iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gga-040912

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase Hakai; Casitas B-lineage lymphoma-transforming sequence-like protein 1; RING-type E3 ubiquitin transferase Hakai; c-Cbl-like protein 1

Genbank Nucleotide ID

AJ720990

Gene Name

CBLL1; HAKAI; RCJMB04_31p12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000038981.2	ENSGALT00000060943.1	ENSGALP00000052986.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	86.61	1.00e-160	563.00	IUUC-Hsa-046501

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Gallus gallus

Functional Description
(View)

Promotes ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation.

Protein Sequence
(Fasta)

MDHNDNDLQG TNSSASLGGL DVRRRIPIKL ISKQTNKTKP APRAPRAMNR MPAKTQAGDE 60
EEFDFNEEER YECKGGEMFG NQRRFPGPIF WDYKINLLGE KDDTPVHFCD KCGLPIKMYG 120

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Nucleotide Sequence
(Fasta)

AGCCACCGCG GCACGGCCGC CGCCGCCGCC GCCGCCCTTC CCTTCCCTTC CCTTCCCGGC 60
CGCGGAGGCT GCCGGGAGCG GGCAACCGCG CTCTGCCATG CGGAGGAGCG GCGGCATCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Gene Ontology

GO:0003676--F:nucleic acid binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007162--P:negative regulation of cell adhesion
GO:0030335--P:positive regulation of cell migration
GO:0045807--P:positive regulation of endocytosis
GO:0030155--P:regulation of cell adhesion

KEGG

gga:417701

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001549	Ailuropoda melanoleuca	86.93	8.00e-156	543.00
IUUC-Apl-003352	Anas platyrhynchos	97.76	7.00e-170	590.00
IUUC-Aca-005084	Anolis carolinensis	84.75	3.00e-147	514.00
IUUC-Bta-013383	Bos taurus	89.27	6.00e-159	553.00
IUUC-Bol-015734	Brassica oleracea	37.23	1.00e-13	71.60
IUUC-Cja-019505	Callithrix jacchus	89.25	8.00e-161	559.00
IUUC-Cfa-020255	Canis familiaris	89.66	5.00e-161	560.00
IUUC-Cpo-022545	Cavia porcellus	84.48	6.00e-127	446.00
IUUC-Cre-022922	Chlamydomonas reinhardtii	38.46	8.00e-06	44.70
IUUC-Csa-023318	Chlorocebus sabaeus	89.45	8.00e-161	560.00
IUUC-Cho-024701	Choloepus hoffmanni	83.56	3.00e-66	244.00
IUUC-Dre-028785	Danio rerio	54.65	9.00e-98	350.00
IUUC-Dor-030317	Dipodomys ordii	89.45	4.00e-160	557.00
IUUC-Eca-033554	Equus caballus	89.25	3.00e-159	554.00
IUUC-Fca-035864	Felis catus	88.96	5.00e-155	540.00
IUUC-Fal-037144	Ficedula albicollis	94.68	7.00e-160	556.00
IUUC-Gmo-039139	Gadus morhua	69.95	1.00e-72	266.00
IUUC-Ggo-044818	Gorilla gorilla	89.45	7.00e-161	560.00
IUUC-Hsa-046501	Homo sapiens	89.25	3.00e-160	558.00
IUUC-Itr-048234	Ictidomys tridecemlineatus	89.45	3.00e-161	561.00
IUUC-Lch-049697	Latimeria chalumnae	80.94	7.00e-122	430.00
IUUC-Lpe-051438	Leersia perrieri	25.42	7.40e-02	33.10
IUUC-Loc-052013	Lepisosteus oculatus	69.55	4.00e-124	437.00
IUUC-Laf-054485	Loxodonta africana	88.44	2.00e-143	501.00
IUUC-Mcc-054964	Macaca mulatta	49.88	3.00e-74	272.00
IUUC-Meu-056453	Macropus eugenii	54.23	7.00e-80	290.00
IUUC-Mga-060082	Meleagris gallopavo	99.79	2.00e-172	598.00
IUUC-Mmr-061363	Microcebus murinus	88.84	8.00e-159	553.00
IUUC-Mdo-062085	Monodelphis domestica	91.48	2.00e-163	568.00
IUUC-Mmu-063370	Mus musculus	88.64	6.00e-160	556.00
IUUC-Mpu-066221	Mustela putorius furo	90.06	2.00e-161	561.00
IUUC-Mlu-067612	Myotis lucifugus	88.46	4.00e-158	550.00
IUUC-Nle-069315	Nomascus leucogenys	88.99	2.00e-141	494.00
IUUC-Opr-070202	Ochotona princeps	87.65	6.00e-143	500.00
IUUC-Ont-071478	Oreochromis niloticus	56.77	1.00e-94	339.00
IUUC-Oan-073158	Ornithorhynchus anatinus	84.76	7.00e-135	473.00
IUUC-Ocu-074385	Oryctolagus cuniculus	87.11	8.00e-148	516.00
IUUC-Obr-076190	Oryza brachyantha	25.42	7.00e-02	33.10
IUUC-Oin-079075	Oryza indica	35.11	1.00e-12	67.80
IUUC-Oni-083087	Oryza nivara	35.11	9.00e-13	68.20
IUUC-Opu-083232	Oryza punctata	35.11	5.00e-13	68.90
IUUC-Osa-085908	Oryza sativa	35.11	1.00e-12	67.80
IUUC-Oar-089223	Ovis aries	89.39	1.00e-156	546.00
IUUC-Ptr-091633	Pan troglodytes	89.25	3.00e-160	558.00
IUUC-Pan-092923	Papio anubis	88.87	7.00e-157	546.00
IUUC-Ppa-095417	Physcomitrella patens	38.61	2.00e-14	73.60
IUUC-Pfo-097005	Poecilia formosa	58.28	4.00e-85	308.00
IUUC-Pab-098077	Pongo abelii	90.50	1.00e-150	525.00
IUUC-Pgr-103634	Puccinia graminis	26.67	2.00e-04	38.90
IUUC-Rno-105254	Rattus norvegicus	89.05	4.00e-161	560.00
IUUC-Sha-106599	Sarcophilus harrisii	91.48	1.00e-163	569.00
IUUC-Sit-110573	Setaria italica	27.12	4.20e-02	33.90
IUUC-Sar-113753	Sorex araneus	80.33	7.00e-147	513.00
IUUC-Ssc-116446	Sus scrofa	89.02	1.00e-167	582.00
IUUC-Tgu-117363	Taeniopygia guttata	96.69	8.00e-161	559.00
IUUC-Tru-118121	Takifugu rubripes	61.43	2.00e-104	372.00
IUUC-Tsy-119618	Tarsius syrichta	86.41	4.00e-101	361.00
IUUC-Tni-119858	Tetraodon nigroviridis	60.46	3.00e-96	345.00
IUUC-Ttr-129190	Tursiops truncatus	89.25	6.00e-160	556.00
IUUC-Vpa-130418	Vicugna pacos	42.86	7.00e-15	74.70
IUUC-Vvi-131653	Vitis vinifera	37.23	2.00e-15	77.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence