iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Stu-112185

Ensembl Protein ID

PGSC0003DMT400052268

UniProt Accession

M1BT38; M1BT38_SOLTU

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
PGSC0003DMG400020283	PGSC0003DMT400052268	PGSC0003DMT400052268
PGSC0003DMG400020283	PGSC0003DMT400052272	PGSC0003DMT400052272

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	2.40e-78	265.1	2	325

Active Site

Position(s)	Description	Evidence
82	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
157	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 7    ewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvi 95
           +w+++esdPg+ft+l+++  vk++ qveelysLd + l+++ +pv+gl++lFk+ + ++  r           v +d   ++ffa qvi
   Q: 2    SWCTIESDPGVFTELMQQMQVKGV-QVEELYSLDLDELNSL-RPVYGLIFLFKWRPGEKDDR----------LVIKDPNPNLFFASQVI 78
           7***********************.****************.**************999998..........44567789********* PP
   S: 96   gNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsyv 184
           +N+Cat+A+ls lln  d+  d+G++ls lke+tk + pe k+la++n+++++ +hns+ar+e++  +e++++ +   +++++hf+sy+
   Q: 79   NNACATQAILSILLNSPDV--DIGPELSALKEFTKNFPPELKGLAINNSEAIRTAHNSFARPEPFVPEEQKAAGK---DDDVYHFISYI 162
           ******************9..********************************************9888886665...9********** PP
   S: 185  ningrlyeldglkpfPldlgkk...keteelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid........... 259
           +++g lyeldglk+ P+ lg++   + + e+   ++ v+   eri+ +++ eirfnl+a+v++r+ ++t+ l+ l+             
   Q: 163  PVDGVLYELDGLKEGPISLGPCpggQGDIEWLRMVQPVI--QERIERYSQSEIRFNLMAVVKNRKEVYTAELKELQKRrerilqqlaas 249
           *********************977667788999999999..*****************************9987666679********* PP
   S: 260  ...........keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklvee 324
                      + L k l +++s +e  + ++  e+ek kk+k ++irR++ny  f++ f+k la++++lr l e+
   Q: 250  qsermvdsspvESLNKSLAEVNSGIEAVSDKILREEEKFKKWKTENIRRKHNYIPFLFNFLKILAEKKQLRPLIEK 325
           ***********99***********************************************************9997 PP

Organism

Solanum tuberosum

Protein Sequence
(Fasta)

MSWCTIESDP GVFTELMQQM QVKGVQVEEL YSLDLDELNS LRPVYGLIFL FKWRPGEKDD 60
RLVIKDPNPN LFFASQVINN ACATQAILSI LLNSPDVDIG PELSALKEFT KNFPPELKGL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCAAATTCCA ATAAGAAAAT CCCTAAACTG AAATCCCTAA CTCCCATCTC TCAACTCGAC 60
TTACGTTAAG CCGCAGCTCG TCTCTCAACT CTCATCTCTC AGCTCGTCGA CTCTTAAGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0010016--P:shoot system morphogenesis
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

sot:102599895

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	75.38	6.00e-144	502.00
IUUC-Aml-001866	Ailuropoda melanoleuca	50.31	2.00e-86	311.00
IUUC-Atr-002966	Amborella trichopoda	80.24	8.00e-152	528.00
IUUC-Apl-003306	Anas platyrhynchos	45.76	4.00e-80	290.00
IUUC-Aca-004763	Anolis carolinensis	49.38	7.00e-86	309.00
IUUC-Aly-005581	Arabidopsis lyrata	81.57	3.00e-145	506.00
IUUC-Ath-007283	Arabidopsis thaliana	80.66	1.00e-147	514.00
IUUC-Ago-007999	Ashbya gossypii	37.02	2.00e-32	131.00
IUUC-Acl-008231	Aspergillus clavatus	54.43	2.00e-65	241.00
IUUC-Afl-008557	Aspergillus flavus	50.00	8.00e-62	229.00
IUUC-Afu-008988	Aspergillus fumigatus	53.59	2.00e-62	231.00
IUUC-Ani-009420	Aspergillus nidulans	42.15	9.00e-63	232.00
IUUC-Ang-009859	Aspergillus niger	50.62	2.00e-59	221.00
IUUC-Aor-010145	Aspergillus oryzae	50.00	8.00e-62	229.00
IUUC-Ate-010347	Aspergillus terreus	49.02	1.00e-60	225.00
IUUC-Ame-010791	Astyanax mexicanus	49.40	2.00e-88	317.00
IUUC-Bgr-012298	Blumeria graminis	42.25	6.00e-60	223.00
IUUC-Bta-013251	Bos taurus	50.31	2.00e-86	310.00
IUUC-Bci-013786	Botrytis cinerea	40.52	2.00e-62	231.00
IUUC-Bdi-014132	Brachypodium distachyon	75.23	2.00e-140	490.00
IUUC-Bol-015611	Brassica oleracea	80.66	5.00e-151	525.00
IUUC-Bra-017769	Brassica rapa	80.66	2.00e-150	523.00
IUUC-Cel-018604	Caenorhabditis elegans	42.55	2.00e-70	257.00
IUUC-Cja-019768	Callithrix jacchus	46.05	1.00e-80	292.00
IUUC-Cfa-020207	Canis familiaris	50.31	2.00e-86	311.00
IUUC-Cpo-021925	Cavia porcellus	47.55	5.00e-80	289.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	50.45	7.00e-84	302.00
IUUC-Csa-023958	Chlorocebus sabaeus	50.31	3.00e-86	310.00
IUUC-Cho-024928	Choloepus hoffmanni	58.11	3.00e-19	87.80
IUUC-Cin-025771	Ciona intestinalis	41.69	2.00e-69	254.00
IUUC-Csv-026149	Ciona savignyi	43.54	6.00e-73	266.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	37.35	4.00e-51	193.00
IUUC-Cne-026955	Cryptococcus neoformans	32.01	4.00e-46	177.00
IUUC-Cme-027104	Cyanidioschyzon merolae	30.36	1.00e-44	172.00
IUUC-Dre-027409	Danio rerio	47.90	1.00e-87	315.00
IUUC-Dno-028921	Dasypus novemcinctus	50.31	3.00e-86	310.00
IUUC-Dor-030891	Dipodomys ordii	48.59	2.00e-38	152.00
IUUC-Dse-031170	Dothistroma septosporum	39.14	6.00e-59	219.00
IUUC-Dme-031677	Drosophila melanogaster	45.95	1.00e-79	288.00
IUUC-Ete-032646	Echinops telfairi	47.06	1.00e-45	176.00
IUUC-Eca-033776	Equus caballus	49.51	5.00e-78	283.00
IUUC-Eeu-035305	Erinaceus europaeus	44.51	1.00e-38	152.00
IUUC-Fca-035846	Felis catus	46.46	9.00e-82	295.00
IUUC-Fal-037597	Ficedula albicollis	47.21	8.00e-76	275.00
IUUC-Fox-037670	Fusarium oxysporum	48.50	2.00e-53	201.00
IUUC-Fso-038243	Fusarium solani	49.36	3.00e-54	204.00
IUUC-Gmo-038499	Gadus morhua	45.09	3.00e-78	283.00
IUUC-Ggr-039975	Gaeumannomyces graminis	46.91	4.00e-54	203.00
IUUC-Gga-040904	Gallus gallus	49.10	9.00e-90	322.00
IUUC-Gac-042058	Gasterosteus aculeatus	48.16	3.00e-86	310.00
IUUC-Gma-043030	Glycine max	89.52	1.00e-174	604.00
IUUC-Ggo-044699	Gorilla gorilla	46.86	1.00e-74	271.00
IUUC-Hsa-046227	Homo sapiens	50.31	2.00e-86	311.00
IUUC-Hvu-047359	Hordeum vulgare	75.08	2.00e-142	497.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	44.85	6.00e-81	293.00
IUUC-Lch-049829	Latimeria chalumnae	49.08	2.00e-86	310.00
IUUC-Lpe-050899	Leersia perrieri	76.23	4.00e-137	479.00
IUUC-Loc-052264	Lepisosteus oculatus	49.23	2.00e-84	304.00
IUUC-Lma-053110	Leptosphaeria maculans	52.19	1.00e-55	209.00
IUUC-Laf-053639	Loxodonta africana	50.31	2.00e-86	311.00
IUUC-Mcc-055506	Macaca mulatta	50.31	3.00e-86	310.00
IUUC-Meu-056267	Macropus eugenii	45.59	3.00e-51	195.00
IUUC-Mor-057001	Magnaporthe oryzae	47.35	3.00e-58	217.00
IUUC-Mpo-057608	Magnaporthe poae	47.59	4.00e-38	149.00
IUUC-Mtr-057731	Medicago truncatula	87.43	2.00e-164	570.00
IUUC-Mla-059016	Melampsora laricipopulina	46.00	2.00e-44	171.00
IUUC-Mga-060178	Meleagris gallopavo	47.92	6.00e-81	292.00
IUUC-Mvi-060353	Microbotryum violaceum	39.16	3.00e-56	210.00
IUUC-Mmr-060738	Microcebus murinus	50.61	1.00e-86	311.00
IUUC-Mdo-062266	Monodelphis domestica	53.85	8.00e-62	228.00
IUUC-Mmu-063619	Mus musculus	50.00	6.00e-86	309.00
IUUC-Mac-065301	Musa acuminata	82.28	3.00e-162	562.00
IUUC-Mpu-066058	Mustela putorius furo	48.78	5.00e-86	309.00
IUUC-Mlu-067292	Myotis lucifugus	49.39	1.00e-85	308.00
IUUC-Nfi-068275	Neosartorya fischeri	42.74	4.00e-64	236.00
IUUC-Ncr-068713	Neurospora crassa	39.10	5.00e-58	216.00
IUUC-Nle-069013	Nomascus leucogenys	50.31	1.00e-86	312.00
IUUC-Opr-070628	Ochotona princeps	42.94	6.00e-75	273.00
IUUC-Ont-072688	Oreochromis niloticus	47.40	6.00e-85	306.00
IUUC-Oan-073004	Ornithorhynchus anatinus	53.18	2.00e-65	241.00
IUUC-Ocu-074303	Oryctolagus cuniculus	48.78	1.00e-85	309.00
IUUC-Oba-075002	Oryza barthii	77.11	3.00e-142	496.00
IUUC-Obr-076392	Oryza brachyantha	75.31	3.00e-138	483.00
IUUC-Ogl-077271	Oryza glaberrima	77.11	3.00e-142	496.00
IUUC-Ogu-078493	Oryza glumaepatula	77.41	3.00e-143	499.00
IUUC-Oin-080084	Oryza indica	77.41	3.00e-143	499.00
IUUC-Olo-080803	Oryza longistaminata	77.11	6.00e-143	498.00
IUUC-Ome-081146	Oryza meridionalis	76.81	7.00e-142	495.00
IUUC-Oni-082146	Oryza nivara	77.41	3.00e-143	499.00
IUUC-Opu-083633	Oryza punctata	77.16	2.00e-138	483.00
IUUC-Oru-084789	Oryza rufipogon	77.41	3.00e-143	499.00
IUUC-Osa-086196	Oryza sativa	77.41	3.00e-143	499.00
IUUC-Ola-087126	Oryzias latipes	48.16	2.00e-85	307.00
IUUC-Olu-087665	Ostreococcus lucimarinus	46.08	2.00e-74	270.00
IUUC-Oga-089140	Otolemur garnettii	46.74	5.00e-82	296.00
IUUC-Oar-090296	Ovis aries	48.93	3.00e-85	306.00
IUUC-Ptr-090566	Pan troglodytes	50.31	2.00e-86	311.00
IUUC-Pan-092052	Papio anubis	50.31	3.00e-86	310.00
IUUC-Psi-093723	Pelodiscus sinensis	48.52	4.00e-78	283.00
IUUC-Pma-094568	Petromyzon marinus	50.92	3.00e-63	233.00
IUUC-Pno-095120	Phaeosphaeria nodorum	51.32	2.00e-56	211.00
IUUC-Ppa-095761	Physcomitrella patens	73.76	5.00e-141	492.00
IUUC-Pfo-096210	Poecilia formosa	48.47	2.00e-86	311.00
IUUC-Pab-098463	Pongo abelii	50.31	2.00e-86	311.00
IUUC-Pop-099109	Populus trichocarpa	84.55	4.00e-165	572.00
IUUC-Pca-100108	Procavia capensis	52.70	2.00e-70	258.00
IUUC-Ppe-101176	Prunus persica	87.43	3.00e-169	586.00
IUUC-Pva-102629	Pteropus vampyrus	53.97	2.00e-72	264.00
IUUC-Pgr-103419	Puccinia graminis	45.42	5.00e-55	206.00
IUUC-Pte-104207	Pyrenophora teres	52.73	7.00e-40	155.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	51.32	3.00e-60	224.00
IUUC-Rno-105579	Rattus norvegicus	44.15	9.00e-74	269.00
IUUC-Sha-106894	Sarcophilus harrisii	50.34	8.00e-75	272.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	42.54	2.00e-63	234.00
IUUC-Spo-108371	Schizosaccharomyces pombe	43.28	4.00e-71	259.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	39.34	5.00e-50	189.00
IUUC-Smo-109396	Selaginella moellendorffii	74.62	1.00e-137	481.00
IUUC-Sit-110630	Setaria italica	76.35	3.00e-144	503.00
IUUC-Sly-110972	Solanum lycopersicum	99.05	0.00e+00	634.00
IUUC-Sar-113294	Sorex araneus	54.64	1.00e-56	212.00
IUUC-Sbi-113951	Sorghum bicolor	76.35	4.00e-144	502.00
IUUC-Ssc-115501	Sus scrofa	47.34	2.00e-79	287.00
IUUC-Tgu-117152	Taeniopygia guttata	47.21	8.00e-76	275.00
IUUC-Tru-118388	Takifugu rubripes	47.55	9.00e-86	308.00
IUUC-Tsy-119109	Tarsius syrichta	50.31	1.00e-86	311.00
IUUC-Tni-120048	Tetraodon nigroviridis	47.55	6.00e-86	309.00
IUUC-Tca-121750	Theobroma cacao	88.06	2.00e-178	617.00
IUUC-Tre-122130	Trichoderma reesei	46.03	3.00e-58	217.00
IUUC-Tvi-122284	Trichoderma virens	41.40	1.00e-54	205.00
IUUC-Tae-124082	Triticum aestivum	75.68	6.00e-144	502.00
IUUC-Tur-126366	Triticum urartu	65.64	2.00e-111	394.00
IUUC-Tme-127187	Tuber melanosporum	42.06	5.00e-69	253.00
IUUC-Tbe-127619	Tupaia belangeri	43.97	3.00e-59	220.00
IUUC-Ttr-128867	Tursiops truncatus	46.96	7.00e-60	223.00
IUUC-Vda-129912	Verticillium dahliae	38.14	1.00e-56	212.00
IUUC-Vpa-130552	Vicugna pacos	53.62	2.00e-61	228.00
IUUC-Vvi-130881	Vitis vinifera	89.22	4.00e-174	602.00
IUUC-Xtr-131934	Xenopus tropicalis	48.66	2.00e-91	327.00
IUUC-Xma-133312	Xiphophorus maculatus	48.47	1.00e-86	311.00
IUUC-Yli-134487	Yarrowia lipolytica	41.67	5.00e-52	196.00
IUUC-Zma-135462	Zea mays	65.48	4.00e-119	419.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence