iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ggr-039965

Ensembl Protein ID

GGTG_07992T0

UniProt Accession

J3P3A4; J3P3A4_GAGT3

Genbank Protein ID

EJT74146.1

Protein Name

Ubiquitin-related modifier 1

Genbank Nucleotide ID

ADBI01000667

Gene Name

URM1; GGTG_07992

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
GGTG_07992	GGTG_07992T0	GGTG_07992T0

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UDP/UBQ/UBQ_Other	41.18	1.00e-18	86.70	IUUC-Sce-106366

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Gaeumannomyces graminis

Functional Description
(View)

Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.

Protein Sequence
(Fasta)

MSPDAAASST VSQAVVPPPT AHPAATAAAA AAAATPPSEK QHAPTLGIVV EFSGGLEMLF 60
SHQVRHQLAL PNADDQGSPA TIAFLIGYLC RHAMKDARRH LFVLDGHLRP GILVLINDAD 120

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Nucleotide Sequence
(Fasta)

GGGAGACGGC TGGCTCTGCT TGGACCCCTC GCCTAACGGA TGGCAGGTGC GAGCGCCATC 60
AGTTGAGTTT GACCTTCCAG CCCAAATCAG GACAGCATCT TTTGATCAAG CCATCTCGTC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway

Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1

Pfam

PF09138--Urm1

Gene Ontology

GO:0005829--C:cytosol
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002254	Ailuropoda melanoleuca	47.12	2.00e-21	91.70
IUUC-Atr-003089	Amborella trichopoda	41.41	5.00e-18	80.50
IUUC-Apl-003382	Anas platyrhynchos	49.47	2.00e-20	88.60
IUUC-Aca-004981	Anolis carolinensis	45.19	2.00e-20	88.60
IUUC-Aly-005517	Arabidopsis lyrata	37.23	4.00e-14	67.80
IUUC-Ath-006718	Arabidopsis thaliana	40.91	2.00e-11	58.90
IUUC-Ago-007917	Ashbya gossypii	46.94	1.00e-22	96.30
IUUC-Acl-008054	Aspergillus clavatus	71.70	2.00e-20	88.20
IUUC-Afl-008704	Aspergillus flavus	59.55	1.00e-29	119.00
IUUC-Aor-009890	Aspergillus oryzae	59.80	5.00e-35	137.00
IUUC-Bta-012448	Bos taurus	47.12	2.00e-21	92.40
IUUC-Bci-013865	Botrytis cinerea	65.69	3.00e-39	151.00
IUUC-Bdi-014980	Brachypodium distachyon	37.65	3.00e-12	61.60
IUUC-Bol-016055	Brassica oleracea	40.00	6.00e-13	63.90
IUUC-Bra-016845	Brassica rapa	40.00	6.00e-13	63.90
IUUC-Cel-018485	Caenorhabditis elegans	31.43	3.00e-09	51.60
IUUC-Cja-019587	Callithrix jacchus	48.08	1.00e-21	92.40
IUUC-Cfa-020653	Canis familiaris	48.08	1.00e-21	92.80
IUUC-Cpo-021622	Cavia porcellus	48.08	1.00e-21	92.40
IUUC-Cre-023015	Chlamydomonas reinhardtii	47.47	8.00e-20	86.70
IUUC-Csa-023756	Chlorocebus sabaeus	44.44	2.00e-13	66.60
IUUC-Cgl-026518	Colletotrichum gloeosporioides	71.29	2.00e-41	158.00
IUUC-Cne-026953	Cryptococcus neoformans	42.86	6.00e-19	84.70
IUUC-Cme-027314	Cyanidioschyzon merolae	48.04	5.00e-18	80.50
IUUC-Dre-027884	Danio rerio	48.08	4.00e-21	91.30
IUUC-Dno-029262	Dasypus novemcinctus	42.39	2.00e-13	67.00
IUUC-Dor-030601	Dipodomys ordii	43.08	1.00e-07	45.80
IUUC-Dme-031893	Drosophila melanogaster	48.08	1.00e-21	92.80
IUUC-Ete-032773	Echinops telfairi	46.46	6.00e-20	87.00
IUUC-Eca-034187	Equus caballus	49.04	9.00e-22	93.20
IUUC-Eeu-034808	Erinaceus europaeus	47.12	2.00e-20	89.00
IUUC-Fca-036107	Felis catus	49.04	4.00e-22	94.40
IUUC-Fal-036607	Ficedula albicollis	48.42	9.00e-20	86.30
IUUC-Fox-037698	Fusarium oxysporum	68.81	2.00e-41	158.00
IUUC-Gmo-039492	Gadus morhua	46.32	5.00e-19	84.00
IUUC-Gga-041268	Gallus gallus	48.08	7.00e-22	93.60
IUUC-Gac-042111	Gasterosteus aculeatus	46.15	8.00e-21	90.10
IUUC-Gma-043240	Glycine max	40.32	2.00e-10	55.50
IUUC-Ggo-045176	Gorilla gorilla	44.87	5.00e-10	55.10
IUUC-Hsa-046077	Homo sapiens	47.12	6.00e-18	80.50
IUUC-Itr-048111	Ictidomys tridecemlineatus	48.39	7.00e-16	73.20
IUUC-Kpa-049157	Komagataella pastoris	47.06	1.00e-20	89.40
IUUC-Lch-049889	Latimeria chalumnae	43.27	9.00e-20	86.70
IUUC-Lpe-050783	Leersia perrieri	40.98	3.00e-09	51.60
IUUC-Loc-052400	Lepisosteus oculatus	44.23	4.00e-19	84.30
IUUC-Lma-053259	Leptosphaeria maculans	65.69	1.00e-37	146.00
IUUC-Laf-053596	Loxodonta africana	47.17	8.00e-21	90.10
IUUC-Mcc-054845	Macaca mulatta	47.42	7.00e-19	83.60
IUUC-Meu-055968	Macropus eugenii	49.04	1.00e-22	96.30
IUUC-Mor-057126	Magnaporthe oryzae	72.64	2.00e-43	166.00
IUUC-Mpo-057311	Magnaporthe poae	87.96	2.00e-54	202.00
IUUC-Mtr-058266	Medicago truncatula	35.29	5.00e-12	60.80
IUUC-Mla-058847	Melampsora laricipopulina	40.20	5.00e-13	64.70
IUUC-Mga-059468	Meleagris gallopavo	49.47	1.00e-20	89.00
IUUC-Mvi-060235	Microbotryum violaceum	35.76	8.00e-18	81.30
IUUC-Mdo-061948	Monodelphis domestica	47.12	3.00e-22	95.10
IUUC-Mmu-063946	Mus musculus	50.00	5.00e-22	94.00
IUUC-Mac-064812	Musa acuminata	51.02	2.00e-11	58.50
IUUC-Mpu-066763	Mustela putorius furo	49.04	9.00e-22	93.20
IUUC-Mlu-066970	Myotis lucifugus	45.68	6.00e-14	66.60
IUUC-Ncr-068824	Neurospora crassa	63.21	1.00e-36	142.00
IUUC-Nle-069849	Nomascus leucogenys	44.87	4.00e-13	65.50
IUUC-Opr-070227	Ochotona princeps	48.08	1.00e-21	92.40
IUUC-Ont-072530	Oreochromis niloticus	47.12	2.00e-21	92.40
IUUC-Oan-073191	Ornithorhynchus anatinus	47.31	2.00e-18	82.00
IUUC-Ocu-074460	Oryctolagus cuniculus	49.50	6.00e-22	93.60
IUUC-Oba-075499	Oryza barthii	37.04	6.00e-10	55.10
IUUC-Obr-076896	Oryza brachyantha	41.94	5.00e-10	56.20
IUUC-Ogl-077834	Oryza glaberrima	37.04	2.00e-10	55.50
IUUC-Ogu-078622	Oryza glumaepatula	37.04	2.00e-10	55.50
IUUC-Oin-079358	Oryza indica	37.04	5.00e-10	55.80
IUUC-Olo-081035	Oryza longistaminata	32.99	9.00e-12	61.20
IUUC-Oni-082425	Oryza nivara	37.04	2.00e-10	55.50
IUUC-Opu-083461	Oryza punctata	36.90	3.00e-09	52.80
IUUC-Oru-084875	Oryza rufipogon	57.89	4.00e-09	50.40
IUUC-Oga-089128	Otolemur garnettii	49.04	1.00e-21	93.20
IUUC-Oar-089896	Ovis aries	47.12	2.00e-21	92.40
IUUC-Ptr-091618	Pan troglodytes	44.87	6.00e-10	55.10
IUUC-Pan-092238	Papio anubis	44.44	1.00e-13	67.00
IUUC-Psi-093879	Pelodiscus sinensis	48.08	4.00e-22	94.40
IUUC-Pma-094484	Petromyzon marinus	45.07	6.00e-14	67.40
IUUC-Ppa-095801	Physcomitrella patens	40.48	2.00e-15	72.00
IUUC-Pfo-097192	Poecilia formosa	46.15	1.00e-19	86.30
IUUC-Pab-098203	Pongo abelii	47.12	8.00e-18	80.10
IUUC-Pop-099614	Populus trichocarpa	44.64	1.00e-11	59.70
IUUC-Pca-100507	Procavia capensis	44.44	9.00e-14	66.20
IUUC-Ppe-101174	Prunus persica	33.66	1.00e-13	66.20
IUUC-Pva-102735	Pteropus vampyrus	50.00	1.00e-20	89.40
IUUC-Pgr-103510	Puccinia graminis	39.62	3.00e-14	68.90
IUUC-Ptt-103918	Puccinia triticina	38.46	1.00e-13	66.60
IUUC-Pte-104173	Pyrenophora teres	63.73	4.00e-38	147.00
IUUC-Pyt-104806	Pyrenophora triticirepentis	63.73	3.00e-38	147.00
IUUC-Rno-105820	Rattus norvegicus	49.04	5.00e-21	90.50
IUUC-Sce-106366	Saccharomyces cerevisiae	41.18	5.00e-20	87.40
IUUC-Sja-107727	Schizosaccharomyces japonicus	44.44	1.00e-21	92.80
IUUC-Spo-108074	Schizosaccharomyces pombe	44.55	3.00e-15	71.20
IUUC-Smo-108944	Selaginella moellendorffii	39.78	3.00e-14	67.80
IUUC-Sit-110277	Setaria italica	39.51	7.00e-12	60.10
IUUC-Sly-111505	Solanum lycopersicum	43.94	7.00e-14	67.00
IUUC-Stu-112076	Solanum tuberosum	43.94	7.00e-14	67.00
IUUC-Sbi-114274	Sorghum bicolor	40.30	8.00e-11	57.00
IUUC-Sre-114953	Sporisorium reilianum	51.92	7.00e-27	110.00
IUUC-Ssc-115418	Sus scrofa	48.08	6.00e-22	94.00
IUUC-Tgu-117311	Taeniopygia guttata	48.42	1.00e-19	85.90
IUUC-Tru-118598	Takifugu rubripes	48.94	3.00e-19	84.30
IUUC-Tni-120109	Tetraodon nigroviridis	44.76	9.00e-18	79.70
IUUC-Tca-120942	Theobroma cacao	36.25	5.00e-12	60.80
IUUC-Tre-122099	Trichoderma reesei	74.47	2.00e-32	128.00
IUUC-Tvi-122285	Trichoderma virens	71.15	1.00e-33	132.00
IUUC-Tae-125193	Triticum aestivum	41.67	5.00e-12	60.80
IUUC-Tur-126677	Triticum urartu	35.71	2.00e-09	52.40
IUUC-Tme-127120	Tuber melanosporum	60.00	1.00e-34	136.00
IUUC-Tbe-128050	Tupaia belangeri	40.38	4.00e-15	70.90
IUUC-Ttr-129019	Tursiops truncatus	46.15	5.00e-20	87.40
IUUC-Uma-129483	Ustilago maydis	49.04	2.00e-25	105.00
IUUC-Vda-129690	Verticillium dahliae	52.68	6.00e-29	117.00
IUUC-Vvi-131174	Vitis vinifera	40.91	1.00e-11	59.70
IUUC-Xma-133862	Xiphophorus maculatus	46.15	1.00e-19	86.30
IUUC-Yli-134398	Yarrowia lipolytica	44.76	3.00e-22	94.70
IUUC-Zma-134964	Zea mays	37.04	9.00e-13	63.50

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence