iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-033994

Ensembl Protein ID

ENSECAP00000013168.1

UniProt Accession

F6TEK7; F6TEK7_HORSE

Protein Name

Uncharacterized protein

Gene Name

RFFL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000015502.1	ENSECAT00000016306.1	ENSECAP00000013168.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	92.56	0.00e+00	679.00	IUUC-Hsa-045798

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Equus caballus

Protein Sequence
(Fasta)

DFIMWATCCN WFCLDGQPEE ASPPQGARTQ AYSNPGYSSF PSPTGLEPSC KACGAHFANT 60
ARKQTCLDCK KNFCMTCSSQ VGNGPRLCLL CQRFRATAFQ REELMKMKVK DLRDYLSLHD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCAGATTTT ATCATGTGGG CAACCTGCTG CAACTGGTTC TGCCTGGATG GACAGCCTGA 60
GGAGGCCTCA CCACCCCAGG GAGCCAGGAC GCAGGCCTAT TCTAACCCTG GGTACAGCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003034--SAP_dom
IPR011011--Znf_FYVE_PHD
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0010008--C:endosome membrane
GO:0005886--C:plasma membrane
GO:0002947--C:tumor necrosis factor receptor superfamily complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:2001271--P:negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1901797--P:negative regulation of signal transduction by p53 class mediator
GO:0010804--P:negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001630	Ailuropoda melanoleuca	91.80	0.00e+00	650.00
IUUC-Apl-004124	Anas platyrhynchos	67.40	4.00e-124	437.00
IUUC-Aly-005548	Arabidopsis lyrata	47.06	2.00e-08	54.70
IUUC-Ath-006731	Arabidopsis thaliana	35.29	3.00e-07	50.80
IUUC-Ame-011616	Astyanax mexicanus	57.77	5.00e-104	370.00
IUUC-Bta-012374	Bos taurus	89.34	0.00e+00	644.00
IUUC-Cja-019780	Callithrix jacchus	90.38	0.00e+00	659.00
IUUC-Cfa-021252	Canis familiaris	93.44	0.00e+00	652.00
IUUC-Cpo-022047	Cavia porcellus	90.16	0.00e+00	658.00
IUUC-Csa-023161	Chlorocebus sabaeus	92.01	0.00e+00	681.00
IUUC-Cho-024316	Choloepus hoffmanni	90.10	1.00e-153	535.00
IUUC-Dre-028596	Danio rerio	54.82	1.00e-106	379.00
IUUC-Dno-029333	Dasypus novemcinctus	92.56	0.00e+00	666.00
IUUC-Ete-033163	Echinops telfairi	84.02	3.00e-164	570.00
IUUC-Eeu-035162	Erinaceus europaeus	86.33	1.00e-130	458.00
IUUC-Fca-036418	Felis catus	91.53	0.00e+00	681.00
IUUC-Fal-037427	Ficedula albicollis	65.67	2.00e-129	455.00
IUUC-Gga-041053	Gallus gallus	67.77	3.00e-130	457.00
IUUC-Ggo-045436	Gorilla gorilla	92.56	0.00e+00	684.00
IUUC-Hsa-045798	Homo sapiens	92.56	0.00e+00	684.00
IUUC-Itr-048077	Ictidomys tridecemlineatus	91.53	0.00e+00	650.00
IUUC-Lch-050639	Latimeria chalumnae	62.81	5.00e-124	437.00
IUUC-Laf-053355	Loxodonta africana	88.08	1.00e-179	621.00
IUUC-Mcc-055222	Macaca mulatta	92.01	0.00e+00	660.00
IUUC-Meu-056692	Macropus eugenii	77.13	4.00e-157	547.00
IUUC-Mga-059298	Meleagris gallopavo	67.40	2.00e-130	458.00
IUUC-Mmr-061792	Microcebus murinus	91.18	0.00e+00	647.00
IUUC-Mdo-062986	Monodelphis domestica	78.90	6.00e-162	563.00
IUUC-Mmu-063356	Mus musculus	89.34	0.00e+00	639.00
IUUC-Mac-064492	Musa acuminata	37.14	5.00e-07	50.10
IUUC-Mpu-066273	Mustela putorius furo	92.35	0.00e+00	683.00
IUUC-Mlu-066953	Myotis lucifugus	92.35	0.00e+00	674.00
IUUC-Nle-070075	Nomascus leucogenys	91.80	0.00e+00	687.00
IUUC-Opr-070838	Ochotona princeps	89.26	0.00e+00	638.00
IUUC-Ont-071967	Oreochromis niloticus	74.13	8.00e-56	210.00
IUUC-Ocu-074807	Oryctolagus cuniculus	90.44	0.00e+00	667.00
IUUC-Obr-076159	Oryza brachyantha	39.29	1.00e-07	49.30
IUUC-Ola-086903	Oryzias latipes	51.08	1.00e-90	326.00
IUUC-Oga-088536	Otolemur garnettii	90.36	0.00e+00	631.00
IUUC-Oar-089838	Ovis aries	89.07	0.00e+00	637.00
IUUC-Ptr-090962	Pan troglodytes	92.29	0.00e+00	684.00
IUUC-Pan-092853	Papio anubis	91.46	0.00e+00	677.00
IUUC-Psi-093164	Pelodiscus sinensis	70.41	3.00e-127	447.00
IUUC-Pma-094104	Petromyzon marinus	45.19	4.00e-54	204.00
IUUC-Pno-094968	Phaeosphaeria nodorum	38.78	9.00e-09	57.00
IUUC-Pab-098304	Pongo abelii	92.35	0.00e+00	688.00
IUUC-Pca-100316	Procavia capensis	90.08	2.00e-179	620.00
IUUC-Ppe-101490	Prunus persica	37.80	3.00e-09	56.60
IUUC-Pva-102612	Pteropus vampyrus	77.69	4.00e-154	536.00
IUUC-Rno-105449	Rattus norvegicus	89.26	0.00e+00	629.00
IUUC-Sha-107578	Sarcophilus harrisii	78.36	7.00e-154	536.00
IUUC-Sar-113638	Sorex araneus	88.43	3.00e-179	620.00
IUUC-Ssc-116401	Sus scrofa	92.08	0.00e+00	684.00
IUUC-Tru-118765	Takifugu rubripes	48.10	5.00e-79	287.00
IUUC-Tsy-118850	Tarsius syrichta	88.78	5.00e-153	533.00
IUUC-Tae-124586	Triticum aestivum	38.18	5.00e-07	49.30
IUUC-Tbe-128086	Tupaia belangeri	83.75	9.00e-173	598.00
IUUC-Ttr-128249	Tursiops truncatus	70.25	7.00e-140	489.00
IUUC-Vpa-130816	Vicugna pacos	88.37	4.00e-41	161.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence