iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067330

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAPE02033840

Gene Name

USP27X

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000009859.2	ENSMLUT00000009844.2	ENSMLUP00000008973.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.70e-90	303.7	181	523

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L+++p lr+++l+ ++++++    ++p+ +l++++ +lf+el++++ +   p +ll+ ++  a+++ gy+qq
   Q: 181  GLINLGNTCFMNCIVQALTHTPILRDFFLS-DRHRCEM---PSPELCLVCEMSSLFRELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQ 265
           9*****************************.9999987...589********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl   ld l++++k                  +  +  +++++ +++i+++F g l+s+++c++c+ vs++ +p +d+sl++pg+
   Q: 266  DAHEFLIAALDVLHRHCKG----------------DDVGKAANNPNHCNCIIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGS 338
           *****************22................2344668899999****************************************9 PP
   S: 180  eetkke...................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksreki 249
            ++  +                   +l+dcL+ ft++e+l ++ k++c +c+++qe++k+l+++klP v ++h+kRf  +++ k+r+ki
   Q: 339  CTSFWPmspgressvngeshipgttTLTDCLRRFTRPEHLGSSAKIKCGSCQSYQESTKQLMMNKLPVVACFHFKRF--EHSAKQRRKI 425
           98766699*********************************************************************..55667999** PP
   S: 250  nkkvefpleLdlspfctspeekqke............kkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleet 326
           +++++fpleLd++pf++s++e+  +            ++kY+L+avv+H+G+l+sGHY+++++++k++W+++dD  +t+ + ++vl   
   Q: 426  TTYISFPLELDMTPFMASSKESRMNgqlqlptssgndENKYSLFAVVNHQGTLESGHYTSFIRHHKDQWFKCDDAVITKASIKDVLD-- 512
           ******************5555444666666666666**************************************************.. PP
   S: 327  gstaYvlfYkrr 338
            s++Y+lfY+++
   Q: 513  -SEGYLLFYHKQ 523
           .********985 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

PRRGPGGGCL DVDFAVGPPG CSHVNSFKVG ENWRQGLRVI YQCFVWCRTP ETRKSKAKSC 60
ICHVCGTHLN RLHSCLSCVF FGCFTEKHIH EHAQAKQHNL AVDLYYGGIY CFMCKDYVYD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCCGGCGCG GCCCTGGGGG CGGATGCTTG GATGTGGATT TCGCTGTGGG TCCACCAGGC 60
TGTTCCCACG TGAACAGCTT TAAGGTGGGA GAGAACTGGA GGCAGGGATT GCGGGTGATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0043065--P:positive regulation of apoptotic process
GO:0050821--P:protein stabilization
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002084	Ailuropoda melanoleuca	98.48	0.00e+00	1091.00
IUUC-Atr-002653	Amborella trichopoda	38.19	3.00e-94	339.00
IUUC-Apl-003433	Anas platyrhynchos	82.44	0.00e+00	838.00
IUUC-Aca-005347	Anolis carolinensis	78.56	0.00e+00	879.00
IUUC-Aly-006565	Arabidopsis lyrata	37.44	3.00e-72	266.00
IUUC-Ath-007536	Arabidopsis thaliana	34.87	2.00e-74	273.00
IUUC-Ago-007811	Ashbya gossypii	30.00	2.00e-51	196.00
IUUC-Afu-008912	Aspergillus fumigatus	30.17	8.00e-52	197.00
IUUC-Ame-011253	Astyanax mexicanus	75.63	0.00e+00	728.00
IUUC-Bgr-012150	Blumeria graminis	29.96	9.00e-48	184.00
IUUC-Bta-013303	Bos taurus	81.73	0.00e+00	894.00
IUUC-Bci-013604	Botrytis cinerea	31.03	4.00e-54	205.00
IUUC-Bdi-014171	Brachypodium distachyon	35.55	3.00e-74	272.00
IUUC-Bra-016962	Brassica rapa	37.47	2.00e-72	266.00
IUUC-Cja-019954	Callithrix jacchus	87.74	0.00e+00	946.00
IUUC-Cfa-020956	Canis familiaris	96.02	0.00e+00	1005.00
IUUC-Cpo-022014	Cavia porcellus	98.28	0.00e+00	1082.00
IUUC-Csa-023145	Chlorocebus sabaeus	81.63	0.00e+00	902.00
IUUC-Cin-025109	Ciona intestinalis	54.88	6.00e-115	407.00
IUUC-Csv-026214	Ciona savignyi	53.28	5.00e-162	564.00
IUUC-Cne-027085	Cryptococcus neoformans	32.46	8.00e-60	224.00
IUUC-Dre-027433	Danio rerio	81.61	0.00e+00	803.00
IUUC-Dno-029905	Dasypus novemcinctus	95.54	0.00e+00	848.00
IUUC-Dor-030832	Dipodomys ordii	95.85	5.00e-110	390.00
IUUC-Dme-032074	Drosophila melanogaster	50.00	1.00e-131	462.00
IUUC-Ete-033175	Echinops telfairi	64.92	8.00e-171	593.00
IUUC-Eca-033957	Equus caballus	96.58	0.00e+00	1064.00
IUUC-Eeu-034814	Erinaceus europaeus	86.19	5.00e-105	374.00
IUUC-Fca-035768	Felis catus	98.11	0.00e+00	1088.00
IUUC-Fal-037645	Ficedula albicollis	82.35	0.00e+00	824.00
IUUC-Fox-038046	Fusarium oxysporum	30.66	8.00e-54	204.00
IUUC-Fso-038321	Fusarium solani	31.34	6.00e-53	201.00
IUUC-Gmo-038474	Gadus morhua	83.78	3.00e-150	525.00
IUUC-Ggr-040044	Gaeumannomyces graminis	32.05	2.00e-56	213.00
IUUC-Gga-040624	Gallus gallus	80.99	0.00e+00	890.00
IUUC-Gac-042197	Gasterosteus aculeatus	77.61	0.00e+00	832.00
IUUC-Ggo-044925	Gorilla gorilla	98.29	0.00e+00	1087.00
IUUC-Hsa-046521	Homo sapiens	81.82	0.00e+00	904.00
IUUC-Itr-048375	Ictidomys tridecemlineatus	81.54	0.00e+00	891.00
IUUC-Kpa-049135	Komagataella pastoris	34.33	1.00e-68	253.00
IUUC-Lch-050537	Latimeria chalumnae	82.88	0.00e+00	892.00
IUUC-Loc-052765	Lepisosteus oculatus	73.92	0.00e+00	789.00
IUUC-Laf-053947	Loxodonta africana	97.14	0.00e+00	1071.00
IUUC-Mcc-055166	Macaca mulatta	81.63	0.00e+00	902.00
IUUC-Mpo-057621	Magnaporthe poae	31.91	2.00e-55	209.00
IUUC-Mga-059709	Meleagris gallopavo	82.44	0.00e+00	838.00
IUUC-Mvi-060530	Microbotryum violaceum	32.73	1.00e-56	214.00
IUUC-Mmr-060988	Microcebus murinus	81.25	0.00e+00	901.00
IUUC-Mdo-063065	Monodelphis domestica	83.66	0.00e+00	900.00
IUUC-Mmu-063829	Mus musculus	81.25	0.00e+00	895.00
IUUC-Mpu-066433	Mustela putorius furo	98.08	0.00e+00	1075.00
IUUC-Nfi-068423	Neosartorya fischeri	28.88	4.00e-52	198.00
IUUC-Ncr-068809	Neurospora crassa	30.40	1.00e-55	210.00
IUUC-Nle-069084	Nomascus leucogenys	96.48	0.00e+00	856.00
IUUC-Opr-070469	Ochotona princeps	69.63	1.00e-171	595.00
IUUC-Ont-071961	Oreochromis niloticus	78.23	0.00e+00	839.00
IUUC-Oan-073565	Ornithorhynchus anatinus	76.41	0.00e+00	808.00
IUUC-Ocu-074951	Oryctolagus cuniculus	96.15	0.00e+00	1053.00
IUUC-Oba-075688	Oryza barthii	35.93	4.00e-75	275.00
IUUC-Obr-076652	Oryza brachyantha	40.32	2.00e-72	266.00
IUUC-Ogl-077910	Oryza glaberrima	36.03	3.00e-76	279.00
IUUC-Ogu-078479	Oryza glumaepatula	35.83	2.00e-76	279.00
IUUC-Oin-079697	Oryza indica	37.87	3.00e-72	266.00
IUUC-Olo-080811	Oryza longistaminata	41.05	3.00e-52	198.00
IUUC-Ome-081706	Oryza meridionalis	36.03	6.00e-76	278.00
IUUC-Oni-083070	Oryza nivara	35.22	3.00e-76	279.00
IUUC-Opu-083605	Oryza punctata	38.74	5.00e-65	241.00
IUUC-Oru-084522	Oryza rufipogon	36.03	3.00e-76	279.00
IUUC-Osa-085351	Oryza sativa	37.84	4.00e-73	268.00
IUUC-Ola-086743	Oryzias latipes	78.38	0.00e+00	658.00
IUUC-Olu-087695	Ostreococcus lucimarinus	31.61	2.00e-49	189.00
IUUC-Oga-088771	Otolemur garnettii	95.98	0.00e+00	1047.00
IUUC-Oar-089610	Ovis aries	95.62	0.00e+00	1001.00
IUUC-Ptr-090783	Pan troglodytes	84.21	0.00e+00	837.00
IUUC-Pan-092253	Papio anubis	96.41	0.00e+00	1009.00
IUUC-Psi-093670	Pelodiscus sinensis	81.71	0.00e+00	842.00
IUUC-Pma-094323	Petromyzon marinus	65.44	0.00e+00	650.00
IUUC-Ppa-095413	Physcomitrella patens	34.01	1.00e-82	300.00
IUUC-Pfo-096473	Poecilia formosa	79.96	0.00e+00	859.00
IUUC-Pab-098324	Pongo abelii	98.30	0.00e+00	1089.00
IUUC-Pop-099893	Populus trichocarpa	36.96	9.00e-86	310.00
IUUC-Pca-100329	Procavia capensis	96.77	0.00e+00	1068.00
IUUC-Ppe-102020	Prunus persica	36.77	1.00e-91	330.00
IUUC-Pva-102721	Pteropus vampyrus	93.27	0.00e+00	998.00
IUUC-Rno-105247	Rattus norvegicus	81.25	0.00e+00	896.00
IUUC-Sce-106247	Saccharomyces cerevisiae	30.66	5.00e-50	191.00
IUUC-Sha-107538	Sarcophilus harrisii	83.87	2.00e-107	381.00
IUUC-Sja-107656	Schizosaccharomyces japonicus	34.81	8.00e-65	241.00
IUUC-Spo-108226	Schizosaccharomyces pombe	33.55	6.00e-60	224.00
IUUC-Ssl-108531	Sclerotinia sclerotiorum	28.37	7.00e-51	194.00
IUUC-Smo-109310	Selaginella moellendorffii	36.67	2.00e-87	317.00
IUUC-Sit-109716	Setaria italica	35.77	1.00e-77	284.00
IUUC-Sly-111077	Solanum lycopersicum	37.66	2.00e-82	299.00
IUUC-Stu-112203	Solanum tuberosum	39.22	2.00e-75	276.00
IUUC-Sar-113174	Sorex araneus	91.26	0.00e+00	940.00
IUUC-Sbi-114205	Sorghum bicolor	35.41	3.00e-78	285.00
IUUC-Sre-115195	Sporisorium reilianum	27.21	2.00e-52	201.00
IUUC-Ssc-115315	Sus scrofa	96.37	0.00e+00	1051.00
IUUC-Tgu-116938	Taeniopygia guttata	83.76	0.00e+00	835.00
IUUC-Tru-117622	Takifugu rubripes	79.24	0.00e+00	868.00
IUUC-Tni-120119	Tetraodon nigroviridis	80.00	0.00e+00	869.00
IUUC-Tca-121154	Theobroma cacao	38.19	2.00e-92	333.00
IUUC-Tvi-122599	Trichoderma virens	30.38	2.00e-53	203.00
IUUC-Tae-125608	Triticum aestivum	35.43	2.00e-83	303.00
IUUC-Ttr-129006	Tursiops truncatus	97.88	0.00e+00	1064.00
IUUC-Vda-129829	Verticillium dahliae	33.11	6.00e-35	140.00
IUUC-Vvi-131477	Vitis vinifera	37.55	5.00e-77	281.00
IUUC-Xtr-132444	Xenopus tropicalis	81.30	0.00e+00	893.00
IUUC-Xma-133514	Xiphophorus maculatus	80.58	0.00e+00	876.00
IUUC-Yli-134357	Yarrowia lipolytica	30.02	9.00e-47	181.00
IUUC-Zma-134945	Zea mays	35.83	3.00e-75	276.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence