iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndex	HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.80e-07	32.4	135	177

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlp.CgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cl++f  ++ +++lp C H+fh++C+  w         + +CPlCr
   Q: 135  CSVCLNEFeeDESLRLLPkCSHAFHLNCIDTW------LLSHKNCPLCR 177
           ********7655599999**************......888999****8 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

E3 ubiquitin-protein ligase that may be involved in positive regulation of programmed cell death (PCD) by facilitating degradation of negative regulators of PCD. May be involved in the early steps of the plant defense signaling pathway. Undergoes auto-ubiquitination.

Protein Sequence
(Fasta)

MAFNHRKMLL SCLQFKDLRF CFRQYPPPPP PPPPPRELSL LLPTSICVVG SIILFLFLVF 60
FLYLHITQQR RISAASVTPG DTNQQEDEDE TEERDFSDFH HVWQIPTVGL HRSAINSITV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCTAGATTC TAACCCATTT TGTGGGTTTT AGTGTCCTAT TTCTTTTTGC TTTCATCAGA 60
AGCAAAAACT TGGAATTGTG TGTCATACCC ATTTTCCCCT GTTCTTGTTC TGTTTTCTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0611--Plant defense
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006952--P:defense response
GO:0043068--P:positive regulation of programmed cell death
GO:0012501--P:programmed cell death
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0016567--P:protein ubiquitination
GO:0009617--P:response to bacterium
GO:0010200--P:response to chitin
GO:0002238--P:response to molecule of fungal origin

KEGG

ath:AT5G10380

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-005829	Arabidopsis lyrata	82.74	6.00e-103	366.00
IUUC-Bol-015095	Brassica oleracea	57.27	6.00e-49	186.00
IUUC-Bra-017929	Brassica rapa	68.39	2.00e-57	215.00
IUUC-Gma-043544	Glycine max	80.49	2.00e-36	145.00
IUUC-Lpe-051048	Leersia perrieri	58.54	1.00e-27	116.00
IUUC-Obr-076146	Oryza brachyantha	57.47	4.00e-27	114.00
IUUC-Pop-098897	Populus trichocarpa	52.48	3.00e-36	145.00
IUUC-Sha-106655	Sarcophilus harrisii	33.64	1.00e-13	69.30
IUUC-Tca-120978	Theobroma cacao	65.05	1.00e-35	143.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence