iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cne-026947

Ensembl Protein ID

AAW43831

UniProt Accession

P0CS28; Q55SA5; Q5KGQ2; ATG18_CRYNJ

Genbank Protein ID

AAW43831.1

Protein Name

Autophagy-related protein 18

Genbank Nucleotide ID

AE017345

Gene Name

ATG18; CNE02750

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CNE02750	AAW43831	AAW43831

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.80e-08	31.8	247	278

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 3    tdsvtclaf...sdtllvsGsdDgtikvWDlrt 32
           ++++++++f   s tll+++sd  ti++++l +
   Q: 247  SARIFSINFnlmS-TLLAVSSDTSTIHIYRLAS 278
           567******9655.9***************865 PP

Organism

Cryptococcus neoformans

Functional Description
(View)

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Protein Sequence
(Fasta)

MSRLAKRHPD LLSCNFNQDY SCIAVGHKKG YTILNCDPFG KVHSNNDQGA TGIVEMLFCT 60
SLVALVGAAE NQPSNSPRKL QIVNTKRQST ICELIFPTSV LAVKMNRKRL IVVLENEIYI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGCCATGTC CCGCCTCGCC AAGCGCCATC CAGACTTGCT CGTCAGTCTC CCCGCGTCCC 60
CCCAGCCCCG CTGACTCTCC CTCTCCAGAG CTGCAACTTC AACCAGGACT ACTCCTGCAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0967--Endosome
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0926--Vacuole
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

SMART

SM00320--WD40

Gene Ontology

GO:0010008--C:endosome membrane
GO:0000329--C:fungal-type vacuole membrane
GO:0005794--C:Golgi apparatus
GO:0034045--C:pre-autophagosomal structure membrane
GO:0016236--P:macroautophagy
GO:0015031--P:protein transport

KEGG

cne:CNE02750

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000966	Aegilops tauschii	33.66	2.00e-50	191.00
IUUC-Aml-001842	Ailuropoda melanoleuca	36.48	2.00e-65	241.00
IUUC-Atr-002710	Amborella trichopoda	34.24	6.00e-48	182.00
IUUC-Apl-003390	Anas platyrhynchos	35.98	5.00e-65	239.00
IUUC-Aca-004975	Anolis carolinensis	36.63	3.00e-68	250.00
IUUC-Aly-006332	Arabidopsis lyrata	33.09	3.00e-49	187.00
IUUC-Ath-007660	Arabidopsis thaliana	33.33	2.00e-45	174.00
IUUC-Ago-007948	Ashbya gossypii	59.72	9.00e-49	186.00
IUUC-Acl-008148	Aspergillus clavatus	51.31	3.00e-105	373.00
IUUC-Afl-008562	Aspergillus flavus	51.33	6.00e-102	362.00
IUUC-Afu-008936	Aspergillus fumigatus	50.70	8.00e-105	371.00
IUUC-Ani-009254	Aspergillus nidulans	51.18	3.00e-107	379.00
IUUC-Ang-009798	Aspergillus niger	51.91	2.00e-105	374.00
IUUC-Aor-010066	Aspergillus oryzae	51.33	6.00e-102	362.00
IUUC-Ate-010266	Aspergillus terreus	51.68	7.00e-108	382.00
IUUC-Ame-010727	Astyanax mexicanus	37.11	1.00e-70	258.00
IUUC-Bta-012655	Bos taurus	36.87	2.00e-69	254.00
IUUC-Bci-013627	Botrytis cinerea	47.64	3.00e-95	340.00
IUUC-Bdi-014739	Brachypodium distachyon	35.05	3.00e-51	193.00
IUUC-Bol-015944	Brassica oleracea	31.33	8.00e-39	152.00
IUUC-Bra-017319	Brassica rapa	31.66	7.00e-39	152.00
IUUC-Cel-018503	Caenorhabditis elegans	31.21	7.00e-46	176.00
IUUC-Cja-018829	Callithrix jacchus	35.10	2.00e-61	227.00
IUUC-Cfa-020858	Canis familiaris	36.23	5.00e-65	239.00
IUUC-Cpo-022235	Cavia porcellus	36.34	3.00e-65	240.00
IUUC-Cre-022613	Chlamydomonas reinhardtii	33.51	6.00e-45	172.00
IUUC-Csa-023963	Chlorocebus sabaeus	34.64	4.00e-62	229.00
IUUC-Cho-024328	Choloepus hoffmanni	37.60	2.00e-61	227.00
IUUC-Cin-025343	Ciona intestinalis	35.31	6.00e-59	219.00
IUUC-Csv-025920	Ciona savignyi	36.88	1.00e-62	231.00
IUUC-Cgl-026425	Colletotrichum gloeosporioides	53.59	4.00e-37	146.00
IUUC-Dre-027490	Danio rerio	36.87	2.00e-70	257.00
IUUC-Dno-030057	Dasypus novemcinctus	36.43	2.00e-64	238.00
IUUC-Dor-030472	Dipodomys ordii	35.43	2.00e-59	221.00
IUUC-Dse-031215	Dothistroma septosporum	42.56	2.00e-87	313.00
IUUC-Dme-031881	Drosophila melanogaster	31.16	1.00e-35	141.00
IUUC-Ete-032276	Echinops telfairi	35.32	2.00e-51	194.00
IUUC-Eca-034362	Equus caballus	36.72	1.00e-65	241.00
IUUC-Eeu-034479	Erinaceus europaeus	33.33	4.00e-22	95.90
IUUC-Fca-036230	Felis catus	36.57	2.00e-65	240.00
IUUC-Fal-036782	Ficedula albicollis	34.82	8.00e-66	242.00
IUUC-Fox-037797	Fusarium oxysporum	45.68	2.00e-93	333.00
IUUC-Fso-038174	Fusarium solani	46.33	2.00e-92	330.00
IUUC-Gmo-039706	Gadus morhua	33.17	8.00e-56	209.00
IUUC-Ggr-040113	Gaeumannomyces graminis	54.81	8.00e-74	269.00
IUUC-Gga-040690	Gallus gallus	36.63	6.00e-69	252.00
IUUC-Gac-041360	Gasterosteus aculeatus	36.54	3.00e-69	253.00
IUUC-Gma-043876	Glycine max	32.94	1.00e-50	191.00
IUUC-Ggo-045610	Gorilla gorilla	31.44	4.00e-33	133.00
IUUC-Hsa-046782	Homo sapiens	34.64	7.00e-62	229.00
IUUC-Hvu-047851	Hordeum vulgare	34.40	2.00e-50	191.00
IUUC-Itr-048693	Ictidomys tridecemlineatus	34.81	3.00e-62	230.00
IUUC-Kpa-049378	Komagataella pastoris	48.25	4.00e-72	263.00
IUUC-Lch-050413	Latimeria chalumnae	36.66	3.00e-62	230.00
IUUC-Lpe-051205	Leersia perrieri	35.09	2.00e-50	191.00
IUUC-Loc-052379	Lepisosteus oculatus	33.98	5.00e-34	136.00
IUUC-Lma-052948	Leptosphaeria maculans	47.53	9.00e-103	365.00
IUUC-Laf-054007	Loxodonta africana	37.11	1.00e-69	254.00
IUUC-Mcc-055304	Macaca mulatta	34.40	2.00e-32	130.00
IUUC-Meu-056020	Macropus eugenii	28.83	3.00e-25	107.00
IUUC-Mor-057125	Magnaporthe oryzae	45.10	5.00e-98	349.00
IUUC-Mpo-057416	Magnaporthe poae	29.59	4.00e-30	123.00
IUUC-Mtr-058536	Medicago truncatula	33.50	2.00e-45	174.00
IUUC-Mla-058885	Melampsora laricipopulina	25.48	3.00e-15	73.20
IUUC-Mga-059795	Meleagris gallopavo	35.98	4.00e-65	239.00
IUUC-Mvi-060219	Microbotryum violaceum	55.42	9.00e-124	434.00
IUUC-Mmr-061096	Microcebus murinus	36.21	7.00e-66	242.00
IUUC-Mdo-062881	Monodelphis domestica	36.43	2.00e-67	247.00
IUUC-Mmu-063787	Mus musculus	36.83	4.00e-68	249.00
IUUC-Mac-064838	Musa acuminata	33.84	4.00e-51	193.00
IUUC-Mpu-066019	Mustela putorius furo	34.97	5.00e-61	226.00
IUUC-Mlu-068016	Myotis lucifugus	36.63	1.00e-68	251.00
IUUC-Nfi-068424	Neosartorya fischeri	51.30	2.00e-105	373.00
IUUC-Ncr-068833	Neurospora crassa	47.42	2.00e-98	350.00
IUUC-Nle-069047	Nomascus leucogenys	35.58	4.00e-38	149.00
IUUC-Opr-070933	Ochotona princeps	35.60	2.00e-45	174.00
IUUC-Ont-072495	Oreochromis niloticus	37.53	9.00e-71	258.00
IUUC-Oan-073084	Ornithorhynchus anatinus	37.30	2.00e-62	231.00
IUUC-Ocu-074689	Oryctolagus cuniculus	35.85	4.00e-64	236.00
IUUC-Oba-075827	Oryza barthii	35.09	1.00e-50	191.00
IUUC-Obr-076476	Oryza brachyantha	34.59	6.00e-50	189.00
IUUC-Ogl-077630	Oryza glaberrima	35.09	1.00e-50	191.00
IUUC-Ogu-078126	Oryza glumaepatula	34.59	3.00e-50	190.00
IUUC-Oin-080115	Oryza indica	35.09	1.00e-50	191.00
IUUC-Olo-080657	Oryza longistaminata	35.34	1.00e-49	190.00
IUUC-Ome-081702	Oryza meridionalis	35.09	4.00e-49	187.00
IUUC-Oni-082884	Oryza nivara	35.09	4.00e-50	191.00
IUUC-Opu-083460	Oryza punctata	35.09	8.00e-50	190.00
IUUC-Oru-084193	Oryza rufipogon	35.09	1.00e-50	191.00
IUUC-Osa-085948	Oryza sativa	35.09	1.00e-50	191.00
IUUC-Ola-086628	Oryzias latipes	35.21	1.00e-40	158.00
IUUC-Olu-087808	Ostreococcus lucimarinus	31.27	2.00e-46	177.00
IUUC-Oga-088894	Otolemur garnettii	34.97	1.00e-62	231.00
IUUC-Oar-089850	Ovis aries	35.98	2.00e-65	241.00
IUUC-Ptr-090456	Pan troglodytes	34.64	7.00e-62	229.00
IUUC-Pan-092111	Papio anubis	36.39	5.00e-66	243.00
IUUC-Psi-094095	Pelodiscus sinensis	35.96	2.00e-65	240.00
IUUC-Pma-094403	Petromyzon marinus	30.47	1.00e-29	121.00
IUUC-Pno-095015	Phaeosphaeria nodorum	46.48	3.00e-93	333.00
IUUC-Ppa-095480	Physcomitrella patens	33.67	1.00e-44	172.00
IUUC-Pfo-096987	Poecilia formosa	36.52	5.00e-69	253.00
IUUC-Pab-097754	Pongo abelii	35.48	1.00e-61	228.00
IUUC-Pop-099157	Populus trichocarpa	32.01	5.00e-43	166.00
IUUC-Pca-100176	Procavia capensis	27.81	4.00e-25	107.00
IUUC-Ppe-101963	Prunus persica	30.81	3.00e-38	150.00
IUUC-Pva-103047	Pteropus vampyrus	35.07	2.00e-64	237.00
IUUC-Pgr-103258	Puccinia graminis	26.86	2.00e-15	75.50
IUUC-Ptt-103915	Puccinia triticina	24.48	1.00e-18	85.90
IUUC-Pte-104139	Pyrenophora teres	47.33	3.00e-96	343.00
IUUC-Pyt-104488	Pyrenophora triticirepentis	48.20	1.00e-95	341.00
IUUC-Rno-105990	Rattus norvegicus	37.07	2.00e-68	251.00
IUUC-Sce-106327	Saccharomyces cerevisiae	56.77	5.00e-50	189.00
IUUC-Sha-106581	Sarcophilus harrisii	36.23	2.00e-65	241.00
IUUC-Sja-107913	Schizosaccharomyces japonicus	44.03	5.00e-85	305.00
IUUC-Spo-108068	Schizosaccharomyces pombe	44.59	5.00e-74	269.00
IUUC-Ssl-108418	Sclerotinia sclerotiorum	48.46	2.00e-104	370.00
IUUC-Smo-109446	Selaginella moellendorffii	35.09	4.00e-52	196.00
IUUC-Sit-110655	Setaria italica	32.13	2.00e-42	164.00
IUUC-Sly-111030	Solanum lycopersicum	33.33	6.00e-46	176.00
IUUC-Stu-111954	Solanum tuberosum	30.92	3.00e-38	150.00
IUUC-Sar-113276	Sorex araneus	34.97	6.00e-22	95.90
IUUC-Sbi-114057	Sorghum bicolor	30.99	1.00e-39	155.00
IUUC-Sre-115219	Sporisorium reilianum	58.60	1.00e-125	441.00
IUUC-Ssc-116360	Sus scrofa	36.39	1.00e-68	251.00
IUUC-Tgu-116951	Taeniopygia guttata	35.98	3.00e-65	240.00
IUUC-Tru-117889	Takifugu rubripes	35.50	2.00e-66	244.00
IUUC-Tsy-119533	Tarsius syrichta	42.17	9.00e-17	78.20
IUUC-Tni-119729	Tetraodon nigroviridis	33.46	2.00e-33	134.00
IUUC-Tca-121459	Theobroma cacao	29.34	2.00e-32	130.00
IUUC-Tre-121895	Trichoderma reesei	46.10	3.00e-103	367.00
IUUC-Tvi-122311	Trichoderma virens	46.15	2.00e-104	370.00
IUUC-Tae-124901	Triticum aestivum	33.66	1.00e-50	191.00
IUUC-Tur-126757	Triticum urartu	32.92	2.00e-48	184.00
IUUC-Ttr-128940	Tursiops truncatus	34.93	2.00e-30	124.00
IUUC-Uma-129438	Ustilago maydis	58.33	2.00e-117	413.00
IUUC-Vda-129782	Verticillium dahliae	42.62	2.00e-67	247.00
IUUC-Vvi-131674	Vitis vinifera	32.58	1.00e-48	184.00
IUUC-Xtr-131806	Xenopus tropicalis	35.21	5.00e-38	149.00
IUUC-Xma-133370	Xiphophorus maculatus	36.52	5.00e-69	253.00
IUUC-Yli-134337	Yarrowia lipolytica	55.25	2.00e-109	387.00
IUUC-Zma-135902	Zea mays	31.48	4.00e-42	164.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence