iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-071849

Ensembl Protein ID

ENSONIP00000009299.1

UniProt Accession

I3JKA5; I3JKA5_ORENI

Genbank Protein ID

ENSONIP00000009299

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AERX01049190

Gene Name

siah1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000007372.1	ENSONIT00000009304.1	ENSONIP00000009299.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	82.35	2.00e-126	449.00	IUUC-Dme-031700
E3 activity/RING/RING	97.53	5.00e-167	584.00	IUUC-Hsa-046357
E3 activity/RING/RING	97.87	7.00e-167	583.00	IUUC-Mmu-064129

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Oreochromis niloticus

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

LLSEMSRQTA TALPTGTSKC PPSQRVPTLS GTTASNSDLA SLFECPVCFD YVLPPILQCQ 60
SGHLVCSNCR PKLTCCPTCR GPLGSIRNLA MEKVANSVLF PCKYASSGCE VTLPHTDKTE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTTGTCAG AAATGAGTCG CCAGACTGCC ACCGCGCTGC CCACAGGAAC ATCTAAGTGC 60
CCTCCCTCTC AGCGCGTGCC CACCCTTTCA GGCACCACAG CCTCCAACAG TGACCTGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000061	Aegilops tauschii	37.36	6.00e-45	174.00
IUUC-Aml-001186	Ailuropoda melanoleuca	97.17	2.00e-167	581.00
IUUC-Atr-002857	Amborella trichopoda	36.57	7.00e-45	174.00
IUUC-Apl-003813	Anas platyrhynchos	97.16	6.00e-167	579.00
IUUC-Aca-005014	Anolis carolinensis	96.50	3.00e-168	584.00
IUUC-Aly-006522	Arabidopsis lyrata	37.35	1.00e-41	163.00
IUUC-Ath-007049	Arabidopsis thaliana	33.45	8.00e-42	164.00
IUUC-Ame-011196	Astyanax mexicanus	98.94	8.00e-170	589.00
IUUC-Bta-012887	Bos taurus	97.17	2.00e-167	581.00
IUUC-Bdi-014200	Brachypodium distachyon	37.73	2.00e-45	176.00
IUUC-Bol-016263	Brassica oleracea	33.80	9.00e-43	167.00
IUUC-Bra-016910	Brassica rapa	36.82	1.00e-41	163.00
IUUC-Cel-018320	Caenorhabditis elegans	72.37	6.00e-116	410.00
IUUC-Cja-019796	Callithrix jacchus	97.53	4.00e-168	583.00
IUUC-Cfa-020642	Canis familiaris	97.17	2.00e-168	584.00
IUUC-Cpo-022348	Cavia porcellus	97.52	2.00e-167	581.00
IUUC-Csa-023974	Chlorocebus sabaeus	97.53	3.00e-168	584.00
IUUC-Cin-025674	Ciona intestinalis	78.72	4.00e-135	473.00
IUUC-Csv-026233	Ciona savignyi	85.04	2.00e-132	464.00
IUUC-Dre-028041	Danio rerio	99.29	1.00e-170	592.00
IUUC-Dno-029764	Dasypus novemcinctus	96.83	2.00e-167	581.00
IUUC-Dme-031700	Drosophila melanogaster	84.27	5.00e-120	423.00
IUUC-Ete-032423	Echinops telfairi	96.27	9.00e-157	546.00
IUUC-Eca-033536	Equus caballus	97.16	6.00e-167	579.00
IUUC-Eeu-035314	Erinaceus europaeus	96.64	3.00e-157	548.00
IUUC-Fca-035362	Felis catus	97.17	2.00e-167	581.00
IUUC-Fal-037487	Ficedula albicollis	97.17	3.00e-167	580.00
IUUC-Gga-040269	Gallus gallus	97.16	6.00e-167	579.00
IUUC-Gac-042282	Gasterosteus aculeatus	100.00	3.00e-170	590.00
IUUC-Gma-042926	Glycine max	34.04	7.00e-41	160.00
IUUC-Ggo-045444	Gorilla gorilla	97.53	3.00e-168	584.00
IUUC-Hsa-046357	Homo sapiens	97.53	3.00e-168	584.00
IUUC-Hvu-047574	Hordeum vulgare	37.00	8.00e-45	174.00
IUUC-Itr-048046	Ictidomys tridecemlineatus	97.52	2.00e-167	581.00
IUUC-Lch-049504	Latimeria chalumnae	97.16	5.00e-167	579.00
IUUC-Lpe-050879	Leersia perrieri	40.25	1.00e-42	167.00
IUUC-Loc-052191	Lepisosteus oculatus	97.53	1.00e-167	582.00
IUUC-Laf-053668	Loxodonta africana	97.16	6.00e-167	579.00
IUUC-Mcc-054640	Macaca mulatta	97.53	3.00e-168	584.00
IUUC-Mtr-058747	Medicago truncatula	34.81	3.00e-42	166.00
IUUC-Mga-059503	Meleagris gallopavo	96.84	1.00e-167	582.00
IUUC-Mmr-060794	Microcebus murinus	97.52	2.00e-167	581.00
IUUC-Mmu-064129	Mus musculus	97.87	4.00e-168	583.00
IUUC-Mac-065670	Musa acuminata	35.79	5.00e-43	168.00
IUUC-Mpu-066488	Mustela putorius furo	97.17	2.00e-167	581.00
IUUC-Mlu-067207	Myotis lucifugus	96.49	4.00e-168	583.00
IUUC-Nle-069706	Nomascus leucogenys	97.53	4.00e-168	583.00
IUUC-Ocu-074876	Oryctolagus cuniculus	97.53	5.00e-168	583.00
IUUC-Oba-075454	Oryza barthii	40.66	4.00e-43	168.00
IUUC-Obr-076037	Oryza brachyantha	35.43	1.00e-40	160.00
IUUC-Ogl-077712	Oryza glaberrima	40.66	4.00e-43	168.00
IUUC-Ogu-078910	Oryza glumaepatula	40.83	8.00e-43	167.00
IUUC-Oin-079749	Oryza indica	40.66	4.00e-43	168.00
IUUC-Olo-080244	Oryza longistaminata	35.43	2.00e-40	160.00
IUUC-Ome-081318	Oryza meridionalis	40.66	5.00e-43	168.00
IUUC-Oni-083109	Oryza nivara	40.66	4.00e-43	168.00
IUUC-Opu-084065	Oryza punctata	41.08	2.00e-43	169.00
IUUC-Oru-084785	Oryza rufipogon	40.66	4.00e-43	168.00
IUUC-Osa-085610	Oryza sativa	40.66	4.00e-43	168.00
IUUC-Ola-086814	Oryzias latipes	100.00	3.00e-170	590.00
IUUC-Oga-088399	Otolemur garnettii	97.52	2.00e-167	581.00
IUUC-Oar-089323	Ovis aries	97.17	3.00e-167	580.00
IUUC-Ptr-090692	Pan troglodytes	96.85	5.00e-169	586.00
IUUC-Pan-092012	Papio anubis	97.53	3.00e-168	584.00
IUUC-Psi-093687	Pelodiscus sinensis	97.17	9.00e-168	582.00
IUUC-Pma-094387	Petromyzon marinus	91.93	3.00e-158	550.00
IUUC-Ppa-095212	Physcomitrella patens	35.82	1.00e-40	160.00
IUUC-Pfo-097134	Poecilia formosa	100.00	3.00e-170	590.00
IUUC-Pab-097555	Pongo abelii	97.53	3.00e-168	584.00
IUUC-Pop-099970	Populus trichocarpa	35.29	1.00e-44	173.00
IUUC-Ppe-101760	Prunus persica	36.10	2.00e-43	169.00
IUUC-Rno-104866	Rattus norvegicus	97.87	4.00e-168	583.00
IUUC-Sha-106547	Sarcophilus harrisii	97.17	2.00e-167	581.00
IUUC-Smo-109412	Selaginella moellendorffii	34.02	5.00e-40	158.00
IUUC-Sit-110595	Setaria italica	37.11	3.00e-42	165.00
IUUC-Sly-111259	Solanum lycopersicum	36.76	1.00e-41	163.00
IUUC-Stu-112571	Solanum tuberosum	36.76	7.00e-42	164.00
IUUC-Sbi-114090	Sorghum bicolor	37.50	5.00e-43	168.00
IUUC-Tgu-116579	Taeniopygia guttata	97.16	6.00e-167	579.00
IUUC-Tru-118250	Takifugu rubripes	94.68	3.00e-160	557.00
IUUC-Tni-120488	Tetraodon nigroviridis	98.94	6.00e-166	576.00
IUUC-Tca-121228	Theobroma cacao	36.61	1.00e-41	163.00
IUUC-Tae-123647	Triticum aestivum	37.36	6.00e-45	174.00
IUUC-Tur-126259	Triticum urartu	35.11	9.00e-40	157.00
IUUC-Ttr-129166	Tursiops truncatus	96.68	1.00e-140	492.00
IUUC-Vvi-131451	Vitis vinifera	37.86	6.00e-42	164.00
IUUC-Xtr-132553	Xenopus tropicalis	97.52	2.00e-167	581.00
IUUC-Xma-133670	Xiphophorus maculatus	100.00	3.00e-170	590.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence