iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074807

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAGW02039181

Gene Name

RFFL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000006315.2	ENSOCUT00000006313.2	ENSOCUP00000005459.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	90.91	0.00e+00	681.00	IUUC-Hsa-045798

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

DFIMWATCCN WFCLDGQPEE VPPSQGARTQ AYSNPGYSSF PSPTGSEPSC KACGAHFANM 60
ARKQTCLDCK KSFCLTCSSQ VGNGPRLCLL CQRFRATAFQ REELMKMKVK ELRDYLSLHD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATTTTATCA TGTGGGCAAC CTGCTGCAAC TGGTTCTGCC TGGATGGACA GCCTGAGGAG 60
GTACCACCGT CCCAGGGAGC CAGGACGCAA GCCTATTCCA ACCCTGGGTA CAGCTCCTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003034--SAP_dom
IPR011011--Znf_FYVE_PHD
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0010008--C:endosome membrane
GO:0005886--C:plasma membrane
GO:0002947--C:tumor necrosis factor receptor superfamily complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:2001271--P:negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1901797--P:negative regulation of signal transduction by p53 class mediator
GO:0010804--P:negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001630	Ailuropoda melanoleuca	89.07	2.00e-180	624.00
IUUC-Apl-004124	Anas platyrhynchos	66.30	4.00e-122	431.00
IUUC-Ame-011616	Astyanax mexicanus	57.97	1.00e-104	372.00
IUUC-Bta-012374	Bos taurus	84.97	3.00e-179	620.00
IUUC-Cja-019780	Callithrix jacchus	88.74	0.00e+00	641.00
IUUC-Cfa-021252	Canis familiaris	91.53	0.00e+00	642.00
IUUC-Cpo-022047	Cavia porcellus	87.98	0.00e+00	638.00
IUUC-Csa-023161	Chlorocebus sabaeus	90.91	0.00e+00	680.00
IUUC-Cho-024316	Choloepus hoffmanni	88.12	1.00e-150	525.00
IUUC-Dre-028596	Danio rerio	54.70	2.00e-107	382.00
IUUC-Dno-029333	Dasypus novemcinctus	89.81	0.00e+00	647.00
IUUC-Ete-033163	Echinops telfairi	82.64	1.00e-162	565.00
IUUC-Eca-033994	Equus caballus	90.44	0.00e+00	661.00
IUUC-Eeu-035162	Erinaceus europaeus	83.67	3.00e-126	444.00
IUUC-Fca-036418	Felis catus	90.44	0.00e+00	681.00
IUUC-Fal-037427	Ficedula albicollis	65.93	1.00e-130	459.00
IUUC-Gga-041053	Gallus gallus	66.49	1.00e-128	452.00
IUUC-Ggo-045436	Gorilla gorilla	90.91	0.00e+00	681.00
IUUC-Hsa-045798	Homo sapiens	90.91	0.00e+00	681.00
IUUC-Itr-048077	Ictidomys tridecemlineatus	89.07	0.00e+00	628.00
IUUC-Lch-050639	Latimeria chalumnae	62.26	8.00e-125	439.00
IUUC-Laf-053355	Loxodonta africana	86.45	1.00e-175	608.00
IUUC-Mcc-055222	Macaca mulatta	90.63	0.00e+00	637.00
IUUC-Meu-056692	Macropus eugenii	76.31	5.00e-155	540.00
IUUC-Mga-059298	Meleagris gallopavo	66.12	7.00e-129	453.00
IUUC-Mmr-061792	Microcebus murinus	89.53	0.00e+00	628.00
IUUC-Mdo-062986	Monodelphis domestica	78.63	3.00e-163	567.00
IUUC-Mmu-063356	Mus musculus	86.89	0.00e+00	637.00
IUUC-Mpu-066273	Mustela putorius furo	90.71	0.00e+00	686.00
IUUC-Mlu-066953	Myotis lucifugus	89.34	0.00e+00	664.00
IUUC-Nle-070075	Nomascus leucogenys	90.44	0.00e+00	686.00
IUUC-Opr-070838	Ochotona princeps	94.74	0.00e+00	677.00
IUUC-Ont-071967	Oreochromis niloticus	52.35	3.00e-91	328.00
IUUC-Obr-076159	Oryza brachyantha	41.07	5.00e-08	50.10
IUUC-Ola-086903	Oryzias latipes	71.22	7.00e-55	207.00
IUUC-Oga-088536	Otolemur garnettii	89.81	4.00e-175	607.00
IUUC-Oar-089838	Ovis aries	85.52	2.00e-175	608.00
IUUC-Ptr-090962	Pan troglodytes	90.63	0.00e+00	681.00
IUUC-Pan-092853	Papio anubis	90.08	0.00e+00	675.00
IUUC-Psi-093164	Pelodiscus sinensis	64.11	8.00e-123	433.00
IUUC-Pma-094104	Petromyzon marinus	44.30	2.00e-56	212.00
IUUC-Pno-094968	Phaeosphaeria nodorum	36.73	3.00e-08	55.50
IUUC-Pab-098304	Pongo abelii	90.98	0.00e+00	686.00
IUUC-Pca-100316	Procavia capensis	88.71	5.00e-175	606.00
IUUC-Ppe-101490	Prunus persica	37.80	2.00e-09	56.60
IUUC-Pva-102612	Pteropus vampyrus	76.31	4.00e-152	530.00
IUUC-Rno-105449	Rattus norvegicus	87.05	0.00e+00	626.00
IUUC-Sha-107578	Sarcophilus harrisii	78.90	3.00e-155	540.00
IUUC-Sar-113638	Sorex araneus	85.95	3.00e-171	593.00
IUUC-Ssc-116401	Sus scrofa	89.89	0.00e+00	679.00
IUUC-Tru-118765	Takifugu rubripes	49.86	7.00e-83	300.00
IUUC-Tsy-118850	Tarsius syrichta	85.81	2.00e-147	514.00
IUUC-Tbe-128086	Tupaia belangeri	82.37	3.00e-174	604.00
IUUC-Ttr-128249	Tursiops truncatus	69.15	1.00e-137	482.00
IUUC-Vpa-130816	Vicugna pacos	87.21	1.00e-40	159.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence