iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein-protein Interaction
iRefIndex	PINA	HINT
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	2.00e-77	261.7	2	321

Active Site

Position(s)	Description	Evidence
82	Nucleophile	{ECO:0000305\|PubMed:17559514}
157	Proton donor	{ECO:0000250\|UniProtKB:P09936}

Domain Profile

DUB/UCH

   S: 7    ewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvigNsCatyAl 104
           +w+++esdPg+ft+l+++  vk++ qveelysLd+++l+ + +pv+gl++lFk++  ++ +r          ++ +d ++++ffa+qvi+N+Cat+A+
   Q: 2    SWCTIESDPGVFTELIQQMQVKGV-QVEELYSLDSDSLNNL-RPVYGLIFLFKWQAGEKDER---------PTI-QDQVSNLFFANQVINNACATQAI 87
           7***********************.****************.**************998888.........223.68899****************** PP
   S: 105  lsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsyvningrlyeldglkpfPld 202
           l  lln  ++  d+G++ls lke+tk + ++ k+la++n++ ++++hns+ar+e++  +e+++++   ++++++hf+sy++++g lyeldglk+ P+ 
   Q: 88   LAILLNSPEV--DIGPELSALKEFTKNFPSDLKGLAINNSDSIRAAHNSFARPEPFVPEEQKAAT---KDDDVYHFISYIPVDGVLYELDGLKEGPIS 180
           *******999..********************************************988877555...59**************************** PP
   S: 203  lgkkkete...elkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid.................keLlkLlkdieseeekieaql 280
           lg++  ++   e+ + ++ v+   eri+ +++ eirfnlla+ ++r+ i+t+ l+ l+ +                 + + +L  ++ s +e  + ++
   Q: 181  LGPCPGDQtgiEWLQMVQPVI--QERIERYSQSEIRFNLLAVIKNRKDIYTAELKELQRQreqllqqantcvdkseaEAVNALIAEVGSGIEAASDKI 276
           ****54442447889999888..******************************998877789**************97788***************** PP
   S: 281  ddekekrkkfkiddirRtenydeficifikdlaregilrklveet 325
             e+ek  k+  ++irR++ny  f++ f+k la++++l+ l e+ 
   Q: 277  VMEEEKFMKWRTENIRRKHNYIPFLFNFLKLLAEKKQLKPLIEKA 321
           ****************************************99984 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Ubiquitin-protein hydrolase involved in the release of ubiquitin attached via both peptide and isopeptide linkages. Able to cleave 'Lys-48'-linked polyubiquitin chains. Involved in the direct or indirect regulation of AUX/IAA proteins stability (PubMed:17559514). Acts as a linker between the TREX-2 complex and 26S proteasome (PubMed:22951400).

Protein Sequence
(Fasta)

MSWCTIESDP GVFTELIQQM QVKGVQVEEL YSLDSDSLNN LRPVYGLIFL FKWQAGEKDE 60
RPTIQDQVSN LFFANQVINN ACATQAILAI LLNSPEVDIG PELSALKEFT KNFPSDLKGL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACGAACCAGA GACTAAACCA GGAAAAGCAA CACGACAAAG CGACTATTTA AAACAAAAAT 60
AAAAATATAA TCGAGCTCTG GCAAAGTTAA ACCCTAATTC CCAAATTGGA GTCACGAAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0010016--P:shoot system morphogenesis
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT1G65650

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	74.92	2.00e-137	481.00
IUUC-Aml-001866	Ailuropoda melanoleuca	47.53	6.00e-84	303.00
IUUC-Atr-002966	Amborella trichopoda	71.47	2.00e-129	455.00
IUUC-Apl-003306	Anas platyrhynchos	43.38	9.00e-76	276.00
IUUC-Aca-004763	Anolis carolinensis	47.35	7.00e-82	296.00
IUUC-Aly-005581	Arabidopsis lyrata	97.88	1.00e-173	601.00
IUUC-Ago-007999	Ashbya gossypii	41.88	5.00e-30	124.00
IUUC-Acl-008231	Aspergillus clavatus	51.05	3.00e-62	231.00
IUUC-Afl-008557	Aspergillus flavus	50.83	8.00e-61	226.00
IUUC-Afu-008988	Aspergillus fumigatus	51.25	3.00e-61	227.00
IUUC-Ani-009420	Aspergillus nidulans	41.89	4.00e-64	237.00
IUUC-Ang-009859	Aspergillus niger	48.57	5.00e-60	223.00
IUUC-Aor-010145	Aspergillus oryzae	50.83	8.00e-61	226.00
IUUC-Ate-010347	Aspergillus terreus	47.45	7.00e-61	226.00
IUUC-Ame-010791	Astyanax mexicanus	48.33	1.00e-85	308.00
IUUC-Bgr-012298	Blumeria graminis	42.28	3.00e-59	221.00
IUUC-Bta-013251	Bos taurus	48.46	5.00e-84	303.00
IUUC-Bci-013786	Botrytis cinerea	42.31	3.00e-63	234.00
IUUC-Bdi-014132	Brachypodium distachyon	76.06	4.00e-134	469.00
IUUC-Bol-015611	Brassica oleracea	89.09	2.00e-160	556.00
IUUC-Bra-017769	Brassica rapa	89.09	1.00e-160	557.00
IUUC-Cel-018604	Caenorhabditis elegans	39.09	2.00e-64	238.00
IUUC-Cja-019768	Callithrix jacchus	43.47	9.00e-79	286.00
IUUC-Cfa-020207	Canis familiaris	47.53	6.00e-84	303.00
IUUC-Cpo-021925	Cavia porcellus	45.06	6.00e-77	280.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	51.70	8.00e-85	306.00
IUUC-Csa-023958	Chlorocebus sabaeus	48.46	3.00e-84	304.00
IUUC-Cho-024928	Choloepus hoffmanni	55.41	5.00e-18	84.30
IUUC-Cin-025771	Ciona intestinalis	44.48	2.00e-72	265.00
IUUC-Csv-026149	Ciona savignyi	44.78	1.00e-75	275.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	35.74	1.00e-48	185.00
IUUC-Cne-026955	Cryptococcus neoformans	32.95	7.00e-47	180.00
IUUC-Cme-027104	Cyanidioschyzon merolae	31.27	6.00e-47	180.00
IUUC-Dre-027409	Danio rerio	47.72	6.00e-84	303.00
IUUC-Dno-028921	Dasypus novemcinctus	47.53	7.00e-84	303.00
IUUC-Dor-030891	Dipodomys ordii	39.34	1.00e-40	160.00
IUUC-Dse-031170	Dothistroma septosporum	41.82	2.00e-61	228.00
IUUC-Dme-031677	Drosophila melanogaster	46.36	6.00e-79	286.00
IUUC-Ete-032646	Echinops telfairi	44.93	3.00e-43	169.00
IUUC-Eca-033776	Equus caballus	46.38	3.00e-75	274.00
IUUC-Eeu-035305	Erinaceus europaeus	44.51	8.00e-39	153.00
IUUC-Fca-035846	Felis catus	43.87	2.00e-79	288.00
IUUC-Fal-037597	Ficedula albicollis	46.51	1.00e-73	268.00
IUUC-Fox-037670	Fusarium oxysporum	47.83	8.00e-52	196.00
IUUC-Fso-038243	Fusarium solani	48.70	6.00e-52	196.00
IUUC-Gmo-038499	Gadus morhua	44.14	1.00e-75	275.00
IUUC-Ggr-039975	Gaeumannomyces graminis	44.35	1.00e-52	199.00
IUUC-Gga-040904	Gallus gallus	47.59	9.00e-86	309.00
IUUC-Gac-042058	Gasterosteus aculeatus	47.53	2.00e-83	301.00
IUUC-Gma-043030	Glycine max	79.58	2.00e-145	508.00
IUUC-Ggo-044699	Gorilla gorilla	43.99	3.00e-72	264.00
IUUC-Hsa-046227	Homo sapiens	47.53	2.00e-84	304.00
IUUC-Hvu-047359	Hordeum vulgare	75.15	1.00e-136	478.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	43.38	2.00e-78	285.00
IUUC-Lch-049829	Latimeria chalumnae	48.29	4.00e-82	297.00
IUUC-Lpe-050899	Leersia perrieri	77.43	1.00e-132	464.00
IUUC-Loc-052264	Lepisosteus oculatus	46.77	2.00e-80	291.00
IUUC-Lma-053110	Leptosphaeria maculans	53.07	8.00e-57	213.00
IUUC-Laf-053639	Loxodonta africana	47.53	6.00e-84	303.00
IUUC-Mcc-055506	Macaca mulatta	48.46	3.00e-84	304.00
IUUC-Meu-056267	Macropus eugenii	44.13	6.00e-50	191.00
IUUC-Mor-057001	Magnaporthe oryzae	47.93	1.00e-58	219.00
IUUC-Mpo-057608	Magnaporthe poae	44.39	1.00e-36	145.00
IUUC-Mtr-057731	Medicago truncatula	79.94	1.00e-143	501.00
IUUC-Mla-059016	Melampsora laricipopulina	44.66	4.00e-44	169.00
IUUC-Mga-060178	Meleagris gallopavo	46.15	2.00e-76	278.00
IUUC-Mvi-060353	Microbotryum violaceum	37.61	6.00e-53	200.00
IUUC-Mmr-060738	Microcebus murinus	47.53	2.00e-84	304.00
IUUC-Mdo-062266	Monodelphis domestica	51.92	3.00e-61	227.00
IUUC-Mmu-063619	Mus musculus	48.46	7.00e-84	303.00
IUUC-Mac-065301	Musa acuminata	75.93	3.00e-145	506.00
IUUC-Mpu-066058	Mustela putorius furo	47.22	2.00e-83	301.00
IUUC-Mlu-067292	Myotis lucifugus	48.15	2.00e-84	305.00
IUUC-Nfi-068275	Neosartorya fischeri	51.05	3.00e-61	228.00
IUUC-Ncr-068713	Neurospora crassa	39.39	1.00e-58	219.00
IUUC-Nle-069013	Nomascus leucogenys	48.77	4.00e-85	307.00
IUUC-Opr-070628	Ochotona princeps	41.71	2.00e-72	265.00
IUUC-Ont-072688	Oreochromis niloticus	46.46	8.00e-82	296.00
IUUC-Oan-073004	Ornithorhynchus anatinus	51.90	2.00e-62	231.00
IUUC-Ocu-074303	Oryctolagus cuniculus	47.22	5.00e-83	301.00
IUUC-Oba-075002	Oryza barthii	76.36	2.00e-133	468.00
IUUC-Obr-076392	Oryza brachyantha	76.80	4.00e-131	460.00
IUUC-Ogl-077271	Oryza glaberrima	76.36	2.00e-133	468.00
IUUC-Ogu-078493	Oryza glumaepatula	76.67	1.00e-134	471.00
IUUC-Oin-080084	Oryza indica	76.67	1.00e-134	471.00
IUUC-Olo-080803	Oryza longistaminata	76.36	3.00e-134	470.00
IUUC-Ome-081146	Oryza meridionalis	75.45	2.00e-133	467.00
IUUC-Oni-082146	Oryza nivara	76.67	1.00e-134	471.00
IUUC-Opu-083633	Oryza punctata	75.55	7.00e-130	456.00
IUUC-Oru-084789	Oryza rufipogon	76.67	1.00e-134	471.00
IUUC-Osa-086196	Oryza sativa	76.67	1.00e-134	471.00
IUUC-Ola-087126	Oryzias latipes	46.91	2.00e-82	298.00
IUUC-Olu-087665	Ostreococcus lucimarinus	44.41	6.00e-70	256.00
IUUC-Oga-089140	Otolemur garnettii	43.87	1.00e-79	289.00
IUUC-Oar-090296	Ovis aries	47.37	1.00e-82	298.00
IUUC-Ptr-090566	Pan troglodytes	47.53	2.00e-84	304.00
IUUC-Pan-092052	Papio anubis	48.46	3.00e-84	304.00
IUUC-Psi-093723	Pelodiscus sinensis	46.84	8.00e-74	269.00
IUUC-Pma-094568	Petromyzon marinus	51.67	9.00e-62	229.00
IUUC-Pno-095120	Phaeosphaeria nodorum	50.88	4.00e-56	210.00
IUUC-Ppa-095761	Physcomitrella patens	69.97	2.00e-129	454.00
IUUC-Pfo-096210	Poecilia formosa	47.53	1.00e-83	302.00
IUUC-Pab-098463	Pongo abelii	47.53	2.00e-84	305.00
IUUC-Pop-099109	Populus trichocarpa	75.38	2.00e-140	491.00
IUUC-Pca-100108	Procavia capensis	52.81	6.00e-69	253.00
IUUC-Ppe-101176	Prunus persica	79.94	1.00e-142	498.00
IUUC-Pva-102629	Pteropus vampyrus	53.28	2.00e-70	258.00
IUUC-Pgr-103419	Puccinia graminis	45.83	1.00e-55	209.00
IUUC-Pte-104207	Pyrenophora teres	53.94	1.00e-39	154.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	52.40	8.00e-60	223.00
IUUC-Rno-105579	Rattus norvegicus	42.48	1.00e-71	262.00
IUUC-Sha-106894	Sarcophilus harrisii	45.49	3.00e-69	254.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	40.36	1.00e-64	238.00
IUUC-Spo-108371	Schizosaccharomyces pombe	43.31	1.00e-70	258.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	40.70	3.00e-50	191.00
IUUC-Smo-109396	Selaginella moellendorffii	72.17	1.00e-128	452.00
IUUC-Sit-110630	Setaria italica	73.94	2.00e-133	467.00
IUUC-Sly-110972	Solanum lycopersicum	79.49	2.00e-142	497.00
IUUC-Stu-112185	Solanum tuberosum	80.66	2.00e-154	537.00
IUUC-Sar-113294	Sorex araneus	41.71	2.00e-71	261.00
IUUC-Sbi-113951	Sorghum bicolor	73.03	6.00e-130	456.00
IUUC-Ssc-115501	Sus scrofa	45.71	1.00e-76	278.00
IUUC-Tgu-117152	Taeniopygia guttata	46.51	1.00e-73	268.00
IUUC-Tru-118388	Takifugu rubripes	46.60	7.00e-83	299.00
IUUC-Tsy-119109	Tarsius syrichta	47.53	2.00e-84	305.00
IUUC-Tni-120048	Tetraodon nigroviridis	46.91	3.00e-83	300.00
IUUC-Tca-121750	Theobroma cacao	79.10	4.00e-151	526.00
IUUC-Tre-122130	Trichoderma reesei	47.44	4.00e-57	214.00
IUUC-Tvi-122284	Trichoderma virens	45.42	3.00e-51	194.00
IUUC-Tae-124082	Triticum aestivum	75.46	6.00e-138	482.00
IUUC-Tme-127187	Tuber melanosporum	43.55	6.00e-70	256.00
IUUC-Tbe-127619	Tupaia belangeri	41.12	4.00e-57	214.00
IUUC-Ttr-128867	Tursiops truncatus	46.61	8.00e-58	216.00
IUUC-Vda-129912	Verticillium dahliae	37.95	7.00e-56	209.00
IUUC-Vpa-130552	Vicugna pacos	53.14	4.00e-62	231.00
IUUC-Vvi-130881	Vitis vinifera	78.74	3.00e-143	500.00
IUUC-Xtr-131934	Xenopus tropicalis	48.93	2.00e-87	315.00
IUUC-Xma-133312	Xiphophorus maculatus	47.20	8.00e-84	303.00
IUUC-Yli-134487	Yarrowia lipolytica	41.70	1.00e-52	199.00
IUUC-Zma-135639	Zea mays	63.76	1.00e-118	419.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence