iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sja-107678

Ensembl Protein ID

EEB05625

UniProt Accession

B6JW74; B6JW74_SCHJY

Genbank Protein ID

EEB05625.1

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

KE651166

Gene Name

SJAG_00644

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SJAG_00644	EEB05625	EEB05625

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.80e-53	179.9	297	757
UBD/Alpha-Helix/UBA	5.90e-21	72.0	631	668

Active Site

Position(s)	Description	Evidence
306	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
717	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkk...................avsprellkalkkeae 82
           tGl+NlgN+CY+ Sv+Q+L++i  +r+ +l+ ++ + ++   ++ +++l+++l kl   l ++k +                      p +l+++++k +e
   Q: 297  TGLRNLGNSCYLSSVVQALFSIDVFRNHYLQVFQTHNAKC--SSATTCLVCQLGKLADGLCSGKFSrpshfvmasedpskipfqdGLRPFMLKDIVGKGHE 395
           7******************************444444433..57899*************6444444455666666667777777999************* PP
   S: 83   efsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetk 183
           efs+ +qqDa Efl +ll++++++                              ++   +s +  ++++++++cl c++   ++ +  +l lp+ ++++  
   Q: 396  EFSTGRQQDAYEFLLYLLKKVKTAK----------------------------DESGLDMSSMVSFTTEQRLQCLGCNRARYSKIETESLALPIVKRNNG- 467
           *********************9988............................2233346778899***************9999999******999965. PP
   S: 184  keslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple..Ldlspfctspeekqke........ 274
           ++ ++dcL+sf++++++e    y ce+c++k  a+ ++++ ++P+vL ++L+Rf  +  ++  +k+n+ v++      dls f++ p ++ +e        
   Q: 468  ESFFEDCLRSFVSQDQME----YTCESCHSKAGAVTQTRFVSFPKVLAVQLNRF--DIVNWELKKVNTAVQLGGDaiYDLSDFLVGPRQEGEEllpeesks 562
           789**************9....********************************..7788***********9855569********776666677777777 PP
   S: 275  ..................................................................................................... 274
                                                                                                                
   Q: 563  qvewnelameqltamgfsvnrcqhallatgnsdaesamnwlfehledpsidepvdlskisepsstevssdhvsslcdmgftvkaakhalketqnnveravd 663
           77888888888888888888888888888888888888888888888888888888888888888888888888888888888888889999999999999 PP
   S: 275  .................................kkkYeLiavvvHsG.slssGHYvayvkn.ekgk..WllfdDskVtevkeeevleetgstaYvlf 334
                                            +  Y+L a+v+H+G s++ GHYva++++  +g+  W lf+D+kV +v+  +  e   st Yv++
   Q: 664  wlfshtddlaaienategatdqnsinvfasttvPALYKLKAIVCHKGgSVHAGHYVAFIRElVDGQdvWALFNDEKVLQVSSLKETE---STSYVYI 757
           9999999999999999999999999************************************6333367************7644333...5556554 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           +d +  l++MGF+ ++a+ aL ++ nn+e+Av++L+++
   Q: 631  SDHVSSLCDMGFTVKAAKHALKETQNNVERAVDWLFSH 668
           678999******************************97 PP

Organism

Schizosaccharomyces japonicus

Protein Sequence
(Fasta)

MTCPHFTEEY AHCPPTGTVI YQEECVRCFI STDSSSGIDL CLCCFESGCT KNDLSHNVSH 60
FDLTKHPIYL NIRRTPKDQE EPPQKLTKLE IKEENEADKF QFYYNAHCIV CDVAIDQENE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGTAGCTTTA ATAATGTTTA AATTGTATCA GGGTCGGACC AGTATGTGGC AGGGAATGGA 60
AGAAGTATTC ATTACCAATA GAGAATGTTG CTTTACGCTC CGTTTTCTTG GTCTCAGTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0005654--C:nucleoplasm
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	31.68	8.00e-86	309.00
IUUC-Aml-002104	Ailuropoda melanoleuca	32.25	2.00e-107	381.00
IUUC-Atr-002580	Amborella trichopoda	31.86	1.00e-95	342.00
IUUC-Apl-003774	Anas platyrhynchos	31.29	2.00e-105	374.00
IUUC-Aca-005368	Anolis carolinensis	31.69	1.00e-110	392.00
IUUC-Aly-005727	Arabidopsis lyrata	33.29	2.00e-96	345.00
IUUC-Ath-006974	Arabidopsis thaliana	33.17	1.00e-96	345.00
IUUC-Ago-007890	Ashbya gossypii	31.78	1.00e-98	352.00
IUUC-Acl-008057	Aspergillus clavatus	41.52	4.00e-165	573.00
IUUC-Afl-008547	Aspergillus flavus	42.88	8.00e-148	515.00
IUUC-Afu-008805	Aspergillus fumigatus	40.52	7.00e-147	512.00
IUUC-Ani-009441	Aspergillus nidulans	38.97	1.00e-133	468.00
IUUC-Ang-009720	Aspergillus niger	41.51	9.00e-169	585.00
IUUC-Aor-010111	Aspergillus oryzae	41.04	4.00e-169	586.00
IUUC-Ate-010531	Aspergillus terreus	39.62	1.00e-141	494.00
IUUC-Ame-011893	Astyanax mexicanus	31.25	2.00e-84	305.00
IUUC-Bgr-012183	Blumeria graminis	40.10	1.00e-161	561.00
IUUC-Bta-013179	Bos taurus	31.86	6.00e-107	379.00
IUUC-Bci-013858	Botrytis cinerea	43.54	0.00e+00	625.00
IUUC-Bdi-014904	Brachypodium distachyon	32.76	1.00e-92	332.00
IUUC-Bol-015296	Brassica oleracea	33.42	1.00e-98	352.00
IUUC-Bra-017619	Brassica rapa	33.20	1.00e-95	342.00
IUUC-Cel-018625	Caenorhabditis elegans	27.56	2.00e-68	251.00
IUUC-Cja-019063	Callithrix jacchus	31.98	7.00e-108	382.00
IUUC-Cfa-020976	Canis familiaris	32.97	2.00e-112	398.00
IUUC-Cpo-022265	Cavia porcellus	32.70	6.00e-111	393.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	29.66	2.00e-52	198.00
IUUC-Csa-024177	Chlorocebus sabaeus	32.95	2.00e-102	364.00
IUUC-Cho-024702	Choloepus hoffmanni	30.73	7.00e-66	243.00
IUUC-Cin-025411	Ciona intestinalis	31.35	4.00e-90	323.00
IUUC-Csv-026347	Ciona savignyi	30.88	4.00e-88	317.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	42.84	2.00e-167	580.00
IUUC-Cne-026831	Cryptococcus neoformans	39.95	4.00e-154	536.00
IUUC-Cme-027335	Cyanidioschyzon merolae	31.67	4.00e-52	198.00
IUUC-Dre-027982	Danio rerio	30.19	8.00e-84	303.00
IUUC-Dno-029034	Dasypus novemcinctus	32.21	2.00e-109	388.00
IUUC-Dor-030479	Dipodomys ordii	30.67	1.00e-44	173.00
IUUC-Dse-031467	Dothistroma septosporum	41.53	3.00e-165	573.00
IUUC-Dme-032075	Drosophila melanogaster	30.13	3.00e-86	311.00
IUUC-Ete-032865	Echinops telfairi	28.39	6.00e-89	320.00
IUUC-Eca-034059	Equus caballus	31.98	4.00e-107	380.00
IUUC-Eeu-035304	Erinaceus europaeus	31.03	7.00e-98	349.00
IUUC-Fca-035515	Felis catus	32.21	2.00e-109	387.00
IUUC-Fal-037271	Ficedula albicollis	31.53	3.00e-105	374.00
IUUC-Fox-037745	Fusarium oxysporum	43.37	2.00e-177	614.00
IUUC-Fso-038158	Fusarium solani	43.58	8.00e-179	618.00
IUUC-Gmo-039071	Gadus morhua	30.45	3.00e-88	317.00
IUUC-Ggr-040098	Gaeumannomyces graminis	41.99	4.00e-167	579.00
IUUC-Gga-040635	Gallus gallus	30.96	3.00e-108	384.00
IUUC-Gac-042528	Gasterosteus aculeatus	31.49	8.00e-89	319.00
IUUC-Gma-043614	Glycine max	32.60	9.00e-96	342.00
IUUC-Ggo-044602	Gorilla gorilla	32.60	7.00e-110	389.00
IUUC-Hsa-045959	Homo sapiens	32.60	7.00e-110	389.00
IUUC-Hvu-047563	Hordeum vulgare	34.69	1.00e-86	312.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	32.06	3.00e-109	387.00
IUUC-Kpa-049156	Komagataella pastoris	39.48	3.00e-150	523.00
IUUC-Lch-049648	Latimeria chalumnae	32.10	1.00e-97	348.00
IUUC-Lpe-051523	Leersia perrieri	31.14	7.00e-87	313.00
IUUC-Loc-052072	Lepisosteus oculatus	28.86	1.00e-89	322.00
IUUC-Lma-053216	Leptosphaeria maculans	44.51	2.00e-170	591.00
IUUC-Laf-054327	Loxodonta africana	31.94	1.00e-108	385.00
IUUC-Mcc-055443	Macaca mulatta	32.09	9.00e-109	385.00
IUUC-Meu-056298	Macropus eugenii	31.27	3.00e-68	251.00
IUUC-Mor-057106	Magnaporthe oryzae	44.54	0.00e+00	637.00
IUUC-Mpo-057589	Magnaporthe poae	42.11	8.00e-168	582.00
IUUC-Mtr-058680	Medicago truncatula	32.80	2.00e-92	331.00
IUUC-Mla-058903	Melampsora laricipopulina	38.53	8.00e-146	509.00
IUUC-Mga-059669	Meleagris gallopavo	30.49	3.00e-102	364.00
IUUC-Mvi-060476	Microbotryum violaceum	40.28	7.00e-150	522.00
IUUC-Mmr-060575	Microcebus murinus	31.63	6.00e-109	386.00
IUUC-Mdo-062183	Monodelphis domestica	31.36	5.00e-107	380.00
IUUC-Mmu-063592	Mus musculus	32.21	4.00e-110	390.00
IUUC-Mac-065634	Musa acuminata	34.96	5.00e-51	194.00
IUUC-Mpu-066082	Mustela putorius furo	32.97	1.00e-111	395.00
IUUC-Mlu-067345	Myotis lucifugus	32.06	5.00e-106	376.00
IUUC-Nfi-068558	Neosartorya fischeri	43.03	2.00e-163	567.00
IUUC-Ncr-068960	Neurospora crassa	40.71	8.00e-159	551.00
IUUC-Nle-070173	Nomascus leucogenys	33.37	2.00e-112	398.00
IUUC-Opr-070556	Ochotona princeps	31.51	1.00e-108	385.00
IUUC-Ont-071502	Oreochromis niloticus	30.89	2.00e-88	318.00
IUUC-Oan-072959	Ornithorhynchus anatinus	35.43	1.00e-30	124.00
IUUC-Ocu-074861	Oryctolagus cuniculus	32.49	4.00e-112	397.00
IUUC-Oba-075109	Oryza barthii	31.77	2.00e-90	324.00
IUUC-Obr-076292	Oryza brachyantha	30.51	8.00e-84	303.00
IUUC-Ogl-077065	Oryza glaberrima	32.64	2.00e-95	341.00
IUUC-Ogu-078776	Oryza glumaepatula	31.32	6.00e-91	326.00
IUUC-Oin-080048	Oryza indica	32.19	3.00e-93	334.00
IUUC-Olo-080711	Oryza longistaminata	31.21	2.00e-83	301.00
IUUC-Ome-081506	Oryza meridionalis	31.25	6.00e-86	310.00
IUUC-Oni-082320	Oryza nivara	30.70	6.00e-87	313.00
IUUC-Opu-083801	Oryza punctata	31.45	4.00e-84	303.00
IUUC-Oru-085139	Oryza rufipogon	30.58	2.00e-87	315.00
IUUC-Osa-085713	Oryza sativa	32.64	3.00e-96	344.00
IUUC-Ola-086951	Oryzias latipes	30.00	6.00e-82	296.00
IUUC-Olu-087822	Ostreococcus lucimarinus	32.46	4.00e-79	287.00
IUUC-Oga-088625	Otolemur garnettii	31.28	3.00e-107	380.00
IUUC-Oar-089995	Ovis aries	32.13	5.00e-106	376.00
IUUC-Ptr-090640	Pan troglodytes	33.10	3.00e-112	397.00
IUUC-Pan-091974	Papio anubis	32.21	1.00e-107	382.00
IUUC-Psi-093957	Pelodiscus sinensis	31.67	6.00e-110	389.00
IUUC-Pma-094242	Petromyzon marinus	30.73	6.00e-48	182.00
IUUC-Pno-094835	Phaeosphaeria nodorum	42.97	1.00e-148	518.00
IUUC-Ppa-095901	Physcomitrella patens	32.40	1.00e-100	358.00
IUUC-Pfo-097148	Poecilia formosa	30.97	6.00e-91	326.00
IUUC-Pab-098068	Pongo abelii	29.76	1.00e-87	315.00
IUUC-Pop-098943	Populus trichocarpa	31.61	2.00e-89	321.00
IUUC-Pca-100738	Procavia capensis	32.90	8.00e-79	286.00
IUUC-Ppe-101315	Prunus persica	31.30	2.00e-87	315.00
IUUC-Pva-102154	Pteropus vampyrus	32.21	7.00e-108	383.00
IUUC-Pgr-103343	Puccinia graminis	38.06	3.00e-118	417.00
IUUC-Ptt-103928	Puccinia triticina	34.62	9.00e-117	412.00
IUUC-Pte-104306	Pyrenophora teres	42.88	7.00e-158	548.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	42.98	6.00e-162	562.00
IUUC-Rno-105801	Rattus norvegicus	32.48	8.00e-110	389.00
IUUC-Sce-106304	Saccharomyces cerevisiae	31.25	2.00e-95	341.00
IUUC-Sha-107635	Sarcophilus harrisii	32.06	1.00e-108	385.00
IUUC-Spo-108144	Schizosaccharomyces pombe	50.90	0.00e+00	815.00
IUUC-Smo-108848	Selaginella moellendorffii	32.17	2.00e-87	315.00
IUUC-Sit-110728	Setaria italica	32.10	2.00e-94	338.00
IUUC-Sly-111523	Solanum lycopersicum	31.53	2.00e-95	341.00
IUUC-Sar-113733	Sorex araneus	34.74	7.00e-43	167.00
IUUC-Sbi-114419	Sorghum bicolor	31.29	3.00e-92	330.00
IUUC-Sre-115225	Sporisorium reilianum	38.19	5.00e-152	529.00
IUUC-Ssc-115686	Sus scrofa	32.06	9.00e-109	385.00
IUUC-Tgu-117346	Taeniopygia guttata	30.64	8.00e-105	372.00
IUUC-Tru-118350	Takifugu rubripes	28.99	6.00e-84	303.00
IUUC-Tsy-119278	Tarsius syrichta	30.32	2.00e-70	258.00
IUUC-Tni-120658	Tetraodon nigroviridis	29.06	5.00e-81	293.00
IUUC-Tca-121585	Theobroma cacao	31.86	9.00e-89	319.00
IUUC-Tre-122043	Trichoderma reesei	43.76	1.00e-171	595.00
IUUC-Tvi-122303	Trichoderma virens	43.95	2.00e-176	610.00
IUUC-Tae-123798	Triticum aestivum	32.27	1.00e-96	345.00
IUUC-Tur-126732	Triticum urartu	30.78	4.00e-87	313.00
IUUC-Tme-126909	Tuber melanosporum	42.19	1.00e-161	561.00
IUUC-Tbe-127261	Tupaia belangeri	31.03	2.00e-38	152.00
IUUC-Ttr-129119	Tursiops truncatus	33.81	1.00e-48	186.00
IUUC-Uma-129599	Ustilago maydis	38.41	3.00e-154	536.00
IUUC-Vda-129688	Verticillium dahliae	41.22	1.00e-167	581.00
IUUC-Vpa-130170	Vicugna pacos	34.80	1.00e-32	132.00
IUUC-Vvi-131116	Vitis vinifera	32.14	5.00e-88	317.00
IUUC-Xtr-131953	Xenopus tropicalis	29.07	4.00e-90	323.00
IUUC-Xma-133837	Xiphophorus maculatus	30.73	3.00e-90	324.00
IUUC-Yli-134510	Yarrowia lipolytica	40.52	2.00e-150	523.00
IUUC-Zma-135786	Zea mays	32.01	3.00e-88	317.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence