• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063713
UUCD1 version UUC-MuM-00378
Ensembl Protein ID ENSMUSP00000027933.5
UniProt Accession Q3TLR7; Q3TTE9; Q6PAN1; Q80WY1; Q80WY2; Q8BW38; Q9CZ76; DTL_MOUSE
Genbank Protein ID BAC76404.1; BAC76405.1; BAB28549.1; BAC35769.1; BAE21543.1; BAE36376.1; BAE38725.1; ENSMUSP00000027933
Protein Name Denticleless protein homolog; Lethal(2) denticleless protein homolog; Meth A retinoic acid-regulated nuclear matrix-associated protein; Retinoic acid-regulated nuclear matrix-associated protein
Genbank Nucleotide ID AB095735; AB095736; AK012919; AK054412; AK133177; AK161401; AK166351; BC060208
Gene Name Dtl; Cdt2; L2dtl; Ramp
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000037474.13 ENSMUST00000195650.5 ENSMUSP00000141218.1
ENSMUSG00000037474.13 ENSMUST00000027933.10 ENSMUSP00000027933.5
ENSMUSG00000037474.13 ENSMUST00000193977.5 ENSMUSP00000142111.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
UniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.40e-34 116.5 358 395
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlrtgvl 35
           gH+ +vt++++  sd t ++++sdD+t+k+W+l +g  
   Q: 358  GHSQEVTSVCWcpSDfTKIATCSDDNTLKIWRLNRGLE 395
           8***********999*****************988866 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBXO18/FBH1 and KMT5A. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis.
 Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBXO18/FBH1 and KMT5A. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis.
Protein Sequence
(Fasta)
MLFNSVLRQP QLGVLRNGWS SHYPLQSLLS GYQCNCNDEH TSYGETGVPV PPFGCTFCTA 60
PSMEHILAVA NEEGFVRLYN TESQTSKKTC FKEWMAHWNA VFDLAWVPGE LKLVTAAGDQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063713|E3,WD_repeat|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGAGTTTGGC GGCCGGGGCT CTTAGTGGCG GGAGTTGGAG GCGAAACCGC GCCGCGTTGT 60
GGAGGGTGCA GACGGCGGCT CCTGTGGAAC TTGGGGGCGA TCTTCTCGGC GTTCCCCTCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063713|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0227--DNA damage
KW-0235--DNA replication
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR003143--Cyt_cd1_C
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005813--C:centrosome
GO:0005694--C:chromosome
GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0031465--C:Cul4B-RING E3 ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0031965--C:nuclear membrane
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006260--P:DNA replication
GO:0031572--P:G2 DNA damage checkpoint
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0051726--P:regulation of cell cycle
GO:0009411--P:response to UV
GO:0019985--P:translesion synthesis
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:76843
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002111 Ailuropoda melanoleuca 88.36 0.00e+00 1206.00
IUUC-Atr-003097 Amborella trichopoda 34.90 2.00e-63 237.00
IUUC-Apl-004088 Anas platyrhynchos 61.06 0.00e+00 807.00
IUUC-Aca-004732 Anolis carolinensis 55.74 0.00e+00 679.00
IUUC-Aly-005686 Arabidopsis lyrata 34.44 2.00e-59 223.00
IUUC-Ath-006970 Arabidopsis thaliana 34.25 1.00e-58 220.00
IUUC-Acl-008219 Aspergillus clavatus 28.08 4.00e-23 103.00
IUUC-Afu-008784 Aspergillus fumigatus 25.70 2.00e-23 104.00
IUUC-Ani-009304 Aspergillus nidulans 28.31 8.00e-20 92.40
IUUC-Ang-009842 Aspergillus niger 23.68 4.00e-24 106.00
IUUC-Aor-009883 Aspergillus oryzae 24.14 2.00e-23 104.00
IUUC-Ate-010454 Aspergillus terreus 28.27 7.00e-23 101.00
IUUC-Ame-010949 Astyanax mexicanus 65.31 7.00e-163 567.00
IUUC-Bta-012333 Bos taurus 88.22 0.00e+00 1191.00
IUUC-Bci-013733 Botrytis cinerea 26.63 7.00e-22 99.40
IUUC-Bdi-014494 Brachypodium distachyon 33.61 7.00e-57 214.00
IUUC-Bol-015301 Brassica oleracea 34.89 3.00e-58 219.00
IUUC-Bra-017384 Brassica rapa 34.44 3.00e-59 223.00
IUUC-Cel-018498 Caenorhabditis elegans 27.32 1.00e-30 128.00
IUUC-Cja-019534 Callithrix jacchus 90.04 0.00e+00 1264.00
IUUC-Cfa-020847 Canis familiaris 88.36 0.00e+00 1181.00
IUUC-Cpo-021695 Cavia porcellus 87.87 0.00e+00 1194.00
IUUC-Cre-022762 Chlamydomonas reinhardtii 28.75 2.00e-40 162.00
IUUC-Csa-023748 Chlorocebus sabaeus 89.86 0.00e+00 1241.00
IUUC-Cho-024445 Choloepus hoffmanni 80.56 4.00e-174 605.00
IUUC-Cgl-026664 Colletotrichum gloeosporioides 24.34 3.00e-18 87.40
IUUC-Cne-027008 Cryptococcus neoformans 24.48 1.00e-13 72.80
IUUC-Dre-027536 Danio rerio 47.70 2.00e-168 586.00
IUUC-Dno-030035 Dasypus novemcinctus 78.52 0.00e+00 1108.00
IUUC-Dor-030814 Dipodomys ordii 81.30 1.00e-136 480.00
IUUC-Dse-031354 Dothistroma septosporum 23.64 5.00e-27 116.00
IUUC-Dme-031691 Drosophila melanogaster 42.33 3.00e-81 296.00
IUUC-Ete-032814 Echinops telfairi 79.62 0.00e+00 804.00
IUUC-Eca-033332 Equus caballus 88.90 0.00e+00 1186.00
IUUC-Fca-035571 Felis catus 88.49 0.00e+00 1180.00
IUUC-Fal-037421 Ficedula albicollis 59.97 0.00e+00 787.00
IUUC-Fox-038069 Fusarium oxysporum 22.78 6.00e-17 82.40
IUUC-Fso-038192 Fusarium solani 22.91 2.00e-15 77.40
IUUC-Gmo-039365 Gadus morhua 64.34 3.00e-155 541.00
IUUC-Ggr-039904 Gaeumannomyces graminis 24.88 4.00e-16 80.50
IUUC-Gga-041153 Gallus gallus 60.75 0.00e+00 789.00
IUUC-Gac-041984 Gasterosteus aculeatus 47.11 4.00e-165 575.00
IUUC-Gma-042679 Glycine max 35.43 7.00e-59 221.00
IUUC-Ggo-044419 Gorilla gorilla 89.06 0.00e+00 1221.00
IUUC-Hsa-045862 Homo sapiens 89.45 0.00e+00 1228.00
IUUC-Hvu-047728 Hordeum vulgare 33.52 1.00e-60 227.00
IUUC-Itr-048786 Ictidomys tridecemlineatus 90.82 0.00e+00 1288.00
IUUC-Lch-050616 Latimeria chalumnae 54.26 0.00e+00 684.00
IUUC-Lpe-051222 Leersia perrieri 34.94 1.00e-58 220.00
IUUC-Loc-052564 Lepisosteus oculatus 53.67 3.00e-177 615.00
IUUC-Lma-053098 Leptosphaeria maculans 25.11 1.00e-25 111.00
IUUC-Laf-053892 Loxodonta africana 85.25 0.00e+00 1114.00
IUUC-Mcc-055854 Macaca mulatta 89.73 0.00e+00 1238.00
IUUC-Mor-057144 Magnaporthe oryzae 26.92 1.00e-15 78.60
IUUC-Mtr-058510 Medicago truncatula 33.24 4.00e-54 205.00
IUUC-Mla-058823 Melampsora laricipopulina 25.64 1.00e-19 91.30
IUUC-Mga-060128 Meleagris gallopavo 60.08 0.00e+00 795.00
IUUC-Mvi-060475 Microbotryum violaceum 33.33 4.00e-43 169.00
IUUC-Mmr-061331 Microcebus murinus 89.03 0.00e+00 1197.00
IUUC-Mdo-063020 Monodelphis domestica 70.48 0.00e+00 985.00
IUUC-Mac-064653 Musa acuminata 33.06 4.00e-57 215.00
IUUC-Mpu-066490 Mustela putorius furo 88.22 0.00e+00 1177.00
IUUC-Mlu-067900 Myotis lucifugus 87.11 0.00e+00 1152.00
IUUC-Nfi-068433 Neosartorya fischeri 24.09 1.00e-24 108.00
IUUC-Ncr-068776 Neurospora crassa 27.55 4.00e-27 116.00
IUUC-Nle-069675 Nomascus leucogenys 85.34 0.00e+00 1140.00
IUUC-Opr-070769 Ochotona princeps 66.99 0.00e+00 780.00
IUUC-Ont-071441 Oreochromis niloticus 66.14 4.00e-154 538.00
IUUC-Oan-072757 Ornithorhynchus anatinus 66.89 0.00e+00 879.00
IUUC-Ocu-074670 Oryctolagus cuniculus 90.27 0.00e+00 1223.00
IUUC-Oba-075844 Oryza barthii 33.98 3.00e-57 216.00
IUUC-Obr-076625 Oryza brachyantha 36.69 1.00e-61 230.00
IUUC-Ogl-077771 Oryza glaberrima 33.98 3.00e-57 216.00
IUUC-Ogu-078475 Oryza glumaepatula 32.87 1.00e-49 190.00
IUUC-Oin-079958 Oryza indica 33.98 3.00e-57 216.00
IUUC-Olo-080311 Oryza longistaminata 33.22 9.00e-46 177.00
IUUC-Ome-081985 Oryza meridionalis 33.15 4.00e-56 212.00
IUUC-Oni-082921 Oryza nivara 33.98 3.00e-57 216.00
IUUC-Opu-083174 Oryza punctata 32.60 2.00e-55 209.00
IUUC-Oru-084338 Oryza rufipogon 32.81 2.00e-57 216.00
IUUC-Osa-085609 Oryza sativa 41.11 2.00e-19 89.00
IUUC-Olu-087907 Ostreococcus lucimarinus 27.15 3.00e-28 119.00
IUUC-Oga-088358 Otolemur garnettii 89.45 0.00e+00 1261.00
IUUC-Oar-089994 Ovis aries 87.53 0.00e+00 1180.00
IUUC-Ptr-091338 Pan troglodytes 89.59 0.00e+00 1263.00
IUUC-Pan-091759 Papio anubis 89.74 0.00e+00 1237.00
IUUC-Psi-093211 Pelodiscus sinensis 59.28 0.00e+00 699.00
IUUC-Pma-094588 Petromyzon marinus 57.52 3.00e-96 344.00
IUUC-Pno-094964 Phaeosphaeria nodorum 25.71 3.00e-27 116.00
IUUC-Ppa-095159 Physcomitrella patens 37.33 6.00e-63 234.00
IUUC-Pfo-096592 Poecilia formosa 42.91 8.00e-143 500.00
IUUC-Pab-098597 Pongo abelii 73.05 0.00e+00 922.00
IUUC-Pop-099255 Populus trichocarpa 36.60 3.00e-62 233.00
IUUC-Pca-100593 Procavia capensis 68.29 0.00e+00 855.00
IUUC-Ppe-101333 Prunus persica 34.67 5.00e-56 211.00
IUUC-Pva-102283 Pteropus vampyrus 84.64 0.00e+00 1124.00
IUUC-Pgr-103383 Puccinia graminis 27.59 9.00e-22 98.20
IUUC-Ptt-103974 Puccinia triticina 27.41 1.00e-19 90.90
IUUC-Pte-104329 Pyrenophora teres 25.58 3.00e-26 113.00
IUUC-Pyt-104424 Pyrenophora triticirepentis 29.78 1.00e-25 111.00
IUUC-Rno-105720 Rattus norvegicus 95.07 0.00e+00 1186.00
IUUC-Sha-106891 Sarcophilus harrisii 66.58 0.00e+00 874.00
IUUC-Sja-107723 Schizosaccharomyces japonicus 26.58 2.00e-24 107.00
IUUC-Spo-108060 Schizosaccharomyces pombe 25.42 1.00e-18 87.80
IUUC-Ssl-108481 Sclerotinia sclerotiorum 27.24 2.00e-19 91.30
IUUC-Sit-109862 Setaria italica 33.05 1.00e-55 211.00
IUUC-Sly-111468 Solanum lycopersicum 34.07 9.00e-60 224.00
IUUC-Stu-112346 Solanum tuberosum 34.18 4.00e-57 215.00
IUUC-Sar-113734 Sorex araneus 77.27 1.00e-99 357.00
IUUC-Sbi-114076 Sorghum bicolor 32.87 3.00e-56 213.00
IUUC-Sre-114918 Sporisorium reilianum 23.30 4.00e-14 73.60
IUUC-Ssc-115561 Sus scrofa 87.14 0.00e+00 1169.00
IUUC-Tgu-117011 Taeniopygia guttata 61.78 0.00e+00 785.00
IUUC-Tru-118411 Takifugu rubripes 45.14 7.00e-155 540.00
IUUC-Tsy-119367 Tarsius syrichta 80.38 0.00e+00 1044.00
IUUC-Tni-120301 Tetraodon nigroviridis 57.88 3.00e-147 515.00
IUUC-Tca-121265 Theobroma cacao 34.99 5.00e-59 221.00
IUUC-Tre-121997 Trichoderma reesei 25.30 2.00e-19 90.90
IUUC-Tvi-122292 Trichoderma virens 25.55 9.00e-21 95.50
IUUC-Tae-123660 Triticum aestivum 31.94 2.00e-58 219.00
IUUC-Tur-126794 Triticum urartu 31.93 2.00e-42 166.00
IUUC-Tme-127090 Tuber melanosporum 27.16 9.00e-18 84.70
IUUC-Tbe-127646 Tupaia belangeri 85.95 0.00e+00 758.00
IUUC-Ttr-128171 Tursiops truncatus 87.40 0.00e+00 1189.00
IUUC-Uma-129525 Ustilago maydis 24.64 8.00e-18 85.90
IUUC-Vda-129871 Verticillium dahliae 29.46 9.00e-20 92.00
IUUC-Vpa-130554 Vicugna pacos 77.01 2.00e-138 486.00
IUUC-Vvi-131698 Vitis vinifera 35.56 8.00e-61 228.00
IUUC-Xtr-131962 Xenopus tropicalis 56.30 0.00e+00 751.00
IUUC-Xma-133803 Xiphophorus maculatus 43.56 9.00e-153 533.00
IUUC-Zma-135693 Zea mays 31.83 4.00e-54 206.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved