iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Afu-009071

Ensembl Protein ID

CADAFUAP00002220

UniProt Accession

Q4WMA4; Q4WMA4_ASPFU

Genbank Protein ID

EAL88910.1

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

AAHF01000006

Gene Name

AFUA_6G10600

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADAFUAG00002220	CADAFUAT00002220	CADAFUAP00002220

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	3.50e-59	200.1	19	547

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagg............lGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaeal 81
           YDRQ+rlw + +q++l++++vllv+ +g             G+E+lKnLvl G+g +t+vD + v+  +l+ +F+++ e+ gks+Ae +++ l
   Q: 19   YDRQLRLWAASGQQALEESRVLLVNSDGswgdqgtgvsgvAGVETLKNLVLPGIGGFTIVDPAVVTEPDLGVNFFLESESLGKSRAEETCRLL 111
           ************************9865444444333333589************************************************** PP
   S: 82   kelnpdvnveaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclna...rvpliesgtlGllGqvrviikg.ltecyscsd....d 165
           +elnpdv++++  +si+e  ++++ F+ ++ +V++    ++ r +++++c +a   ++p +  ++ G+++  +  ++  +++ + ++d    +
   Q: 112  RELNPDVEGSFRPKSISEVLQQEPdFLAQHRLVLISGP-VK-RSTLDTVCNAAkalNIPVLYLRSVGFYSVFSLQLPAdFPIVETHPDpeatQ 202
           **********************99*********87644.33.44799999777888******************9997256666676699999 PP
   S: 166  ppqktiPfctlketpn..........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks....edeenfeeaieiavka 244
           ++++ +P+++l+   +           ++ +++++ l+ ++le+++++++++ +++++ek+e+++ v++++++      een++ea+++++k+
   Q: 203  DLRLLNPWPELAAAGAsisnldsmddHQHGHVPYVLLLLHYLEKWKQAHDGKVPSNYKEKSEFREFVRASARTnnaeGGEENYDEAVAAVLKS 295
           ************99666667777777*******************************************999966665699************ PP
   S: 245  fakttins.ikqllksfecdivtkskspfwv.............................................................. 274
           +++++  + i++++++++c+++ +++++fw+                                                              
   Q: 296  LNPFSLRGsIREIFEMDQCKNLKQNSAEFWLiaaavhefyqthkvlplpgslpdmkaqsadyvslqniykskarkdveevtatvrrleaqlgp 388
           *****9999************************************************************************************ PP
   S: 275  ...........sfcsnaealq............vpekvekdeevvkasap...lylllralerfekk.kgrkpgelsfekdddsavdlvtaaa 340
                       fc+na+ ++              ++ +  + ++++s++   + ++ ++l+   ++ ++++ +++s+++++     + + ++
   Q: 389  raavipdkdieIFCKNAAHIKvihgrdipringDAQTLKAITDNLSSSEAlvpIFIACQILDDIVTDiQESNIADVSLDDESLWNTHIQQVIS 481
           *********************666555444443337777777777777778888888888887765514455555555555543333333333 PP
   S: 341  nlra..eslgiep.kldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfda 403
           nl    + ++ ++ +   ++++e+ +++ ++++ ++a  gGl+aqE++Kv++ +++pl+n+ +fd+
   Q: 482  NLASdpTAIDERArEKILEATQELRRTEGGELHNISALTGGLVAQEALKVITRQYVPLDNTCIFDG 547
           44332244444444455567899*****************************************97 PP

Organism

Aspergillus fumigatus

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.

Protein Sequence
(Fasta)

MTDTFPAALV GPSSKERKYD RQLRLWAASG QQALEESRVL LVNSDGSWGD QGTGVSGVAG 60
VETLKNLVLP GIGGFTIVDP AVVTEPDLGV NFFLESESLG KSRAEETCRL LRELNPDVEG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACTGATA CTTTCCCTGC TGCCCTGGTA GGGCCGTCTT CGAAGGAGAG GAAGTACGAT 60
CGCCAACTAC GTTTGTGGGC TGCGAGCGGG CAGCAAGCTC TTGAAGAGTC TCGTGTTTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

KEGG

afm:AFUA_6G10600

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	32.51	2.00e-74	271.00
IUUC-Aml-002333	Ailuropoda melanoleuca	33.93	2.00e-87	314.00
IUUC-Atr-002644	Amborella trichopoda	32.97	3.00e-68	250.00
IUUC-Apl-003446	Anas platyrhynchos	33.52	1.00e-77	281.00
IUUC-Aca-004450	Anolis carolinensis	32.91	3.00e-83	300.00
IUUC-Aly-006187	Arabidopsis lyrata	34.06	9.00e-80	289.00
IUUC-Ath-007600	Arabidopsis thaliana	33.64	6.00e-78	283.00
IUUC-Ago-007900	Ashbya gossypii	24.37	1.00e-30	125.00
IUUC-Acl-008333	Aspergillus clavatus	83.69	0.00e+00	947.00
IUUC-Afl-008529	Aspergillus flavus	77.24	0.00e+00	863.00
IUUC-Ani-009443	Aspergillus nidulans	73.61	0.00e+00	814.00
IUUC-Ang-009669	Aspergillus niger	77.26	0.00e+00	900.00
IUUC-Aor-009914	Aspergillus oryzae	76.73	0.00e+00	858.00
IUUC-Ate-010450	Aspergillus terreus	75.63	0.00e+00	861.00
IUUC-Ame-011183	Astyanax mexicanus	34.65	1.00e-91	328.00
IUUC-Bgr-012111	Blumeria graminis	45.18	4.00e-120	422.00
IUUC-Bta-012583	Bos taurus	33.75	2.00e-87	314.00
IUUC-Bci-013892	Botrytis cinerea	48.11	8.00e-138	481.00
IUUC-Bdi-014592	Brachypodium distachyon	33.52	4.00e-75	273.00
IUUC-Bol-016401	Brassica oleracea	32.25	5.00e-78	283.00
IUUC-Bra-017506	Brassica rapa	32.36	2.00e-74	271.00
IUUC-Cel-018456	Caenorhabditis elegans	29.90	6.00e-59	219.00
IUUC-Cja-020007	Callithrix jacchus	33.69	2.00e-87	314.00
IUUC-Cfa-020324	Canis familiaris	33.51	2.00e-87	315.00
IUUC-Cpo-022248	Cavia porcellus	30.42	1.00e-47	182.00
IUUC-Csa-023149	Chlorocebus sabaeus	31.18	3.00e-64	237.00
IUUC-Cho-024537	Choloepus hoffmanni	27.22	2.00e-48	185.00
IUUC-Cin-025763	Ciona intestinalis	35.08	4.00e-84	303.00
IUUC-Csv-026113	Ciona savignyi	32.80	5.00e-85	306.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	43.12	1.00e-123	434.00
IUUC-Cne-026884	Cryptococcus neoformans	30.51	1.00e-66	245.00
IUUC-Dre-028140	Danio rerio	34.53	1.00e-88	318.00
IUUC-Dno-030033	Dasypus novemcinctus	37.29	4.00e-78	283.00
IUUC-Dor-030513	Dipodomys ordii	49.57	4.00e-24	104.00
IUUC-Dse-031536	Dothistroma septosporum	45.71	4.00e-138	483.00
IUUC-Dme-031683	Drosophila melanogaster	35.02	3.00e-80	290.00
IUUC-Ete-032420	Echinops telfairi	29.57	1.00e-66	245.00
IUUC-Eca-033992	Equus caballus	30.48	2.00e-61	227.00
IUUC-Eeu-034713	Erinaceus europaeus	51.85	4.00e-26	110.00
IUUC-Fca-036548	Felis catus	33.39	1.00e-86	311.00
IUUC-Fal-037600	Ficedula albicollis	31.69	2.00e-73	268.00
IUUC-Fox-038037	Fusarium oxysporum	46.18	3.00e-133	466.00
IUUC-Fso-038387	Fusarium solani	45.71	5.00e-135	472.00
IUUC-Gmo-038562	Gadus morhua	33.98	4.00e-89	320.00
IUUC-Ggr-040005	Gaeumannomyces graminis	47.08	2.00e-139	487.00
IUUC-Gga-041129	Gallus gallus	34.41	1.00e-82	298.00
IUUC-Gac-042558	Gasterosteus aculeatus	33.69	8.00e-87	312.00
IUUC-Gma-043610	Glycine max	33.27	5.00e-73	266.00
IUUC-Ggo-045611	Gorilla gorilla	33.87	3.00e-87	314.00
IUUC-Hsa-046563	Homo sapiens	33.87	1.00e-88	318.00
IUUC-Hvu-047790	Hordeum vulgare	29.18	4.00e-44	170.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	34.05	6.00e-88	316.00
IUUC-Kpa-049309	Komagataella pastoris	33.09	1.00e-72	265.00
IUUC-Lch-050038	Latimeria chalumnae	33.75	9.00e-79	285.00
IUUC-Lpe-051535	Leersia perrieri	30.40	1.00e-55	209.00
IUUC-Loc-051917	Lepisosteus oculatus	31.80	2.00e-76	278.00
IUUC-Lma-053112	Leptosphaeria maculans	49.56	5.00e-157	545.00
IUUC-Laf-053690	Loxodonta africana	33.51	1.00e-88	318.00
IUUC-Mcc-055117	Macaca mulatta	32.92	1.00e-83	302.00
IUUC-Meu-056761	Macropus eugenii	26.56	3.00e-56	210.00
IUUC-Mor-057230	Magnaporthe oryzae	46.77	6.00e-142	495.00
IUUC-Mpo-057514	Magnaporthe poae	46.23	5.00e-130	456.00
IUUC-Mtr-058551	Medicago truncatula	31.75	2.00e-66	244.00
IUUC-Mla-059183	Melampsora laricipopulina	33.22	1.00e-81	295.00
IUUC-Mga-060144	Meleagris gallopavo	33.21	1.00e-78	285.00
IUUC-Mvi-060221	Microbotryum violaceum	38.39	2.00e-69	254.00
IUUC-Mmr-061325	Microcebus murinus	33.04	2.00e-82	297.00
IUUC-Mdo-062532	Monodelphis domestica	33.69	1.00e-87	315.00
IUUC-Mmu-063956	Mus musculus	33.87	1.00e-88	318.00
IUUC-Mac-064521	Musa acuminata	32.26	2.00e-73	268.00
IUUC-Mpu-066716	Mustela putorius furo	33.01	6.00e-78	283.00
IUUC-Mlu-067459	Myotis lucifugus	34.00	3.00e-90	323.00
IUUC-Nfi-068245	Neosartorya fischeri	95.69	0.00e+00	1073.00
IUUC-Ncr-068910	Neurospora crassa	47.14	1.00e-145	508.00
IUUC-Nle-070034	Nomascus leucogenys	32.29	1.00e-79	288.00
IUUC-Opr-070552	Ochotona princeps	34.94	4.00e-65	240.00
IUUC-Ont-071426	Oreochromis niloticus	35.24	7.00e-92	329.00
IUUC-Oan-073389	Ornithorhynchus anatinus	31.44	2.00e-56	211.00
IUUC-Ocu-074911	Oryctolagus cuniculus	33.75	2.00e-87	314.00
IUUC-Oba-075437	Oryza barthii	31.69	7.00e-63	233.00
IUUC-Obr-076684	Oryza brachyantha	30.84	4.00e-57	214.00
IUUC-Ogl-077170	Oryza glaberrima	31.69	7.00e-63	233.00
IUUC-Ogu-078844	Oryza glumaepatula	31.24	9.00e-56	209.00
IUUC-Oin-079105	Oryza indica	31.69	4.00e-63	233.00
IUUC-Olo-080943	Oryza longistaminata	28.74	2.00e-49	188.00
IUUC-Oni-082891	Oryza nivara	29.33	6.00e-57	213.00
IUUC-Opu-083457	Oryza punctata	31.69	1.00e-61	229.00
IUUC-Oru-084960	Oryza rufipogon	28.71	1.00e-49	189.00
IUUC-Osa-085358	Oryza sativa	31.69	1.00e-62	232.00
IUUC-Ola-086420	Oryzias latipes	31.84	3.00e-53	200.00
IUUC-Olu-087625	Ostreococcus lucimarinus	25.64	2.00e-41	161.00
IUUC-Oga-088810	Otolemur garnettii	33.51	6.00e-88	316.00
IUUC-Oar-089196	Ovis aries	33.51	3.00e-86	310.00
IUUC-Ptr-090617	Pan troglodytes	33.69	1.00e-87	315.00
IUUC-Pan-092761	Papio anubis	34.05	5.00e-89	320.00
IUUC-Psi-093191	Pelodiscus sinensis	32.54	2.00e-78	284.00
IUUC-Pma-094380	Petromyzon marinus	38.88	4.00e-78	283.00
IUUC-Pno-095084	Phaeosphaeria nodorum	46.33	4.00e-134	471.00
IUUC-Ppa-095875	Physcomitrella patens	31.17	1.00e-70	258.00
IUUC-Pfo-096467	Poecilia formosa	34.83	1.00e-90	325.00
IUUC-Pab-098255	Pongo abelii	37.80	8.00e-79	285.00
IUUC-Pop-099871	Populus trichocarpa	32.97	5.00e-76	276.00
IUUC-Pca-100807	Procavia capensis	35.92	3.00e-28	117.00
IUUC-Ppe-101280	Prunus persica	33.15	9.00e-79	285.00
IUUC-Pva-102333	Pteropus vampyrus	32.85	2.00e-79	288.00
IUUC-Pgr-103401	Puccinia graminis	30.58	2.00e-65	241.00
IUUC-Ptt-103889	Puccinia triticina	30.34	1.00e-67	249.00
IUUC-Pte-104355	Pyrenophora teres	50.26	3.00e-157	546.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	50.09	5.00e-156	542.00
IUUC-Rno-105810	Rattus norvegicus	33.51	1.00e-86	311.00
IUUC-Sha-106770	Sarcophilus harrisii	39.45	1.00e-52	197.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	31.68	8.00e-75	272.00
IUUC-Spo-108276	Schizosaccharomyces pombe	33.27	9.00e-77	279.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	48.57	7.00e-142	495.00
IUUC-Smo-109296	Selaginella moellendorffii	32.25	2.00e-74	271.00
IUUC-Sit-110157	Setaria italica	32.61	2.00e-74	271.00
IUUC-Sly-111105	Solanum lycopersicum	32.26	5.00e-76	276.00
IUUC-Stu-112469	Solanum tuberosum	32.98	1.00e-77	282.00
IUUC-Sar-113083	Sorex araneus	38.56	1.00e-24	105.00
IUUC-Sbi-113813	Sorghum bicolor	32.19	3.00e-72	264.00
IUUC-Sre-115058	Sporisorium reilianum	38.77	2.00e-69	255.00
IUUC-Tgu-116772	Taeniopygia guttata	32.25	4.00e-75	273.00
IUUC-Tru-118686	Takifugu rubripes	34.71	7.00e-93	332.00
IUUC-Tsy-119111	Tarsius syrichta	34.59	8.00e-43	166.00
IUUC-Tni-120231	Tetraodon nigroviridis	31.25	3.00e-75	274.00
IUUC-Tca-121491	Theobroma cacao	33.21	2.00e-70	258.00
IUUC-Tre-122103	Trichoderma reesei	45.99	8.00e-135	472.00
IUUC-Tvi-122672	Trichoderma virens	44.68	7.00e-133	465.00
IUUC-Tae-125684	Triticum aestivum	32.51	1.00e-74	272.00
IUUC-Tur-126487	Triticum urartu	31.55	3.00e-70	257.00
IUUC-Tme-127097	Tuber melanosporum	37.94	4.00e-95	340.00
IUUC-Ttr-128465	Tursiops truncatus	31.72	2.00e-72	265.00
IUUC-Uma-129645	Ustilago maydis	38.33	3.00e-70	257.00
IUUC-Vda-129989	Verticillium dahliae	40.60	5.00e-105	372.00
IUUC-Vpa-130529	Vicugna pacos	31.90	4.00e-76	277.00
IUUC-Vvi-131059	Vitis vinifera	32.42	1.00e-73	268.00
IUUC-Xtr-132002	Xenopus tropicalis	35.44	7.00e-93	332.00
IUUC-Xma-133930	Xiphophorus maculatus	34.71	5.00e-89	319.00
IUUC-Yli-134505	Yarrowia lipolytica	33.88	1.00e-80	291.00
IUUC-Zma-135619	Zea mays	32.55	9.00e-70	256.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence