IUUC-Meu-056298	Macropus eugenii	50.52	3.00e-156	545.00
IUUC-Mor-057106	Magnaporthe oryzae	33.70	1.00e-112	400.00
IUUC-Mpo-057589	Magnaporthe poae	32.77	1.00e-106	380.00
IUUC-Mtr-058680	Medicago truncatula	68.90	0.00e+00	1137.00
IUUC-Mla-058903	Melampsora laricipopulina	32.93	2.00e-102	366.00
IUUC-Mga-059669	Meleagris gallopavo	47.71	0.00e+00	727.00
IUUC-Mvi-060476	Microbotryum violaceum	32.51	8.00e-98	350.00
IUUC-Mmr-060575	Microcebus murinus	48.95	0.00e+00	768.00
IUUC-Mdo-062183	Monodelphis domestica	48.15	0.00e+00	764.00
IUUC-Mmu-063592	Mus musculus	48.59	0.00e+00	768.00
IUUC-Mac-065634	Musa acuminata	75.48	0.00e+00	673.00
IUUC-Mpu-066082	Mustela putorius furo	49.70	0.00e+00	771.00
IUUC-Mlu-067345	Myotis lucifugus	47.78	0.00e+00	763.00
IUUC-Nfi-068558	Neosartorya fischeri	33.98	5.00e-111	394.00
IUUC-Ncr-068960	Neurospora crassa	31.21	6.00e-100	358.00
IUUC-Nle-070173	Nomascus leucogenys	49.82	0.00e+00	778.00
IUUC-Opr-070556	Ochotona princeps	48.24	0.00e+00	777.00
IUUC-Ont-071502	Oreochromis niloticus	45.14	0.00e+00	686.00
IUUC-Oan-072959	Ornithorhynchus anatinus	54.59	1.00e-66	244.00
IUUC-Ocu-074861	Oryctolagus cuniculus	49.58	0.00e+00	786.00
IUUC-Oba-075109	Oryza barthii	87.03	0.00e+00	1399.00
IUUC-Obr-076292	Oryza brachyantha	88.30	0.00e+00	1382.00
IUUC-Ogl-077065	Oryza glaberrima	89.29	0.00e+00	1452.00
IUUC-Ogu-078776	Oryza glumaepatula	87.03	0.00e+00	1416.00
IUUC-Oin-080048	Oryza indica	89.04	0.00e+00	1445.00
IUUC-Olo-080711	Oryza longistaminata	84.94	0.00e+00	1306.00
IUUC-Ome-081506	Oryza meridionalis	86.85	0.00e+00	1316.00
IUUC-Oni-082320	Oryza nivara	84.70	0.00e+00	1391.00
IUUC-Opu-083801	Oryza punctata	87.78	0.00e+00	1376.00
IUUC-Oru-085139	Oryza rufipogon	84.58	0.00e+00	1387.00
IUUC-Osa-085713	Oryza sativa	89.29	0.00e+00	1454.00
IUUC-Ola-086951	Oryzias latipes	43.72	0.00e+00	660.00
IUUC-Olu-087822	Ostreococcus lucimarinus	41.17	9.00e-169	586.00
IUUC-Oga-088625	Otolemur garnettii	47.71	0.00e+00	763.00
IUUC-Oar-089995	Ovis aries	47.37	0.00e+00	758.00
IUUC-Ptr-090640	Pan troglodytes	47.42	0.00e+00	767.00
IUUC-Pan-091974	Papio anubis	47.55	0.00e+00	761.00
IUUC-Psi-093957	Pelodiscus sinensis	47.09	0.00e+00	776.00
IUUC-Pma-094242	Petromyzon marinus	47.29	1.00e-100	359.00
IUUC-Pno-094835	Phaeosphaeria nodorum	35.48	3.00e-92	332.00
IUUC-Ppa-095901	Physcomitrella patens	61.56	0.00e+00	1032.00
IUUC-Pfo-097148	Poecilia formosa	44.13	0.00e+00	679.00
IUUC-Pab-098068	Pongo abelii	43.74	0.00e+00	639.00
IUUC-Pop-098943	Populus trichocarpa	72.89	0.00e+00	1159.00
IUUC-Pca-100738	Procavia capensis	45.80	3.00e-146	511.00
IUUC-Ppe-101315	Prunus persica	71.11	0.00e+00	1137.00
IUUC-Pva-102154	Pteropus vampyrus	48.13	0.00e+00	761.00
IUUC-Pgr-103343	Puccinia graminis	32.22	1.00e-95	343.00
IUUC-Ptt-103928	Puccinia triticina	29.71	9.00e-91	327.00
IUUC-Pte-104306	Pyrenophora teres	32.93	1.00e-90	327.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	33.05	2.00e-94	339.00
IUUC-Rno-105801	Rattus norvegicus	48.83	0.00e+00	771.00
IUUC-Sce-106304	Saccharomyces cerevisiae	29.91	1.00e-67	250.00
IUUC-Sha-107635	Sarcophilus harrisii	49.40	0.00e+00	768.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	32.64	4.00e-93	335.00
IUUC-Spo-108144	Schizosaccharomyces pombe	33.70	2.00e-107	382.00
IUUC-Smo-108848	Selaginella moellendorffii	61.17	0.00e+00	949.00
IUUC-Sly-111523	Solanum lycopersicum	69.19	0.00e+00	1163.00
IUUC-Sar-113733	Sorex araneus	46.21	4.00e-94	338.00
IUUC-Sbi-114419	Sorghum bicolor	95.72	0.00e+00	1535.00
IUUC-Sre-115225	Sporisorium reilianum	33.29	2.00e-105	375.00
IUUC-Ssc-115686	Sus scrofa	47.19	0.00e+00	764.00
IUUC-Tgu-117346	Taeniopygia guttata	47.72	0.00e+00	755.00
IUUC-Tru-118350	Takifugu rubripes	43.34	0.00e+00	666.00
IUUC-Tsy-119278	Tarsius syrichta	39.78	3.00e-164	571.00
IUUC-Tni-120658	Tetraodon nigroviridis	43.64	0.00e+00	655.00
IUUC-Tca-121585	Theobroma cacao	71.36	0.00e+00	1135.00
IUUC-Tre-122043	Trichoderma reesei	34.48	6.00e-109	387.00
IUUC-Tvi-122303	Trichoderma virens	34.48	6.00e-110	390.00
IUUC-Tae-123798	Triticum aestivum	86.42	0.00e+00	1412.00
IUUC-Tur-126732	Triticum urartu	81.26	0.00e+00	1319.00
IUUC-Tme-126909	Tuber melanosporum	34.22	8.00e-102	363.00
IUUC-Tbe-127261	Tupaia belangeri	41.25	7.00e-121	427.00
IUUC-Ttr-129119	Tursiops truncatus	53.93	2.00e-111	396.00
IUUC-Uma-129599	Ustilago maydis	33.18	1.00e-113	403.00
IUUC-Vda-129688	Verticillium dahliae	33.04	2.00e-103	369.00
IUUC-Vpa-130170	Vicugna pacos	37.17	1.00e-145	509.00
IUUC-Vvi-131116	Vitis vinifera	72.13	0.00e+00	1144.00
IUUC-Xtr-131953	Xenopus tropicalis	46.15	0.00e+00	718.00
IUUC-Xma-133837	Xiphophorus maculatus	43.97	0.00e+00	677.00
IUUC-Yli-134510	Yarrowia lipolytica	34.53	3.00e-105	375.00
IUUC-Zma-135786	Zea mays	93.08	0.00e+00	1452.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence