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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064105
Ensembl Protein ID ENSMUSP00000038489.4
UniProt Accession Q9CQY1; Q3TKE5; Q9D7Y5; ATG12_MOUSE
Genbank Protein ID BAB62092.1; BAB25839.1; BAB30256.1; BAB24005.1; BAE39200.1; AAH70470.1
Protein Name Ubiquitin-like protein ATG12; Autophagy-related protein 12
Genbank Nucleotide ID AB066216; AK008698; AK016474; AK005405; AK167027; BC070470
Gene Name Atg12; Apg12; Apg12l
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000032905.4 ENSMUST00000035648.4 ENSMUSP00000038489.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
mUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UBL/ATG12 88.65 1.00e-58 222.00 IUUC-Hsa-046903
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.
 Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.
Protein Sequence
(Fasta)
MSEDSEVVLQ LPSAPVGAGG ESLPELSPET ATPEPPSSAA VSPGTEEPPG DTKKKIDILL 60
KAVGDTPIMK TKKWAVERTR TIQGLIDFIK KFLKLVASEQ LFIYVNQSFA PSPDQEVGTL 120
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Protein Fasta Sequence


>IUUC-Mmu-064105|ULD,ATG12|Mus musculus
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Nucleotide Sequence
(Fasta)
GTCACTTCCG CCGCCGCCTC TCAGCAAGCA AAGATGTCGG AAGATTCAGA GGTTGTGCTG 60
CAGCTCCCCT CGGCTCCTGT AGGAGCCGGC GGCGAGAGCC TTCCAGAGCT CTCCCCGGAA 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064105|ULD,ATG12|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0399--Innate immunity
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR007242--Atg12
IPR029071--Ubiquitin-rel_dom
Pfam

PF04110--APG12
Gene Ontology

GO:0034274--C:Atg12-Atg5-Atg16 complex
GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0034045--C:pre-autophagosomal structure membrane
GO:0019776--F:Atg8 ligase activity
GO:0000045--P:autophagosome assembly
GO:0006914--P:autophagy
GO:0006501--P:C-terminal protein lipidation
GO:0045087--P:innate immune response
GO:0016236--P:macroautophagy
GO:0000422--P:mitophagy
GO:0032480--P:negative regulation of type I interferon production
GO:0044804--P:nucleophagy
KEGG mmu:67526
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001177 Aegilops tauschii 36.26 3.00e-15 72.80
IUUC-Aml-002116 Ailuropoda melanoleuca 87.94 8.00e-56 209.00
IUUC-Atr-002615 Amborella trichopoda 44.44 1.00e-18 84.30
IUUC-Apl-003753 Anas platyrhynchos 97.50 2.00e-20 90.10
IUUC-Aca-005231 Anolis carolinensis 93.81 4.00e-44 169.00
IUUC-Aly-006172 Arabidopsis lyrata 43.01 2.00e-18 83.20
IUUC-Ath-006953 Arabidopsis thaliana 42.86 8.00e-19 84.30
IUUC-Ago-007970 Ashbya gossypii 46.34 3.00e-06 45.10
IUUC-Acl-008072 Aspergillus clavatus 28.74 8.00e-11 58.50
IUUC-Afl-008725 Aspergillus flavus 30.34 7.00e-12 63.50
IUUC-Afu-008967 Aspergillus fumigatus 28.74 9.00e-12 62.80
IUUC-Ani-009248 Aspergillus nidulans 27.59 2.00e-11 61.60
IUUC-Ang-009684 Aspergillus niger 29.07 3.00e-11 61.60
IUUC-Aor-009947 Aspergillus oryzae 30.34 7.00e-12 63.50
IUUC-Ame-011656 Astyanax mexicanus 81.52 4.00e-42 162.00
IUUC-Bgr-012174 Blumeria graminis 31.11 3.00e-13 67.40
IUUC-Bta-012483 Bos taurus 98.98 3.00e-54 203.00
IUUC-Bci-013755 Botrytis cinerea 28.42 2.00e-09 53.90
IUUC-Bdi-014156 Brachypodium distachyon 35.23 9.00e-15 71.20
IUUC-Bol-015683 Brassica oleracea 42.27 1.00e-18 84.30
IUUC-Bra-016802 Brassica rapa 44.32 1.00e-17 80.90
IUUC-Cel-018242 Caenorhabditis elegans 34.07 8.00e-13 65.50
IUUC-Cja-019514 Callithrix jacchus 87.23 9.00e-61 226.00
IUUC-Cfa-020748 Canis familiaris 88.65 3.00e-56 210.00
IUUC-Cpo-021965 Cavia porcellus 88.65 4.00e-55 206.00
IUUC-Cre-023009 Chlamydomonas reinhardtii 32.58 2.00e-11 59.70
IUUC-Csa-023494 Chlorocebus sabaeus 88.65 3.00e-57 213.00
IUUC-Cho-024631 Choloepus hoffmanni 92.20 3.00e-59 220.00
IUUC-Cin-025609 Ciona intestinalis 57.14 9.00e-31 124.00
IUUC-Cgl-026722 Colletotrichum gloeosporioides 37.17 1.00e-14 72.40
IUUC-Dre-027479 Danio rerio 72.32 1.00e-44 171.00
IUUC-Dno-029693 Dasypus novemcinctus 76.60 1.00e-39 155.00
IUUC-Dse-031440 Dothistroma septosporum 27.13 7.00e-12 62.80
IUUC-Dme-031892 Drosophila melanogaster 54.21 2.00e-31 127.00
IUUC-Ete-032550 Echinops telfairi 89.80 2.00e-47 180.00
IUUC-Eca-033553 Equus caballus 88.65 7.00e-56 208.00
IUUC-Fca-036524 Felis catus 86.52 3.00e-53 200.00
IUUC-Fal-036942 Ficedula albicollis 93.02 5.00e-47 178.00
IUUC-Fox-037753 Fusarium oxysporum 30.47 3.00e-12 64.70
IUUC-Gmo-039498 Gadus morhua 76.92 4.00e-43 166.00
IUUC-Ggr-039852 Gaeumannomyces graminis 28.09 2.00e-09 55.80
IUUC-Gga-041263 Gallus gallus 75.17 2.00e-57 214.00
IUUC-Gac-042346 Gasterosteus aculeatus 80.95 4.00e-39 152.00
IUUC-Gma-042896 Glycine max 43.18 6.00e-18 81.60
IUUC-Ggo-045601 Gorilla gorilla 89.36 1.00e-58 219.00
IUUC-Hsa-046903 Homo sapiens 88.65 4.00e-59 219.00
IUUC-Hvu-047239 Hordeum vulgare 37.36 2.00e-15 73.20
IUUC-Itr-048445 Ictidomys tridecemlineatus 90.78 8.00e-59 219.00
IUUC-Kpa-049355 Komagataella pastoris 27.56 1.00e-09 55.10
IUUC-Lch-050619 Latimeria chalumnae 86.52 4.00e-44 169.00
IUUC-Loc-052102 Lepisosteus oculatus 78.18 8.00e-21 91.30
IUUC-Lma-053299 Leptosphaeria maculans 29.41 3.00e-06 43.50
IUUC-Laf-054205 Loxodonta africana 87.94 6.00e-67 245.00
IUUC-Meu-056804 Macropus eugenii 91.96 2.00e-57 214.00
IUUC-Mor-057052 Magnaporthe oryzae 28.95 7.00e-11 60.10
IUUC-Mtr-057961 Medicago truncatula 44.32 1.00e-18 83.60
IUUC-Mla-059045 Melampsora laricipopulina 39.08 8.00e-18 82.00
IUUC-Mvi-060360 Microbotryum violaceum 40.23 8.00e-19 85.50
IUUC-Mmr-061654 Microcebus murinus 80.88 7.00e-57 211.00
IUUC-Mdo-062649 Monodelphis domestica 81.56 7.00e-62 228.00
IUUC-Mac-065532 Musa acuminata 38.83 1.00e-17 80.50
IUUC-Mpu-066269 Mustela putorius furo 87.94 5.00e-68 249.00
IUUC-Mlu-067631 Myotis lucifugus 93.55 1.00e-63 235.00
IUUC-Nfi-068468 Neosartorya fischeri 28.74 4.00e-11 59.70
IUUC-Ncr-068750 Neurospora crassa 31.11 1.00e-11 62.00
IUUC-Nle-069483 Nomascus leucogenys 88.65 3.00e-57 214.00
IUUC-Opr-070936 Ochotona princeps 97.96 1.00e-53 202.00
IUUC-Obr-076322 Oryza brachyantha 33.71 1.00e-14 70.90
IUUC-Ogl-077226 Oryza glaberrima 34.15 2.00e-13 67.00
IUUC-Oin-079220 Oryza indica 42.11 9.00e-11 58.50
IUUC-Olo-080688 Oryza longistaminata 34.15 2.00e-13 67.00
IUUC-Ome-081265 Oryza meridionalis 34.15 2.00e-13 67.00
IUUC-Oru-084342 Oryza rufipogon 33.71 2.00e-14 72.80
IUUC-Osa-086212 Oryza sativa 34.15 2.00e-13 67.00
IUUC-Ola-087277 Oryzias latipes 68.03 2.00e-43 166.00
IUUC-Olu-087780 Ostreococcus lucimarinus 33.67 8.00e-12 61.60
IUUC-Oga-088175 Otolemur garnettii 88.65 1.00e-59 221.00
IUUC-Oar-089477 Ovis aries 98.98 5.00e-54 203.00
IUUC-Ptr-091129 Pan troglodytes 88.65 7.00e-58 216.00
IUUC-Psi-093351 Pelodiscus sinensis 76.06 3.00e-52 196.00
IUUC-Pno-094948 Phaeosphaeria nodorum 26.36 5.00e-06 43.10
IUUC-Ppa-095788 Physcomitrella patens 40.59 7.00e-20 88.20
IUUC-Pfo-096993 Poecilia formosa 75.00 5.00e-43 165.00
IUUC-Pab-098502 Pongo abelii 88.65 5.00e-58 216.00
IUUC-Pop-098819 Populus trichocarpa 40.66 3.00e-17 79.30
IUUC-Pca-100144 Procavia capensis 75.89 7.00e-47 179.00
IUUC-Ppe-101560 Prunus persica 42.86 4.00e-16 75.50
IUUC-Pva-102810 Pteropus vampyrus 86.07 8.00e-54 202.00
IUUC-Pgr-103531 Puccinia graminis 34.95 1.00e-18 84.70
IUUC-Ptt-103753 Puccinia triticina 37.93 2.00e-18 84.00
IUUC-Pyt-104733 Pyrenophora triticirepentis 31.40 2.00e-10 58.20
IUUC-Rno-106072 Rattus norvegicus 93.75 2.00e-60 223.00
IUUC-Sce-106275 Saccharomyces cerevisiae 31.82 3.00e-10 58.20
IUUC-Sha-107554 Sarcophilus harrisii 94.44 2.00e-57 214.00
IUUC-Sja-107682 Schizosaccharomyces japonicus 29.21 3.00e-13 67.00
IUUC-Spo-108275 Schizosaccharomyces pombe 35.96 1.00e-16 78.60
IUUC-Smo-109151 Selaginella moellendorffii 29.07 6.00e-11 58.50
IUUC-Sit-110270 Setaria italica 35.87 1.00e-15 73.90
IUUC-Sly-111862 Solanum lycopersicum 44.32 5.00e-18 81.60
IUUC-Stu-112663 Solanum tuberosum 53.49 9.00e-10 55.10
IUUC-Sbi-114148 Sorghum bicolor 35.87 1.00e-15 73.90
IUUC-Sre-115216 Sporisorium reilianum 37.93 4.00e-19 87.00
IUUC-Ssc-116051 Sus scrofa 87.94 4.00e-56 209.00
IUUC-Tgu-117008 Taeniopygia guttata 86.27 6.00e-22 95.50
IUUC-Tru-118466 Takifugu rubripes 81.40 6.00e-40 154.00
IUUC-Tsy-119334 Tarsius syrichta 84.40 2.00e-62 231.00
IUUC-Tni-119792 Tetraodon nigroviridis 82.56 1.00e-40 156.00
IUUC-Tca-121861 Theobroma cacao 43.18 1.00e-17 81.30
IUUC-Tvi-122499 Trichoderma virens 28.00 2.00e-12 63.90
IUUC-Tae-123431 Triticum aestivum 36.26 3.00e-15 72.80
IUUC-Tme-126934 Tuber melanosporum 32.18 4.00e-13 67.40
IUUC-Ttr-129001 Tursiops truncatus 85.82 2.00e-50 191.00
IUUC-Uma-129324 Ustilago maydis 40.23 7.00e-20 89.40
IUUC-Vda-129846 Verticillium dahliae 30.09 1.00e-10 58.90
IUUC-Vpa-130202 Vicugna pacos 53.92 5.00e-24 103.00
IUUC-Vvi-131474 Vitis vinifera 35.62 9.00e-10 55.80
IUUC-Xtr-132782 Xenopus tropicalis 74.19 3.00e-51 193.00
IUUC-Xma-134140 Xiphophorus maculatus 76.00 1.00e-43 168.00
IUUC-Yli-134517 Yarrowia lipolytica 36.25 2.00e-10 58.90
IUUC-Zma-134764 Zea mays 35.87 1.00e-15 73.90
Created Date 25-Jun-2017

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