iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000005192.2	ENSMMUT00000007312.2	ENSMMUP00000006871.1
ENSMMUG00000005192.2	ENSMMUT00000056105.1	ENSMMUP00000054047.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.60e-63	216.1	326	855
UBD/Alpha-Helix/UBA	2.20e-22	79.5	725	762

Active Site

Position(s)	Description	Evidence
335	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
818	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel....................wkskkkavs 69
           tG++NlgN+CY+NSv+Q+L++ip++++ + + k ek+ +++p++p+++++++++kl + l                    +k+ +  ++
   Q: 326  TGIQNLGNSCYLNSVVQVLFSIPDFQRKYVD-KLEKIFQNAPTDPTQDFSTQVAKLGHGLlsgeyskpvpesgdgervpeQKEVQDGIA 413
           7******************************.99999999********************67766666666666655443366666*** PP
   S: 70   prellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikcle 158
           pr++++ ++k ++efs+++qqDaqEf+ +l++ +e+++                             ++++  +++F++ ++++ikcl+
   Q: 414  PRMFKALIGKGHPEFSTNRQQDAQEFFLHLINMVERNC-----------------------------RSSENPNEVFRFLVEEKIKCLA 473
           **************************************.............................6788899*************** PP
   S: 159  cdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeaekk 220
            ++v+ ++   + ++lpvp++   +ke                            +++cLe++ ++e++++   ++++  ++k+ a+k+
   Q: 474  TEKVKYTQRVDYIMQLPVPMDAALNKEelleyeekkrqaeeekmplpelvraqvPFSSCLEAYGAPEQVDD---FWSTALQAKSVAVKT 559
           **********************999989*****************************************97...*************** PP
   S: 221  lklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts.......................................... 267
           +++ ++P++L++++k+f+f  + ++++k++ ++e+p+eLd+s+   +                                          
   Q: 560  TRFASFPDYLVIQIKKFTFGLD-WVPKKLDVSIEMPEELDISQLRGTglqpgeeelpdiapplvtpdepkgslgfygnededsfcsphf 647
           *******************997.*******************98888788888888888888888888888888888888777777777 PP
   S: 268  .................................................................................peekqke. 274
                                                                                            +     + 
   Q: 648  ssptspmldesviiqlvemgfpmdacrkavyytgnsgaeaamnwvmshmddpdfanplilpgssgpgstsaaadpppedcvT-----Ti 731
           7777777777777777777777777777777777666666666666666666666666666666665555555555555550.....05 PP
   S: 275  ..................................................................kkkYeLiavvvHsG.slssGHYv 296
                                                                             + kY+L+a ++H+G s+ +GHYv
   Q: 732  vsmgfsrdqalkalratnnsleravdwifshiddldaeaamdisegrsaadsisesvpvgpkvrdgPGKYQLFAFISHMGtSTMCGHYV 820
           555555555555566666666667777777777777777777777777778888888888888888*********************** PP
   S: 297  ayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           +++k+ +g+W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 821  CHIKK-EGRWVIYNDQKVCAS--EKPPK---DLGYIYFYQR 855
           *****.9***********999..78888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ed +  +v+MGF+r++al+aLra+nn+le+Av++++++
   Q: 725  EDCVTTIVSMGFSRDQALKALRATNNSLERAVDWIFSH 762
           889999******************************97 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MAELSEEALL SVLPTIRVPK AGDRVHKDEC AFSFDTPESE GGLYICMNTF LGFGKQYVER 60
HFNKTGQRVY LHLRRTRRLK EEDPATGTGD PPRKKPTRLA IGVEGGFDLS EEKFELDEDV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCAAGCGCGG GGCAGGGGCG GAGCACCGGC AGGCAGGCTG TGTCCAACTG CCATTCTCGC 60
GCGTCGTCCC CGCGGCGCAT GCCCCTAACG AGTGGCGCTC ATTGGACGGC AGGGACAGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071108--P:protein K48-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	44.31	0.00e+00	645.00
IUUC-Aml-002104	Ailuropoda melanoleuca	97.76	0.00e+00	1637.00
IUUC-Atr-002580	Amborella trichopoda	46.20	0.00e+00	738.00
IUUC-Apl-003774	Anas platyrhynchos	91.43	0.00e+00	1524.00
IUUC-Aca-005368	Anolis carolinensis	86.25	0.00e+00	1504.00
IUUC-Aly-005727	Arabidopsis lyrata	46.93	0.00e+00	728.00
IUUC-Ath-006974	Arabidopsis thaliana	47.26	0.00e+00	730.00
IUUC-Ago-007890	Ashbya gossypii	29.48	4.00e-83	302.00
IUUC-Acl-008057	Aspergillus clavatus	33.72	3.00e-124	439.00
IUUC-Afl-008547	Aspergillus flavus	36.40	4.00e-118	418.00
IUUC-Afu-008805	Aspergillus fumigatus	34.48	2.00e-114	406.00
IUUC-Ani-009441	Aspergillus nidulans	32.04	5.00e-98	352.00
IUUC-Ang-009720	Aspergillus niger	33.64	9.00e-118	417.00
IUUC-Aor-010111	Aspergillus oryzae	34.10	6.00e-127	448.00
IUUC-Ate-010531	Aspergillus terreus	32.06	9.00e-104	371.00
IUUC-Ame-011893	Astyanax mexicanus	65.23	0.00e+00	994.00
IUUC-Bgr-012183	Blumeria graminis	33.45	1.00e-120	427.00
IUUC-Bta-013179	Bos taurus	97.99	0.00e+00	1644.00
IUUC-Bci-013858	Botrytis cinerea	34.73	7.00e-130	457.00
IUUC-Bdi-014904	Brachypodium distachyon	46.97	0.00e+00	710.00
IUUC-Bol-015296	Brassica oleracea	47.67	0.00e+00	746.00
IUUC-Bra-017939	Brassica rapa	47.79	0.00e+00	751.00
IUUC-Cel-018625	Caenorhabditis elegans	34.93	4.00e-136	479.00
IUUC-Cja-019063	Callithrix jacchus	97.88	0.00e+00	1633.00
IUUC-Cfa-020976	Canis familiaris	95.63	0.00e+00	1589.00
IUUC-Cpo-022265	Cavia porcellus	95.64	0.00e+00	1583.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	39.57	7.00e-113	401.00
IUUC-Csa-024177	Chlorocebus sabaeus	96.83	0.00e+00	1479.00
IUUC-Cho-024702	Choloepus hoffmanni	89.12	0.00e+00	991.00
IUUC-Cin-025411	Ciona intestinalis	49.94	0.00e+00	828.00
IUUC-Csv-026347	Ciona savignyi	46.30	0.00e+00	791.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	34.52	2.00e-114	406.00
IUUC-Cne-026831	Cryptococcus neoformans	35.33	2.00e-128	452.00
IUUC-Dre-027982	Danio rerio	67.48	0.00e+00	1107.00
IUUC-Dno-029034	Dasypus novemcinctus	98.58	0.00e+00	1669.00
IUUC-Dor-030479	Dipodomys ordii	93.65	0.00e+00	712.00
IUUC-Dse-031467	Dothistroma septosporum	36.23	3.00e-132	466.00
IUUC-Dme-032075	Drosophila melanogaster	49.02	0.00e+00	801.00
IUUC-Ete-032865	Echinops telfairi	87.06	0.00e+00	1462.00
IUUC-Eca-034059	Equus caballus	98.60	0.00e+00	1660.00
IUUC-Eeu-035304	Erinaceus europaeus	92.44	0.00e+00	1498.00
IUUC-Fca-035515	Felis catus	98.35	0.00e+00	1648.00
IUUC-Fal-037271	Ficedula albicollis	87.68	0.00e+00	1421.00
IUUC-Fox-037745	Fusarium oxysporum	35.01	1.00e-128	454.00
IUUC-Fso-038158	Fusarium solani	35.69	1.00e-128	453.00
IUUC-Gmo-039071	Gadus morhua	65.18	0.00e+00	1078.00
IUUC-Ggr-040098	Gaeumannomyces graminis	34.14	4.00e-119	422.00
IUUC-Gga-040635	Gallus gallus	90.91	0.00e+00	1592.00
IUUC-Gac-042528	Gasterosteus aculeatus	64.30	0.00e+00	1093.00
IUUC-Gma-043614	Glycine max	46.62	0.00e+00	704.00
IUUC-Ggo-044602	Gorilla gorilla	99.65	0.00e+00	1666.00
IUUC-Hsa-045959	Homo sapiens	99.65	0.00e+00	1666.00
IUUC-Hvu-047563	Hordeum vulgare	47.66	8.00e-170	590.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	98.00	0.00e+00	1641.00
IUUC-Kpa-049156	Komagataella pastoris	33.06	4.00e-114	405.00
IUUC-Lch-049648	Latimeria chalumnae	81.66	0.00e+00	1367.00
IUUC-Lpe-051523	Leersia perrieri	46.66	0.00e+00	712.00
IUUC-Loc-052520	Lepisosteus oculatus	62.08	0.00e+00	1012.00
IUUC-Lma-053216	Leptosphaeria maculans	34.44	7.00e-114	406.00
IUUC-Laf-054327	Loxodonta africana	97.28	0.00e+00	1632.00
IUUC-Meu-056298	Macropus eugenii	92.88	0.00e+00	1056.00
IUUC-Mor-057106	Magnaporthe oryzae	35.17	2.00e-130	459.00
IUUC-Mpo-057589	Magnaporthe poae	34.79	9.00e-124	437.00
IUUC-Mtr-058680	Medicago truncatula	48.08	0.00e+00	730.00
IUUC-Mla-058903	Melampsora laricipopulina	32.31	4.00e-119	422.00
IUUC-Mga-059669	Meleagris gallopavo	90.06	0.00e+00	1509.00
IUUC-Mvi-060476	Microbotryum violaceum	34.47	5.00e-119	422.00
IUUC-Mmr-060575	Microcebus murinus	98.35	0.00e+00	1649.00
IUUC-Mdo-062183	Monodelphis domestica	91.50	0.00e+00	1527.00
IUUC-Mmu-063592	Mus musculus	98.23	0.00e+00	1646.00
IUUC-Mac-065634	Musa acuminata	42.90	0.00e+00	686.00
IUUC-Mpu-066082	Mustela putorius furo	95.28	0.00e+00	1584.00
IUUC-Mlu-067345	Myotis lucifugus	96.24	0.00e+00	1613.00
IUUC-Nfi-068558	Neosartorya fischeri	35.26	9.00e-123	434.00
IUUC-Ncr-068960	Neurospora crassa	34.88	1.00e-116	414.00
IUUC-Nle-070173	Nomascus leucogenys	96.69	0.00e+00	1600.00
IUUC-Opr-070556	Ochotona princeps	97.40	0.00e+00	1638.00
IUUC-Ont-071502	Oreochromis niloticus	64.97	0.00e+00	1090.00
IUUC-Ocu-074861	Oryctolagus cuniculus	95.16	0.00e+00	1583.00
IUUC-Oba-075109	Oryza barthii	46.37	0.00e+00	715.00
IUUC-Obr-076292	Oryza brachyantha	47.66	0.00e+00	709.00
IUUC-Ogl-077065	Oryza glaberrima	47.66	0.00e+00	744.00
IUUC-Ogu-078776	Oryza glumaepatula	46.37	0.00e+00	726.00
IUUC-Oin-080048	Oryza indica	47.20	0.00e+00	739.00
IUUC-Olo-080711	Oryza longistaminata	44.54	0.00e+00	657.00
IUUC-Ome-081506	Oryza meridionalis	45.59	0.00e+00	669.00
IUUC-Oni-082320	Oryza nivara	45.82	0.00e+00	712.00
IUUC-Opu-083801	Oryza punctata	46.55	0.00e+00	707.00
IUUC-Oru-085139	Oryza rufipogon	45.82	0.00e+00	714.00
IUUC-Osa-085713	Oryza sativa	47.78	0.00e+00	747.00
IUUC-Ola-086951	Oryzias latipes	65.65	0.00e+00	1081.00
IUUC-Olu-087822	Ostreococcus lucimarinus	41.36	1.00e-180	627.00
IUUC-Oga-088625	Otolemur garnettii	97.88	0.00e+00	1637.00
IUUC-Oar-089995	Ovis aries	95.41	0.00e+00	1611.00
IUUC-Ptr-090640	Pan troglodytes	96.93	0.00e+00	1643.00
IUUC-Pan-091974	Papio anubis	99.06	0.00e+00	1655.00
IUUC-Psi-093957	Pelodiscus sinensis	90.00	0.00e+00	1599.00
IUUC-Pma-094242	Petromyzon marinus	71.92	1.00e-165	575.00
IUUC-Pno-094835	Phaeosphaeria nodorum	34.78	3.00e-107	382.00
IUUC-Ppa-095901	Physcomitrella patens	49.37	0.00e+00	784.00
IUUC-Pfo-097148	Poecilia formosa	66.32	0.00e+00	1100.00
IUUC-Pab-098068	Pongo abelii	91.74	0.00e+00	1483.00
IUUC-Pop-098943	Populus trichocarpa	46.85	0.00e+00	717.00
IUUC-Pca-100738	Procavia capensis	97.84	0.00e+00	1136.00
IUUC-Ppe-101315	Prunus persica	47.21	0.00e+00	726.00
IUUC-Pva-102154	Pteropus vampyrus	96.34	0.00e+00	1614.00
IUUC-Pgr-103343	Puccinia graminis	33.24	8.00e-108	384.00
IUUC-Ptt-103928	Puccinia triticina	30.21	2.00e-104	373.00
IUUC-Pte-104306	Pyrenophora teres	32.16	7.00e-104	371.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	33.26	1.00e-106	380.00
IUUC-Rno-105801	Rattus norvegicus	97.87	0.00e+00	1642.00
IUUC-Sce-106304	Saccharomyces cerevisiae	28.00	2.00e-72	267.00
IUUC-Sha-107635	Sarcophilus harrisii	91.62	0.00e+00	1538.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	32.37	5.00e-109	388.00
IUUC-Spo-108144	Schizosaccharomyces pombe	32.03	3.00e-112	399.00
IUUC-Smo-108848	Selaginella moellendorffii	48.41	0.00e+00	738.00
IUUC-Sit-110728	Setaria italica	48.14	0.00e+00	768.00
IUUC-Sly-111523	Solanum lycopersicum	47.62	0.00e+00	761.00
IUUC-Sbi-114419	Sorghum bicolor	47.15	0.00e+00	748.00
IUUC-Sre-115225	Sporisorium reilianum	34.73	3.00e-125	442.00
IUUC-Ssc-115686	Sus scrofa	97.05	0.00e+00	1631.00
IUUC-Tgu-117346	Taeniopygia guttata	90.45	0.00e+00	1560.00
IUUC-Tru-118350	Takifugu rubripes	65.08	0.00e+00	1110.00
IUUC-Tni-120658	Tetraodon nigroviridis	65.93	0.00e+00	1094.00
IUUC-Tca-121585	Theobroma cacao	47.50	0.00e+00	723.00
IUUC-Tre-122043	Trichoderma reesei	34.22	2.00e-119	423.00
IUUC-Tvi-122303	Trichoderma virens	34.49	2.00e-125	443.00
IUUC-Tae-123798	Triticum aestivum	46.74	0.00e+00	727.00
IUUC-Tur-126732	Triticum urartu	44.72	0.00e+00	682.00
IUUC-Tme-126909	Tuber melanosporum	34.83	2.00e-118	419.00
IUUC-Tbe-127261	Tupaia belangeri	91.18	0.00e+00	1038.00
IUUC-Uma-129599	Ustilago maydis	33.62	2.00e-127	450.00
IUUC-Vda-129688	Verticillium dahliae	33.37	3.00e-120	426.00
IUUC-Vvi-131116	Vitis vinifera	47.39	0.00e+00	706.00
IUUC-Xtr-131953	Xenopus tropicalis	79.39	0.00e+00	1354.00
IUUC-Xma-133837	Xiphophorus maculatus	66.43	0.00e+00	1102.00
IUUC-Yli-134510	Yarrowia lipolytica	35.50	4.00e-130	458.00
IUUC-Zma-135786	Zea mays	47.26	0.00e+00	715.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence