iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	miRNAMap	RAID2
Post-translational Modifications (PTMs)
CPLM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	4.70e-130	434.9	13	525

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
           YDRQ+rlwG+++qe+l+sa+v+l++a+++G+E+lKnLvl G+gs+t++D+++v+ +++ + F++++ ++gk++A++a+e+l+eln+dv+
   Q: 13   YDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDVVNHFFLQKCSIGKNRAQAAMEFLQELNSDVS 101
           ***************************************************************************************** PP
   S: 90   veaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfc 174
           ++++ees+++l ++++ Ff++f++Vv+++  +++ ++++++++n ++pl++++t+Gl+G++r+iik++++++s++d   +++++++Pf+
   Q: 102  GSFVEESPENLLDNDPsFFCRFTIVVATQLLESTLLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDnalEDLRLDKPFP 190
           ***************************************************************************************** PP
   S: 175  tlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafakt 248
           +l+e+++         +++++++w+v+++k+l+++++e++++ +++++eke++++++++++ +      edeenfeeai+++++a+++t
   Q: 191  ELREHFQsydldhmekKDHSHTPWIVIIAKYLAQWYSETNGRIPKSYKEKEDFRELIRQGILKnengapEDEENFEEAIKNVNTALNTT 279
           *****99999999998***********************************************9************************* PP
   S: 249  tins.ikqllksfecdivtkskspfwv.............................................................. 274
           +i+s i++++++++c ++tk++++fw+                                                              
   Q: 280  QIPSsIEDIFNDDRCINITKQTPSFWIlaralkefvakegqgnlpvrgtipdmiadsskyiklqnvyrekakkdaaavgnhvakllqsv 368
           ***************************************************************************************** PP
   S: 275  .............sfcsnaealqvp...........ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..a 332
                         +csn++ l+v            ++v+kde+++++++p     lyl+lra++rf+k++gr+pg++++++++d+  +
   Q: 369  gqapesisekelkLLCSNSAFLRVVrcrslaeeyglHTVNKDEIISSMDNPdneivLYLMLRAVDRFHKQHGRYPGVSNYQVEEDIgkL 457
           *************99********7777777788888************99999*********************************999 PP
   S: 333  vdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
            +++t ++    +++g++ +++dd+++e++++++++ +t++a++gG+aaqEviK+++++f+ ++n++++ ++
   Q: 458  KSCLTGFL----QEYGLSVMVKDDYVHEFCRYGAAEPHTVAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGM 525
           ********....********************************************************9776 PP

Organism

Rattus norvegicus

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

MAQQGKILKE QKYDRQLRLW GDHGQEALES AHVCLINATA TGTEILKNLV LPGIGSFTII 60
DGNQVSGEDV VNHFFLQKCS IGKNRAQAAM EFLQELNSDV SGSFVEESPE NLLDNDPSFF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCCTACTTA CGCGGCTCTG CTGATCGTGG GGCAAGCGCG GCCATGGCTC AGCAAGGGAA 60
GATACTCAAG GAGCAAAAGT ACGACCGGCA GCTGAGGTGA GCCGGGGTTT CCGAGTAAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0033314--P:mitotic DNA replication checkpoint
GO:0051402--P:neuron apoptotic process
GO:0045116--P:protein neddylation
GO:0043523--P:regulation of neuron apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	41.59	7.00e-123	434.00
IUUC-Aml-002333	Ailuropoda melanoleuca	95.71	0.00e+00	1071.00
IUUC-Atr-002644	Amborella trichopoda	41.07	2.00e-113	402.00
IUUC-Apl-003446	Anas platyrhynchos	84.01	0.00e+00	916.00
IUUC-Aca-004450	Anolis carolinensis	80.52	0.00e+00	918.00
IUUC-Aly-006187	Arabidopsis lyrata	40.75	2.00e-124	439.00
IUUC-Ath-007600	Arabidopsis thaliana	40.65	3.00e-125	441.00
IUUC-Ago-007900	Ashbya gossypii	26.64	3.00e-40	159.00
IUUC-Acl-008333	Aspergillus clavatus	34.17	4.00e-81	295.00
IUUC-Afl-008529	Aspergillus flavus	36.01	1.00e-86	313.00
IUUC-Afu-009071	Aspergillus fumigatus	33.51	2.00e-80	293.00
IUUC-Ani-009443	Aspergillus nidulans	32.68	5.00e-77	281.00
IUUC-Ang-009669	Aspergillus niger	32.97	2.00e-81	296.00
IUUC-Aor-009914	Aspergillus oryzae	35.34	3.00e-83	302.00
IUUC-Ate-010450	Aspergillus terreus	33.87	7.00e-83	301.00
IUUC-Ame-011183	Astyanax mexicanus	71.91	0.00e+00	824.00
IUUC-Bgr-012111	Blumeria graminis	33.58	7.00e-66	244.00
IUUC-Bta-012583	Bos taurus	96.07	0.00e+00	1077.00
IUUC-Bci-013892	Botrytis cinerea	32.60	3.00e-66	246.00
IUUC-Bdi-014592	Brachypodium distachyon	42.56	2.00e-125	442.00
IUUC-Bol-016399	Brassica oleracea	39.50	2.00e-122	432.00
IUUC-Bra-017506	Brassica rapa	38.86	1.00e-118	419.00
IUUC-Cel-018456	Caenorhabditis elegans	35.42	3.00e-92	332.00
IUUC-Cja-020007	Callithrix jacchus	95.72	0.00e+00	1073.00
IUUC-Cfa-020324	Canis familiaris	96.44	0.00e+00	1079.00
IUUC-Cpo-022248	Cavia porcellus	64.68	0.00e+00	633.00
IUUC-Csa-023149	Chlorocebus sabaeus	95.12	0.00e+00	931.00
IUUC-Cho-024537	Choloepus hoffmanni	85.03	0.00e+00	805.00
IUUC-Cin-025763	Ciona intestinalis	48.98	2.00e-153	535.00
IUUC-Csv-026113	Ciona savignyi	46.30	2.00e-145	509.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	31.99	5.00e-65	241.00
IUUC-Cne-026884	Cryptococcus neoformans	30.07	1.00e-71	264.00
IUUC-Cme-027210	Cyanidioschyzon merolae	26.67	9.00e-19	88.60
IUUC-Dre-028140	Danio rerio	73.35	0.00e+00	844.00
IUUC-Dno-030033	Dasypus novemcinctus	95.98	0.00e+00	950.00
IUUC-Dor-030513	Dipodomys ordii	67.41	7.00e-114	404.00
IUUC-Dse-031536	Dothistroma septosporum	34.40	9.00e-84	304.00
IUUC-Dme-031683	Drosophila melanogaster	44.65	3.00e-126	445.00
IUUC-Ete-032420	Echinops telfairi	82.75	0.00e+00	884.00
IUUC-Eca-033992	Equus caballus	97.30	0.00e+00	910.00
IUUC-Eeu-034713	Erinaceus europaeus	79.53	5.00e-117	414.00
IUUC-Fca-036548	Felis catus	95.13	0.00e+00	1064.00
IUUC-Fal-037600	Ficedula albicollis	81.61	0.00e+00	886.00
IUUC-Fox-038037	Fusarium oxysporum	33.27	9.00e-76	277.00
IUUC-Fso-038387	Fusarium solani	34.53	3.00e-77	282.00
IUUC-Gmo-038562	Gadus morhua	71.97	0.00e+00	823.00
IUUC-Ggr-040005	Gaeumannomyces graminis	33.63	8.00e-73	267.00
IUUC-Gga-041129	Gallus gallus	84.49	0.00e+00	941.00
IUUC-Gac-042558	Gasterosteus aculeatus	72.69	0.00e+00	827.00
IUUC-Gma-043610	Glycine max	41.06	4.00e-120	424.00
IUUC-Ggo-045611	Gorilla gorilla	95.90	0.00e+00	1074.00
IUUC-Hsa-046563	Homo sapiens	96.44	0.00e+00	1078.00
IUUC-Hvu-047790	Hordeum vulgare	37.60	3.00e-76	278.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	95.51	0.00e+00	1074.00
IUUC-Kpa-049309	Komagataella pastoris	35.10	2.00e-82	299.00
IUUC-Lch-050038	Latimeria chalumnae	75.75	0.00e+00	850.00
IUUC-Lpe-051535	Leersia perrieri	40.85	8.00e-110	390.00
IUUC-Loc-051917	Lepisosteus oculatus	70.22	0.00e+00	798.00
IUUC-Lma-053112	Leptosphaeria maculans	35.16	3.00e-88	319.00
IUUC-Laf-053690	Loxodonta africana	94.76	0.00e+00	1066.00
IUUC-Mcc-055117	Macaca mulatta	95.35	0.00e+00	1066.00
IUUC-Meu-056761	Macropus eugenii	75.14	0.00e+00	811.00
IUUC-Mor-057230	Magnaporthe oryzae	34.23	2.00e-76	280.00
IUUC-Mpo-057514	Magnaporthe poae	33.45	2.00e-70	260.00
IUUC-Mtr-058551	Medicago truncatula	40.56	7.00e-117	414.00
IUUC-Mla-059183	Melampsora laricipopulina	36.10	7.00e-95	341.00
IUUC-Mga-060144	Meleagris gallopavo	83.52	0.00e+00	918.00
IUUC-Mvi-060221	Microbotryum violaceum	35.06	2.00e-80	293.00
IUUC-Mmr-061325	Microcebus murinus	93.85	0.00e+00	1051.00
IUUC-Mdo-062532	Monodelphis domestica	90.57	0.00e+00	1012.00
IUUC-Mmu-063956	Mus musculus	97.57	0.00e+00	1086.00
IUUC-Mac-064521	Musa acuminata	40.56	5.00e-122	431.00
IUUC-Mpu-066716	Mustela putorius furo	95.22	0.00e+00	1008.00
IUUC-Mlu-067459	Myotis lucifugus	94.03	0.00e+00	1048.00
IUUC-Nfi-068245	Neosartorya fischeri	33.87	1.00e-80	293.00
IUUC-Ncr-068910	Neurospora crassa	33.69	3.00e-76	279.00
IUUC-Nle-070034	Nomascus leucogenys	94.48	0.00e+00	1037.00
IUUC-Opr-070552	Ochotona princeps	85.63	0.00e+00	875.00
IUUC-Ont-071426	Oreochromis niloticus	73.53	0.00e+00	843.00
IUUC-Oan-073389	Ornithorhynchus anatinus	83.37	0.00e+00	775.00
IUUC-Ocu-074911	Oryctolagus cuniculus	94.38	0.00e+00	1066.00
IUUC-Oba-075437	Oryza barthii	42.18	9.00e-116	410.00
IUUC-Obr-076684	Oryza brachyantha	42.02	7.00e-111	394.00
IUUC-Ogl-077170	Oryza glaberrima	42.18	9.00e-116	410.00
IUUC-Ogu-078844	Oryza glumaepatula	42.91	6.00e-109	387.00
IUUC-Oin-079105	Oryza indica	42.18	4.00e-115	408.00
IUUC-Olo-080943	Oryza longistaminata	40.44	2.00e-105	376.00
IUUC-Oni-082891	Oryza nivara	40.08	5.00e-111	394.00
IUUC-Opu-083457	Oryza punctata	42.18	2.00e-115	409.00
IUUC-Oru-084960	Oryza rufipogon	40.44	1.00e-105	376.00
IUUC-Osa-085358	Oryza sativa	42.37	5.00e-116	411.00
IUUC-Ola-086420	Oryzias latipes	71.85	1.00e-168	585.00
IUUC-Olu-087625	Ostreococcus lucimarinus	31.56	7.00e-61	228.00
IUUC-Oga-088810	Otolemur garnettii	95.32	0.00e+00	1068.00
IUUC-Oar-089196	Ovis aries	95.90	0.00e+00	1074.00
IUUC-Ptr-090617	Pan troglodytes	96.63	0.00e+00	1080.00
IUUC-Pan-092761	Papio anubis	96.44	0.00e+00	1081.00
IUUC-Psi-093191	Pelodiscus sinensis	86.07	0.00e+00	956.00
IUUC-Pma-094380	Petromyzon marinus	61.87	0.00e+00	660.00
IUUC-Pno-095084	Phaeosphaeria nodorum	32.79	2.00e-75	278.00
IUUC-Ppa-095875	Physcomitrella patens	40.04	5.00e-119	421.00
IUUC-Pfo-096467	Poecilia formosa	72.97	0.00e+00	827.00
IUUC-Pab-098255	Pongo abelii	95.72	0.00e+00	894.00
IUUC-Pop-099722	Populus trichocarpa	40.65	3.00e-123	435.00
IUUC-Pca-100807	Procavia capensis	76.98	3.00e-115	408.00
IUUC-Ppe-101280	Prunus persica	40.11	2.00e-122	432.00
IUUC-Pva-102333	Pteropus vampyrus	90.88	0.00e+00	1007.00
IUUC-Pgr-103401	Puccinia graminis	31.58	3.00e-81	296.00
IUUC-Ptt-103889	Puccinia triticina	27.50	2.00e-57	216.00
IUUC-Pte-104355	Pyrenophora teres	35.94	2.00e-90	326.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	35.94	2.00e-91	329.00
IUUC-Sce-106397	Saccharomyces cerevisiae	27.11	6.00e-38	151.00
IUUC-Sha-106770	Sarcophilus harrisii	87.28	7.00e-150	522.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	32.95	2.00e-76	280.00
IUUC-Spo-108276	Schizosaccharomyces pombe	33.96	2.00e-81	296.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	32.36	6.00e-68	251.00
IUUC-Smo-109296	Selaginella moellendorffii	42.42	2.00e-122	432.00
IUUC-Sit-110157	Setaria italica	43.66	1.00e-132	466.00
IUUC-Sly-111105	Solanum lycopersicum	39.59	2.00e-120	425.00
IUUC-Stu-112469	Solanum tuberosum	39.78	1.00e-122	433.00
IUUC-Sar-113083	Sorex araneus	72.29	0.00e+00	741.00
IUUC-Sbi-113813	Sorghum bicolor	43.66	8.00e-132	463.00
IUUC-Sre-115058	Sporisorium reilianum	38.89	5.00e-85	308.00
IUUC-Tgu-116772	Taeniopygia guttata	80.46	0.00e+00	882.00
IUUC-Tru-118686	Takifugu rubripes	71.83	0.00e+00	829.00
IUUC-Tsy-119111	Tarsius syrichta	87.99	1.00e-146	513.00
IUUC-Tni-120231	Tetraodon nigroviridis	66.23	0.00e+00	744.00
IUUC-Tca-121491	Theobroma cacao	40.15	1.00e-115	410.00
IUUC-Tre-122103	Trichoderma reesei	36.65	2.00e-82	300.00
IUUC-Tvi-122672	Trichoderma virens	36.43	1.00e-75	277.00
IUUC-Tae-125316	Triticum aestivum	42.18	6.00e-125	441.00
IUUC-Tur-126487	Triticum urartu	40.84	1.00e-118	419.00
IUUC-Tme-127097	Tuber melanosporum	38.90	3.00e-94	339.00
IUUC-Ttr-128465	Tursiops truncatus	89.39	0.00e+00	989.00
IUUC-Uma-129645	Ustilago maydis	33.33	5.00e-89	322.00
IUUC-Vda-129989	Verticillium dahliae	31.05	6.00e-56	211.00
IUUC-Vpa-130529	Vicugna pacos	91.62	0.00e+00	1017.00
IUUC-Vvi-131059	Vitis vinifera	40.68	2.00e-120	426.00
IUUC-Xtr-132002	Xenopus tropicalis	78.65	0.00e+00	899.00
IUUC-Xma-133930	Xiphophorus maculatus	73.38	0.00e+00	833.00
IUUC-Yli-134505	Yarrowia lipolytica	35.05	8.00e-87	314.00
IUUC-Zma-135895	Zea mays	43.89	2.00e-130	459.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence