iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-054390

Ensembl Protein ID

ENSLAFP00000016774.2

UniProt Accession

G5E772; G5E772_LOXAF

Protein Name

tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; WD repeat-containing protein 4

Gene Name

WDR4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000021675.2	ENSLAFT00000021742.2	ENSLAFP00000016774.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.10e-07	29.7	187	226

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sd..tllvsGsdDgtikvWDlrtgvllk 37
           gHt+ v+ + f  +d   ll+s s+Dgt+++W++r+g+ l+
   Q: 187  GHTEFVSRI-FvvPDhpELLLSTSGDGTLRLWEYRSGRELH 226
           677777777.7997777999*****************9876 PP

Organism

Loxodonta africana

Functional Description
(View)

Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.

Protein Sequence
(Fasta)

MASSAGLSLC GQALVVRGGS RFLATTIANS NDDSIFIYDC STAEKKPQEN KGEDGQPVEK 60
GSDTILASTF SESGSYFALT DDSKRLILFR TKPWQCLSVR TVVRRCTALT FTASEEKVLV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGAGTT CGGCGGGGCT GTCGCTGTGC GGGCAGGCGC TGGTGGTGCG GGGCGGTAGC 60
CGGTTCCTGG CCACCACTAT TGCAAATAGG TGAGCAGAGA GCCCAGGCTA CAGGCTGGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0819--tRNA processing
KW-0853--WD repeat

Interpro

IPR028884--Trm82
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0008176--F:tRNA (guanine-N7-)-methyltransferase activity

KEGG

lav:100658148

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000556	Aegilops tauschii	27.20	2.00e-11	63.50
IUUC-Apl-003975	Anas platyrhynchos	57.57	2.00e-125	442.00
IUUC-Aca-005170	Anolis carolinensis	56.28	2.00e-111	395.00
IUUC-Aly-005769	Arabidopsis lyrata	31.06	9.00e-27	114.00
IUUC-Ath-006733	Arabidopsis thaliana	31.75	3.00e-26	112.00
IUUC-Acl-008151	Aspergillus clavatus	42.86	6.00e-14	72.40
IUUC-Afl-008518	Aspergillus flavus	43.30	5.00e-15	75.10
IUUC-Afu-009102	Aspergillus fumigatus	30.00	8.00e-16	78.60
IUUC-Ani-009442	Aspergillus nidulans	30.03	5.00e-16	79.00
IUUC-Aor-010133	Aspergillus oryzae	30.77	1.00e-18	87.40
IUUC-Ate-010465	Aspergillus terreus	30.49	2.00e-16	80.10
IUUC-Ame-010613	Astyanax mexicanus	46.56	3.00e-92	332.00
IUUC-Bgr-012067	Blumeria graminis	28.63	2.00e-17	84.00
IUUC-Bta-012788	Bos taurus	75.06	2.00e-177	615.00
IUUC-Bdi-014458	Brachypodium distachyon	36.27	3.00e-18	86.30
IUUC-Bol-016398	Brassica oleracea	39.78	2.00e-27	116.00
IUUC-Bra-016644	Brassica rapa	41.21	9.00e-27	115.00
IUUC-Cpo-021963	Cavia porcellus	75.13	7.00e-164	569.00
IUUC-Csa-024148	Chlorocebus sabaeus	77.72	4.00e-155	540.00
IUUC-Cne-026834	Cryptococcus neoformans	35.76	1.00e-20	94.70
IUUC-Dre-028427	Danio rerio	47.18	5.00e-94	337.00
IUUC-Dno-028881	Dasypus novemcinctus	70.91	3.00e-161	561.00
IUUC-Dor-030522	Dipodomys ordii	73.62	4.00e-165	573.00
IUUC-Dme-032136	Drosophila melanogaster	33.97	8.00e-24	104.00
IUUC-Fca-035833	Felis catus	76.28	3.00e-169	587.00
IUUC-Fal-037497	Ficedula albicollis	59.76	1.00e-123	436.00
IUUC-Gga-040547	Gallus gallus	55.91	2.00e-128	451.00
IUUC-Gac-041761	Gasterosteus aculeatus	45.21	2.00e-85	308.00
IUUC-Gma-043722	Glycine max	31.58	9.00e-22	97.80
IUUC-Ggo-045340	Gorilla gorilla	78.21	2.00e-170	591.00
IUUC-Hsa-046403	Homo sapiens	77.97	3.00e-169	587.00
IUUC-Hvu-047643	Hordeum vulgare	31.84	4.00e-21	95.90
IUUC-Itr-048103	Ictidomys tridecemlineatus	76.76	3.00e-173	600.00
IUUC-Kpa-049283	Komagataella pastoris	30.33	2.00e-19	90.10
IUUC-Lch-050682	Latimeria chalumnae	52.22	1.00e-115	409.00
IUUC-Lpe-050712	Leersia perrieri	32.38	2.00e-25	110.00
IUUC-Loc-052599	Lepisosteus oculatus	52.44	1.00e-117	416.00
IUUC-Mcc-054747	Macaca mulatta	77.24	5.00e-162	563.00
IUUC-Mtr-058600	Medicago truncatula	36.52	2.00e-25	110.00
IUUC-Mla-059129	Melampsora laricipopulina	25.37	4.00e-13	68.60
IUUC-Mga-059876	Meleagris gallopavo	56.84	1.00e-128	452.00
IUUC-Mvi-060359	Microbotryum violaceum	31.14	2.00e-13	70.90
IUUC-Mmr-061518	Microcebus murinus	75.54	1.00e-171	595.00
IUUC-Mac-065625	Musa acuminata	35.20	2.00e-21	97.10
IUUC-Nfi-068402	Neosartorya fischeri	28.51	1.00e-14	74.70
IUUC-Nle-069914	Nomascus leucogenys	76.27	5.00e-158	550.00
IUUC-Ont-071555	Oreochromis niloticus	42.78	3.00e-82	298.00
IUUC-Oan-072951	Ornithorhynchus anatinus	68.12	2.00e-155	541.00
IUUC-Ocu-074679	Oryctolagus cuniculus	75.00	7.00e-159	553.00
IUUC-Oba-075355	Oryza barthii	26.81	1.00e-13	71.20
IUUC-Obr-076769	Oryza brachyantha	32.26	3.00e-26	112.00
IUUC-Ogl-077168	Oryza glaberrima	32.78	1.00e-26	114.00
IUUC-Ogu-078275	Oryza glumaepatula	26.38	1.00e-13	71.20
IUUC-Oin-079207	Oryza indica	32.78	1.00e-26	114.00
IUUC-Oni-082437	Oryza nivara	26.86	5.00e-13	68.90
IUUC-Opu-084031	Oryza punctata	33.20	3.00e-25	109.00
IUUC-Oru-084380	Oryza rufipogon	29.78	6.00e-13	68.90
IUUC-Osa-085327	Oryza sativa	32.37	6.00e-26	111.00
IUUC-Ola-086716	Oryzias latipes	42.86	9.00e-76	277.00
IUUC-Olu-087708	Ostreococcus lucimarinus	30.48	7.00e-15	74.70
IUUC-Oar-090239	Ovis aries	77.66	8.00e-169	586.00
IUUC-Ptr-090851	Pan troglodytes	78.45	1.00e-170	592.00
IUUC-Pan-092558	Papio anubis	77.11	1.00e-153	536.00
IUUC-Psi-093792	Pelodiscus sinensis	62.23	5.00e-140	490.00
IUUC-Ppa-095757	Physcomitrella patens	38.12	1.00e-23	103.00
IUUC-Pfo-096465	Poecilia formosa	43.19	2.00e-87	316.00
IUUC-Pab-097722	Pongo abelii	77.24	1.00e-167	582.00
IUUC-Pop-098979	Populus trichocarpa	36.22	6.00e-23	101.00
IUUC-Pca-100753	Procavia capensis	86.85	7.00e-138	483.00
IUUC-Ppe-101515	Prunus persica	35.71	1.00e-20	94.40
IUUC-Sja-107780	Schizosaccharomyces japonicus	26.70	2.00e-13	70.10
IUUC-Spo-108251	Schizosaccharomyces pombe	26.44	2.00e-13	70.50
IUUC-Smo-108938	Selaginella moellendorffii	38.34	1.00e-24	107.00
IUUC-Sit-110020	Setaria italica	32.26	1.00e-24	107.00
IUUC-Sly-111543	Solanum lycopersicum	34.20	6.00e-24	105.00
IUUC-Stu-111925	Solanum tuberosum	34.20	8.00e-23	101.00
IUUC-Sbi-114061	Sorghum bicolor	37.23	3.00e-25	109.00
IUUC-Tgu-117321	Taeniopygia guttata	59.06	5.00e-115	407.00
IUUC-Tru-118454	Takifugu rubripes	44.53	5.00e-81	294.00
IUUC-Tni-119894	Tetraodon nigroviridis	43.98	1.00e-74	273.00
IUUC-Tca-121746	Theobroma cacao	34.67	5.00e-24	105.00
IUUC-Tae-124459	Triticum aestivum	30.56	6.00e-22	98.60
IUUC-Tur-126254	Triticum urartu	27.62	8.00e-14	71.20
IUUC-Tbe-127683	Tupaia belangeri	48.15	1.00e-55	210.00
IUUC-Ttr-129056	Tursiops truncatus	74.33	2.00e-162	565.00
IUUC-Vvi-131428	Vitis vinifera	36.98	1.00e-24	107.00
IUUC-Xma-133605	Xiphophorus maculatus	41.94	2.00e-85	308.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence