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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Ath-007612
UUCD1 version UUC-ArT-01663
Ensembl Protein ID AT1G22920.1
UniProt Accession Q8LAZ7; A1A6G7; F4I325; O23130; O82524; Q84WE7; CSN5A_ARATH
Genbank Protein ID AAC36344.1; AAL58105.1; AAB96974.1; AAB72159.1; AEE30309.1; AEE30310.1; ABL66743.1; AAM65053.1; AAO41956.1
Protein Name COP9 signalosome complex subunit 5a; Jun activation domain-binding homolog 1
Genbank Nucleotide ID AF087413; AF395062; AF042334; AF000657; CP002684; CP002684; BT029486; AY087510; BT003909
Gene Name CSN5B; CSN5A; AJH1; At1g22920; F19G10.12
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT1G22920 AT1G22920.1 AT1G22920.1
AT1G22920 AT1G22920.2 AT1G22920.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
Protein-protein Interaction
PINAHINTMentha
Post-translational Modifications (PTMs)
dbPPTUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/JAMM 2.00e-07 31.8 142 155
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/JAMM
   S: 1    HSHPgftcwlSsVD 14
           HSHPg++cwlS++D
   Q: 142  HSHPGYGCWLSGID 155
           *************9 PP
   
Organism Arabidopsis thaliana
Functional Description
(View)

Functional Description


     Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex (By similarity). The CSN complex is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of PSIAA6 by regulating the activity of the Ubl ligase SCF-TIR complex. Involved in CSN's deneddylation/derubylation activity (PubMed:15486099). Required for the deneddylation of all cullins (PubMed:15923347, PubMed:17307927). Essential for the structural integrity of the CSN holocomplex (PubMed:17307927).
 Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex (By similarity). The CSN complex is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of PSIAA6 by regulating the activity of the Ubl ligase SCF-TIR complex. Involved in CSN's deneddylation/derubylation activity (PubMed:15486099). Required for the deneddylation of all cullins (PubMed:15923347, PubMed:17307927). Essential for the structural integrity of the CSN holocomplex (PubMed:17307927).
Protein Sequence
(Fasta)
MEGSSSAIAR KTWELENNIL PVEPTDSASD SIFHYDDASQ AKIQQEKPWA SDPNYFKRVH 60
ISALALLKMV VHARSGGTIE IMGLMQGKTE GDTIIVMDAF ALPVEGTETR VNAQSDAYEY 120
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Protein Fasta Sequence


>IUUC-Ath-007612|DUB,JAMM|Arabidopsis thaliana
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Nucleotide Sequence
(Fasta)
AGTAAATCCA TTTTGAGTTT TGTTCTCGCA AACCGGTTTA ACCCAAGAAC CCAAAGATCT 60
CTCTCTATTT GTTTGCCTTC TTCTTTCTTT CTGACTCAAA CCCTCAAATC AATTCTCGCG 120
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Nucleotide Fasta Sequence


>IUUC-Ath-007612|DUB,JAMM|Arabidopsis thaliana
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Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0539--Nucleus
KW-0607--Phytochrome signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0736--Signalosome
KW-0862--Zinc
Interpro

IPR000555--JAMM/MPN+_dom
Pfam

PF01398--JAB
SMART

SM00232--JAB_MPN
Gene Ontology

GO:0008180--C:COP9 signalosome
GO:0005737--C:cytoplasm
GO:0046872--F:metal ion binding
GO:0008237--F:metallopeptidase activity
GO:0010387--P:COP9 signalosome assembly
GO:0010100--P:negative regulation of photomorphogenesis
GO:0010971--P:positive regulation of G2/M transition of mitotic cell cycle
GO:0000338--P:protein deneddylation
GO:0009585--P:red, far-red light phototransduction
GO:0031347--P:regulation of defense response
GO:0009733--P:response to auxin
GO:0010093--P:specification of floral organ identity
KEGG ath:AT1G22920
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000468 Aegilops tauschii 76.88 2.00e-154 537.00
IUUC-Aly-006559 Arabidopsis lyrata 97.20 0.00e+00 699.00
IUUC-Ago-007860 Ashbya gossypii 47.96 5.00e-54 204.00
IUUC-Bci-013645 Botrytis cinerea 60.49 3.00e-108 384.00
IUUC-Bdi-014727 Brachypodium distachyon 76.40 8.00e-150 522.00
IUUC-Bol-015205 Brassica oleracea 92.09 0.00e+00 647.00
IUUC-Bra-017649 Brassica rapa 92.09 0.00e+00 647.00
IUUC-Cel-018469 Caenorhabditis elegans 55.19 3.00e-105 374.00
IUUC-Cre-022735 Chlamydomonas reinhardtii 64.74 3.00e-119 420.00
IUUC-Cho-024915 Choloepus hoffmanni 71.71 3.00e-81 294.00
IUUC-Cin-025353 Ciona intestinalis 65.87 4.00e-113 400.00
IUUC-Csv-026118 Ciona savignyi 65.57 1.00e-113 401.00
IUUC-Cgl-026511 Colletotrichum gloeosporioides 54.25 4.00e-97 347.00
IUUC-Dse-031497 Dothistroma septosporum 56.55 5.00e-96 343.00
IUUC-Ete-032739 Echinops telfairi 64.74 3.00e-58 218.00
IUUC-Fox-037945 Fusarium oxysporum 52.55 6.00e-96 343.00
IUUC-Fso-038385 Fusarium solani 52.25 5.00e-96 343.00
IUUC-Ggr-039968 Gaeumannomyces graminis 51.69 8.00e-99 352.00
IUUC-Ggo-044523 Gorilla gorilla 61.63 2.00e-101 361.00
IUUC-Kpa-049139 Komagataella pastoris 61.49 1.00e-60 226.00
IUUC-Lpe-050737 Leersia perrieri 77.03 2.00e-158 550.00
IUUC-Mor-057084 Magnaporthe oryzae 54.63 1.00e-101 362.00
IUUC-Mtr-057781 Medicago truncatula 84.38 3.00e-170 590.00
IUUC-Mla-059106 Melampsora laricipopulina 53.69 9.00e-103 365.00
IUUC-Mpu-066096 Mustela putorius furo 60.06 2.00e-90 324.00
IUUC-Ncr-068953 Neurospora crassa 50.00 1.00e-90 325.00
IUUC-Opr-070215 Ochotona princeps 58.93 2.00e-98 351.00
IUUC-Oba-075884 Oryza barthii 73.68 1.00e-155 541.00
IUUC-Obr-076874 Oryza brachyantha 77.87 1.00e-157 548.00
IUUC-Ogl-077169 Oryza glaberrima 78.87 2.00e-159 553.00
IUUC-Ogu-078258 Oryza glumaepatula 79.10 7.00e-159 552.00
IUUC-Oin-079101 Oryza indica 73.95 6.00e-156 542.00
IUUC-Olo-080708 Oryza longistaminata 64.74 1.00e-126 445.00
IUUC-Ome-081571 Oryza meridionalis 73.95 6.00e-156 542.00
IUUC-Oni-082888 Oryza nivara 73.95 6.00e-156 542.00
IUUC-Opu-083182 Oryza punctata 78.87 2.00e-159 553.00
IUUC-Oru-084895 Oryza rufipogon 73.95 6.00e-156 542.00
IUUC-Osa-085331 Oryza sativa 78.87 2.00e-159 553.00
IUUC-Pop-098905 Populus trichocarpa 82.55 5.00e-170 589.00
IUUC-Pgr-103452 Puccinia graminis 51.08 7.00e-96 343.00
IUUC-Ptt-103777 Puccinia triticina 52.52 9.00e-91 326.00
IUUC-Sce-106319 Saccharomyces cerevisiae 49.66 6.00e-40 157.00
IUUC-Sja-107822 Schizosaccharomyces japonicus 44.93 7.00e-48 183.00
IUUC-Ssl-108428 Sclerotinia sclerotiorum 60.49 1.00e-107 382.00
IUUC-Smo-108821 Selaginella moellendorffii 77.50 6.00e-155 539.00
IUUC-Sly-110851 Solanum lycopersicum 83.66 4.00e-174 603.00
IUUC-Stu-112776 Solanum tuberosum 83.84 3.00e-173 600.00
IUUC-Tre-122030 Trichoderma reesei 54.38 5.00e-99 353.00
IUUC-Tvi-122506 Trichoderma virens 53.27 5.00e-98 350.00
IUUC-Tae-125382 Triticum aestivum 77.44 2.00e-155 540.00
IUUC-Tur-126517 Triticum urartu 78.98 1.00e-148 518.00
IUUC-Tme-127122 Tuber melanosporum 60.54 1.00e-110 392.00
IUUC-Uma-129390 Ustilago maydis 52.14 2.00e-100 358.00
IUUC-Vda-129932 Verticillium dahliae 50.42 5.00e-95 340.00
Created Date 25-Jun-2017

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