iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Ath-007486

UUCD1 version

UUC-ArT-01637

Ensembl Protein ID

AT5G25760.1

UniProt Accession

Q8LGF7; PEX4_ARATH

Genbank Protein ID

AAY44861.1; AED93482.1; AED93483.1; AAM60888.1; ABF59034.1

Protein Name

Protein PEROXIN-4; E2 ubiquitin-conjugating enzyme 21; Probable ubiquitin-conjugating enzyme E2 21; Ubiquitin carrier protein 21

Genbank Nucleotide ID

DQ027035; AC005405; CP002688; AY084297; BT025616

Gene Name

PEX4; UBC21; At5g25760; F18A17.10

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT5G25760	AT5G25760.1	AT5G25760.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
PINA	HINT
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	2.60e-41	141.5	7	136

Active Site

Position(s)	Description	Evidence
90	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    Rlkkelkelekdpp..egisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsilkeeekWspa 95
           Rl ke+ke++++++  + i++ ++d  ++++w +li Gp++tpYeggvF+l +++pe YP++PP+v+fltkifhPnv+ + G++Cl+ilk  ++Wspa
   Q: 7    RLFKEYKEVQREKVadPDIQLICDDT-NIFKWTALIKGPSETPYEGGVFQLAFSVPEPYPLQPPQVRFLTKIFHPNVHFKtGEICLDILK--NAWSPA 101
           899******99998446677666666.9**************************************************888********9..****** PP
   S: 96   lsvesvllsiqsllaepnpesplneeaaellkknr 130
           ++++sv+ +i++l+a+p+p+spln ++ +ll++ +
   Q: 102  WTLQSVCRAIIALMAHPEPDSPLNCDSGNLLRSGD 136
           **************************999988754 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Required for peroxisome biogenesis. Necessary for the developmental elimination of obsolete peroxisome matrix proteins. May be involved in the ubiquitination of PEX5, targeting it for recycling. Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.

Protein Sequence
(Fasta)

MQASRARLFK EYKEVQREKV ADPDIQLICD DTNIFKWTAL IKGPSETPYE GGVFQLAFSV 60
PEPYPLQPPQ VRFLTKIFHP NVHFKTGEIC LDILKNAWSP AWTLQSVCRA IIALMAHPEP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACATAATCAT CGCTATTCTC TCTCTCTCTC TCTCTCTCTC TCTCTCTCGC TCTCATATTT 60
GCAGGTAAAG CTTCGTTGAT TCGTCCTCTT TATGTTCAAT TATAGTTTCG CATCCCTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0576--Peroxisome
KW-0962--Peroxisome biogenesis
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0808--Transferase
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005778--C:peroxisomal membrane
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006635--P:fatty acid beta-oxidation
GO:0007031--P:peroxisome organization
GO:0016558--P:protein import into peroxisome matrix

KEGG

ath:AT5G25760

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000555	Aegilops tauschii	90.97	7.00e-85	305.00
IUUC-Atr-002740	Amborella trichopoda	92.36	4.00e-87	312.00
IUUC-Aly-006113	Arabidopsis lyrata	98.09	9.00e-92	327.00
IUUC-Afl-008430	Aspergillus flavus	41.89	6.00e-31	125.00
IUUC-Ani-009452	Aspergillus nidulans	43.05	2.00e-32	130.00
IUUC-Aor-010187	Aspergillus oryzae	41.89	6.00e-31	125.00
IUUC-Bdi-014648	Brachypodium distachyon	92.31	3.00e-86	309.00
IUUC-Bol-016138	Brassica oleracea	96.82	2.00e-90	323.00
IUUC-Bra-017259	Brassica rapa	97.40	1.00e-89	320.00
IUUC-Cre-022583	Chlamydomonas reinhardtii	68.92	2.00e-62	230.00
IUUC-Cgl-026528	Colletotrichum gloeosporioides	41.10	7.00e-30	122.00
IUUC-Cme-027300	Cyanidioschyzon merolae	60.98	1.00e-37	147.00
IUUC-Gma-043907	Glycine max	94.27	2.00e-88	317.00
IUUC-Kpa-049387	Komagataella pastoris	32.98	6.00e-29	119.00
IUUC-Lpe-051399	Leersia perrieri	92.72	5.00e-84	303.00
IUUC-Lma-053321	Leptosphaeria maculans	44.53	4.00e-30	122.00
IUUC-Mtr-058439	Medicago truncatula	93.63	6.00e-88	315.00
IUUC-Mvi-060238	Microbotryum violaceum	55.56	1.00e-38	150.00
IUUC-Mac-064623	Musa acuminata	92.99	6.00e-87	313.00
IUUC-Nfi-068258	Neosartorya fischeri	40.79	9.00e-32	128.00
IUUC-Oba-075919	Oryza barthii	92.90	5.00e-85	306.00
IUUC-Obr-076554	Oryza brachyantha	93.63	9.00e-88	314.00
IUUC-Ogu-078897	Oryza glumaepatula	93.15	2.00e-80	291.00
IUUC-Oni-082318	Oryza nivara	75.98	1.00e-75	275.00
IUUC-Opu-083715	Oryza punctata	93.42	1.00e-84	305.00
IUUC-Oru-084851	Oryza rufipogon	93.55	7.00e-86	308.00
IUUC-Osa-085417	Oryza sativa	93.63	9.00e-88	314.00
IUUC-Pno-095034	Phaeosphaeria nodorum	45.21	2.00e-27	114.00
IUUC-Ppa-095796	Physcomitrella patens	79.35	1.00e-73	267.00
IUUC-Pop-098843	Populus trichocarpa	94.27	4.00e-88	315.00
IUUC-Ppe-101953	Prunus persica	93.63	4.00e-88	315.00
IUUC-Pte-104310	Pyrenophora teres	51.72	7.00e-32	129.00
IUUC-Pyt-104497	Pyrenophora triticirepentis	50.43	3.00e-31	127.00
IUUC-Sja-107788	Schizosaccharomyces japonicus	50.41	3.00e-38	150.00
IUUC-Spo-108341	Schizosaccharomyces pombe	47.10	9.00e-40	155.00
IUUC-Sit-110558	Setaria italica	93.63	9.00e-88	314.00
IUUC-Sly-111535	Solanum lycopersicum	92.99	4.00e-88	315.00
IUUC-Stu-112232	Solanum tuberosum	92.99	4.00e-88	315.00
IUUC-Sbi-113774	Sorghum bicolor	93.63	6.00e-88	315.00
IUUC-Sre-114982	Sporisorium reilianum	47.24	1.00e-41	161.00
IUUC-Tca-121736	Theobroma cacao	94.87	1.00e-88	317.00
IUUC-Tre-121936	Trichoderma reesei	37.25	8.00e-23	99.00
IUUC-Tvi-122646	Trichoderma virens	37.58	3.00e-30	123.00
IUUC-Tae-124241	Triticum aestivum	91.67	6.00e-86	308.00
IUUC-Tur-126566	Triticum urartu	90.97	1.00e-84	304.00
IUUC-Tme-127194	Tuber melanosporum	39.19	2.00e-31	127.00
IUUC-Uma-129494	Ustilago maydis	47.59	1.00e-36	144.00
IUUC-Vda-129894	Verticillium dahliae	38.19	8.00e-26	108.00
IUUC-Vvi-131056	Vitis vinifera	93.63	2.00e-88	317.00
IUUC-Yli-134417	Yarrowia lipolytica	46.00	1.00e-39	154.00
IUUC-Zma-135372	Zea mays	93.63	6.00e-88	315.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence