iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
circBase
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.00e-84	283.4	230	544

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle.....kkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeqqDaqEf 95
           G++N+gNtC+mN+vLQ+L++i+e+re++ +      + ++ +e ++ ++   l+++++kl+ +    s ++ ++p+e+ +a+ ++ ++f+g++q+D++Ef
   Q: 230  GMRNVGNTCFMNAVLQALASISEFREYIMSlssleDYIHDEKEPKNGGNYCYLTDEYRKLLISQSaRSFREPTAPNEFREAFISVCPRFRGFRQHDSHEF 329
           9*****************************86544222222223334455599999999887776799999***************************** PP
   S: 96   laflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesft 195
           +++++d+l++e+ k              ++l        +  ++++is+ F+g+l+s+++c++c+n s++ ++f+dlsl++p +++ +k  l+dcL+ f+
   Q: 330  MRYFMDSLHTEMRK-------------CRKL-----PGMPDDKHTPISKYFEGTLQSSVICQTCRNCSNKIDEFMDLSLDIPAQRNASKVRLSDCLSTFF 411
           ************22.............1222.....34467789******************************************************** PP
   S: 196  keeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsG.slssG 293
           k e+le+ +k +c kck kq+++k++ ++klP+vL+lh+kRf     +++  k++  ++fp   Ld+++f+t+++++   +++Y+L +++vH G +++sG
   Q: 412  KLEMLEKGEKPECAKCKTKQTCSKQMFIRKLPQVLCLHMKRF-----RDNGGKNDAIIDFPMGqLDVTQFLTDDSDEA--PCTYSLQSIIVHIGyGCGSG 504
           ******************************************.....4556799*******989*********77776..******************** PP
   S: 294  HYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           HY+a+ k  +g+W++fdD+ V+ v+e+ v +   ++aYvl+Y++
   Q: 505  HYIAFGKR-NGRWFQFDDTVVKGVDEAHVSK---QKAYVLLYTK 544
           *******9.999*******************...********87 PP

Organism

Caenorhabditis elegans

Protein Sequence
(Fasta)

MLCTHIKAED CVERVPKGMF RKKQDMEDNN LFLEGNSNRG KVVKNQEIIK TFCDECDNCN 60
KSLMCLTCGR ILCGRNDSGH ALHHFEETSH PVVIDCISFE LYCYSCDDEV SLDFEPSLYG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTTTGCA CCCATATAAA GGCGGAAGAT TGTGTGGAGC GTGTGCCCAA GGGGATGTTC 60
CGCAAGAAAC AGGACATGGA GGACAATAAT TTGTTCTTGG AGGGAAATTC GAATCGTGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

cel:CELE_Y71A12B.9

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001017	Aegilops tauschii	37.92	8.00e-35	140.00
IUUC-Aml-001537	Ailuropoda melanoleuca	36.80	1.00e-49	189.00
IUUC-Atr-002832	Amborella trichopoda	32.93	8.00e-38	150.00
IUUC-Apl-003358	Anas platyrhynchos	37.85	1.00e-43	169.00
IUUC-Aca-004454	Anolis carolinensis	37.08	1.00e-43	169.00
IUUC-Aly-006389	Arabidopsis lyrata	33.23	9.00e-41	160.00
IUUC-Ath-006710	Arabidopsis thaliana	33.03	6.00e-41	161.00
IUUC-Acl-008124	Aspergillus clavatus	29.85	1.00e-32	132.00
IUUC-Afl-008464	Aspergillus flavus	28.99	2.00e-28	118.00
IUUC-Afu-008912	Aspergillus fumigatus	28.65	1.00e-32	132.00
IUUC-Ani-009168	Aspergillus nidulans	28.70	2.00e-28	119.00
IUUC-Ang-009694	Aspergillus niger	29.46	9.00e-30	123.00
IUUC-Aor-010035	Aspergillus oryzae	33.20	1.00e-26	112.00
IUUC-Ate-010382	Aspergillus terreus	29.52	9.00e-31	126.00
IUUC-Ame-011544	Astyanax mexicanus	36.97	3.00e-47	181.00
IUUC-Bgr-012150	Blumeria graminis	25.80	6.00e-24	104.00
IUUC-Bta-012738	Bos taurus	37.08	2.00e-43	168.00
IUUC-Bci-013604	Botrytis cinerea	25.58	2.00e-30	125.00
IUUC-Bdi-014036	Brachypodium distachyon	33.64	1.00e-39	157.00
IUUC-Bol-016356	Brassica oleracea	33.13	2.00e-37	149.00
IUUC-Bra-018096	Brassica rapa	33.13	3.00e-36	145.00
IUUC-Cja-018893	Callithrix jacchus	36.77	2.00e-40	159.00
IUUC-Cfa-020607	Canis familiaris	37.08	3.00e-43	168.00
IUUC-Cpo-021828	Cavia porcellus	36.97	4.00e-43	167.00
IUUC-Csa-023884	Chlorocebus sabaeus	37.08	1.00e-43	169.00
IUUC-Cho-024863	Choloepus hoffmanni	37.42	3.00e-34	138.00
IUUC-Cin-025797	Ciona intestinalis	31.12	9.00e-45	172.00
IUUC-Csv-026132	Ciona savignyi	32.19	3.00e-44	171.00
IUUC-Cgl-026457	Colletotrichum gloeosporioides	27.07	9.00e-28	116.00
IUUC-Cme-027339	Cyanidioschyzon merolae	32.94	1.00e-39	155.00
IUUC-Dre-028452	Danio rerio	37.25	6.00e-51	194.00
IUUC-Dno-029531	Dasypus novemcinctus	37.08	4.00e-44	171.00
IUUC-Dor-030574	Dipodomys ordii	33.14	2.00e-44	172.00
IUUC-Dse-031415	Dothistroma septosporum	26.32	2.00e-28	119.00
IUUC-Dme-032208	Drosophila melanogaster	29.88	3.00e-36	145.00
IUUC-Ete-032611	Echinops telfairi	34.73	1.00e-39	156.00
IUUC-Eca-033622	Equus caballus	37.64	9.00e-44	169.00
IUUC-Eeu-035268	Erinaceus europaeus	35.77	2.00e-37	149.00
IUUC-Fca-035801	Felis catus	37.57	6.00e-44	170.00
IUUC-Fal-036749	Ficedula albicollis	36.52	4.00e-43	167.00
IUUC-Fox-038046	Fusarium oxysporum	26.50	6.00e-26	110.00
IUUC-Fso-038321	Fusarium solani	27.64	1.00e-26	112.00
IUUC-Gmo-039598	Gadus morhua	37.08	8.00e-53	199.00
IUUC-Ggr-040044	Gaeumannomyces graminis	27.65	6.00e-28	117.00
IUUC-Gga-040883	Gallus gallus	37.08	1.00e-43	169.00
IUUC-Gac-042235	Gasterosteus aculeatus	35.47	2.00e-48	185.00
IUUC-Gma-044075	Glycine max	33.43	5.00e-39	155.00
IUUC-Ggo-044767	Gorilla gorilla	36.90	4.00e-40	157.00
IUUC-Hsa-046581	Homo sapiens	37.08	2.00e-43	169.00
IUUC-Itr-047898	Ictidomys tridecemlineatus	37.57	4.00e-44	171.00
IUUC-Kpa-049135	Komagataella pastoris	32.22	1.00e-36	146.00
IUUC-Lch-049732	Latimeria chalumnae	37.85	3.00e-51	194.00
IUUC-Lpe-051574	Leersia perrieri	34.36	3.00e-40	159.00
IUUC-Loc-052371	Lepisosteus oculatus	36.97	1.00e-49	189.00
IUUC-Lma-053105	Leptosphaeria maculans	27.54	1.00e-29	123.00
IUUC-Laf-054565	Loxodonta africana	37.99	4.00e-44	171.00
IUUC-Mcc-055522	Macaca mulatta	37.08	2.00e-43	169.00
IUUC-Meu-056542	Macropus eugenii	32.84	3.00e-43	168.00
IUUC-Mor-057103	Magnaporthe oryzae	26.90	2.00e-24	105.00
IUUC-Mpo-057621	Magnaporthe poae	27.61	6.00e-27	114.00
IUUC-Mtr-058537	Medicago truncatula	32.22	1.00e-36	147.00
IUUC-Mla-059185	Melampsora laricipopulina	29.52	7.00e-35	140.00
IUUC-Mga-060020	Meleagris gallopavo	33.92	5.00e-46	177.00
IUUC-Mmr-060839	Microcebus murinus	37.08	2.00e-43	169.00
IUUC-Mdo-062339	Monodelphis domestica	37.08	1.00e-43	169.00
IUUC-Mmu-063638	Mus musculus	36.49	1.00e-39	156.00
IUUC-Mac-065596	Musa acuminata	32.32	4.00e-30	124.00
IUUC-Mpu-066647	Mustela putorius furo	37.08	2.00e-43	169.00
IUUC-Mlu-067921	Myotis lucifugus	35.96	1.00e-47	182.00
IUUC-Nfi-068423	Neosartorya fischeri	28.65	2.00e-32	132.00
IUUC-Ncr-068809	Neurospora crassa	28.14	1.00e-29	122.00
IUUC-Nle-069752	Nomascus leucogenys	37.08	2.00e-43	169.00
IUUC-Opr-070907	Ochotona princeps	32.45	3.00e-43	168.00
IUUC-Ont-071638	Oreochromis niloticus	36.57	2.00e-53	202.00
IUUC-Oan-073417	Ornithorhynchus anatinus	37.29	7.00e-44	170.00
IUUC-Ocu-074620	Oryctolagus cuniculus	37.05	2.00e-43	168.00
IUUC-Oba-075866	Oryza barthii	34.67	3.00e-41	162.00
IUUC-Obr-076408	Oryza brachyantha	34.77	2.00e-41	163.00
IUUC-Ogl-077239	Oryza glaberrima	34.46	2.00e-41	162.00
IUUC-Ogu-078064	Oryza glumaepatula	34.46	2.00e-41	162.00
IUUC-Oin-079157	Oryza indica	34.46	2.00e-41	162.00
IUUC-Olo-080569	Oryza longistaminata	32.22	1.00e-40	160.00
IUUC-Ome-081746	Oryza meridionalis	34.46	2.00e-41	162.00
IUUC-Oni-082339	Oryza nivara	34.46	2.00e-41	163.00
IUUC-Opu-083194	Oryza punctata	34.46	4.00e-41	162.00
IUUC-Oru-085083	Oryza rufipogon	34.46	2.00e-41	162.00
IUUC-Osa-086180	Oryza sativa	34.46	2.00e-41	162.00
IUUC-Ola-087281	Oryzias latipes	35.08	2.00e-48	184.00
IUUC-Oga-088448	Otolemur garnettii	37.08	2.00e-43	169.00
IUUC-Oar-090132	Ovis aries	36.77	4.00e-43	167.00
IUUC-Ptr-090696	Pan troglodytes	37.08	1.00e-43	169.00
IUUC-Pan-092124	Papio anubis	36.80	3.00e-43	168.00
IUUC-Psi-093801	Pelodiscus sinensis	37.78	7.00e-44	169.00
IUUC-Pma-094300	Petromyzon marinus	40.75	5.00e-43	166.00
IUUC-Pno-095141	Phaeosphaeria nodorum	28.95	1.00e-29	122.00
IUUC-Ppa-095241	Physcomitrella patens	33.13	1.00e-40	159.00
IUUC-Pfo-096330	Poecilia formosa	36.74	1.00e-51	196.00
IUUC-Pab-098191	Pongo abelii	37.08	2.00e-43	169.00
IUUC-Pop-099067	Populus trichocarpa	33.74	1.00e-39	157.00
IUUC-Pca-100205	Procavia capensis	31.31	2.00e-43	168.00
IUUC-Ppe-101583	Prunus persica	28.61	4.00e-31	128.00
IUUC-Pva-103177	Pteropus vampyrus	36.80	1.00e-40	159.00
IUUC-Pgr-103270	Puccinia graminis	30.46	8.00e-37	147.00
IUUC-Ptt-103887	Puccinia triticina	30.67	6.00e-37	147.00
IUUC-Pte-104340	Pyrenophora teres	25.38	1.00e-22	99.40
IUUC-Pyt-104782	Pyrenophora triticirepentis	28.01	2.00e-30	125.00
IUUC-Rno-105048	Rattus norvegicus	36.49	1.00e-39	156.00
IUUC-Sce-106247	Saccharomyces cerevisiae	29.41	7.00e-28	117.00
IUUC-Sha-107429	Sarcophilus harrisii	37.08	1.00e-43	169.00
IUUC-Sja-107805	Schizosaccharomyces japonicus	29.19	4.00e-32	130.00
IUUC-Spo-108119	Schizosaccharomyces pombe	30.53	2.00e-38	151.00
IUUC-Ssl-108531	Sclerotinia sclerotiorum	25.48	2.00e-28	119.00
IUUC-Smo-108763	Selaginella moellendorffii	33.03	1.00e-37	149.00
IUUC-Sit-109895	Setaria italica	34.46	3.00e-40	159.00
IUUC-Sly-111383	Solanum lycopersicum	33.23	4.00e-37	148.00
IUUC-Stu-112476	Solanum tuberosum	32.42	5.00e-37	148.00
IUUC-Sar-113024	Sorex araneus	37.25	2.00e-43	169.00
IUUC-Sbi-114477	Sorghum bicolor	33.95	3.00e-40	159.00
IUUC-Sre-114924	Sporisorium reilianum	31.46	1.00e-38	153.00
IUUC-Ssc-115955	Sus scrofa	32.45	3.00e-41	162.00
IUUC-Tgu-117277	Taeniopygia guttata	36.52	4.00e-43	167.00
IUUC-Tru-117844	Takifugu rubripes	35.99	5.00e-49	187.00
IUUC-Tsy-119456	Tarsius syrichta	35.51	2.00e-40	158.00
IUUC-Tni-120251	Tetraodon nigroviridis	34.70	2.00e-55	208.00
IUUC-Tca-120936	Theobroma cacao	34.04	6.00e-41	161.00
IUUC-Tre-122139	Trichoderma reesei	29.38	5.00e-30	124.00
IUUC-Tvi-122599	Trichoderma virens	29.10	8.00e-29	120.00
IUUC-Tae-125558	Triticum aestivum	34.05	5.00e-40	158.00
IUUC-Tur-126014	Triticum urartu	34.05	4.00e-40	159.00
IUUC-Tme-127115	Tuber melanosporum	29.86	6.00e-34	137.00
IUUC-Tbe-127423	Tupaia belangeri	37.07	1.00e-33	136.00
IUUC-Ttr-128401	Tursiops truncatus	35.59	3.00e-39	154.00
IUUC-Vda-129829	Verticillium dahliae	30.62	1.00e-25	108.00
IUUC-Vpa-130044	Vicugna pacos	30.82	1.00e-35	142.00
IUUC-Vvi-131535	Vitis vinifera	32.72	1.00e-37	150.00
IUUC-Xtr-132658	Xenopus tropicalis	35.99	3.00e-47	181.00
IUUC-Xma-133369	Xiphophorus maculatus	36.74	5.00e-52	197.00
IUUC-Zma-135556	Zea mays	33.64	7.00e-39	154.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence