iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108168

UUCD1 version

UUC-ScP-00043

Ensembl Protein ID

SPAC17G8.10c.1:pep

UniProt Accession

Q10322; DMA1_SCHPO

Genbank Protein ID

CAA57466.1; CAA93693.1

Protein Name

Probable E3 ubiquitin-protein ligase dma1; RING-type E3 ubiquitin transferase dma1

Genbank Nucleotide ID

X81883; CU329670

Gene Name

dma1; SPAC17G8.10c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPAC17G8.10c	SPAC17G8.10c.1	SPAC17G8.10c.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	21131906; 18597043

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.054	12.1	192	236

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCl +   ++ ++v pC H +h +C+       n+s + f+C +Cr
   Q: 192  CCICLMPVlpCQALFVAPCSHSYHYKCIRPT---LNESHPYFSCFICR 236
           9***99778744499*************333...5899*********8 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Probable E3 ubiquitin-protein ligase which is a component of the spindle assembly checkpoint, required to prevent septum formation and premature exit from mitosis if spindle function is compromised. Inhibits the septation initiation netwok (SIN) during spindle checkpoint activation. The effect appears to be mediated through preventing the SIN activator, plo1 kinase, from localizing to the SPB.

Protein Sequence
(Fasta)

MTKSVEGYLK EQELAAETDS EKDDDKISIR LTNFVGPNAH SFSFDPLVRY WNRKQNNLPI 60
YIGRYTERYN GGDVSAIVFR SKVVSRRHAQ IFYENNTWYI QDMGSSSGTF LNHVRLSPPS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTACTGTG TGCAATTTAC TTGTTCTACT AAATTGGCTT CATAATTTAT AACATATTTT 60
TCTGATAACA GCGAAAACTA TCATTTTTTC GATTGCTTTT CATTTACAGC TAAATTCTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000253--FHA_dom
IPR008984--SMAD_FHA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50006--FHA_DOMAIN
PS50089--ZF_RING_2

Pfam

PF00498--FHA
PF17123--zf-RING_11

SMART

SM00240--FHA
SM00184--RING

Gene Ontology

GO:0032153--C:cell division site
GO:0005829--C:cytosol
GO:0044732--C:mitotic spindle pole body
GO:0061630--F:ubiquitin protein ligase activity
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0044810--P:Dma1-dependent checkpoint
GO:0007094--P:mitotic spindle assembly checkpoint
GO:1902364--P:negative regulation of protein localization to spindle pole body
GO:0031030--P:negative regulation of septation initiation signaling
GO:0051865--P:protein autoubiquitination
GO:0016567--P:protein ubiquitination

KEGG

spo:SPAC17G8.10c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000514	Aegilops tauschii	44.68	9.00e-06	43.50
IUUC-Atr-002751	Amborella trichopoda	30.00	3.00e-05	40.40
IUUC-Aly-006403	Arabidopsis lyrata	30.00	5.00e-07	47.40
IUUC-Ath-006857	Arabidopsis thaliana	32.05	1.00e-06	45.10
IUUC-Ago-007705	Ashbya gossypii	42.86	2.00e-47	181.00
IUUC-Acl-008234	Aspergillus clavatus	43.44	1.00e-43	169.00
IUUC-Afl-008606	Aspergillus flavus	42.00	6.00e-37	146.00
IUUC-Afu-008908	Aspergillus fumigatus	36.76	2.00e-29	121.00
IUUC-Ani-009177	Aspergillus nidulans	38.07	2.00e-32	131.00
IUUC-Ang-009606	Aspergillus niger	41.98	9.00e-43	166.00
IUUC-Aor-009904	Aspergillus oryzae	44.98	2.00e-41	162.00
IUUC-Ate-010354	Aspergillus terreus	43.18	3.00e-43	167.00
IUUC-Bci-013695	Botrytis cinerea	43.85	1.00e-51	195.00
IUUC-Bdi-014422	Brachypodium distachyon	42.59	2.00e-05	42.40
IUUC-Bol-015277	Brassica oleracea	34.62	2.00e-07	48.90
IUUC-Bra-017697	Brassica rapa	33.33	6.00e-07	47.00
IUUC-Cgl-026486	Colletotrichum gloeosporioides	46.38	3.00e-55	207.00
IUUC-Cne-026927	Cryptococcus neoformans	43.88	1.00e-45	176.00
IUUC-Dse-031157	Dothistroma septosporum	47.51	3.00e-53	201.00
IUUC-Eeu-035117	Erinaceus europaeus	48.84	6.00e-06	44.30
IUUC-Fox-037681	Fusarium oxysporum	44.34	1.00e-54	205.00
IUUC-Fso-038129	Fusarium solani	37.18	6.00e-41	160.00
IUUC-Ggr-039871	Gaeumannomyces graminis	43.87	1.00e-55	209.00
IUUC-Gma-044309	Glycine max	40.74	4.00e-06	44.30
IUUC-Hvu-047585	Hordeum vulgare	46.81	3.00e-06	45.40
IUUC-Kpa-049298	Komagataella pastoris	45.61	2.00e-43	167.00
IUUC-Lma-053220	Leptosphaeria maculans	48.02	1.00e-51	196.00
IUUC-Mor-057012	Magnaporthe oryzae	43.95	5.00e-55	207.00
IUUC-Mpo-057371	Magnaporthe poae	58.00	2.00e-11	62.00
IUUC-Mtr-057720	Medicago truncatula	40.74	4.00e-06	44.30
IUUC-Mla-058879	Melampsora laricipopulina	43.67	1.00e-45	175.00
IUUC-Mvi-060480	Microbotryum violaceum	44.73	7.00e-50	190.00
IUUC-Mac-065116	Musa acuminata	44.07	6.00e-06	43.90
IUUC-Mlu-068174	Myotis lucifugus	39.34	7.00e-07	47.40
IUUC-Nfi-068378	Neosartorya fischeri	44.75	3.00e-44	171.00
IUUC-Ncr-068692	Neurospora crassa	44.22	9.00e-58	216.00
IUUC-Oba-075359	Oryza barthii	41.67	4.00e-06	44.70
IUUC-Obr-076924	Oryza brachyantha	41.67	4.00e-06	44.70
IUUC-Ogl-077314	Oryza glaberrima	43.40	8.00e-06	44.30
IUUC-Ogu-078254	Oryza glumaepatula	41.67	4.00e-06	44.70
IUUC-Oin-079660	Oryza indica	41.67	4.00e-06	44.70
IUUC-Olo-080750	Oryza longistaminata	41.67	4.00e-06	44.70
IUUC-Ome-081469	Oryza meridionalis	28.97	7.00e-07	45.40
IUUC-Oni-083041	Oryza nivara	41.67	4.00e-06	44.70
IUUC-Oru-084708	Oryza rufipogon	41.67	4.00e-06	44.70
IUUC-Osa-085436	Oryza sativa	31.48	3.00e-08	49.70
IUUC-Pno-094949	Phaeosphaeria nodorum	43.40	3.00e-30	124.00
IUUC-Ppa-095371	Physcomitrella patens	37.04	1.00e-05	40.40
IUUC-Pop-099340	Populus trichocarpa	41.51	4.00e-06	44.30
IUUC-Pca-100201	Procavia capensis	39.34	7.00e-07	47.40
IUUC-Ppe-101750	Prunus persica	39.13	6.00e-06	44.30
IUUC-Ptt-103791	Puccinia triticina	47.52	6.00e-33	133.00
IUUC-Pte-104124	Pyrenophora teres	48.47	1.00e-50	191.00
IUUC-Pyt-104430	Pyrenophora triticirepentis	47.96	7.00e-50	189.00
IUUC-Sce-106402	Saccharomyces cerevisiae	44.39	7.00e-48	182.00
IUUC-Sha-107202	Sarcophilus harrisii	39.34	8.00e-07	47.40
IUUC-Sja-107979	Schizosaccharomyces japonicus	67.70	4.00e-106	375.00
IUUC-Ssl-108562	Sclerotinia sclerotiorum	41.20	2.00e-43	168.00
IUUC-Sly-111728	Solanum lycopersicum	35.71	2.00e-08	52.00
IUUC-Stu-112177	Solanum tuberosum	33.75	6.00e-09	53.50
IUUC-Sbi-114156	Sorghum bicolor	43.33	1.00e-06	46.60
IUUC-Sre-115012	Sporisorium reilianum	47.62	7.00e-47	180.00
IUUC-Tca-121030	Theobroma cacao	34.62	9.00e-07	45.80
IUUC-Tre-121954	Trichoderma reesei	41.70	8.00e-53	199.00
IUUC-Tvi-122295	Trichoderma virens	43.95	8.00e-55	206.00
IUUC-Tae-124293	Triticum aestivum	44.68	1.00e-05	42.70
IUUC-Tur-126549	Triticum urartu	44.68	1.00e-05	43.10
IUUC-Tme-126881	Tuber melanosporum	42.91	3.00e-56	210.00
IUUC-Uma-129400	Ustilago maydis	49.46	1.00e-47	182.00
IUUC-Vda-130024	Verticillium dahliae	44.94	4.00e-57	214.00
IUUC-Vvi-130879	Vitis vinifera	42.59	3.00e-06	45.10
IUUC-Yli-134472	Yarrowia lipolytica	45.06	5.00e-52	197.00
IUUC-Zma-135019	Zea mays	43.33	1.00e-06	46.60

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence